CN105793247B - 咪唑甲酰胺类及其作为faah抑制剂的用途 - Google Patents
咪唑甲酰胺类及其作为faah抑制剂的用途 Download PDFInfo
- Publication number
- CN105793247B CN105793247B CN201480041611.9A CN201480041611A CN105793247B CN 105793247 B CN105793247 B CN 105793247B CN 201480041611 A CN201480041611 A CN 201480041611A CN 105793247 B CN105793247 B CN 105793247B
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- China
- Prior art keywords
- compound
- purposes
- pharmaceutical composition
- imidazole
- mmol
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 0 *c1cccc(-c(nc2)c[n]2C(Oc2ccccc2)=O)c1 Chemical compound *c1cccc(-c(nc2)c[n]2C(Oc2ccccc2)=O)c1 0.000 description 1
- FYSAKCNZCNLMRT-UHFFFAOYSA-N CCC(N(CC1)CCC1N(C)C(N(C1)C=NC1c(cc1C)ccc1O)=O)=O Chemical compound CCC(N(CC1)CCC1N(C)C(N(C1)C=NC1c(cc1C)ccc1O)=O)=O FYSAKCNZCNLMRT-UHFFFAOYSA-N 0.000 description 1
- LZBWETIWUYDTJJ-UHFFFAOYSA-N CCC(N(CC1)CCC1N(C)C([n]1cnc(-c(cc2)cc(C)c2OC)c1)=O)=O Chemical compound CCC(N(CC1)CCC1N(C)C([n]1cnc(-c(cc2)cc(C)c2OC)c1)=O)=O LZBWETIWUYDTJJ-UHFFFAOYSA-N 0.000 description 1
- NVPIRDDUWLQGHI-UHFFFAOYSA-N CN(C1CCOCC1)C([n]1cnc(-c2cc([N+]([O-])=O)ccc2)c1)=O Chemical compound CN(C1CCOCC1)C([n]1cnc(-c2cc([N+]([O-])=O)ccc2)c1)=O NVPIRDDUWLQGHI-UHFFFAOYSA-N 0.000 description 1
- WGYZZCUTSHNMET-UHFFFAOYSA-N CNC1CCOCC1 Chemical compound CNC1CCOCC1 WGYZZCUTSHNMET-UHFFFAOYSA-N 0.000 description 1
- KMUNZMOVTRPCQQ-UHFFFAOYSA-N Cc(cc(cc1)-c2c[n](C(N(C)C3CCNCC3)O)cn2)c1OC Chemical compound Cc(cc(cc1)-c2c[n](C(N(C)C3CCNCC3)O)cn2)c1OC KMUNZMOVTRPCQQ-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Cardiology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pulmonology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Ophthalmology & Optometry (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Anesthesiology (AREA)
- Otolaryngology (AREA)
- Gastroenterology & Hepatology (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1313202.2 | 2013-07-24 | ||
| GB201313202A GB201313202D0 (en) | 2013-07-24 | 2013-07-24 | Urea Compound And Its Use As An Enzyme Inhibitor |
| GB1313203.0 | 2013-07-24 | ||
| GB201313204A GB201313204D0 (en) | 2013-07-24 | 2013-07-24 | Urea compound and its use as an enzyme inhibitor |
| GB1313204.8 | 2013-07-24 | ||
| GB201313203A GB201313203D0 (en) | 2013-07-24 | 2013-07-24 | Urea compound and its use as an enzyme inhibitor |
| PCT/PT2014/000049 WO2015012708A1 (en) | 2013-07-24 | 2014-07-24 | Imidazolecarboxamides and their use as faah inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105793247A CN105793247A (zh) | 2016-07-20 |
| CN105793247B true CN105793247B (zh) | 2018-03-16 |
Family
ID=51358056
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201480041611.9A Expired - Fee Related CN105793247B (zh) | 2013-07-24 | 2014-07-24 | 咪唑甲酰胺类及其作为faah抑制剂的用途 |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US10501447B2 (enExample) |
| EP (1) | EP3024825B1 (enExample) |
| JP (1) | JP6449277B2 (enExample) |
| KR (1) | KR20160034359A (enExample) |
| CN (1) | CN105793247B (enExample) |
| AU (1) | AU2014293731B2 (enExample) |
| CA (1) | CA2918993C (enExample) |
| CY (1) | CY1119482T1 (enExample) |
| DK (1) | DK3024825T3 (enExample) |
| ES (1) | ES2640800T3 (enExample) |
| HR (1) | HRP20171378T1 (enExample) |
| HU (1) | HUE033615T2 (enExample) |
| LT (1) | LT3024825T (enExample) |
| MX (1) | MX362315B (enExample) |
| PL (1) | PL3024825T3 (enExample) |
| PT (1) | PT3024825T (enExample) |
| RS (1) | RS56297B1 (enExample) |
| RU (1) | RU2671404C2 (enExample) |
| SI (1) | SI3024825T1 (enExample) |
| WO (1) | WO2015012708A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201802129QA (en) | 2017-07-05 | 2019-02-27 | Frimline Private Ltd | A pharmaceutical composition for neuropathic pain |
| US10702487B2 (en) | 2017-08-19 | 2020-07-07 | Frimline Private Limited | Pharmaceutical composition for prevention of diet induced obesity |
| SG10201807034XA (en) | 2017-09-05 | 2019-04-29 | Frimline Private Ltd | A pharmaceutical composition for improving or preventing progression of Chronic Kidney Disease |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102333568A (zh) * | 2008-12-24 | 2012-01-25 | 比亚尔-珀特拉和Ca股份公司 | 药物化合物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2458965C3 (de) | 1974-12-13 | 1979-10-11 | Bayer Ag, 5090 Leverkusen | 3-Amino-indazol-N-carbonsäure-Derivate, Verfahren zu ihrer Herstellung sowie sie enthaltende Arzneimittel |
| EP0014810A3 (en) | 1979-01-18 | 1980-11-26 | Fbc Limited | Pesticidal pyrazoles, their production, compositions and uses, as well as intermediates and their preparation |
| JPH01203366A (ja) | 1988-02-10 | 1989-08-16 | Mitsui Petrochem Ind Ltd | N−置換イミダゾール誘導体 |
| AU674358B2 (en) | 1992-10-28 | 1996-12-19 | Toyama Chemical Co. Ltd. | Novel 1,2-benzoisoxazole derivative or its salt and brain -protecting agent comprising the same |
| DE102004005172A1 (de) | 2004-02-02 | 2005-08-18 | Aventis Pharma Deutschland Gmbh | Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase |
| DK1836179T3 (en) * | 2004-12-30 | 2015-05-26 | Janssen Pharmaceutica Nv | PIPERIDINE AND PIPERAZINE-1-CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS MODULATORS OF FAT ACID AMIDE HYDRALASE (FAAH) FOR THE TREATMENT OF ANCIENT, PAIN AND OTHER CONDITIONS |
| FI20075264A0 (fi) | 2007-04-18 | 2007-04-18 | Kuopion Yliopisto | Heterosykliset fenyylikarbamaatit uusina FAAH-inhibiittoreina |
| WO2009126624A1 (en) | 2008-04-11 | 2009-10-15 | Bristol-Myers Squibb Company | Triazolo compounds useful as dgat1 inhibitors |
| CA2806701A1 (en) | 2010-07-29 | 2012-02-02 | Bial - Portela & Ca, S.A. | Process for the synthesis of substituted urea compounds |
| FR2965262A1 (fr) | 2010-09-24 | 2012-03-30 | Sanofi Aventis | Derives de nicotinamide, leur preparation et leur application en therapeutique |
| HRP20180543T1 (hr) | 2012-07-24 | 2018-06-29 | Bial-Portela & Ca, S.A. | Spojevi uree i njihova upotreba kao inhibitora enzima |
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2014
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|---|---|---|---|---|
| CN102333568A (zh) * | 2008-12-24 | 2012-01-25 | 比亚尔-珀特拉和Ca股份公司 | 药物化合物 |
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| CN105793247A (zh) | 2016-07-20 |
| EP3024825B1 (en) | 2017-06-21 |
| ES2640800T3 (es) | 2017-11-06 |
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| US10501447B2 (en) | 2019-12-10 |
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| CY1119482T1 (el) | 2018-03-07 |
| PT3024825T (pt) | 2017-09-28 |
| PL3024825T3 (pl) | 2017-12-29 |
| LT3024825T (lt) | 2017-12-11 |
| MX2016000797A (es) | 2016-09-08 |
| AU2014293731B2 (en) | 2018-03-08 |
| WO2015012708A1 (en) | 2015-01-29 |
| CA2918993A1 (en) | 2015-01-29 |
| JP2016525543A (ja) | 2016-08-25 |
| US20160176854A1 (en) | 2016-06-23 |
| MX362315B (es) | 2019-01-11 |
| RU2671404C2 (ru) | 2018-10-31 |
| CA2918993C (en) | 2021-08-24 |
| EP3024825A1 (en) | 2016-06-01 |
| DK3024825T3 (en) | 2017-10-02 |
| RU2016104221A (ru) | 2017-08-29 |
| AU2014293731A1 (en) | 2016-02-11 |
| SI3024825T1 (sl) | 2017-11-30 |
| RS56297B1 (sr) | 2017-12-29 |
| HRP20171378T1 (hr) | 2017-12-15 |
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