KR20160034359A - 이미다졸카복스아미드 및 faah 억제제로서 이들의 용도 - Google Patents

이미다졸카복스아미드 및 faah 억제제로서 이들의 용도 Download PDF

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Publication number
KR20160034359A
KR20160034359A KR1020167004236A KR20167004236A KR20160034359A KR 20160034359 A KR20160034359 A KR 20160034359A KR 1020167004236 A KR1020167004236 A KR 1020167004236A KR 20167004236 A KR20167004236 A KR 20167004236A KR 20160034359 A KR20160034359 A KR 20160034359A
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KR
South Korea
Prior art keywords
disease
compound
mmol
imidazole
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
KR1020167004236A
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English (en)
Korean (ko)
Inventor
칼라 패트리시아 다 코스타 페레이라 로사
리타 구스마오 데 노론하
라즐로 어노 키스
Original Assignee
바이알 - 포르텔라 앤드 씨에이 에스에이
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Filing date
Publication date
Priority claimed from GB201313204A external-priority patent/GB201313204D0/en
Priority claimed from GB201313203A external-priority patent/GB201313203D0/en
Priority claimed from GB201313202A external-priority patent/GB201313202D0/en
Application filed by 바이알 - 포르텔라 앤드 씨에이 에스에이 filed Critical 바이알 - 포르텔라 앤드 씨에이 에스에이
Publication of KR20160034359A publication Critical patent/KR20160034359A/ko
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Ophthalmology & Optometry (AREA)
  • Psychology (AREA)
  • Anesthesiology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
KR1020167004236A 2013-07-24 2014-07-24 이미다졸카복스아미드 및 faah 억제제로서 이들의 용도 Abandoned KR20160034359A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB1313204.8 2013-07-24
GB1313202.2 2013-07-24
GB1313203.0 2013-07-24
GB201313204A GB201313204D0 (en) 2013-07-24 2013-07-24 Urea compound and its use as an enzyme inhibitor
GB201313203A GB201313203D0 (en) 2013-07-24 2013-07-24 Urea compound and its use as an enzyme inhibitor
GB201313202A GB201313202D0 (en) 2013-07-24 2013-07-24 Urea Compound And Its Use As An Enzyme Inhibitor
PCT/PT2014/000049 WO2015012708A1 (en) 2013-07-24 2014-07-24 Imidazolecarboxamides and their use as faah inhibitors

Publications (1)

Publication Number Publication Date
KR20160034359A true KR20160034359A (ko) 2016-03-29

Family

ID=51358056

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020167004236A Abandoned KR20160034359A (ko) 2013-07-24 2014-07-24 이미다졸카복스아미드 및 faah 억제제로서 이들의 용도

Country Status (20)

Country Link
US (2) US10501447B2 (enExample)
EP (1) EP3024825B1 (enExample)
JP (1) JP6449277B2 (enExample)
KR (1) KR20160034359A (enExample)
CN (1) CN105793247B (enExample)
AU (1) AU2014293731B2 (enExample)
CA (1) CA2918993C (enExample)
CY (1) CY1119482T1 (enExample)
DK (1) DK3024825T3 (enExample)
ES (1) ES2640800T3 (enExample)
HR (1) HRP20171378T1 (enExample)
HU (1) HUE033615T2 (enExample)
LT (1) LT3024825T (enExample)
MX (1) MX362315B (enExample)
PL (1) PL3024825T3 (enExample)
PT (1) PT3024825T (enExample)
RS (1) RS56297B1 (enExample)
RU (1) RU2671404C2 (enExample)
SI (1) SI3024825T1 (enExample)
WO (1) WO2015012708A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG10201802129QA (en) 2017-07-05 2019-02-27 Frimline Private Ltd A pharmaceutical composition for neuropathic pain
US10702487B2 (en) 2017-08-19 2020-07-07 Frimline Private Limited Pharmaceutical composition for prevention of diet induced obesity
PH12018000227B1 (en) 2017-09-05 2019-03-11 Frimline Private Ltd A pharmaceutical composition for improving or preventing progression of chronic kidney disease

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2458965C3 (de) 1974-12-13 1979-10-11 Bayer Ag, 5090 Leverkusen 3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel
EP0014810A3 (en) 1979-01-18 1980-11-26 Fbc Limited Pesticidal pyrazoles, their production, compositions and uses, as well as intermediates and their preparation
JPH01203366A (ja) 1988-02-10 1989-08-16 Mitsui Petrochem Ind Ltd Ｎ−置換イミダゾール誘導体
CA2146755A1 (en) 1992-10-28 1994-05-11 Kenji Takeda Novel 1,2-benzoisoxazole derivative or its salt and brain-protecting agent comprising the same
DE102004005172A1 (de) 2004-02-02 2005-08-18 Aventis Pharma Deutschland Gmbh Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
WO2006074025A1 (en) * 2004-12-30 2006-07-13 Janssen Pharmaceutica N.V. Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase
FI20075264A0 (fi) 2007-04-18 2007-04-18 Kuopion Yliopisto Heterosykliset fenyylikarbamaatit uusina FAAH-inhibiittoreina
US8324241B2 (en) 2008-04-11 2012-12-04 Bristol-Myers Squibb Company Triazolo compounds useful as DGAT1 inhibitors
AU2009330821B2 (en) 2008-12-24 2015-06-11 Bial - Portela & Ca, S.A. Pharmaceutical compounds
WO2012015324A1 (en) 2010-07-29 2012-02-02 Bial - Portela & Ca, S.A. Process for the synthesis of substituted urea compounds
FR2965262A1 (fr) 2010-09-24 2012-03-30 Sanofi Aventis Derives de nicotinamide, leur preparation et leur application en therapeutique
CA2879726A1 (en) 2012-07-24 2014-01-30 Bial- Portela & Ca, S.A. Urea compounds and their use as enzyme inhibitors

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EP3024825B1 (en) 2017-06-21
HRP20171378T1 (hr) 2017-12-15
US20160176854A1 (en) 2016-06-23
PL3024825T3 (pl) 2017-12-29
SI3024825T1 (sl) 2017-11-30
CN105793247B (zh) 2018-03-16
RU2671404C2 (ru) 2018-10-31
JP2016525543A (ja) 2016-08-25
WO2015012708A1 (en) 2015-01-29
CA2918993A1 (en) 2015-01-29
US20200255412A1 (en) 2020-08-13
DK3024825T3 (en) 2017-10-02
CA2918993C (en) 2021-08-24
CN105793247A (zh) 2016-07-20
JP6449277B2 (ja) 2019-01-09
AU2014293731A1 (en) 2016-02-11
US10501447B2 (en) 2019-12-10
AU2014293731B2 (en) 2018-03-08
ES2640800T3 (es) 2017-11-06
PT3024825T (pt) 2017-09-28
MX362315B (es) 2019-01-11
MX2016000797A (es) 2016-09-08
CY1119482T1 (el) 2018-03-07
LT3024825T (lt) 2017-12-11
HUE033615T2 (hu) 2017-12-28
RU2016104221A (ru) 2017-08-29
EP3024825A1 (en) 2016-06-01
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