KR20160062981A - Cosmetic Composition for Blocking Ultraviolet Comprising Extract of Crataegus oxyacantha - Google Patents

Abstract

The present invention relates to an ultraviolet-blocking cosmetic composition containing a Crataegus oxyacantha extract as an active ingredient. The cosmetic composition exhibits antioxidative effects, and helps protect skin against ultraviolet light and restore damaged skin due to ultraviolet light when being used in the ultraviolet-blocking cosmetics. Thus, the cosmetic composition can be useful as a cosmetic ingredient for protecting skin against ultraviolet light.

Description

(Cosmetic Composition for Blocking Ultraviolet Comprising Extract of Crataegus oxyacantha)

The present invention relates to a cosmetic composition having an ultraviolet blocking effect by containing a western scarab extract as an active ingredient.

Generally, ultraviolet rays contained in the sunlight are divided into long wavelength ultraviolet rays (UVA, 320 to 400 nm), medium ultraviolet rays (UVB, 280 to 320 nm) and short wavelength ultraviolet rays (UVC, 200 to 280 nm) UV rays are known to cause many side effects on the skin. Ultraviolet rays are the major cause of skin aging, pigmentation of spots and freckles, black spot, and skin cancer. In addition, ultraviolet rays reach 80% of the surface of the earth even on shady or cloudy days and pass through almost all glass, including automotive glass and house glass. Also, in the case of clothes, synthetic fibers have almost no blocking effect, and natural fibers such as cotton products can only block about 70%.

UVC in ultraviolet rays is very harmful to the human body but it is absorbed into the ozone layer in the atmosphere so far and hardly reaches to the surface of the earth. UV rays affecting the skin are divided into UVA and UVB. UVB causes sunburn (skin erythema, It promotes the deposition and skin protein denaturation and skin cell keratinization. UVA induces pigmentation, phototoxicity, photoallergy and penetrates into the skin dermis layer, destroying collagen and elastin, causing skin aging and causing spots and dullness. To protect the skin from harmful ultraviolet rays, various kinds of ultraviolet screening agents have been developed.

Conventional ultraviolet screening agents have used organic substances such as benzophenone derivatives, p-aminobenzoic acid derivatives, cinnamic acid derivatives and triazine derivatives as ultraviolet absorbers, and inorganic pigments such as titanium dioxide and zinc oxide as ultraviolet scattering agents have been used. Organic materials, which are ultraviolet absorbents, can cause side effects such as allergies, irritation and troubles of the skin, and inorganic pigments are opaque when they are used in a large amount and have a disadvantage in that the feeling on use when applying the skin is poor.

Therefore, studies for finding a substance that protects the skin from ultraviolet rays, having an effective ultraviolet absorbing effect while overcoming the disadvantages of the existing ultraviolet screening agents, are being continued.

For example, Korean Patent Laid-Open Publication No. 2011-0125058 has an excellent effect of absorbing ultraviolet ray A to suppress direct irradiation of ultraviolet rays to skin, preventing cell membrane oxidation caused by ultraviolet rays, and restoring skin damage due to ultraviolet rays Discloses a cosmetic composition for protecting against UV rays containing an excellent extract of cornucopia, and Korean Patent No. 10-1326556 discloses a cosmetic composition for protecting against UV rays containing an extract of Oylum and Coleoptera as an active ingredient.

KR 2011-0125058 A KR 10-1326556 R

Accordingly, the present inventors have made various efforts to develop a cosmetic composition having an ultraviolet screening effect while containing a natural extract as an active ingredient. As a result, it has been found that the extract of western hawthorn tree absorbs ultraviolet rays, blocks ultraviolet rays affecting the skin, The present invention has been accomplished by confirming that it is a safe material without skin irritation and can be applied to a cosmetic composition for ultraviolet shielding, which can help the ultraviolet ray shielding effect as well as the skin damaged by ultraviolet rays.

Accordingly, an object of the present invention is to provide a cosmetic composition comprising an effective ingredient of a natural extract which helps the skin to be restored by ultraviolet rays.

To this end, the present invention provides a cosmetic composition for protecting against ultraviolet rays, which contains a western Crest extract as an active ingredient.

The horseradish peroxidase extract according to the present invention has excellent antioxidative effect and is excellent in ultraviolet ray shielding effect without side effects, so that it can be effectively used as a cosmetic composition for ultraviolet ray shielding.

Hereinafter, the present invention will be described in more detail.

