KR20160132067A - 암 공격성, 예후 및 치료에 대한 반응성의 결정 - Google Patents

암 공격성, 예후 및 치료에 대한 반응성의 결정 Download PDF

Info

Publication number
KR20160132067A
KR20160132067A KR1020167027926A KR20167027926A KR20160132067A KR 20160132067 A KR20160132067 A KR 20160132067A KR 1020167027926 A KR1020167027926 A KR 1020167027926A KR 20167027926 A KR20167027926 A KR 20167027926A KR 20160132067 A KR20160132067 A KR 20160132067A
Authority
KR
South Korea
Prior art keywords
genes
gene
expression
cancer
expressed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020167027926A
Other languages
English (en)
Korean (ko)
Inventor
파레스 알-에제
Original Assignee
더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from AU2014900813A external-priority patent/AU2014900813A0/en
Application filed by 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치 filed Critical 더 카운실 오브 더 퀸즐랜드 인스티튜트 오브 메디컬 리서치
Publication of KR20160132067A publication Critical patent/KR20160132067A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/575Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57515Immunoassay; Biospecific binding assay; Materials therefor for cancer of the breast
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/112Disease subtyping, staging or classification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/136Screening for pharmacological compounds
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Pathology (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
KR1020167027926A 2014-03-11 2015-03-11 암 공격성, 예후 및 치료에 대한 반응성의 결정 Withdrawn KR20160132067A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
AU2014900813 2014-03-11
AU2014900813A AU2014900813A0 (en) 2014-03-11 Determining cancer agressiveness, prognosis and responsiveness to treatment
AU2014901212 2014-04-03
AU2014901212A AU2014901212A0 (en) 2014-04-03 Determining cancer agressiveness, prognosis and responsiveness to treatment
AU2014904716 2014-11-21
AU2014904716A AU2014904716A0 (en) 2014-11-21 Determining cancer agressiveness, prognosis and responsiveness to treatment
PCT/AU2015/050096 WO2015135035A2 (en) 2014-03-11 2015-03-11 Determining cancer agressiveness, prognosis and responsiveness to treatment

Publications (1)

Publication Number Publication Date
KR20160132067A true KR20160132067A (ko) 2016-11-16

Family

ID=54072534

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167027926A Withdrawn KR20160132067A (ko) 2014-03-11 2015-03-11 암 공격성, 예후 및 치료에 대한 반응성의 결정

Country Status (11)

Country Link
US (1) US20170107577A1 (https=)
EP (1) EP3119908A4 (https=)
JP (1) JP2017508469A (https=)
KR (1) KR20160132067A (https=)
CN (1) CN106661614A (https=)
AU (1) AU2015230677A1 (https=)
BR (1) BR112016020897A2 (https=)
CA (1) CA2941769A1 (https=)
MX (1) MX2016011612A (https=)
SG (2) SG10201807838SA (https=)
WO (1) WO2015135035A2 (https=)

