WO2015182799A1 - Composition for improving skin diseases comprising hovenia dulcis and semen allii tuberosi - Google Patents

Abstract

The present invention relates to a composition capable of improving skin diseases, the composition comprising Semen Allii and Hovenia dulcis in a dry weight ratio of 1:0.2-5, and further comprising at least one medicinal herb selected from the group consisting of Astragalus membranaceus, Angelica gigas, Poria cocos, Pueraria lobata, citrus unshiu peel and liquorice. The composition of the present invention is composed of plant extracts which have been used for food for a long time. Thus, the composition is safe even for long-term use, and does not have the side effects of steroid preparations. Furthermore, the composition can be used effectively for improving intractable skin diseases such as atopic dermatitis, psoriasis, eczema, keratosis, prurigo and dyshidrotic eczema.

Description

 【Specification】

 [Name of invention]

Composition for improvement of skin disease including earth disease and furniture

The present invention relates to a composition for improving skin diseases, and more particularly, to a new herbal composition capable of improving intractable skin diseases such as atopic dermatitis, eczema, psoriasis, keratosis, ulcer, and herpes. Background Art

 The cause of atopic dermatitis is not known yet, but it is generally recognized that the disease is caused by a combination of environment, food, and genetic predisposition. In addition, dry skin, skin that is more easily itched than normal people, infections caused by bacteria, viruses, bears, etc.

Atopic dermatitis is the most important symptom of itching. The skin is usually dry, and when it is scratched, itching leads to 發 ^ and then itches again. ^{'In the} acute phase, the boundary is accompanied by uncertain 紅斑 丘 ^, severely, 浮腫, 물, 擦傷, ¾ 皮, ^, 羅 化, degradation. If scratched and injured, there may be a secondary infection caused by Staphylococcus aureus, with 膜 瘤 and ¾ 皮. Chronic repeated scratching of the skin results in aging, cracks with pain, and pigmentation due to repeated eye irritation. However, this problem is not only because of recurrence, but also due to increased medical expenses, normal academic and social activities, depression and popular avoidance, and suicide.

 In the past, 'Taeyeol' was known to appear to young children, but recently, the onset of adulthood is increasing. Increasing number of adult atopic patients who are unable to engage in social or economic activities.

 For the treatment of atopic dermatitis, both are using steroid preparations and immunosuppressants. However, in the case of steroid preparations, the symptom may be temporarily improved. However, when stopped after continuous use, many side effects have been reported that atopic symptoms become worse due to rebound phenomenon. Immunosuppressants are known to replace steroids and are increasing in import and use. Recently, the KFDA stated that some drugs should not be used by children under 2 years of age or those with weakened immune systems due to the risk of carcinogenesis. In addition, the range of use was limited to the second prescription drug when the efficacy was not obtained with other therapeutic agents or when it was resistant to atopy, and the expiration date was also instructed to be used for a short time or intermittently.

 Recently, a large number of patients with atopic dermatitis have tended to rely on herbal treatments and various folk remedies derived from nature to avoid the risk of side effects caused by bilateral therapies, but the scientific basis for this has not been fully presented.

Alternative Paper (Article 26) Detailed Description of the Invention

 [Technical problem]

 As a result of diligent efforts to solve this problem, the inventors have found that the novel composition of the present invention (the inventors call it "Yuppiche") is effective in improving atopic symptoms. The present invention has been completed by verifying the effects of the present invention in patients with refractory skin diseases such as adult atopic dermatitis, eczema, psoriasis, keratosis, yangjinhyeong and han herpes. Accordingly, it is an object of the present invention to provide a novel herbal composition that can improve the intractable skin diseases such as atopy without side effects.

 Technical Solution

 In order to achieve the above object, according to an aspect of the present invention, it is possible to provide a composition for improving skin diseases, including furniture and earth disease. In one embodiment of the present invention furniture and earth bottle may be included in a ratio of 1: 0.2 to 5 by dry weight ratio. In addition, the composition of the present invention may further include one or more medicinal herbs selected from the group consisting of Astragalus, Angelica, Fuling, Root, Dermis and Licorice.

 In one embodiment, the composition of the present invention may include furnishings, terrestrial disease and Astragalus. In another embodiment, the compositions of the present invention may include furniture, earth disease and Angelica. In another embodiment, the composition of the present invention may include furniture, earth sickness and ghost. In another embodiment, the composition of the present invention may include furniture, earth sickness and reeds. In another embodiment, the composition of the present invention may include furniture, earth disease and dermis. In another embodiment, the composition of the present invention may include furniture, earth sickness and licorice. The weight of these added medicinal herbs may be included in the dry weight ratio of 0.2 to 5 when the householder 1 respectively. In addition, the composition of the present invention may be an extract prepared by extracting each material.

 On the other hand, the composition of the present invention in one embodiment may include all furniture, earth disease, Astragalus, Angelica, Fuling, root, dermis and licorice, furniture, earth disease, Astragalus, Angelica, reed, dermis and licorice It may also include. The ratio of the material (dry weight ratio) may be set so that when the householder is 1, the other medicinal herbs are 0.2 to 5, respectively. In one embodiment, the householder: Earth disease: Astragalus ： Angelica ： Roots ： Dermis ： Licorice 1: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5: 0.2 to 5 have. In addition, the composition may be an extract prepared by extracting each material.

 Skin diseases to which the composition of the present invention is applicable are intractable skin diseases selected from the group consisting of atopy, psoriasis, eczema, keratosis, sinus and herpes zoster. The composition can be used for internal use.