Western hawthorn ( Crataegus oxyacantha ) is known to vasodilatation, coercion, arteriosclerosis, digestive stimulation, cardiovascular, gastrointestinal, and analgesic effects. Partially dried fruits are preferably used, and berries contain uronic acid, oleanolic acid, rutin, etc., seeds include amigallin, hyperperin, and fat oil, and bark contains asuculine

In the present invention, the Western Crest Factor extract is obtained by extracting from various organs or parts, and is prepared by adding a solvent to at least one selected from leaves, flowers, stems, branches, roots, outposts, bark and fruit of Western hawthorn .

The western Crestacea extract used as a raw material in the present invention can be obtained by extracting an extract obtained by leaching and transferring from western white hawthorn tree or a concentrate obtained by partially or wholly concentrating the leaching solution or an extract obtained by drying the concentrate again and And the chemical substance itself exhibiting the main effect contained in the extract.

The extract of the present invention can be produced by a conventional method known in the art, that is, by using a conventional solvent, such as a commonly used method such as cold-water treatment, reflux cooling, hot water extraction, room temperature extraction, warm- Extraction, and the like.

Specific examples thereof include purified water, alcohols having 1 to 6 carbon atoms, glycerin, alkylene glycols having 2 to 6 carbon atoms, alkanes having 1 to 6 carbon atoms, halogenated hydrocarbons having 1 to 6 carbon atoms, alkylalkanoates having 2 to 6 carbon atoms, and mixtures thereof Can be used. More specifically, extraction solvents selected from purified water, methanol, ethanol, glycerin, ethylene glycol, butylene glycol, propylene glycol, dichloromethane, dichloroethane, hexane, ethyl acetate and mixtures thereof can be used.

In this case, the amount of the extraction solvent used is 10 to 30 times the volume of the raw material, more preferably 10 to 20 times.

The extraction temperature can be varied by a person skilled in the art in a variety of temperature ranges suitable for the extraction method, for example, but not limited to, from 20 캜 to 100 캜. In addition, the extraction time differs depending on the extraction method, and a person skilled in the art can adopt an appropriate extraction time, and can be performed in a single or multiple cycles in a range of about 1 hour to several days, though it is not limited thereto. The extract obtained by performing the extraction with the primary extraction solvent may be obtained in the form of a liquid in which impurities are removed by filtration according to a conventional method, or the obtained liquid form extract may be concentrated under reduced pressure and / Can be obtained.

The content of the western Crest extract according to the present invention is preferably 0.001 to 30.0% by weight based on the whole composition. The content of the extract is preferably at least the above-mentioned minimum value so that the ultraviolet ray shielding effect can be achieved, and the content of the extract is preferably below the maximum value in consideration of the deterioration of the feeling of use due to the excessive addition and applicability to various formulations. At this time, it is preferable that the content of the extract is appropriately controlled within the above range according to the content of the components contained in the formulation.

In addition, when used as a composition component, the western Crest extract according to the present invention can be used not only in the form of a lyophilized powder, but also in a liquid form dispersed or dissolved in water or a conventional organic solvent.

In addition, the cosmetic composition according to the present invention may contain, in addition to the above-mentioned extract components, other components which can give synergistic effects to the main effect, within the range not impairing the intended main effect of the present invention.

The ingredients contained in the cosmetic composition of the present invention contain, in addition to the above-mentioned effective ingredients, the ingredients commonly used in cosmetic compositions and may contain conventional additives such as stabilizers, solubilizers, vitamins, pigments and fragrances, have.

The cosmetic composition of the present invention can be prepared in any form conventionally produced in the art and specifically includes a solution, a suspension, an emulsion, a gel, a lotion, an essence, a cream, a powder, a soap, a pack mask, , Foundation, spray, and the like.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Hydroxides, microcrystalline cellulose, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is a cream or a gel, wax, paraffin, trachant, animal oil, starch, cellulose derivative, silicone, bentonite, polyethylene glycol, silica, zinc oxide or talc may be used as the carrier component.

When the formulation of the present invention is a powder or a spray, the carrier component may include a propellant such as silica, talc, aluminum hydroxide, lactose, calcium silicate, chlorofluorohydrocarbons, propane / butane or dimethyl ether.

When the formulation of the present invention is a surfactant-containing cleansing, it is preferable to use, as a carrier component, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, imidazolinium derivative, isethionate, methyltaurate, sarcosinate, fatty acid amide ether Aliphatic alcohols, alkylamidobetaines, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives, or ethoxylated glycerol fatty acid esters.

Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided to further understand the present invention, and the present invention is not limited by the examples.

Example 1: Western hawthorn tree water extract

200 g of western blotch was pulverized by grinding machine and pulverized. Then, 1.5 L of water was added and the mixture was extracted at 100 ° C for 3 hours, and then concentrated under reduced pressure with a rotary evaporator (EYELA Digital water bath SB-1000, Japan).

