KR20160126027A - 급성 림프아구성 백혈병을 치료하기 위한 항-cd38 항체 - Google Patents

급성 림프아구성 백혈병을 치료하기 위한 항-cd38 항체 Download PDF

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KR20160126027A
KR20160126027A KR1020167026218A KR20167026218A KR20160126027A KR 20160126027 A KR20160126027 A KR 20160126027A KR 1020167026218 A KR1020167026218 A KR 1020167026218A KR 20167026218 A KR20167026218 A KR 20167026218A KR 20160126027 A KR20160126027 A KR 20160126027A
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antibody
seq
ser
val
cells
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Korean (ko)
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파울 도시
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얀센 바이오테크 인코포레이티드
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Application filed by 얀센 바이오테크 인코포레이티드 filed Critical 얀센 바이오테크 인코포레이티드
Priority to KR1020227028429A priority Critical patent/KR102588587B1/ko
Publication of KR20160126027A publication Critical patent/KR20160126027A/ko
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/475—Quinolines; Isoquinolines having an indole ring, e.g. yohimbine, reserpine, strychnine, vinblastine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C07K2317/734—Complement-dependent cytotoxicity [CDC]

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Oncology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020167026218A 2014-02-28 2015-02-25 급성 림프아구성 백혈병을 치료하기 위한 항-cd38 항체 Ceased KR20160126027A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227028429A KR102588587B1 (ko) 2014-02-28 2015-02-25 급성 림프아구성 백혈병을 치료하기 위한 항-cd38 항체

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201461946008P 2014-02-28 2014-02-28
US61/946,008 2014-02-28
US201462004540P 2014-05-29 2014-05-29
US62/004,540 2014-05-29
PCT/US2015/017425 WO2015130732A2 (en) 2014-02-28 2015-02-25 Anti-cd38 antibodies for treatment of acute lymphoblastic leukemia

Related Child Applications (1)

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KR1020227028429A Division KR102588587B1 (ko) 2014-02-28 2015-02-25 급성 림프아구성 백혈병을 치료하기 위한 항-cd38 항체

Publications (1)

Publication Number Publication Date
KR20160126027A true KR20160126027A (ko) 2016-11-01

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Family Applications (2)

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KR1020227028429A Active KR102588587B1 (ko) 2014-02-28 2015-02-25 급성 림프아구성 백혈병을 치료하기 위한 항-cd38 항체
KR1020167026218A Ceased KR20160126027A (ko) 2014-02-28 2015-02-25 급성 림프아구성 백혈병을 치료하기 위한 항-cd38 항체

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KR1020227028429A Active KR102588587B1 (ko) 2014-02-28 2015-02-25 급성 림프아구성 백혈병을 치료하기 위한 항-cd38 항체

Country Status (30)

Country Link
US (3) US9732154B2 (OSRAM)
EP (2) EP3110440B9 (OSRAM)
JP (1) JP6543262B2 (OSRAM)
KR (2) KR102588587B1 (OSRAM)
CN (1) CN106456731B (OSRAM)
AU (3) AU2015223209A1 (OSRAM)
BR (1) BR112016019871A2 (OSRAM)
CA (1) CA2940865C (OSRAM)
CL (1) CL2016002157A1 (OSRAM)
CR (1) CR20160387A (OSRAM)
DK (1) DK3110440T5 (OSRAM)
DO (1) DOP2016000225A (OSRAM)
EA (1) EA037597B1 (OSRAM)
ES (1) ES2959504T3 (OSRAM)
FI (1) FI3110440T3 (OSRAM)
GT (1) GT201600171A (OSRAM)
HR (1) HRP20231021T1 (OSRAM)
HU (1) HUE063044T2 (OSRAM)
IL (1) IL247403B (OSRAM)
LT (1) LT3110440T (OSRAM)
MX (2) MX388464B (OSRAM)
MY (1) MY176517A (OSRAM)
PE (1) PE20161389A1 (OSRAM)
PH (1) PH12016501672A1 (OSRAM)
SG (1) SG11201607029QA (OSRAM)
SI (1) SI3110440T1 (OSRAM)
SV (1) SV2016005266A (OSRAM)
UA (1) UA122961C2 (OSRAM)
WO (1) WO2015130732A2 (OSRAM)
ZA (2) ZA201606683B (OSRAM)

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EA202092609A1 (ru) 2014-12-04 2021-10-29 Янссен Байотек, Инк. Антитела к cd38 для лечения острого миелолейкоза
CN108136218B (zh) 2015-05-20 2022-12-13 詹森生物科技公司 用于治疗轻链淀粉样变性及其它cd38阳性血液恶性肿瘤的抗cd38抗体
NZ777133A (en) 2015-06-22 2025-05-02 Janssen Biotech Inc Combination therapies for heme malignancies with anti-cd38 antibodies and survivin inhibitors
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JP7720871B2 (ja) 2020-06-23 2025-08-08 ジアンスー カニョン ファーマシューティカル カンパニー リミテッド 抗ｃｄ３８抗体及びその使用
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