 In addition, according to another aspect of the present invention, it is possible to provide a health functional food for improving skin diseases comprising the composition.

 In addition, according to another aspect of the present invention, it is possible to provide a cosmetic for improving skin diseases comprising the composition.

 Advantageous Effects

 The composition of the present invention can effectively improve refractory skin diseases such as atopic dermatitis, psoriasis, eczema, keratosis, ulcer and herpes. The composition of the present invention is composed of plant extracts that have been used for food for a long time, so it is safe to take for a long time, and there are no side effects such as steroids.

Alternative Paper (Article 26) It is useful for improvement.

 [Brief Description of Drawings]

 La is applied to the composition according to an embodiment of the present invention to atopy patients looked at the clinical results for hundreds, improved through the same step of treatment process is a schematic of the process step by step.

 Figures lb to Id is a photograph of skin divided into three stages before, during, and after treatment of a 18-year-old (male) college student atopic patient taking months of the composition of the present invention. Atopic dermatitis, which started from febrile fever, persists from childhood to adolescence, and has been here.

 FIG. 2 is a graph showing the improvement in the SCORAD index over time after administering the composition according to an embodiment of the present invention by dividing 161 atopic patients into three groups of severe, moderate, and mild according to severity. Figure 2a shows the average value of the SCORAD Index every six weeks, the symptom was a long treatment period, was treated in the order of moderate, mild. Figure 2b shows the results of treating severe atopic dermatitis using a composition according to an embodiment of the present invention as a change in the SCORAD Index. There were many differences in the treatment process between patients who used steroids and those who did not.

 3A to 3F are skin photographs showing the progression of a 17-year-old (male) atopic patient for several months with the composition of the present invention, showing an example of the treatment process of a patient who had a history of using a strong steroid before applying the present composition. Shows. In the case of using steroids, the reaction may appear to temporarily deteriorate in the process of stopping steroids, but it will soon improve and have normal clean atopic skin.

 4A to 4E are skin photographs sequentially showing the progression of months of taking a composition of the present invention for a 26-year-old (female) atopic patient, and a treatment process of a patient having a history of not using a steroid before applying the present composition. Shows an example. Patients who do not use steroids are treated with a gradual improvement without transient deterioration.

 5A to 5C are skin photographs of stages before and after treatment, treatment, and treatment of a 15-month (male) baby atopy patient taking months of the composition of the present invention.

 6A to 6C are skin photographs showing elapsed months of eczema patients of 17-year-old (male) high school students taking the compositions of the present invention for several months before, during and after treatment.

 7A to 7C are skin photographs showing the progress of months of taking a composition of the present invention for a 22 year old (female) eczema patient.

 8A to 8F are skin photographs sequentially showing the progression of the psoriasis patients 25 years old (female) taking months of the composition of the present invention. An example of the course of treatment of patients with a history of using dibobet (psoriasis treatment) prior to application of the composition is shown. As you stop using DyboBet, you may experience temporary reactionary reactions.

 9A to 9E are skin photographs showing the progression of a psoriasis patient aged 50 years (male) for several months with the composition of the present invention. Steroids and Divonex

Alternative Paper (Article 26) An example of the treatment of a patient with a history of concurrent use of immunosuppressants (psoriasis drugs) is shown.

 10A to 10D are skin photographs showing the course of months of taking a composition of the present invention by a 10 year old (male) patient with keratosis.

 11A to 11C are skin photographs showing the course of months of taking a composition of the present invention for a keratosis patient aged 63 years (female).

 12A to 12D are skin photographs showing the progression of months of taking a composition of the present invention by a 20-year-old female (female) before, during, and after treatment.

 13A to 13C are photographs of skin showing progress of months of taking a composition of the present invention from a positive patient of 5 years old (male). This is an example of the treatment of patients whose side effects of steroids have been shown by the use of strong steroids.

 14A to WC are skin photographs showing the progress of months of treatment of the composition of the present invention by a 38-year-old (male) herpes zoster patient.

 15A to 15C are skin photographs showing the course of months of taking a composition of the present invention by a 9-year-old (male) herpes zoster patient. This is an example of the treatment history of a patient with history of using steroids caused by a herpes zoster that developed at 17 months of age.

 [Best form for implementation of the invention]

 Hereinafter, specific details for carrying out the present invention will be described in detail including definitions of terms used in the present specification.

 "Atopy c dermat itis" is a chronic, recurrent inflammatory skin disease that usually begins in infancy and childhood.It refers to dermatitis with pruritus (itch), dry skin, and characteristic eczema. Itching, blister papules, hemorrhage, and edema are observed, and in chronic periods, edema and blisters are reduced, but wrinkles or thickening of the skin appear, such as lichenitis, scales, pigmentation, etc. In general, atopic dermatitis and eczema are used synonymously. However, dermatitis is a term that refers to all inflammation, and in strict terms, dermatitis has a broader meaning than eczema.

 "Eczema" is a generic term for a group of skin diseases with common clinical and histological characteristics. Clinically, itching, ecchymosis, scales and clustered papules, blisters, histologically superficial dermatitis with spongy skin on the epidermis and inflammatory skin reaction with inflammatory cells infiltrating the blood vessels in the dermis. Collectively.