After the extraction, the filtrate was filtered to obtain a filtrate. Water was added thereto to adjust the total volume to 100 ml. The adjusted solution was left at 4 ° C for 6 days, and the resulting precipitates were filtered through a 0.45-μm membrane to obtain a western Crest extract .

Experimental Example 1: Measurement of total polyphenol content

The total polyphenol content of the extract was measured by modifying the Folin-Denis method. 80 μl of the sample solution dissolved in methanol at a concentration of 1 mg / ml and 80 μl of Folin-Denis reagent were mixed and reacted for 3 minutes, followed by mixing 80 μl of 10% Na ₂ CO _3. , 120 μl of the supernatant was transferred to a 96-well plate, and the absorbance at 700 nm was measured. The content of polyphenol was determined by using gallic acid as a standard curve. The results are shown in Table 1 below.

division Western hawthorn tree Total polyphenol content 81.62 + 0.481 mg

Experimental Example 2: Measurement of antioxidative effect

The DPPH (2,2-Diphenyl-1-picrylhydrazyl) method was used to measure the electron donating ability of the extracts. The electron donating ability is a measure of oxidation inhibition by donating electrons to free radicals. If the electron donating ability to DPPH is high, high antioxidant activity and scavenging effect on other radicals including active oxygen can be expected. The extract was diluted as described below, and the free radical scavenging ability was compared with a dilution of 0.1 wt% of ascorbic acid, an antioxidant commonly used in the art.

2 ml of each diluted solution of the extract of Table 2 was added to 1 ml of 0.2 mM DPPH ethanol solution, mixed well at room temperature for 10 seconds, and reacted at 37 캜 for 30 minutes. The absorbance was measured using a UV / VIS spectrometer at 517 nm and the electron donating ability calculated according to the following formula 1 is shown in Table 2 below.

Free radical scavenging ability (%) Ascorbic acid Western hawthorn extract
(0.1% by weight) 84% 82%

Experimental Example 3: Confirmation of ultraviolet absorption effect

The absorbance was measured at a wavelength of 250 nm to 400 nm using a UV / VIS spectrometer to measure ultraviolet absorption. Specifically, the extract was diluted with ethanol to a concentration of 100 ppm, and the ultraviolet absorption spectrum thereof was measured and shown in Table 3.

Wavelength EE x I Absorbance Western hawthorn tree
(Crataegus oxyacantha) 320 0.0180 1.6370 315 0.0837 1.7893 310 0.1864 2.0083 305 0.3278 2.4380 300 0.2874 3.1997 295 0.0817 5.0000 290 0.0150 5.0000

As shown in Table 3 above, the western hornblende extract showed excellent ultraviolet absorbing power. This is considered to be an excellent result considering that the extract of the present invention is a natural product of low concentration.

Experimental Example 4: Confirmation of ultraviolet blocking index

In order to confirm the UVB blocking effect, the SPF (Sun Protection Factor) was measured by an SPF analyzer (SPF Analyzer) according to the general method reported in the literature (J. Soc. Cosmet. Chem., 40, pp127-133, Optometrics USA, SPF290S), and the results are shown below.

The UVB blocking effect is indicated by the Sun Protection Factor (SPF), which is the blocking index of UVB, where the ultraviolet screening agent is applied to the amount of ultraviolet light required to produce MED (minimal erythemal) on untreated skin Is defined as the amount of ultraviolet light required to produce MED on the skin and is calculated by the following equation (2). Therefore, the higher the SPF, the better the UVB blocking effect. Here, MED refers to Minimal Erythemal Dose ("MED"), which is the minimum amount of erythema that causes skin erythema.

No. Natural extract SPF values One Western hawthorn extract 27.56

Example 1 and Comparative Examples 1 and 2 composed of the compositions shown in the following Table 5 were prepared. Comparative Example 2 is a cosmetic composition containing OMC (octyl 4-methoxycinnamate) which is a commonly used UV absorbent. The SPF indexes of Example 1 and Comparative Examples 1 and 2 were measured by the method described above, and the results are shown in Table 6.

ingredient Example 1 Comparative Example 1 Comparative Example 2 Western hawthorn extract 5 - - OMC - - 1.5 glycerin 4 4 4 Butylenecylicol 4 4 4 Beta Glucan 6 6 6 Carbomer 0.1 0.1 0.1 Caprylic Capricc
Triglyceride 9 9 9 Squalene 0.5 0.5 0.5 Stearyl glucoside 1.5 1.5 1.5 Sorbitan stearate 0.4 0.4 0.4 Stearyl alcohol 1.0 1.0 1.0 Purified water Balance Balance Balance system 100.0 100.0 100.0

Formulation Sun Protection Factor (SPF) Example 1 34 Comparative Example 1 4 Comparative Example 2 29

As can be seen from Table 6, the cosmetic composition of Example 1 containing the western Crest extract of the present invention was superior to the cosmetic composition of Comparative Example 1 which did not contain a UV-blocking substance. In addition, similar to Comparative Example 2 containing OMC, which is a conventional ultraviolet screening agent, showed a high ultraviolet blocking effect. Therefore, it was confirmed that the composition containing the western white crane extract according to the present invention has an effect of blocking ultraviolet rays.