Families Citing this family (61)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
GB201216017D0 (en) 2012-09-07 2012-10-24 Cancer Rec Tech Ltd Inhibitor compounds
CA2947624A1 (en) * 2014-05-13 2015-11-19 Myriad Genetics, Inc. Gene signatures for cancer prognosis
WO2017085326A1 (en) * 2015-11-20 2017-05-26 Universite De Strasbourg Method for identifying personalized therapeutic strategies for patients affected with a cancer
CA3044086A1 (en) * 2015-11-20 2017-05-26 Universite De Strasbourg Method for identifying personalized therapeutic strategies for patients affected with a cancer
WO2017134000A1 (en) * 2016-02-01 2017-08-10 Bayer Pharma Aktiengesellschaft Copanlisib biomarkers
GB201608000D0 (en) 2016-05-06 2016-06-22 Oxford Biodynamics Ltd Chromosome detection
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Hdac抑制劑與pd-l1抑制劑之組合治療
CN107574243B (zh) * 2016-06-30 2021-06-29 博奥生物集团有限公司 分子标志物、内参基因及其应用、检测试剂盒以及检测模型的构建方法
CN118108847A (zh) * 2016-08-07 2024-05-31 诺华股份有限公司 mRNA介导的免疫方法
US9725769B1 (en) * 2016-10-07 2017-08-08 Oncology Venture ApS Methods for predicting drug responsiveness in cancer patients
US11672801B2 (en) 2016-10-19 2023-06-13 United States Government As Represented By The Department Of Veterans Affairs Compositions and methods for treating cancer
WO2018152585A1 (en) * 2017-02-23 2018-08-30 The Council Of The Queensland Institute Of Medical Research "biomarkers for diagnosing conditions"
WO2018161081A1 (en) * 2017-03-03 2018-09-07 Board Of Regents, The University Of Texas System Gene signatures to predict drug response in cancer
KR20190133038A (ko) * 2017-03-28 2019-11-29 난토믹스, 엘엘씨 PARADIGM을 이용한 유방암에서의 miRNA 유도 침묵 모델링(MODELING miRNA INDUCED SILENCING IN BREAST CANCER WITH PARADIGM)
WO2018183762A1 (en) 2017-03-29 2018-10-04 United States Government As Represented By The Department Of Veterans Affairs Methods and compositions for treating cancer
US10854338B2 (en) * 2017-03-29 2020-12-01 Imaging Endpoints II LLC Predicting breast cancer responsiveness to hormone treatment using quantitative textural analysis
WO2018177326A1 (en) * 2017-03-29 2018-10-04 Crown Bioscience Inc. (Taicang) System and method for determining karenitecin sensitivity on cancer
WO2018183921A1 (en) * 2017-04-01 2018-10-04 The Broad Institute, Inc. Methods and compositions for detecting and modulating an immunotherapy resistance gene signature in cancer
GB202209539D0 (en) * 2017-06-13 2022-08-10 Bostongene Corp Systems and methods for identifying cancer treatments from normalized biomarker scores
EP3641745A1 (en) * 2017-06-20 2020-04-29 The Institute of Cancer Research : The Royal Cancer Hospital Methods and medical uses
GB201709840D0 (en) 2017-06-20 2017-08-02 Inst Of Cancer Research: Royal Cancer Hospital Methods and medical uses
US20200124604A1 (en) * 2017-06-30 2020-04-23 National Institutes Of Biomedical Innovation, Health And Nutrition Biomarker for detecting colorectal cancer
AU2018300007A1 (en) 2017-07-10 2020-02-27 Cornell University Targeting chromosomal instability and downstream cytosolic DNA signaling for cancer treatment
WO2019070755A1 (en) * 2017-10-02 2019-04-11 The Broad Institute, Inc. METHODS AND COMPOSITIONS FOR DETECTING AND MODULATING A GENETIC SIGNATURE OF IMMUNOTHERAPY RESISTANCE IN CANCER
CN107868825A (zh) * 2017-11-21 2018-04-03 山东省千佛山医院 一种诊治肺腺癌的分子标记物
WO2019173456A1 (en) * 2018-03-06 2019-09-12 Board Of Regents, The University Of Texas System Replication stress response biomarkers for immunotherapy response
EP4552696A3 (en) * 2018-05-15 2025-11-05 Allarity Therapeutics Europe ApS Methods for predicting drug responsiveness in cancer patients
CN108704135A (zh) * 2018-05-24 2018-10-26 江苏大学附属医院 Chaf1a抑制剂在制备胃癌治疗药物中的用途
CN108866189B (zh) * 2018-07-12 2022-03-01 吉林大学 一种喉鳞状细胞癌易感性预测试剂盒及系统
CN108841959B (zh) * 2018-07-12 2022-03-01 吉林大学 一种口腔及头颈部恶性肿瘤易感性预测试剂盒及系统
CN108949984B (zh) * 2018-07-25 2022-01-11 中山大学肿瘤防治中心(中山大学附属肿瘤医院、中山大学肿瘤研究所) 基因desi2在三阴乳腺癌诊断、预后评估及治疗中的应用
CN109593771B (zh) * 2018-07-27 2022-03-29 四川大学华西医院 一种人类map2k5第1100位碱基突变基因及其检测试剂盒
CN110787296B (zh) * 2018-08-01 2024-04-16 复旦大学附属肿瘤医院 一种用于预防或治疗胰腺癌的药物组合物及检测胰腺癌的试剂盒
WO2020092924A1 (en) * 2018-11-02 2020-05-07 Board Of Regents, The University Of Texas System Combination therapy for the treatment of egfr tyrosine kinase inhibitor resistant cancer
CN110286219A (zh) * 2019-04-16 2019-09-27 福建师范大学 死亡相关蛋白激酶1在制备肾透明细胞癌术后预后评估试剂盒中的应用
CN111370056B (zh) * 2019-05-22 2021-03-30 深圳思勤医疗科技有限公司 确定待测样本预定染色体不稳定指数的方法、系统和计算机可读介质
JP7352937B2 (ja) * 2019-07-19 2023-09-29 公立大学法人福島県立医科大学 乳癌のサブタイプを鑑別又は分類するための鑑別マーカー遺伝子セット、方法およびキット
US11715565B2 (en) * 2019-11-08 2023-08-01 Tempus Labs, Inc. Evaluating effect of event on condition using propensity scoring
WO2021168200A1 (en) * 2020-02-19 2021-08-26 United States Government As Represented By The Department Of Veterans Affairs Identification of an egfr-bin3 pathway that actively suppresses invasion and reduces tumor size in glioblastoma
WO2021231237A2 (en) * 2020-05-11 2021-11-18 Augmenta Bioworks, Inc. Antibodies for sars-cov-2 and uses thereof
EP4181926A4 (en) * 2020-07-15 2024-08-21 Queensland University Of Technology DETERMINING THE RESPONSIVENESS OF A CANCER TO A TREATMENT
CN112133369B (zh) * 2020-08-26 2023-09-22 吴安华 基于活性氧评估肿瘤患者预后性的系统以及药物敏感性评价与改善方法
WO2022058427A1 (en) * 2020-09-16 2022-03-24 Novigenix Sa Biomarkers for immune checkpoint inhibitors treatment
CN112111575B (zh) * 2020-09-22 2023-01-10 重庆医科大学附属第一医院 胰岛素样生长因子2在恶性肿瘤预后和治疗选择中的应用
GB2628478A (en) 2020-10-29 2024-09-25 Ambergen Inc Novel photocleavable mass-tags for multiplexed mass spectrometric imaging of tissues using biomolecular probes
EP4247977A2 (en) * 2020-11-23 2023-09-27 Sanofi Panel of er regulated genes for use in monitoring endocrine therapy in breast cancer
AU2021410776A1 (en) * 2020-12-23 2023-05-04 Chan Zuckerberg Biohub, Inc. Bacteria-engineered to elicit antigen-specific t cells
WO2022217060A1 (en) * 2021-04-09 2022-10-13 Cardiff Oncology, Inc. Cancer treatment using parp inhibitors and plk1 inhibitors
CN113292643A (zh) * 2021-05-31 2021-08-24 南京市第二医院 一种肝癌肿瘤标志物及其应用
CN113355419B (zh) * 2021-06-28 2022-02-18 广州中医药大学(广州中医药研究院) 一种乳腺癌预后风险预测标志组合物及应用
CN113502329A (zh) * 2021-07-12 2021-10-15 隋雨桐 检测腺苷受体a2b表达量的试剂在制备肺腺癌的诊断和/或预后试剂盒中的应用
CA3240376A1 (en) * 2021-12-08 2023-06-15 Alexander MEVES Assessing and treating melanoma
CN114540500A (zh) * 2022-03-21 2022-05-27 深圳市陆为生物技术有限公司 评价乳腺癌患者整体生存的产品
CN115369173A (zh) * 2022-09-23 2022-11-22 河北医科大学第三医院 基因标志物组合在预测膀胱尿路上皮癌预后中的应用
EP4494152A4 (en) 2023-06-09 2025-10-08 Seekin Inc Shenzhen China METHODS FOR DETECTING CANCER
CN119913252A (zh) * 2023-10-31 2025-05-02 南京安吉生物科技有限公司 Gemin4基因及Gemin4蛋白在肿瘤中的应用
CN120290720B (zh) * 2025-04-11 2025-12-23 新疆医科大学第三附属医院 靶向RPS4X基因的siRNA、LAMB3-PI3K-AKT信号通路抑制剂、卵巢癌药物及应用
CN120594831B (zh) * 2025-05-30 2026-03-13 南方医科大学南方医院 细胞外囊泡膜蛋白在制备早期胃癌诊断试剂盒中的应用
CN120536581B (zh) * 2025-06-19 2026-04-17 十堰市太和医院(湖北医药学院附属医院) Ul16结合蛋⽩2作为结直肠癌标志物

