KR20150143672A - Ras/raf/mek/erk 및 pi3k/akt/pten/mtor 경로의 이중 억제제로서의 퀴나졸린 및 아자퀴나졸린 - Google Patents

Ras/raf/mek/erk 및 pi3k/akt/pten/mtor 경로의 이중 억제제로서의 퀴나졸린 및 아자퀴나졸린 Download PDF

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KR20150143672A
KR20150143672A KR1020157032374A KR20157032374A KR20150143672A KR 20150143672 A KR20150143672 A KR 20150143672A KR 1020157032374 A KR1020157032374 A KR 1020157032374A KR 20157032374 A KR20157032374 A KR 20157032374A KR 20150143672 A KR20150143672 A KR 20150143672A
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sulfonamide
fluorophenyl
fluoropropane
phenyl
alkyl
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스콧 케이. 톰슨
로저 에이. 스미스
산지바 레디
타일러 엠. 존
비제이 쿠마르 냐바난디
호사할리 수브라만야
비제이 포틀루리
수닐 쿠마르 파니그라히
프라브하카라 라오 나디팔리
사우미트라 센굽타
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아사나 바이오사이언시스 엘엘씨
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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KR1020157032374A 2013-04-12 2014-04-11 Ras/raf/mek/erk 및 pi3k/akt/pten/mtor 경로의 이중 억제제로서의 퀴나졸린 및 아자퀴나졸린 Abandoned KR20150143672A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361811408P 2013-04-12 2013-04-12
US61/811,408 2013-04-12
PCT/US2014/033727 WO2014169167A1 (en) 2013-04-12 2014-04-11 Quinazolines and azaquinazolines as dual inhibitors of ras/raf/mek/erk and pi3k/akt/pten/mtor pathways

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KR20150143672A true KR20150143672A (ko) 2015-12-23

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US (5) US9499495B2 (enExample)
EP (1) EP2984088B1 (enExample)
JP (1) JP6496301B2 (enExample)
KR (1) KR20150143672A (enExample)
CN (1) CN105283454B (enExample)
AU (1) AU2014250836C1 (enExample)
BR (1) BR112015025901A8 (enExample)
CA (1) CA2909310A1 (enExample)
IL (2) IL242020B (enExample)
MX (1) MX2015014387A (enExample)
RU (1) RU2015148359A (enExample)
WO (1) WO2014169167A1 (enExample)
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WO2018009638A1 (en) * 2016-07-06 2018-01-11 The Regents Of The University Of Michigan MULTIFUNCTIONAL INHIBITORS OF MEK/PI3K AND mTOR/MEK/PI3K BIOLOGICAL PATHWAYS AND THERAPEUTIC METHODS USING THE SAME
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CA3174865A1 (en) * 2016-12-26 2018-07-05 Institute Of Materia Medica, Chinese Academy Of Medical Sciences Quinazoline compound and preparation method, application, and pharmaceutical composition thereof
CN108239074B (zh) * 2016-12-26 2021-07-06 中国医学科学院药物研究所 喹唑啉类化合物及其制备方法、用途和药物组合物
CN108239076B (zh) * 2016-12-26 2021-07-06 中国医学科学院药物研究所 喹唑啉类化合物及其制备方法、用途和药物组合物
WO2018212774A1 (en) * 2017-05-17 2018-11-22 Vanderbilt University Quinazoline compounds as modulators of ras signaling
CA3066939A1 (en) 2017-06-21 2018-12-27 SHY Therapeutics LLC Compounds that interact with the ras superfamily for the treatment of cancers, inflammatory diseases, rasopathies, and fibrotic disease
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JP7407461B2 (ja) 2018-12-19 2024-01-04 シャイ・セラピューティクス・エルエルシー がん、炎症性疾患、ｒａｓ病、及び線維性疾患の処置のためのｒａｓスーパーファミリーと相互作用する化合物
CN111499634B (zh) * 2019-01-31 2023-05-12 贝达药业股份有限公司 一种喹唑啉化合物及其在医药上的应用
CN112341434B (zh) * 2019-08-08 2021-11-26 恩瑞生物医药科技（上海）有限公司 PI3K/mTOR蛋白降解靶向嵌合体类化合物及其制备方法和医药用途
MA56056A (fr) 2019-11-01 2022-04-06 Fmc Agro Singapore Pte Ltd Nouveau procédé efficace de synthèse de 2-amino-5-chloro-n-,3-diméthylbenzamide
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CN117683049A (zh) 2020-09-15 2024-03-12 锐新医药公司 作为ras抑制剂以治疗癌症的吲哚衍生物
WO2022109001A1 (en) * 2020-11-18 2022-05-27 Deciphera Pharmaceuticals, Llc Gcn2 and perk kinase inhibitors and methods of use thereof
JP2024517845A (ja) 2021-05-05 2024-04-23 レボリューション メディシンズ インコーポレイテッド がん治療のためのｒａｓ阻害剤
CN113416181B (zh) * 2021-08-02 2022-05-03 四川大学 喹唑啉类衍生物及其用途
AR127308A1 (es) 2021-10-08 2024-01-10 Revolution Medicines Inc Inhibidores ras
WO2023131122A1 (zh) * 2022-01-04 2023-07-13 劲方医药科技(上海)有限公司 稠环取代的六元杂环化合物及其制法和用途
CN115894211A (zh) * 2022-11-10 2023-04-04 山东龙立恒医药有限公司 一种3-羟基-4-甲基苯甲酸的制备方法

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US20190151327A1 (en) 2019-05-23
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US9757382B2 (en) 2017-09-12
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US9499495B2 (en) 2016-11-22
MX2015014387A (es) 2017-04-10
EP2984088B1 (en) 2019-03-20
US20210113578A1 (en) 2021-04-22
US20160068496A1 (en) 2016-03-10
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US10912779B2 (en) 2021-02-09

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