Hereinafter, a preferred formulation example is provided to facilitate understanding of the present invention. However, the following formulation examples are provided only for a better understanding of the present invention, and the present invention is not limited by the formulation examples.

Formulation Example 1: Softening Longevity (Skin)

The number of softening times containing the extract of Example 1 was prepared according to a conventional method as shown in Table 7 below.

ingredient Content (% by weight) The extract of Example 1 1.0 glycerin 5.0 1,3-butylene glycol 3.0 Betaine 1.0 Allantoin 0.1 EDTA-2Na 0.02 Sodium hyaruronate powder 0.05 ethanol 5.0 Octyldodec-16 0.2 Polyoxyethylene hardened castor oil 0.2 antiseptic Suitable amount Purified water Balance Sum 100

Formulation Example 2: Nourishing lotion (lotion)

As shown in Table 8 below, a nutritional lotion containing the extract of Example 1 was prepared according to a conventional method.

ingredient Content (% by weight) The extract of Example 1 2.0 Glyceryl stearate SE 1.5 Cetearyl alcohol 1.0 Sheer butter 1.5 Polysorbate 60 1.3 Sorbitan stearate 0.5 Hardened vegetable oil 1.0 Mineral oil 5.0 Squalane 3.0 Cyclomethicone 2.0 Dimethicone 0.8 Tocopheryl acetate 0.5 Carbomer 0.12 glycerin 5.0 1,3-butylene glycol 3.0 Sodium hyaruronate powder 0.05 Triethanolamine 0.12 antiseptic Suitable amount Purified water Balance Sum 100

Formulation Example 3: Massage cream

A massage cream containing the extract of Example 1 was prepared according to a conventional method as shown in Table 9 below.

ingredient Content (% by weight) The extract of Example 1 2.0 Glycerin monostearate 1.5 Cetearyl alcohol 1.5 Stearic acid 1.0 Polysorbate 60 1.5 Sorbitan stearate 0.6 Isostearyl isoserate 5.0 Squalane 5.0 Mineral oil 35.0 Dimethicone 0.5 Hydroxyethylcellulose 0.12 glycerin 6.0 1,3-butylene glycol 3.0 Triethanolamine 0.3 antiseptic Suitable amount Purified water Balance Sum 100

Formulation Example 4: Essence

Essences containing the extract of Example 1 were prepared according to a conventional method as shown in Table 10 below.

ingredient Content (% by weight) The extract of Example 1 2.0 glycerin 6.0 Betaine 5.0 PEG 1500 2.0 Allantoin 0.1 EDTA-2Na 0.02 Hydrogenated lecithin 0.6 Hydroxyethylcellulose 0.1 Sodium hyaruronate powder 0.08 Carboxyvinyl polymer 0.2 Triethanolamine 0.2 Ceramide 0.2 Octyldodecanol 3.0 Squalane 3.0 Polysorbate 60 0.4 Glyceryl stearate SE 1.5 antiseptic Suitable amount Purified water Balance Sum 100

Claims (6)

A cosmetic composition for protecting against UV rays containing an extract of Crataegus oxyacantha as an active ingredient. The method of claim 1, wherein the extract
Wherein the cosmetic composition contains 0.001 to 30.0% by weight based on the total weight of the cosmetic composition. The method of claim 1, wherein the extract
Wherein the cosmetic composition has a liquid phase, a concentrated solid phase and a lyophilized powder form. The method according to claim 1, wherein the Western Crest extract
Characterized in that the composition is extracted with an extraction solvent selected from water, purified water, methanol, ethanol, glycerin, ethylene glycol, propylene glycol, butylene glycol, hexane, dichloromethane, dichloroethane, ethyl acetate and mixtures thereof. The method of claim 1, wherein the extract
Characterized in that the composition is extracted from a cold extraction, an ultrasonic extraction, a reflux cooling extraction, a hot water extraction, a room temperature extraction, a warming extraction and a supercritical extraction method. 6. The cosmetic composition according to any one of claims 1 to 5,
The cosmetic composition for ultraviolet blocking has a formulation selected from the group consisting of a solution, a suspension, an emulsion, a gel, a lotion, an essence, a cream, a powder, a soap, a pack mask, a cleansing oil, a foundation and a spray.