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4679149B2 (ja) * 2002-09-30 2011-04-27 オンコセラピー・サイエンス株式会社 ヒト膵癌に関連する遺伝子およびポリペプチド
ES2504242T3 (es) * 2004-02-20 2014-10-08 Janssen Diagnostics, Llc Pronóstico de cáncer de mama
JP2005270093A (ja) * 2004-02-24 2005-10-06 Nippon Medical School 乳癌の術後予後予測に関与する遺伝子
EP1777523A1 (en) * 2005-10-19 2007-04-25 INSERM (Institut National de la Santé et de la Recherche Médicale) An in vitro method for the prognosis of progression of a cancer and of the outcome in a patient and means for performing said method
WO2007072225A2 (en) * 2005-12-01 2007-06-28 Medical Prognosis Institute Methods and devices for identifying biomarkers of treatment response and use thereof to predict treatment efficacy
MX2009002535A (es) * 2006-09-05 2009-03-20 Veridex Llc Metodos para predecir la metastasis distante de cancer de mama primario negativo en el nodo linfatico, utilizando el analisis de expresion del gen de la trayectoria biologica.
NZ589143A (en) * 2008-05-14 2012-02-24 Genomic Health Inc Colorectal cancer response prediction based on AREG EREG DUSP6 and SLC26A3 expression levels
WO2010076322A1 (en) * 2008-12-30 2010-07-08 Siemens Healthcare Diagnostics Inc. Prediction of response to taxane/anthracycline-containing chemotherapy in breast cancer
WO2010129965A1 (en) * 2009-05-08 2010-11-11 The Regents Of The University Of California Cancer specific mitotic network
KR101287600B1 (ko) * 2011-01-04 2013-07-18 주식회사 젠큐릭스 초기유방암의 예후 예측용 유전자 및 이를 이용한 초기유방암의 예후예측 방법
WO2013163134A2 (en) * 2012-04-23 2013-10-31 The Trustees Of Columbia University In The City Of New York Biomolecular events in cancer revealed by attractor metagenes
WO2013169388A1 (en) * 2012-05-08 2013-11-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Predictive biomarkers for ctla-4 blockade therapy and for pd-1 blockade therapy

