KR20160056866A - COMPOSITION FOR PREVENTING, TREATING OR IMPROVING SKIN DISEASE, COMPRISING EXTRACT OF Cassia obtussifolia L. AND EXTRACT OF Hovenia ducis - Google Patents

Abstract

The present invention relates to a composition for preventing, treating or alleviating skin disease, which comprises an extract of Cassia obtusifolia l. and an extract of Hovenia dulcis in a dry weight ratio of 1 : 0.5-5, and may further comprise extracts of one or more herbs selected from the group consisting of Allium tuberosum seeds, Astragalus membranaceus, Angelica gigas, Pueraria thunbergiana, Atractylodes japonica Koidzumi, Paeonia lactiflora Pallas, the mature skin of Citrus unshiu and Glycyrrhiza uralensis. Since the composition of the present invention is made from plant extracts that have been used for human consumption for a long time and does not have side effects such as those caused by steroids, it is safe for long-term consumption and can be effectively used in treating intractable skin diseases such as atopic dermatitis, psoriasis, eczema, keratosis, prurigo, and warts.

Description

TECHNICAL FIELD The present invention relates to a composition for preventing, treating or ameliorating a skin disease, which comprises an extract of Listeria monocytogenes and an extract of Listeria monocytogenes,

The present invention relates to a composition for preventing, treating or ameliorating skin diseases, and more particularly, to a new herbal composition capable of improving intractable skin diseases such as atopy, psoriasis, eczema, keratosis,

Although the cause of atopic dermatitis has not been clarified yet, it is generally recognized that the environment, food, and genetic susceptibility act in a complex manner. Other factors include dry skin, skin that is more pruritic than normal skin, infections caused by bacteria, viruses, mold, and emotional factors.

Atopic dermatitis is the most important symptom of itching, usually the skin is dry, and when it is scratched, itching leads to rash and itching again. The acute phase is accompanied by erythematous papules with uncertain boundaries and is accompanied by edema, dirt, scratches, crusts, dryness, lichenification, Darkening). Scratches can cause secondary infection by staphylococci, pustules and scabs. Chronic skin scratches repeatedly, resulting in the formation of lichen (lichenification) phenomenon, cracks accompanied by pain, and repetitive stimuli are deposited pigmentation occurs (darkening) phenomenon occurs. However, this problem is not only due to increased incidence of medical expenses due to frequent recurrence, restriction of normal academic and social activities, depression, gangrene, and suicidal impetus.

In the past, it was known as 'Taejil', which appeared to young children. Recently, however, there has been an increase in the number of adult cases. The increase in the number of serious atopic patients who can not do social activities or economic activities is also very large at the national level.

Both steroids and immunosuppressants are used for the treatment of atopic dermatitis. However, in the case of steroid medication, the improvement of the symptoms can be seen temporarily. However, there are many side effects that the symptoms of atopy become worse due to the recoil phenomenon at the time of continuous use. Immunosuppressants are known to be substitutes for steroids and are increasing in terms of imports and use. Recently, the KFDA has expressed its position that some drugs should not be used by children under 2 years of age or by weakened immune systems due to the risk of cancer. And the scope of its use was restricted to the second prescription drugs that were not efficacious with other treatments or those resistant to atopy, and the guidelines were to be used shortly or intermittently.

In recent years, many of atopic patients have been increasingly dependent on the treatment of herbal medicines and various folk remedies derived from natural sources in order to avoid the risk of side effects caused by such bilateral treatment, but the scientific basis for this is not sufficiently presented.

As a result of intensive efforts to solve such problems, the present inventors have found that the novel composition of the present invention is effective for the treatment of intractable skin diseases such as atopy, psoriasis, eczema, keratosis, and water warts, The present invention has been completed by verifying the effect of the present invention.

Accordingly, an object of the present invention is to provide a novel herbal composition which can improve intractable skin diseases such as psoriasis without side effects.

According to one aspect of the present invention, there is provided a pharmaceutical composition for preventing or treating skin diseases, which comprises Cercariae extract and globe extract. In one embodiment of the present invention, the Cassiae Extract and the Earth Disease Extract may be contained in a ratio of 1: 0.5 to 5 in a dry weight ratio.

In addition, the composition of the present invention may further comprise one or more kinds of medicinal herbs selected from the group consisting of Cereal extract and Earth disease extract together with a family extract, Huanggui extract, Angelica gigantosa extract, Puerariae radix extract, Extract. ≪ / RTI >

In one embodiment, the compositions of the present invention may include a Cassiae Extract, an Earth Disease Extract, and a Household Extract. In another embodiment, the composition of the present invention may comprise a Cassiae Extract, a Global Disease Extract, and a Hwanggi Extract. In another embodiment, the composition of the present invention may include a Cercy extract, a globe bottle extract, and a Guanyin guinea extract. In another embodiment, the composition of the present invention may include a Cassiae Extract, an Earth Disease Extract, and a Puerariae Radix Extract. In another embodiment, the composition of the present invention may comprise a Cassiae Extract, an Earth Disease Extract, and a Parsley Extract. In another embodiment, the composition of the present invention may include a Cassiae Extract, an Earth Disease Extract, and a Peony Extract. In another embodiment, the composition of the present invention may include a Cercy extract, a globe bottle extract and a dermis extract. In another embodiment, the composition of the present invention may include a Cassiae Extract, an Earth Disease Extract, and a licorice extract. The weight of the medicinal materials to be added may be 0.5 to 5 in the case of the Cassiae Extract, 1 to 5 in the Earth Disease Extract, and 0.2 to 5 in the other extracts, in terms of the dry weight ratio.

Meanwhile, in one embodiment, the composition of the present invention may include all of the following: Cryptomeria japonica extract, Earth jar extract, Household jar extract, Hwanggi extract, Angelica japonica extract, Puerariae Radix extract, Radix extract, Peony root extract, Dermatophyte extract and Licorice root extract. The ratio (dry weight ratio) of the above ingredients can be adjusted so that when the Cassiae Extract is 1, the ratio of the Earth's Disease Extract is 0.5 to 5, and the other medicines are 0.2 to 5.

In one embodiment, the composition of the present invention is used in a ratio of 1: 0.5 to 5: 1, preferably 1: 0.5 to 5: 1, to a dry weight ratio of Cassiae Extract: Earth Disease Extract: Furniture Extract: Huangzi Extract: Danggui Extract: Puerariae Radix Extract: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5.

The skin diseases to which the pharmaceutical composition of the present invention is applicable are intractable skin diseases selected from the group consisting of atopy, psoriasis, eczema, keratosis, ovulation and water warts. The pharmaceutical composition may be used for internal administration.

According to another aspect of the present invention, there is provided a food composition for improving skin diseases, which comprises a composition comprising a Cassiae japonica extract and a globe extract. In one embodiment, the Cassiae Extract and the Earth Disease Extract may be contained in a ratio of 1: 0.5 to 5 in a dry weight ratio. The food composition of the present invention may further comprise at least one herbal extract selected from the group consisting of a herbal extract, a Hwanggi extract, a Guanyin extract, a Puerariae radix extract, an extract, a peony extract, a dermis extract and a licorice extract .

According to another aspect of the present invention, there is provided a cosmetic composition for improving skin diseases, which comprises a composition comprising a Cassiae japonica extract and a globe bottle extract. In one embodiment, the Cassiae Extract and the Earth Disease Extract may be contained in a ratio of 1: 0.5 to 5 in a dry weight ratio. In addition, the cosmetic composition of the present invention may further comprise one or more kinds of medicinal plant extracts selected from the group consisting of household extract, Hwanggi extract, Angelica gigantosa extract, Puerariae Radix extract, Paeoniae extract, Peony extract, Dermatophyte extract and Licorice extract .

The composition of the present invention can effectively improve intractable skin diseases such as atopy, psoriasis, eczema, keratosis, ovarian hyperplasia and water warts. The composition of the present invention is composed of plant extracts that have been used for a long time and is safe for long-term use, and is useful for the improvement of skin diseases since there are no side effects such as steroids.

Figs. 1 (a) and 1 (b) are photographs of skin obtained by applying the composition of Example 1 to atopic patients in Test Example 1 and dividing the course of oral administration for 6 months before and after treatment.
FIGS. 2 (a) and 2 (b) are photographs of skin obtained by applying the composition of Example 2 to atopic patients in Test Example 1 and dividing the course of oral administration for 3 months before and after treatment.
FIGS. 3 (a) and 3 (b) are photographs showing the results obtained by applying the composition of Example 3 to atopic patients in Test Example 1 divided into 8 months before and after treatment.
FIGS. 4 (a) and 4 (b) are photographs of skin obtained by applying the composition of Example 4 to atopic patients in Test Example 1 and dividing the course of oral administration for 4 months before and after treatment.
Figures 5 (a) and 5 (b) are photographs of the skin of the composition of Example 2 in Test Example 2 divided between before and after treatment with 6 months oral administration applied to psoriasis patients.
FIGS. 6 (a) and 6 (b) are photographs showing the results obtained by applying the composition of Example 4 to patients suffering from psoriasis in Test Example 2 and dividing the time taken for oral administration for 5 months before and after treatment.
Figs. 7 (a) and 7 (b) are photographs of skin obtained by applying the composition of Example 5 to patients suffering from psoriasis in Test Example 2 and dividing the course of oral administration for 6 months before and after treatment.
8 (a) and 8 (b) are photographs showing the results obtained by applying the composition of Example 6 to patients suffering from psoriasis in Test Example 2 divided into 4 months before and after treatment.
9 (a) and 9 (b) are photographs of skin obtained by applying the composition of Example 1 to patients suffering from eczema in Test Example 3 and dividing the course of 8 months oral administration before and after treatment.
FIGS. 10 (a) and 10 (b) are photographs showing the results obtained by applying the composition of Example 7 to patients suffering from eczema in Test Example 3 and dividing the course of 9 months oral administration before and after treatment.
11 (a) and 11 (b) are photographs of skin obtained by applying the composition of Example 2 to a patient with keratosis in Test Example 4 and dividing the course of oral administration for 5 months before and after treatment.
FIGS. 12 (a) and 12 (b) are photographs showing the results obtained by applying the composition of Example 8 to a patient with keratosis in Test Example 4 and dividing the course of 12 months oral treatment before and after treatment.
13 (a) and 13 (b) are photographs showing the results of a 5-month oral administration of the composition of Example 3 applied to a positive patient in Test Example 5 before and after treatment.
14 (a) and 14 (b) are photographs showing the results of the oral administration of the composition of Example 9 to the patients of Positive Example for 8 weeks in Test Example 5 before and after the treatment.
15 (a) and 15 (b) are photographs showing the results of the oral administration of the composition of Example 10 applied to patients with water warts in Test Example 6 for four weeks before and after treatment.

Hereinafter, specific details for carrying out the present invention will be described in detail, including definitions of terms used in this specification.

"Atopic dermatitis" is a chronic, recurrent, inflammatory skin disease that usually starts in infancy or childhood. It refers to dermatitis accompanied by pruritus (itching), dry skin, and characteristic eczema. In the early stage, it usually causes itching, pus, papules, erythema and edema. In the chronic phase, swelling and blistering are noticeably reduced, but skin wrinkles become noticeable or skin becomes thickened, scales and pigmentation. In general, atopic dermatitis and eczema are used as synonyms, but dermatitis is a term referring to all inflammation. In strict definition, dermatitis has a wider meaning than eczema.

"Psoriasis" is a chronic inflammatory skin disease that is covered with silvery white scales, has a clear boundary, and has a red papule or plate rash that occurs repeatedly in the skin of the whole body. And inflammation of the dermis.

"Eczema" is a generic term for a group of skin disorders that exhibit common clinical and histological features. Clinically, itching, erythema, scaly and clustered papules, blisters, histologically superficial dermatitis, with epidermis on the epidermis, and dermis on the skin with inflammatory skin reactions that infiltrate inflammatory cells around the blood vessels Collectively.

 The term "keratosis" refers to a dermatosis of the upper stratum of the epidermis that grows, changes or becomes harder or harder. "Not only does the keratinization of the epidermis proliferate, but sometimes the layers of the epidermis are more proliferated than the layers of the epidermis The keratin is formed by the keratinization of the epidermal cells, and in normal keratinization process, the nucleus can not be found in each layer. In case of keratinization, the nucleus is well stained.

"Prurigo" is an itchy nervous skin disease, typical of Hebra. In addition, there is an acute inflammation similar to the inhalation that occurs well in people aged 15 to 30 and rapidly declines, a nodular enlargement that appears to be like a chronic urticaria, a stubborn urticaria, And pregnancy outbreaks. Pregnancy is manifested in midsection, which is cured at the same time as birth.

"Water wart" is caused by a virus (HPV, human papillomavirus) infection caused by a decrease in immunity. It is a small hemispherical shape of about 2 to 5 mm and has a smooth surface. Color is skin color or pink, Such as the face, the back of the hand, the instep, the body, the anus, the perioral region, the lips, the mucous membrane or the scalp.

As used herein, the term "improvement" is an episode that underlies the present invention, as well as a partial cure, improvement, and alleviation of the aforementioned skin disease.

The medicinal herbs used for preparing the composition of the present invention are as follows.

The other name of Cassia obtussifolia L. is Cucumis japonica and Yangmyeong, which can be used after drying or pre-boiling the lentil seeds of soybean plants, Lightening, diuretic action and thinning of the stomach, so that the stool works well. Specifically, it is used when the eyes are red due to hepatic fever or heat (wind heat), and it is used when sick or tears come out with a lot of boiling. It is also good to boil or eat in constipation caused by heat constipation or dryness, Lowering or lowering the cholesterol of the blood, but the anthraquinone compound in the cadaver has been found to cause diarrhea when the hyperlipidemic activity of the large intestine is increased and used.

Globe ( Hovenia dulcis ) contains beneficial ingredients such as fruit, roots, branches and leaves in the body, including glucose, malic acid, calcium, furanguranin, hobenin, robein seed, and hasan. It is said that the active chemicals of Hovenia japonica have an excellent effect on eliminating hangover, eliminating toxins, removing bad breath and detoxifying liver and constipation. In the preparation of the composition of the present invention, fruits, branches, roots and leaves of Hovenia dulcis may be used respectively, or these parts may be mixed.

Household (semen of Allium tuberosum ) is called a donor, a mushroom, a mushroom, and a citron. Leuco, the outpost, is also called a tongue, a sole, and is used to loosen the ebony. This medicine has no odor and the medicine is spicy and warm. Knee and back are cold and sore, treating erectile dysfunction and diarrhea. Urine is frequent and muscles and bones are sore. In addition, blood pressure enhancement and cardiac excitation were reported. For the preparation of the composition of the present invention, the household appliance may be roasted and simmered once to remove the odor.

Astragalus membranaceus ) is a perennial herbaceous plant belonging to the soybean family. Root is used as a medicinal ingredient, and its active ingredients are polyacid, choline, and the like. In animal experiments, central nervous system excitement and diuretic effect were remarkable, and nephritis, proteinuria and cholesterolemia were suppressed or delayed, and hypotensive effect was also reported. It is easily fatigued, weak in strength, low in voice and has been used extensively as a substitute for ginseng in people who sweat a lot. It is widely used for uterine drainage, gastrointestinal tract, esophagus, and uterine bleeding. It also increases the physical strength and increases the tension of the whole body muscles.

Angelica gigas is well known for its blood-producing (blood-clotting) effects when blood is scarce. Chinese roots of Angelica or Angelica gigas are excellent in blood circulation, and medicinal materials made from root of Angelica angustifolia have strong antitumor activity, anticancer effect and blood pressure lowering effect which cause blood to circulate more smoothly than blood. Pharmacologically, it promotes the blood flow of the coronary arteries and makes the production of red blood cells active.

Pueraria thunbergiana has tinnitus such as mulberry, mung bean, dry giganta, ganggal, bangal, and hwangryeong, and sweat It feels high fever, cures headaches and stops thirst. Indigestion, headache, anemia, dysentery, abdominal pain, digestion, cold, vomiting, is used to treat hemorrhoids in women and helps digestion. It blooms raw roots and sucks and drinks.

It is a dried medicinal substance by removing the roots or juniors of Atractylodes japonica Koidzumi or Atractylodes macrocephala Koidzumi. It is weak in the function of the stomach, resulting in a feeling of malaise, yellowish facial color, It is good for diarrhea, and the water is stagnant and helps to excrete the water when the whole body is swollen and not digested. It is also used for boobs, coughs, and clear phlegm due to accumulation of water and wetness in the spleen. It is also used for the vomiting of pregnancy when sweating on the skin spontaneously due to weakness. do. It is also used for colds and limb pain with gastrointestinal disorders.

Paeonia lactiflora Pallas) is a perennial herbaceous perennial plant of peonies and peonies, and is dried to the roots of peonies. It is about 1m in height, and is divided into black and white depending on the flower color. The glycoside components contained in these peonies inhibit the central nervous system and give analgesic effect. Not only does it exert an excellent effect in treating digestive problems, abdominal pain, diarrhea, and double blindness which may be caused by misapplication, but also gastrointestinal It also helps to alleviate.

The dermis is the mature peri of the citrus unshiu or relative plants in Korea. The dermis cleanses the gums and strengthens the function of the spleen, treating only the abdominal cavity, trimming, vomiting, nausea, indigestion, sluggishness, lingering symptoms, and thin stools. Seawater, sputum and diuretic action. Essential oil components have been reported to exert digestive stimulation, digestive stimulation, germane, anti-ulcer, and antidiarrheal secretion.

Licorice ( Glycyrrhiza uralensis ) is a medicinal plant, distributed in northeastern China, Siberia and Mongolia, and its roots are used as sweeteners and herbal medicines. It has the effect of neutralizing poison of medicine and promoting digestion and absorption.

The composition of the present invention is prepared including a Cercy extract and a globe bottle extract. The inventors of the present invention have found that the composition according to the present invention is useful for improving and treating intractable skin diseases such as atopy, psoriasis, eczema, keratosis, And has reached the present invention. In one embodiment of the present invention, the Cassiae Extract and the Earth Disease Extract may be contained in a ratio of 1: 0.5 to 5 in a dry weight ratio.

In addition, the composition of the present invention may further comprise one or more kinds of medicinal herbs selected from the group consisting of Cereal extract and Earth disease extract together with a family extract, Huanggui extract, Angelica gigantosa extract, Puerariae radix extract, The composition may further comprise an extract.

In one embodiment, the compositions of the present invention may include a Cassiae Extract, an Earth Disease Extract, and a Household Extract. In another embodiment, the composition of the present invention may comprise a Cassiae Extract, a Global Disease Extract, and a Hwanggi Extract. In another embodiment, the composition of the present invention may include a Cercy extract, a globe bottle extract, and a Guanyin guinea extract. In another embodiment, the composition of the present invention may include a Cassiae Extract, an Earth Disease Extract, and a Puerariae Radix Extract. In another embodiment, the composition of the present invention may comprise a Cassiae Extract, an Earth Disease Extract, and a Parsley Extract. In another embodiment, the composition of the present invention may include a Cassiae Extract, an Earth Disease Extract, and a Peony Extract. In another embodiment, the composition of the present invention may include a Cercy extract, a globe bottle extract and a dermis extract. In another embodiment, the composition of the present invention may include a Cassiae Extract, an Earth Disease Extract, and a licorice extract.

However, the composition of the present invention is not limited to the above-mentioned combination, and it is not limited to the above-mentioned combination, but it is preferable that the composition of the present invention includes the Cassiae Extract and the Earth Disease Extract as essential components, Extracts and licorice extracts of the present invention. In one embodiment, the composition of the present invention may include all of the following: Cryptomeria japonica Extract, Earth Disease Extract, Household Extract, Hwanggi Extract, Angelica keiskei Radix Extract, Puerariae Radix Extract, Leaf Extract, Peony Extract, Dermatophyte Extract and Licorice Extract.

In the composition of the present invention, the weight of the Cassiae Extract and the Drug Extract added to the Disease Extract may be 0.2 to 5, respectively, when the Cassiae is 1 at a dry weight ratio.

In one embodiment, the composition of the present invention is used in a ratio of 1: 0.5 to 5: 1, preferably 1: 0.5 to 5: 1, to a dry weight ratio of Cassiae Extract: Earth Disease Extract: Furniture Extract: Huangzi Extract: Danggui Extract: Puerariae Radix Extract: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5.

In addition, the composition of the present invention may further include medicinal materials conventionally added in the art for taste, flavor, etc., in addition to the medicaments described above.

In addition, the composition of the present invention may include extracts prepared by extracting a pharmacological agent for use as an internal or external use. In one embodiment, the composition of the present invention may comprise a mixture of the extracts of each of the medicaments, and in other embodiments may comprise an extract obtained from the mixed medicament.

At this time, the extract of the medicinal material can be produced by a conventional extraction method. That is, a method may be used in which an extraction solvent is added to the above-mentioned medicinal material and extraction is carried out at a high temperature under a low pressure or a high pressure. As the extraction solvent, for example, water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent obtained by mixing them can be used. There is no particular limitation on the amount of the solvent to be used, but the amount of the solvent may be about 1 to 50 times the dry weight of the drug substance to be extracted, considering the extraction efficiency, the efficacy or economical efficiency of the composition, and the like.

In one embodiment, the composition of the present invention may be prepared by extracting each medicament (wherein each medicament may be ground or chopped with a grinder prior to extraction) using a suitable solvent and mixing them, Can be extracted together, and the extracts can be prepared in a mixed form from the time of extraction.

Needless to say, it is also possible to use the powder after the powder is prepared by an additional process such as vacuum distillation, freeze-drying, or spray drying.

A specific method for producing the composition of the present invention is as follows.

In addition to the severer and the earth disease, one or more kinds of medicinal materials selected from the group consisting of furniture, hwanggi, angelica, crabgrass, peony, peony, dermis and licorice are selected and water is added in an amount of 1 to 50 times To extract hot water. The extraction conditions may be extracted at 50 to 130 ° C for 2 to 10 hours, preferably 80 to 130 ° C for 3 to 6 hours, but are not limited thereto. In one embodiment of the present invention, the amount extracted from a single bath was extracted at a large capacity of about 95,000 mL to reduce the compositional change of the contents.

The composition of the present invention prepared as described above may be packaged for underwear, and may be packed in a capacity of 20 to 150 ml per one time. In the case of underwear, it can be drunk three times a day, but the capacity and the number of underwear can be adjusted appropriately considering the age, the severity of the symptoms and the improvement of the symptoms. In addition, in order to reduce the feeling of rejection upon ingestion of infants, the composition of the present invention may further include oligosaccharides.

Meanwhile, one aspect of the present invention can be used as a pharmaceutical composition for preventing or treating skin diseases.

Here, the pharmaceutical composition of the present invention may further comprise an appropriate carrier, excipient or diluent according to a conventional method. Examples of carriers, excipients and diluents that can be included in the pharmaceutical composition of the present invention include Tagatose, Lactose, Dextrose, Sucrose, Sorbitol, Mannitol, Xylitol, Erythritol, Maltitol, Starch, Acacia Rubber, Alginate, Gelatin , Calcium phosphate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil.

In addition, the pharmaceutical composition according to the present invention can be formulated in the form of oral, granule, tablet, capsule, suspension, emulsion, syrup, aerosol or the like, oral preparation, suppository or sterilized injection solution, Can be used. More specifically, when formulating the composition, it can be prepared using a diluent or an excipient such as a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, and the like. Solid formulations for oral administration include tablets, pills, powders, granules, capsules and the like. Such solid preparations can be prepared by mixing the pharmaceutical composition of the present invention with at least one excipient such as starch, calcium carbonate, Sucrose, lactose, gelatin, and the like. In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Examples of the liquid preparation for oral use include suspensions, solutions, emulsions, syrups and the like, and various excipients such as wetting agents, sweeteners, fragrances, preservatives, etc. in addition to commonly used diluents such as water and liquid paraffin . Formulations for parenteral administration include sterile aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations and suppositories. Examples of the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, injectable ester such as ethyl oleate, and the like. Examples of the suppository base include witepsol, macrogol, tween 61, cacao paper, laurin, glycerogelatin and the like.

In another aspect, the composition of the present invention can be used in various ways as a food composition for the improvement of skin diseases. The food composition containing the composition of the present invention as an active ingredient may be prepared in the form of various foods such as beverage, gum, tea, vitamin complex, powder, granule, tablet, capsule, . Since the food composition of the present invention is composed of a plant extract having little toxicity and side effects, it can be safely used for prolonged use even for prophylactic purposes.

When the composition of the present invention is contained in the food composition, the amount thereof may be added in a proportion of 0.1 to 50% of the total weight.

Here, when the food composition is prepared in a beverage form, there are no particular limitations other than those containing the food composition at the indicated ratios and may contain various flavors or natural carbohydrates such as ordinary beverages as an additional ingredient. That is, natural carbohydrates include monosaccharides such as glucose, disaccharides such as fructose, sucrose and the like and sugar sugars such as polysaccharide, dextrin and cyclodextrin, and sugar alcohols such as xylitol, sorbitol and erythritol can do. Examples of the above-mentioned flavors include natural flavors (such as tau martin and stevia extract (for example, rebaudioside A and glycyrrhizin) and synthetic flavors (for example, saccharine and aspartame).

In addition, the food composition of the present invention can be used as a flavoring agent such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, colorants, pectic acid and its salts, alginic acid and its salts, , a pH adjusting agent, a stabilizer, a preservative, a glycerin, an alcohol, a carbonating agent used in a carbonated drink, and the like.

These components may be used independently or in combination. The proportion of such additives is not so critical, but is generally selected in the range of 0.1 to about 50 parts by weight per 100 parts by weight of the composition of the present invention.

In another aspect, the composition of the present invention can be used in cosmetic compositions for improving skin diseases. The cosmetic composition comprising the composition of the present invention as an active ingredient can be used as a skin lotion, a nutritional lotion, a nutrition essence, a massage cream, a cosmetic bath additive, a body lotion, a body milk, a bath oil, a baby oil, Skin lotions, skin creams, sunscreen cosmetics, cleansing milks, hair removal products, cosmetics, face and body lotions, face and body creams, skin whitening creams, hand lotions, hair lotions, (Non-medical use), cream soap, facial wash, hair rinse, make-up soap, tooth whitening gel, toothpaste, etc. . ≪ / RTI > To this end, the compositions of the present invention may further comprise suitable carriers, excipients or diluents conventionally used in the preparation of cosmetic compositions.

The carrier, excipient or diluent which may further be added to the cosmetic composition of the present invention include purified water, oil, wax, fatty acid, fatty acid alcohol, fatty acid ester, surfactant, humectant, thickener, antioxidant, Buffers, lower alcohols, and the like, but are not limited thereto. Further, if necessary, it may contain a whitening agent, a moisturizing agent, a vitamin, an ultraviolet screening agent, a perfume, a dye, an antibiotic, an antibacterial agent, and an antifungal agent.

As the oil, hydrogenated vegetable oil, castor oil, cottonseed oil, olive oil, palm oil, jojoba oil and avocado oil may be used. Examples of the wax include wax, wax, carnauba, candelilla, montan, ceresin, liquid paraffin, Can be used.

As the fatty acid, stearic acid, linoleic acid, linolenic acid and oleic acid may be used. As the fatty acid alcohol, cetyl alcohol, octyldodecanol, oleyl alcohol, panthenol, lanolin alcohol, stearyl alcohol and hexadecanol may be used As fatty acid esters, isopropyl myristate, isopropyl palmitate, and butyl stearate may be used. As the surfactant, a cationic surfactant, an anionic surfactant and a nonionic surfactant known in the art can be used, and a surfactant derived from a natural material is preferably used.

In addition, it may contain a hygroscopic agent, a thickening agent, an antioxidant and the like widely known in the field of cosmetics, and the kind and amount thereof are well known in the art.

Example

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood that the scope of the present invention is not limited by these examples in accordance with the gist of the present invention, and it is to be understood by those skilled in the art that the present invention is not limited thereto It will be obvious.

Example 1: Preparation of composition

20kg of purified water was added to 2kg of the commercially available herbaceous herb and 1kg of the globe (Hovenia fruit and branch), and the extract was extracted at 100 ° C for 6 hours.

Example 2: Preparation of composition

30 kg of purified water was added to 1 kg of commercially available herbaceous herb, 2.5 kg of globe disease (hovenous fruit and eggplant), 1 kg of Puerariae crassa and 300 g of licorice, and extracted at 120 ° C for 3 hours to prepare an extract.

Example 3: Preparation of composition

Extracts were prepared by adding 40 L of purified water to 1 kg of commercially available herbivorous herbaceous herb, 3 kg of globe disease (hovenous fruit and branches), 2 kg of pears, 2 kg of pears, 600 g of licorice and 6 g of purified water.

Example 4: Preparation of composition

Extracts were prepared by adding 40 L of purified water to 1 kg of commercially available herbaceous herb, 4 kg of Angelica japonica, 4 kg of Angelica keiskei, 1 kg of Angelica gigas, 2 kg of vetch, 1 kg of dermis, 500 g of caramel and 500 g of licorice.

Example 5: Preparation of composition

Extracts were prepared by adding 40 L of purified water to 1 kg of a commercially available herbaceous herb, 4 kg of globular disease (Hovenia dulcifera and branches), 1 kg of Angelica gigas, 1 kg of dill, 500 g of dermis and 500 g of licorice.

Example 6: Preparation of composition

Extracts were prepared by adding 30 L of purified water to 2 kg of commercially available herbivorous herbivorous products, 0.5 kg of gloves (hovenous fruit and branches), 1 kg of Hwanggi, 2 kg of crabgrass, 2 kg of crabgrass and 600 g of licorice and then extracted at 100 ° C for 6 hours.

Example 7: Preparation of composition

60kg of purified water was added to 2kg of the commercially available herbaceous herb, 5kg of globe disease, 2kg of vetch, 1kg of dandruff and 2kg of licorice, and extracted at 120 DEG C for 3 hours to prepare an extract.

Example 8: Preparation of composition

Extracts were prepared by adding 40 L of purified water to 1 kg of commercially available herbivorous herbivore, 1.5 kg of dwarf bark, 3 kg of dwarf, 1 kg of dandruff, 2 kg of garlic, 1 kg of Puerariae and 500 g of licorice, .

Example 9: Preparation of composition

The extract was prepared by adding 60 L of purified water to 3 kg of the commercially available herbaceous herbaceous herb, 3 kg of the globe, 2 kg of Angelica gigas, 2 kg of Hwanggi, 1 kg of Puerariae, and 1 kg of licorice and then extracted at 120 ° C for 3 hours.

Example 10: Preparation of composition

Extracts were prepared by adding 60 L of purified water to 1 kg of commercially available herbivorous herbivorous products, 5 kg of Hwanggi, 1 kg of Hwanggi, 2 kg of dwarf, 1.5 kg of dermis and 500 g of licorice, and then extracted with 100 L of distilled water at 100 ° C for 4 hours.

Formulation example

Formulation Example 1: Preparation of beverage (unit:% by weight)

A health drink is prepared by blending 5% of honey, 3% of fructose, 0.0001% of riboflavin sodium chloride, 0.0001% of pyridoxine hydrochloride, and 81.9998% of water and 10% of the composition obtained in Example 1.

Formulation example  2: Production of lotion (unit: weight% )

Composition 3.00 of Example 4

Ascorbic acid-2-phosphate magnesium salt 1.00

Water soluble collagen (1% aqueous solution) 1.00

Sodium citrate 0.10

Citric acid 0.0 [0093] 5

1,3-butylene glycol 3.00

Purified water balance

Formulation example  3: Manufacture of lotion (Unit: weight% )

Composition 2.00 of Example 3

Hydroxyethylene Cellulose (2% aqueous solution) 12.00

Xanthan gum (2% aqueous solution) 2.00

1,3-butylene glycol 6.00

Glycerin 4.00

Sodium hyaluronate (1% aqueous solution) 5.00

Purified water balance

Test Example

Test Example 1: Confirmation of atopy treatment effect

From July 2012 to September 2013, 40 patients with atopic dermatoses among the patients with skin diseases who visited the Shinchang Korean Oriental Medical Clinic were grouped into 10 groups. The composition of each of the above Examples 1 to 4 was divided into 20 ~ 70 ml each was orally administered for a total of 6 months, and the degree of improvement of symptoms was evaluated. The results are shown in Tables 1 to 4 below.

In order to visually confirm the therapeutic effects of the composition of the present invention, photographs according to the degree of improvement for one atopic patient in each group are shown in Figs. 1 to 4. 1 to 4 (a) are photographs before the start of treatment, and (b) are photographs after oral administration of the compositions of Examples 1 to 4 at 6 months, 3 months, 8 months and 4 months, respectively.

When the composition of Example 1 was administered division personnel My symptoms are completely gone 5 Symptoms improve (no more than 50% of atopic area) 3 No change in symptoms 2 My symptoms get worse 0

When the composition of Example 2 was administered division personnel My symptoms are completely gone 5 Symptoms improve (no more than 50% of atopic area) 4 No change in symptoms One My symptoms get worse 0

When the composition of Example 3 was administered division personnel My symptoms are completely gone 3 Symptoms improve (no more than 50% of atopic area) 4 No change in symptoms One My symptoms get worse One

When the composition of Example 4 was administered division personnel My symptoms are completely gone 5 Symptoms improve (no more than 50% of atopic area) 3 No change in symptoms One My symptoms get worse One

As shown in Tables 1 to 4, the composition of the present invention showed an excellent effect of treating atopic dermatitis when administered orally. In particular, when the composition of Example 4 was administered, the treatment activity of atopic dermatitis was very high.

As a result of comparing the photographs (a) and (b) of each of Figs. 1 to 4, it was found that the administration of the composition of the present invention significantly improved atopic symptoms in various skin regions, regardless of sex and age, You can see that you have.

Test Example 2: Confirmation of Psoriasis Treatment Effect

From July 2012 to September 2013, 20 patients diagnosed as psoriasis skin disease among the patients with skin diseases who visited the Shinchang Oriental Medical Clinic were grouped into 5 groups, and the compositions of Examples 2, 4 to 6 After oral administration for 70 minutes at a total of 6 months three times a day, the degree of improvement of symptoms was evaluated and the results are shown in Tables 5 to 8 below.

In order to visually confirm the effect of the composition of the present invention on psoriasis, photographs according to the degree of improvement for one psoriasis patient in each group are shown in Figs. 5 to 8. 5 to 8 are photographs before the start of treatment, and (b) are photographs after oral administration of the compositions of Examples 2 and 4 to 6 at 6, 5, 6 and 4 months, respectively.

When the composition of Example 2 was administered division personnel My symptoms are completely gone 2 Symptoms improve (no more than 50% of psoriasis area) 2 No change in symptoms One My symptoms get worse 0

When the composition of Example 4 was administered division personnel My symptoms are completely gone 3 Symptoms improve (no more than 50% of psoriasis area) 2 No change in symptoms 0 My symptoms get worse 0

When the composition of Example 5 was administered division personnel My symptoms are completely gone 4 Symptoms improve (no more than 50% of psoriasis area) One No change in symptoms 0 My symptoms get worse 0

When the composition of Example 6 was administered division personnel My symptoms are completely gone 2 Symptoms improve (no more than 50% of psoriasis area) 3 No change in symptoms 0 My symptoms get worse 0

As shown in Tables 5 to 8, when the composition of the present invention is orally administered, it has an excellent effect of treating psoriasis.

5 to 8, (a) and (b) respectively show skin photographs before and after oral administration of the composition of Examples 2 and 4 to 6 to patients with psoriasis.

As a result of comparing the photographs (a) and (b) of each of FIGS. 5 to 8, it was found that administration of the composition of the present invention significantly improved psoriasis symptoms in various skin areas and completely or almost completely eliminated psoriasis .

Test Example 3: Confirmation of efficacy of eczema treatment

In order to confirm the efficacy of the composition of the present invention, two patients with eczema among the patients who visited Gangnam-dong, Shinchang-gu, from July 2012 to September 2013 were administered 70 ml of the compositions of Examples 1 and 7 three times a day Were administered orally for a total of 8 months and 9 months.

9 to 10 (a) and (b) are photographs of the composition of the present invention before the start of treatment and after oral administration of the composition of the present invention for a certain period so that the effect of the eczema treatment of the composition of the present invention can be visually confirmed .

As a result of comparing the photographs (a) and (b) of FIGS. 9 to 10 with each other, it was found that the administration of the composition of the present invention resulted in the disappearance of eczema symptoms in various skin areas regardless of sex and age, , But in some areas, the eczema symptom disappeared, and then the skin coloration appeared to be dark. However, when the composition of the present invention is continuously orally administered, the pigment gradually disappears and normally changes to the surrounding skin color.

Test Example 4: Confirmation of the effect of keratosis treatment

In order to confirm the therapeutic effect of the composition of the present invention, the compositions of Examples 2 and 8 were administered three times per day to each of two patients with keratosis among patients who visited Kangnam-myeon, Shinchang-ku from July 2012 to September 2013 ~ 70ml in total for 5 months and 12 months.

Figs. 11 to 12 show photographs (a) and (b) of the photographs of the patients before the start of treatment and after oral administration of the composition of the present invention for a certain period so that the effect of treating the keratosis of the present invention can be visually confirmed .

As a result of comparing the photographs (a) and (b) of FIGS. 11 to 12 with each other, it was confirmed that the composition of the present invention was cured by soft, smooth, In the whole soles of the foot, the symptoms that the skin exfoliates disappear, and it is confirmed that the whole skin is restored to smooth skin.

Test Example 5: Confirmation of the effect of the positive treatment

In order to confirm the efficacy of the composition of the present invention, the compositions of Examples 3 and 9 were administered three times daily to 20 patients who were admitted to Gangnam Hospital from July 2012 to September 2013 ~ 70ml for a total of 5 months and 8 weeks.

13 to 14 (a) and (b) are photographs of each patient before the start of treatment and after oral administration of the composition of the present invention for a certain period in order to visually confirm the effect of the positive treatment of the composition of the present invention .

As a result of comparing the photographs (a) and (b) of each of FIGS. 13 to 14, it can be seen that the administration of the composition of the present invention greatly improved the symptoms of widespread distribution in the arms and legs. However, Yangjin is not only a visible part of the skin, but also the itching is very severe, which causes pain to the patients.

Test Example 6: Confirmation of water wart treatment effect

In order to confirm the effect of the composition of the present invention on water wart treatment, one of the patients who visited the Shinchang Korean Medical Center from July 2012 to September 2013 was given the composition of Example 10 30 ml Total oral administration for 4 weeks.

15 (a) and 15 (b) are photographs of the warts before treatment and before 4 weeks after oral administration of the composition of the present invention, Respectively.

As a result of comparing the photographs of FIGS. 15 (a) and 15 (b), it can be seen that water warts, which were present in the axilla partly in red color, completely disappeared as the composition of the present invention was administered for 4 weeks.

While the embodiments of the present invention have been described in detail, the scope of the present invention is not limited thereto. Particularly, the drawings show typical treatment examples. As a matter of course, It is easy to know that a composition comprising an acaricide and a globe as an essential ingredient in the invention has excellent effects in the improvement and treatment of various skin diseases.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit and scope of the invention as defined in the appended claims.

Claims (12)

A method for preventing or treating skin diseases, The method according to claim 1,
Wherein said composition comprises at least one selected from the group consisting of a herbal extract and a globe extract in a dry weight ratio of 1: 0.5 to 5. The method according to claim 1,
A pharmaceutical composition for the prevention or treatment of skin diseases, which further comprises at least one medicinal extract selected from the group consisting of extracts of tea extract, Huanggui extract, Angelica gigantosa extract, Puerariae radix extract, Paeoniae extract, Peony root extract, Dermatophyte extract and Licorice root extract . The method of claim 3,
Wherein each of the additional pharmacological extracts is contained at a ratio of 0.2 to 5, in terms of the dry weight ratio, to the Cassiae Extract. 5. The method according to any one of claims 1 to 4,
Wherein the skin disease is selected from the group consisting of atopy, psoriasis, eczema, keratosis, ovarian hyperstimulation and water warts. 5. The method according to any one of claims 1 to 4,
Wherein said composition is for underwear. A composition for improving skin diseases, which comprises Cercariae extract and Earth disease extract. 8. The method of claim 7,
Wherein the composition comprises 1: 0.5 ~ 5 in terms of a dry weight ratio. 8. The method of claim 7,
A composition for improving skin diseases, which further comprises at least one herbal extract selected from the group consisting of extracts of tea extract, Huanggui extract, Angelica keiskei extract, Puerariae radix extract, Paeoniae extract, Peony root extract, Dermatophyte extract and Licorice root extract. A cosmetic composition for improving skin diseases, which comprises an extract of Lactobacillus japonica and an extract of a globe. 11. The method of claim 10,
Wherein said composition comprises at least one selected from the group consisting of a herbaceous perennial herb extract and a globular herb extract at a dry weight ratio of 1: 0.5 to 5. 11. The method of claim 10,
A cosmetic composition for the improvement of skin diseases, which further comprises at least one herbal extract selected from the group consisting of a herbal extract, a herbal extract, a Angelica keiskei extract, a Puerariae Radix extract, a Paeonia extract, a Peony root extract, a Dermatophyte extract and a licorice extract.

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