 "Psoriasis (psor i asi s)" is a chronic inflammatory skin disease that is covered with silver-white scales, with red and red papules or platy-shaped rashes on the skin of the entire body. It is characterized by the proliferation of keratinocytes of the epidermis and inflammation of the dermis.

"Keratosi s ¹ " refers to a skin disease in which the stratum corneum at the top of the skin's epidermis proliferates and becomes rough or hardened. In addition to the growth of the keratin of the epidermis, sometimes the layers of the hair follicles proliferate more severely than the cornea of the epidermis, forming papules. Keratin is a result of keratinization of epidermal cells, and cell nuclei cannot be found in each layer during normal eye keratinization. But of keratin proliferation

Alternative Paper (Article 26) In this case, the cell nucleus is well stained.

 "Pur igo" is a severe itching neurological disorder, which is representative of Hebra's positivity. Acute rashes, similar to those in a 15-15 year-old outbreak, are rapidly developing and rapidly declining insoles, as well as chronic palpitations, nodular papules appearing as stubborn urticaria, gradually appearing on the outside of the extremities at 3-4 months of pregnancy. There is becoming a gestational lamb. The gestational rash develops in the mother's womb and heals at the same time as childbirth.

 Dyshidrot i c eczema is a sudden, chronic recurrent eczema that causes blisters in the hands or feet, and itching and burning are similar to atopic dermatitis.

 As used herein, the term "improvement" includes the cure of the above described skin diseases as well as partial cure, improvement and alleviation as the course of the present invention. Herbal medicines used to prepare the composition of the present invention are as follows.

 The furrows (semen of Al lium tuberosum) are also known as seeders, seeders, and elders. Leek, a forerunner outpost, is also known as tennis and solji, and is used to release blood. The medicine is odorless and the medicine is hot, sweet and warm. Knee and waist cold and ache, treat erectile dysfunction and diarrhea. Urine finds and controls pain in muscles and bones In addition, blood pressure strengthening and cardiac redness have been reported. In order to prepare the composition of the present invention, the furniture may be roasted and then boiled once to remove the smell.

 Earth disease (Horrhea, Hovenia dulci s) contains fruit, roots, branches, and leaves with beneficial ingredients for humans such as glucose, malic acid, calcium, furangurinine, hobenin, hobenside, and habenic acid. The active chemicals of the bark tree are said to have an excellent effect on relieving hangovers, eliminating bad breath, eliminating bad breath and detoxifying the liver and constipation. In the preparation of the composition of the present invention, the fruit, the branch, the root, and the leaves of the liana may be used, respectively, and these parts may be mixed and used.

 Astragalus membranaceus is a perennial herb that belongs to the legume family. The root is used as a medicine and the active ingredients are pully acid and chol ine. In animal experiments, the inflammatory and diuretic effects of the central nervous system were remarkable. The incidence of nephritis, proteinuria and cholesterol was also suppressed or delayed, and hypotension was reported. Easily tired, weak strength, low voice, sweaty people have been used a lot as a substitute for ginseng. It is widely used in uterine sewage, stomach sewage, dehydration, and uterine bleeding, and it is also effective in increasing physical strength and increasing tension of whole body muscles.

Angelica (Angel i ca gigas) is ^"the blood to act (補血作用) to create a well-known blood when the blood is low. It is made of the roots of Jeung-Duk-Gi or Dwarf-Dang-Gi and has excellent blood-reinforcing effects, and the medicine made from the roots of Cham-Dang-Gi-Gi has strong blood-activating effect (activ 보다는 作用), anti-cancer effect and blood pressure-lowering effect that allows blood to circulate smoothly. Pharmacologically promotes blood flow in the coronary arteries and stimulates red blood cell production. Pooryeong (Por ia cocos) is a fungal nucleus of Pori a cocos, which is a parasitic antler rooted in pine roots. Piss

Alternative Paper (Article 26) It is used for edema of the belly and whole body, seawater due to soaking, vomiting, diarrhea, forgetfulness due to nerve hypersensitivity, oil well, and also used for heart edema. Pharmacological actions include diuresis, intestinal relaxation, ulcer prevention effect, and hypoglycemic effect. ^"

 Brown root (Puerar ia thunbergiana) has tinnitus, gynecology, mung beans, dried dried walnuts, dried persimmons, dried bran, and yellow roots. It helps to ward off high fever, headaches and quench thirst. Indigestion, headache, anemia, dysentery, abdominal pain, alcohol poisoning, colds, vomiting, used to treat women's bleeding. The roots are crushed to drink juice.

 Dermis refers to the cirrus unshiu or mature rind of the same plant in Korea. The dermis releases the clumps. Strengthens the function of the spleen to treat only the abdominal window, belching, vomiting, nausea, indigestion, flatulence and drowsiness, and stool diarrhea. It removes sea water and phlegm and acts as a diuretic. Essential oils have been reported to have digestive stimulation, digestion promotion, expectoration, anti-ulcer and antigastric secretion.

 Licorice (Glycyrrhi za uralensi s) is a medicinal plant, distributed in the northeastern part of the country, Siberia and Mongolia. The root is sweet and is used as a sweetener and herbal medicine. It is effective in increasing the poison of medicine and improving digestive absorption. The composition for improving skin diseases of the present invention is prepared including furrows and earth diseases, and their use for improving skin diseases such as atopic dermatitis, eczema, psoriasis, keratosis, yangjinhyeong and herpes zoster was first discovered by the present inventors. None known until. In one embodiment of the present invention furniture and earth jars may be included in a ratio of 1: 0.2-5 by dry weight ratio.

 In addition, in one embodiment of the present invention, the composition of the present invention may be formulated to further include one or more medicinal herbs selected from the group consisting of Astragalus, Angelica, Fukryeong, root, dermis and licorice. In one embodiment, the composition of the present invention may include furnishings, terrestrial disease and Astragalus. In another embodiment, the composition of the present invention may include furniture, earth disease and donkey. In another embodiment, the composition of the present invention may include furniture, earth sickness and ghost. In another embodiment, the composition of the present invention may include furniture, earth sickness and reeds. In another embodiment, the composition of the present invention may include furniture, earth disease and dermis. In another embodiment, the composition of the present invention may include furniture, earth sickness and licorice. In another embodiment, the composition of the present invention may include all of the above medicines. The weight of these added drugs may be included in a ratio of 0.2 to 5 when the householder is 1 in dry weight ratio.

 In addition, in addition to the above medicines may also additionally include medicines commonly added in the art for taste or flavor.

 In addition, in one embodiment, the composition of the present invention is a dry weight ratio of furnishings: Earth disease: Astragalus ： Angelica: Brown root: Dermis: Licorice 1: 0.2-5: 0.2-5: 0.2-5: 0.2-5: 0.2- 5: It can contain in the ratio of 0.2-5.

 In one embodiment, the composition of the present invention may be an extract prepared by extracting the herbal medicine for internal or external use.

The extract can be prepared using a conventional extraction method. ^"That is extracted

Alternative Paper (Article 26) The solvent can be added to the medicine to extract at high or low pressure or high pressure. As the extraction solvent, for example, water, a lower alcohol having 1 to 4 carbon atoms, or a mixed solvent of sons may be used. There is no particular limitation on the amount of the solvent used ₍ when considering the extraction efficiency, efficacy of the composition, or economic efficiency). The amount of the solvent may be used about 1 to 50 times the dry weight of the drug to be extracted.

 In one embodiment, the composition of the present invention may be prepared by mixing the respective medicines (wherein each medicine may be pulverized or finely chopped with a pulverizer before extraction) using a suitable solvent, and then mixed and mixed with them. By extracting together, each extract can be prepared in a mixed form from the time of extraction.

 Meanwhile, the powder may be used after the extract is prepared in a powder state by an additional process such as vacuum distillation and freeze drying or spray drying.

As a specific manufacturing method of the composition of the present invention, there are the following methods. Extract hot water by adding 1 to 50 times the amount of water to the total dry weight of the medicine by selecting one or more medicines selected from the group consisting of Astragalus, Angelica, Fuling, Root, Dermis, Licorice, and others do. The extraction conditions may be extracted for 2 to 10 hours at 50 to 130 ^° C, preferably for 4 to 6 hours at 80 to 130 ^° C, but is not limited thereto. In one embodiment of the present invention, the amount of extract from the hot water was extracted to a large capacity of about 95, 000mL to reduce the component changes of the contents.

 The composition of the present invention prepared as described above may be packaged for underwear, in which case it may be packaged in a 20 to 150 cc capacity per time. In the case of oral medicine, it is possible to drink three times a day, but the dose or the number of times of oral administration may be appropriately adjusted in consideration of age, mildness of symptoms or improvement of symptoms. In addition, in order to enjoy the refusal of the intake of the infant, the composition of the present invention may further comprise sugar.

 On the other hand, the composition of the present invention can be used in various functional foods for the improvement of skin diseases. The health functional food comprising the composition of the present invention as an active ingredient may be prepared in the form of various foods, for example, beverages, gums, teas, vitamin complexes, powders, granules, tablets, capsules, sweets, rice cakes, and bread. have. Since the composition of the present invention is composed of plant extracts having almost no toxicity and side effects, it can be used with confidence even for long-term use for prophylactic purposes.

 When the composition of the present invention is included in the dietary supplement, the amount may be added at a ratio of 0.1 to 5W of the total weight.

 When the health functional food of the present invention is prepared in the form of a beverage, there is no special limitation other than containing the composition in the ratio indicated, and may contain various flavors or natural carbohydrates as additional ingredients, like ordinary drinks. . That is, as natural carbohydrates, sugars such as monosaccharides such as glucose, disaccharides such as fructose, sucrose and the like, and common sugars such as pullisaccharides, dextrins, cyclodextrins and sugars such as xylitol, sorbitol and erythritol And the like. Examples of the flavourant include natural flavourants (tauumatin, stevia extract (for example, rebaudioside A, glycyrrhizin, etc.), synthetic flavors (saccharin, aspartame, etc.).

Alternative Paper (Article 26) In addition, the health functional food of the present invention includes various nutrients, vitamins, minerals (electrolytes), flavors such as synthetic flavors and natural flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickeners. , PH adjusters, stabilizers, preservatives, glycerin alcohols, carbonation agents used in carbonated drinks and the like.

 These components can be used independently or in combination. The proportion of such additives is not so critical but is generally selected in the range of from 0.01 to about 50 parts by weight per 100 parts by weight of the composition of the present invention. In addition, the composition of the present invention prepared as described above may be used in cosmetics for the improvement of skin diseases. Cosmetics comprising the composition of the present invention as an active ingredient, lotion, nutrition lotion, nutrition essence, massage cream, beauty bath additives, body lotion, body milk, bath oil, baby oil, baby powder, shower gel, shower cream, sunscreen Lotion, sunscreen cream, suntan cream, skin lotion, skin cream, sunscreen cosmetic cleansing milk, depilatory {cosmetic}, face and body lotion, face and body cream, skin whitening cream, hand lotion, hair lotion, cosmetic Cream, Jasmine Oil, Bath Soap, Water Soap, Beauty Soap, Shampoo, Hand Soap (Hand Cleaner), Medicated Soap {Non-Medical}, Cream Soap, Facial Wash, Hairrin, Cosmetic Soap, Tooth Whitening Gel, Toothpaste, etc. It can be prepared as. To this end, the composition of the present invention may further comprise a suitable carrier, excipient or diluent commonly used in the manufacture of cosmetics.

 Carriers, excipients or diluents which may be further added to the compositions of the present invention include purified water, oils, waxes, fatty acids, fatty acid alcohols, fatty acid esters, surfactants, humectants, thickeners, antioxidants, viscosity stabilizers, kills Rating agents, buffers, lower alcohols, and the like. In addition, it may include a whitening agent, moisturizer, vitamins, sunscreen, perfume, dyes, antibiotics, antibacterial agents, antifungal agents as needed.

 The oil may be hydrogenated vegetable oil, castor oil, cottonseed oil, euleeve oil, palm oil, jojoba oil, avocado oil, wax, beeswax, carnauba, candelilla, montan, ceresin, liquid paraffin, Lanolin may be used. As fatty acids, stearic acid, linoleic acid, linolenic acid, oleic acid may be used, and fatty acid alcohols may be cetyl alcohol, octyl dodecane, oleyl alcohol, panthenol, lanolin egg, stearyl alcohol, nucleodecaneol. Isopropyl myristate, isopropyl palmitate, butyl stearate may be used as the fatty acid ester. As the surfactant, cationic surfactants, anionic surfactants and nonionic surfactants known in the art can be used, and surfactants derived from natural products are preferred as much as possible.

 In addition to the hygroscopic agents, thickeners, antioxidants and the like that are widely known in the cosmetic field, these types and amounts are known in the art.

 [Form for implementation of invention]

 Hereinafter, the present invention will be described in more detail with reference to Examples. These examples are only for illustrating the present invention in more detail, and the scope of the present invention is not limited by these examples in accordance with the gist of the present invention to those skilled in the art. Will be self-evident.

Alternative Paper (Article 26) Example

 Example 1 Preparation of Composition

1 kg ᅳ fruit and eggplant 1kg 제거한 was removed to remove impurities, and 6L of purified water was added to extract the extract at 100 ^° C. for 6 hours.

 Example 2: Preparation of Composition

 The well was trimmed to remove impurities, lkg, lychee fruit and eggplant lkg, 250g of Angelica gigao 6L purified water was added and extracted for 6 hours at 10C C extract was prepared. Example 3: Preparation of Composition

 1 kg of bark fruit and eggplant fruit and eggplant lkg, and 250 g of roots were added to the well-groomed and removed impurities to extract 6 hours at 100 ° C for 6 hours. Example 4: Preparation of Composition

 Well-groomed and removed impurities, furnishings 1kg, 500g of bark fruit and eggplant, Astragalus lkg, 2kg, licorice lkg 6L of purified water was added and extracted for 6 hours in lCXrc to prepare an extract.

 Example 5 Preparation of Composition

 Well-groomed and removed pure impurities lkg, bark fruit and eggplant lkg, Astragalus 2kg, Angelica 500g, Root 3kg, Dermis lkg, Licorice 500g was added to the purified water 9L and extracted for 6 hours in KXTC to prepare an extract.

 Example 6: Preparation of Composition

 Well-groomed lkg, bark fruit and eggplant lkg, Astragalus lkg, Angelica lkg, Brown root 5kg, Dermis lkg, Licorice 250g, 9L of purified water was added to extract 10 (C for 6 hours).

 Example 7: Preparation of Composition

 Finely trimmed and removed impurity 3kg, larch fruit and eggplant lkg, Astragalus 2kg, Angelica 500g, Bokyeong 500g, Brown root 1.5kg, Dermal lkg, Licorice 250g, 9L of purified water was added and i (xrc was extracted for 4 hours to extract the extract. Prepared.

 Example 8 Preparation of Composition

 Well-groomed lkg, bark fruit and eggplant 500g, Astragalus 500g, Angelica lkg, Bokryeong lkg, Brown root 4kg, Dermis 500g, Licorice 500g, 9L of purified water was added and extracted for 6 hours at loot: .

 Example 9 Preparation of Composition

 Well-groomed lkg, bark fruit and eggplant lkg, Astragalus 3.5kg, Angelica lkg, brown root 500g, dermis lkg, licorice 500g were added to 9L purified water and extracted for 6 hours in KXTC.

 Example 10 Preparation of Composition

 Well-groomed 2g, 500g of bark fruit and eggplants, Angelica lkg, Bokyeong 2kg, 2 kg, dermis 2kg, dermis 2kg, licorice 500g was added to 9L purified water and extracted for 6 hours at 10CTC.

 Example 11 Preparation of Composition

 1 kg of purified water was added to lkg, bark fruit, eggplant- 3 kg, Bokyeong lkg, larch, lkg, dermis 250g, licorice 500g, and then extracted from ltXTC for 6 hours.

 Example 12 Preparation of Composition

Alternative Paper (Article 26) Well-groomed 1kg, barley fruit and eggplant 2kg, Astragalus 500g, Angelica 1kg, Bokyeong 500g, Brown root 2.5kg, Dermis 1.5kg, Licorice 1.5kg were ground for about 30 seconds. The pulverized product was extracted with 70% ethane using an extractor equipped with a reflux apparatus at 15 C for 72 hours using an aqueous solution, filtered and the filtrate was concentrated under reduced pressure and dried to obtain an extract powder. Formulation example

 Formulation Example 1: Preparation of beverages (unit: weight ¾)

 5%, fructose 3%, sodium riboflavin hydrochloride 0.0001%, pyridoxine hydrochloride 0.00¾, and water 81.9998% and the composition 1 obtained in Example 1 is combined to prepare a health beverage in a conventional manner.

 Formulation Example 2: Preparation of Tablet (Unit: Increase%)

 * 110

 Composition 33.0 of Example 12

 Lactose 33.0

 Corn Starch 33.3

 Magnesium Stearate 0.7

 After mixing the above components and tableting according to a conventional tablet production method to produce a tablet.

 Formulation Example 3 Preparation of Lotion (Unit: Weight%)

 Composition 3.00 of Example 3

 Ascorbic Acid-2-Magnesium Phosphate 1.00

 Soluble collagen (1% aqueous solution) 1.00

 Sodium Citrate 0.10

 Citric Acid 0.0 5

 1,3-butylene glycol 3.00

 Purified water level

 Formulation Example 4 Preparation of Lotion (Unit: Weight ¾)

 Composition 2.00 of Example 4

 Hydroxyethylene Cellulose (2% aqueous solution) 12.00

 Xanthan gum (2¾ aqueous solution) 2.00

 1,3-butylene glycol 6.00.

 Glycerin 4.00.

 Sodium Hyaluronate (1% aqueous solution) 5.00

 Purified water residual amount test example

 1. Development of the composition

 When the composition of Example 1 was administered 70 ml three times a day to twenty atopic patients, it was confirmed that the symptoms of symptoms such as lb to Id improved. The picture in the figure shows a representative treatment, the progress of the improvement of other patients is similar. To increase the level of improvement or to shorten the duration of treatment.

Alternative Paper (Article 26) By further adding the medicines, the composition of Examples 2 to 12 (including the case of Example 1, called the composition of the present invention, commonly referred to as Yun-pye) was tested. In the case of the composition of Example 12, 10 g of the extract powder was dissolved in 70 ml of water and used.

 As a result, the efficacy of the compositions of Examples 2 to 12 was almost similar to that of Example 1, or there was some enhancement depending on the additive medicine. Of these, the composition of Example 5 was chosen to conduct the following studies.

 2. Research subject

 Atopic dermatitis was treated by applying the composition of Example 5 to 161 patients who had been diagnosed as atopic dermatitis among patients with skin disease who visited Shin-Chang clinic Gangnam branch from April 2010 to March 2012. Of the 161, 23 were younger than 2 years old, 46 from 3 to 15 years old, and 92 over 16 years old. In 161 cases, the symptoms were classified according to SCORAD Index. 54 cases were mild, 60 cases were moderate, and 47 cases were mildly distributed (Table 1).

 3. Research method

 The composition of the present invention was administered to all patients in a single prescription, and at the same time was applied to the diet to eat vegetables-based heat cooked food to block the factors that exacerbate atopic dermatitis.

 4. Standard of diagnosis

 Atopic dermatitis is currently difficult to treat atopic dermatitis objectively and systematically because there is no clear standard of diagnosis anywhere in Western medicine. In this paper, we applied the Scoring of Atopic Dermatitis (SCORAD) Index, which is commonly used in the medical community and the world, every six weeks to quantify the improvement and deterioration of symptoms. In general, SCORAD Index scores from 77.26 to the highest score, 103, are severe, 54.3 ~ 77.26 are moderate, and 25.76 ~ 54.3 are mild, and 25.76 or less need no treatment.

 5. Method of administration

 The single dose of the composition of Example 5, extracted directly from here with purified water, is very small at 70 mL. Adults were taken three times a day after meals, and children and adolescents were reduced according to the severity of symptoms, especially infants under the first stone, divided into 1-2 bags per day depending on the severity of symptoms and steroid use. did.

 6. Results

 The results of observing the course while applying the composition of Example 5 of the present invention to 161 patients with atopic dermatitis are shown in the SCORAD index score of FIG. 2.

The treatment effect of conventional atopic dermatitis is evaluated when the SCORAD index score decreases by more than 30% due to the change of the lesions. Therefore, 131 patients showed a significant decrease during the treatment period of the compositions of the present invention showed a statistically significant difference. In addition, there was a statistically significant difference when the degree of improvement of the severity index was divided and checked. The results of the treatment are plotted as follows. A total of 161 patients started treatment, and the 131 patients treated to the rare and management stage of FIG. 1 had a treatment rate of 81 ^< ¾, and 30 patients were delayed or discontinued treatment (19%) (Table 1).

Alternative Paper (Article 26) Table 1

 Of the 161, 23 were younger than 2 years old, 46 from 3 to 15 years old, and 92 over 16 years old. Among the 161 patients, the SCORAD Index was used to classify symptom severity. 54 patients were mild, 60 were eclampsia and 47 were symptomatic.

 Unlike the treatment with steroids, the administration of yunjeopje of the present invention not only improves the symptoms of atopic dermatitis, but also improves gradually with repeated improvement and deterioration with the formation and dropping of keratin.

 In addition, as a result of taking yunpiche in breast, infants and adults, it is common to be exfoliated → wound recovery → sprouting of new life → sweating → recovery and care (hair growth)

5 steps in order to confirm that atopic dermatitis is being treated (see Figure 1)

 In the case of the history of steroid use, symptoms were temporarily aggravated by the reaction to desteroid in the early stage of treatment, and steroids were gradually treated without temporary deterioration. Severe cure rate was 64%, moderate severity rate was 85%, mild cure rate was 93%, and long term treatment was required in order of severe, moderate and mild. A total of 161 patients with atopic dermatitis who started treatment had 131 patients treated until the recovery and management stage, and 31 patients (19%) had the treatment.

 Below 3 pictures are clinical pictures that can directly check the skin condition that improves as you yunpiche.

 3A to 3F are photographs showing the progress of treatment of a 17-year-old male student. After eight months of administration, you can see that atopic dermatitis improves significantly. The symptom of the worsening of the course of treatment was Rebound Phenomenon following the discontinuation of the strong steroids used in previous treatments, but it was finally cured by the continuous administration of Yunpicheong.

 4A to 4E are photographs showing the progress of treatment of a 26 year old woman. At the time of first visit, atopic dermatitis such as lichenitis, cancer, hemorrhoids, dryness, exudation, and edema in the whole body was severe enough to appear in the whole body, especially on the elbows, stomach, back, shoulders, etc. ) And Taeseonhwa were in severe condition. However, since the steroid was treated only in a general clinic without a history of internal or external use, it was cured by taking Yunpocheong for about 4 months.

 5A to 5C are photographs showing the progress of treatment of a 15 month old baby boy. In order to treat atopic dermatitis that occurred only after 1 month of birth, various oriental treatments were used, but there was a history of using lacticare, a weak steroid, for about 2 months. When symptoms worsen, thick limbs progress not only on the face, but also on the entire body and limbs, and hair loss on the forehead begins to appear.

Alternative Site (Article 26) I started taking the compositions herein. After taking the present composition for 3 months, as the thick scab was eliminated and the keratin was eliminated several times, the skin of the whole body gradually became clear and cured. On the other hand, the composition of the present invention showing an excellent effect on atopic patients was applied to other skin diseases such as eczema, psoriasis, keratosis, yangjeok and han herpes. The results of applying the composition of Example 5 of the present invention to patients with eczema, psoriasis, keratosis, yangjin and herpes zoster visited to Shinchang Clinic Gangnam from April 2010 to March 2012 are described below.

 As shown in Figure 6a to 7c, as a result of applying the composition of Example 5 of the present invention to the eczema patient for several months and the same management as the atopic dermatitis patient, the eruption from the eczema is quickly stopped and treated as the wound heals I could see the senses. After the disappearance of eczema, the darkly colored skin was cured as the pigment gradually disappeared and turned into a normal, pale skin similar to the surrounding skin color. Treatment of the eczema by the composition of the present invention had a difference in the duration of treatment depending on the size and depth of the eczema onset, the time of first occurrence, the type of drug being treated, or whether or not it occurred in the joint. 6A to 6C are photographs showing the eczema of a 17-year-old (male) high school student taking a year of the composition of the present invention for each year before, during and after treatment. Dozens of molar eczema with a diameter of 3 ~ 5cm on the trunk and upper and lower body as well as the arm developed hospital treatment at dermatology hospital, but it was not cured and was treated with Yunpicheung herbal medicine.

 7A to 7C are skin photographs showing the progression of eczema patients 22 years old (female) taking 10 months of the composition of the present invention. Although daily life was almost impossible due to local eczema with extreme acute severe atopic dermatitis throughout the whole body, and was concerned about using a first-class steroid drug called domohoron at the time of the visit, If it is.

 8A to 9E show the same course of administration as the atopic dermatitis patient while applying the composition of Example 5 to the psoriasis patient for several months. In severe cases of severe psoriasis, psoriasis in the psoriasis area was larger and thicker, and psoriasis was larger in size, but as psoriasis disappeared, psoriasis gradually decreased in size and psoriasis. The skin got thinner. In severe cases, psoriasis in the shape of small water droplets was formed and disappeared for a while after the skin was restored to normal, and finally it returned to normal smooth and pale skin. On the other hand, early psoriasis-like psoriasis improved rapidly as the skin thinned as the drought dropped out quickly. Psoriasis was less itching than atopic dermatitis, so did not strictly follow the diet. Factors deciding on the duration of psoriasis were the thickness of the scale, the ratio of the developed psoriasis to the whole body (¾), the strength and duration of the steroids used, and the use of immunosuppressants.

 8A to 8F are skin photographs sequentially showing the progress of the psoriasis patients 25 years old (female) taking 1 year of the composition of the present invention. At the time of the visit, Dibovetra used psoriasis treatment at the dermatology clinic, but after long-term use, it became more resistant.

Alternative Site (Article 26) We visited here in the absence of an abnormal effect. It seemed to temporarily deteriorate when discontinuing the use of dibobet while applying the composition of the present application, but immediately healed. In this case, severe psoriasis appears to deteriorate at the beginning of treatment, but gradually improves and appears to be cured at once. there was.

 9A to 9E are skin photographs showing the progression of a 50-year-old (male) psoriasis patient taking the composition of the present invention for 5 months. While taking a steroid in a dermatology clinic while simultaneously administering a psoriasis drug called Dynex, an immunosuppressant, the efficacy of the drug was reduced and treatment was started with the composition of the present application. There was a difficulty in managing the treatment, but he was treated as a result of taking Yunpicheong.

 In addition, the progress of applying the composition of Example 5 of the present invention to keratosis patients for several months is shown in FIGS. 10A to 11C. Because keratosis has little itching, the diet is rarely administered. Treatment progressed and produced dozens of dead skin cells on hard and rough skin, and the general duration of treatment required much longer treatment than atopic dermatitis by comparing the severity of symptoms.

 10A to 10D are skin photographs showing a course of taking a composition of the present invention for about one year by a keratosis patient aged 10 years (male). At 5 years of age, keratosis developed at the age of 2, and went to treat both dermatology and university hospitals, but there is no difference in the treatment began with the composition of the present-. Herbal medicine is taken twice a day, almost improved, and reduced to once a day after completing the treatment.

 11A to 11C are skin photographs showing the progress of 6 months of the 63-year-old grandmother keratosis patient taking the composition of the present invention in order before treatment, after treatment, and after treatment. As a child, keratosis developed during the treatment of both dermatology and university hospitals, but did not improve, began treatment with the composition of the present application. Healed with keratin over his lifetime with atopy symptoms, stiff and stiff palms softened and smoothed.

 12A-13C show the progress of applying the composition of Example 5 of the present invention to months of positive patients. As a result of administration of the composition of the present invention in the same manner as the atopic dermatitis patient, the latent symptom was revealed as skin at the beginning of treatment, but gradually disappeared and improved without newly appearing lesions. Yang Jin had severe itching and needed thorough food management, and sometimes healed itching by taking antihistamines.

 12A to 12C are skin photographs showing the progression of six months of treatment of the composition of the present invention by a 20 year old (female) female college graduate patient before, during, and after treatment. From childhood, he suffered from conjunctivitis and suffered from severe itching due to frequent use of weak steroids in ophthalmology. Treatment of atopy and yangjin at the same time using the yunpiche of our company.

 13A to 13C are skin photographs showing the progress of a 10-year-old male patient taking the composition of the present invention for 5 months (male). , The effect is almost

Alternative Paper (Article 26) Side effects of steroids (thinning of the skin of the face and the whole body and ancestors appear) began to appear and were treated and visited here.

 Figures 14a to 15c shows the progress of applying the composition of Example 5 of the present invention to the herpes zoster patient for several months. As a result of applying the composition of the present invention, the same treatment as in patients with atopic dermatitis, the latent shingles appeared on the skin, and the already developed shingles were rapidly expelled and treated with normal skin while listening to new flesh. Hanpozi had a much shorter treatment period compared to atopic dermatitis.

 14A to 14C are skin photographs showing the progression of 38 months of age (male) patients with herpes zoster for 3 months with the composition of the present invention. Because of the herpes zoster that developed 4 years ago, various treatments were attempted, but the patient was admitted to a condition that had no remission. 15A to 15C are skin photographs showing the progression of a 9-year-old (male) elementary school student with a herpes zoster for 3 months with the composition of the present invention. Atopic dermatitis caused by 17 months of age was treated with steroids with atopic dermatitis, and suffered from the symptoms of getting worse.

 The course of treatment for patients with each of these skin diseases was evaluated to improve similarly to that of atopy, although not shown here as specific statistics as for atopy.

Industrial Applicability

 The composition of the present invention can effectively improve intractable skin diseases such as atopic dermatitis, psoriasis, eczema, keratosis, ulcers and herpes. The composition of the present invention is composed of plant extracts that have been used for a long time since it is safe to take for a long time, there is no side effects such as steroids is useful for the improvement of the refractory skin disease.

Alternative Site (Article 26)

Claims

 [Range of request]  ί claim 1  Composition for improving skin diseases, including furniture and earth disease.  [Claim 2]  According to claim 1, Household furniture and earth diseases are included in the ratio of 1: 1 to 0.2 in a dry increase ratio, the composition for improving skin diseases.  [Claim 3]  The composition for improving skin diseases according to claim 1, further comprising one or more medicines selected from the group consisting of Astragalus, Angelica, Bokryeong, Root, Dermis, and Licorice. [Claim 4]  A composition for improving skin diseases comprising the extract prepared by extracting the composition of claim 1 as an active ingredient.  [Claim 5]  A composition for improving skin diseases, including furniture, earth disease, coriander, donkey, root, dermis and licorice. The ratio (dry weight ratio) of the above ingredients is furnishing ： Earth disease ： Astragalus ： Angelica ： Root ： Dermis 1: 0.2-5: 0.2-5: 0.2-5: 0.2-5: 0.2-5: The composition for skin disease improvement of 0.2-5.  (Claim 6)  A composition for improving skin diseases comprising an extract prepared by extracting the composition of claim 5 as an active ingredient.  [Claim 7] The composition for improving skin diseases according to any one of claims 1 to 6, wherein the skin disease is selected from the group consisting of atopic dermatitis, psoriasis, eczema, keratosis, sinusitis and herpes zoster. ^' [Claim 8]  The composition for improving skin diseases according to any one of claims 1 to 6, wherein the composition is for internal use.  [Claim 9]  Claim 1 to 6 health functional foods for improving skin diseases comprising the composition of any one of claims.  [Claim 10] Cosmetics for improving skin diseases comprising the composition of any one of claims 1 to ₆ . Alternative Paper (Article 26)