Also Published As

Publication number Publication date
MX2016011612A (es) 2016-12-12
US20170107577A1 (en) 2017-04-20
BR112016020897A2 (en) 2018-01-23
CA2941769A1 (en) 2015-09-17
AU2015230677A1 (en) 2016-10-27
EP3119908A2 (en) 2017-01-25
SG11201607448PA (en) 2016-10-28
CN106661614A (zh) 2017-05-10
WO2015135035A2 (en) 2015-09-17
WO2015135035A3 (en) 2016-09-15
EP3119908A4 (en) 2018-02-21
JP2017508469A (ja) 2017-03-30
SG10201807838SA (en) 2018-10-30

Similar Documents

Publication Publication Date Title
KR20160132067A (ko) 암 공격성, 예후 및 치료에 대한 반응성의 결정
ES2656487T3 (es) Evaluación de la respuesta a la terapia de neoplasmas neuroendocrinos gastroenteropancreáticas (GEP-NEN)
CA2807557C (en) Diagnosis of primary and metastatic basal-like breast cancer and other cancer types
JP6144695B2 (ja) タキサン療法を用いて乳癌を処置する方法
US11788148B2 (en) Prognostic and treatment response predictive method
US12545961B2 (en) Method of predicting risk of recurrence of cancer
US20120323594A1 (en) Prognostic and predictive gene signature for non-small cell lung cancer and adjuvant chemotherapy
JP2017532959A (ja) Mdm2阻害剤に対する感受性の遺伝子シグネチャーに基づく予測因子に関するアルゴリズム
WO2014085666A1 (en) Methods of characterizing and treating molecular subset of muscle-invasive bladder cancer
JP2017508442A (ja) Mdm2阻害剤に対する感受性と関連する遺伝子シグネチャー
EP3102700A1 (en) Molecular diagnostic test for predicting response to anti-angiogenic drugs and prognosis of cancer
WO2012066451A1 (en) Prognostic and predictive gene signature for colon cancer
Wu et al. Long noncoding RNA HOTTIP expression predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation
Yamaguchi et al. Molecular and clinical features of the TP53 signature gene expression profile in early-stage breast cancer
US20110320392A1 (en) Methods for predicting cancer response to egfr inhibitors
CN110225984A (zh) 鉴别癌症风险的方法和治疗选择
US9200328B1 (en) Methods and kits for diagnosing the prognosis of cancer patients
Lerebours et al. Hemoglobin overexpression and splice signature as new features of inflammatory breast cancer?
WO2015127101A1 (en) Method and composition for diagnosis of aggressive prostate cancer
Mendiola et al. Angiogenesis-related gene expression profile with independent prognostic value in advanced ovarian carcinoma
KR102939030B1 (ko) 전이성 신장암 예후 예측용 신규 바이오마커 및 이의 용도
Cui et al. MicroRNA expression and regulation in human ovarian carcinoma cells by luteinizing hormone
JP2022023238A (ja) 多発性骨髄腫のためのgep5モデル
Doisneau-Sixou et al. From genomic data analysis to drug development: a new generation of trials using molecular marker assessment in breast cancer
Rotbauer Exploring the Role of Circulating Tumour Cell-Associated Genes in Estrogen Receptor-Positive Breast Cancer

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20161007

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination