KR20150109783A - Cosmetic composition for atopic care product that contains natural conjugated materials and growth factors, and manufacturing method thereof, and skin care composition with it - Google Patents

Cosmetic composition for atopic care product that contains natural conjugated materials and growth factors, and manufacturing method thereof, and skin care composition with it Download PDF

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KR20150109783A
KR20150109783A KR1020140033077A KR20140033077A KR20150109783A KR 20150109783 A KR20150109783 A KR 20150109783A KR 1020140033077 A KR1020140033077 A KR 1020140033077A KR 20140033077 A KR20140033077 A KR 20140033077A KR 20150109783 A KR20150109783 A KR 20150109783A
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국 배 도
형 록 도
순 섭 김
교 성 서
병 소 김
재 천 신
동 목 이
시 원 최
재 훈 김
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(주)메디웨이코리아
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • AHUMAN NECESSITIES
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18Magnoliophyta (angiosperms)
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    • A61K36/32Burseraceae (Frankincense family)
    • A61K36/328Commiphora, e.g. mecca myrrh or balm of Gilead
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • A61K38/1808Epidermal growth factor [EGF] urogastrone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/85Products or compounds obtained by fermentation, e.g. yoghurt, beer, wine

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Abstract

The present invention relates to a cosmetic composition for atopic dermatitis containing a natural compound and a growth factor, a manufacturing method thereof, and a skin care composition containing the same as active components. The cosmetic composition for atopic dermatitis is characterized by containing 10-13 parts by weight of a fermented dandelion solution; 20-25 parts by weight of a water parsley extract, 1-4 parts by weight of a myrrh concentrate, and 0.1-3.5 parts by weight of an epidermal growth factor (EGF) for 100 parts by weight of a lotus extract, thereby having an excellent atopic dermatitis relieving effect by a strong anti-inflammatory function of myrrh and not causing troubles on the sensitive skin by being manufactured with natural components.

Description

천연복합물과 성장인자를 함유한 아토피용 화장료 조성물, 이의 제조방법 및 이를 유효성분으로 함유하는 스킨 케어용 조성물 {Cosmetic composition for atopic care product that contains natural conjugated materials and growth factors, and manufacturing method thereof, and skin care composition with it}TECHNICAL FIELD The present invention relates to a cosmetic composition for atopic use containing a natural complex and a growth factor, a method for preparing the composition, and a composition for skin care containing the same as an active ingredient. care composition with it}

본 발명은 천연복합물과 성장인자를 함유한 아토피용 화장료 조성물, 이의 제조방법 및 이를 유효성분으로 함유하는 스킨 케어용 조성물에 관한 것이다.
The present invention relates to a cosmetic composition for atopic use containing a natural complex and a growth factor, a method for producing the composition, and a skin care composition containing the same as an active ingredient.

아토피 피부염은 피부건조증, 습진 등으로 다양하게 나타나기 때문에 발병 원인이 어느 한 가지로만 설명될 수는 없지만, 환경적인 요인과 유전적인 소인, 면역학적 반응 및 피부보호막의 이상 등이 주요 원인으로 여겨지고 있다. 특히, 환경적인 요인으로는 산업화로 인한 매연 등 환경 공해, 식품첨가물 사용의 증가, 서구식 주거 형태로 인한 카펫, 침대, 소파의 사용 증가, 실내 온도 상승으로 인한 집먼지 진드기 등의 알레르기를 일으키는 원인 물질(알레르겐)의 증가 등이 있다.Since atopic dermatitis is manifested by skin dryness, eczema, etc., the cause of the disease can not be explained in any one way, but environmental factors, genetic predisposition, immunological reaction and skin barrier abnormalities are considered to be the main causes. In particular, environmental factors include environmental pollution caused by industrialization, increase in the use of food additives, increase in use of carpet, bed, sofa due to western type of residence, cause of allergy such as house dust mites caused by room temperature rise (Allergen), and so on.

또한 실내에서 애완동물을 키우는 일이 많아지면서 원인 물질에 노출되는 것도 원인이 된다. 한편 아토피 피부염이 유전적인 영향을 받는 점은 많은 아토피 피부염 환자들이 가족력이 있다는 사실에서 알 수 있다.Also, it is caused by exposure to the causative substances as the number of pets is increased in the room. The fact that atopic dermatitis is genetically affected can be seen in the fact that many patients with atopic dermatitis have family history.

이와 같이 아토피 피부염을 진정시키기 위한 화장료 개발이 집중적으로 육성되고 있으나 그 연구결과는 아직 미약한 실정에 있다.
The development of cosmetics for sedating atopic dermatitis has been intensively developed, but the results of the research are still weak.

이러한 아토피 피부염을 진정시키기 위해 제안된 대한민국 등록특허 제0733869호(등록일자: 2007. 6. 25., 발명의 명칭: 고삼, 창이자, 백선피, 사상자 및 어성초를 이용한 천연추출물과 이를 이용한 화장료 및 그 제조방법)는 고삼, 창이자, 백선피, 사상자, 어성초를 혼합한 원료에 상기 혼합한 원료의 건조중량을 기준으로 1 ~ 20배의 용매를 가하여 상기 용매가 증발되는 것을 방지한 상태에서 40 ~ 100℃에서 2 ~ 24시간 가열하여 얻은 천연 추출물로서, 상기 용매는 물, 에탄올, 부틸렌글리콜, 프로필렌글리콜, 글리세린, 메탄올 중 어느 하나 또는 둘 이상이 혼합되어서 이루어진 제1의 천연 추출물, 상기 제1의 천연 추출물에서 상기 원료는 건조중량을 기준으로 고삼 18 ~ 58%, 창이자 9 ~ 19%, 백선피 14 ~ 22%, 사상자 9 ~ 19%, 어성초 10 ~ 22%로 이루어진 제2의 천연 추출물, 고삼, 창이자, 백선피, 사상자, 어성초를 혼합한 원료에 상기 혼합한 원료의 건조중량을 기준으로 1 ~ 20배의 용매를 가하여 5 ~ 40℃에서 1 ~ 15일간 침적시켜서 얻은 천연 추출물로서, 상기 용매는 물, 에탄올, 부틸렌글리콜, 프로필렌글리콜, 글리세린, 메탄올 중 어느 하나 또는 둘 이상이 혼합되어서 이루어진 제3의 천연 추출물, 상기 제3의 천연 추출물에서 상기 원료는 건조중량을 기준으로 고삼 18 ~ 58%, 창이자 9 ~ 19%, 백선피 14 ~ 22%, 사상자 9 ~ 19%, 어성초 10 ~ 22%로 이루어진 제4의 천연 추출물들 중 어느 하나의 천연 추출물을 중량대비 0.1% ~ 10% 첨가한 화장료가 개시되어 있다.Korean Patent No. 0733869 (registered on June 25, 2007, title of the invention: natural extracts using gosam, Changsai, white pine, casualty and horseradish, cosmetics using them, and the like) proposed to sedate these atopic dermatitis A manufacturing method) is a method in which a solvent containing 1 to 20 times the amount of the dry weight of the mixed raw materials is added to a raw material containing a mixture of red ginseng, red ginseng, white ginseng, casualties and cashews to prevent the solvent from evaporating, Wherein the solvent is selected from the group consisting of a first natural extract obtained by mixing one or more of water, ethanol, butylene glycol, propylene glycol, glycerin and methanol, In the natural extract, the raw material is a second natural extract consisting of 18 to 58% of ginseng, 9 to 19% of ginseng, 14 to 22% of white ginseng, 9 to 19% of casualties and 10 to 22% of ginseng A natural extract obtained by adding 1 to 20 times of a solvent based on the dry weight of the mixed raw material to a raw material mixed with ginseng, sorghum, white tiger blood, casualties, and perch, and immersing the mixture at 5 to 40 ° C for 1 to 15 days, Wherein the solvent is a third natural extract made by mixing any one or more of water, ethanol, butylene glycol, propylene glycol, glycerin and methanol, and in the third natural extract, To about 10% by weight of the natural extract of any one of the fourth natural extracts consisting of ~ 58%, ginseng 9 ~ 19%, white ginseng 14 ~ 22%, casualties 9 ~ 19%, ginseng 10 ~ A cosmetic additive is disclosed.

또한, 대한민국 등록특허 제0905386호(등록일자: 2009. 6. 23., 발명의 명칭: 생약추출물을 함유하는 아토피 피부용 한방화장료 조성물)는 우엉(1~3) : 금은화(1~3) : 소태나무(1~3) : 인진쑥(1~3) : 자소엽(1~3) 중량비율 혼합 생약의 프로필렌글라이콜 또는 알코올 추출물을 유효성분으로 함유하되, 우엉은 프로필렌글라이콜 추출물이고, 금은화, 소태나무, 인진쑥 및 자소엽은 알코올 추출물을 유효성분으로 함유하고, 상기 우엉, 금은화, 소태나무, 인진쑥, 자소엽의 추출용매인 프로필렌글라이콜과 에탄올은 각각 30 내지 100% 프로필렌글라이콜 수용액이고, 50 내지 100% 에탄올 수용액을 사용하는 것을 특징으로 하는 아토피 피부질환 개선용 조성물이 개시되어 있다.Korean Patent No. 0905386 (registered on June 23, 2009, entitled "Atopic skin cosmetic composition for atopic skin containing herbal extracts") contains burdock (1 to 3): gold silver (1 to 3) (1) to (3): propyleneglycol or an alcohol extract of a mixed herb contains as an active ingredient, the burdock is a propylene glycol extract, Propylene glycol and ethanol which are extractants of burdock, gingkojite, aloe vera, arthaxidopsis and japanese lobule are contained in an amount of 30 to 100% by weight of propylene glycol Wherein the aqueous solution is an aqueous solution of 50 to 100% ethanol.

또한, 대한민국 등록특허 제1142977호(등록일자: 2012. 4. 27., 발명의 명칭: 백련오행차 혼합 추출물을 함유하는 아토피 피부 개선 효과를 가지는 화장료 조성물 및 그 제조방법 및 그를 함유하는 화장료)는 화장료 조성물 제조방법으로서, 건조된 녹차, 백차, 홍차, 황차, 흑차 및 백련초를 2:1:1:0.5:0.5:5의 중량비로 혼합한 백련오행차를 그 부피에 대하여 5 내지 10배 부피의 용매에 넣은 후, 냉각 콘덴서가 달린 추출기를 사용하여 50 내지 100℃에서 2 내지 20 시간 동안 가열하거나 5 내지 40℃에서 1 내지 15일간 침적시켜 혼합물을 추출하는 단계; 상기 추출한 혼합물을 여과포를 사용하여 여과하고, 15 내지 25℃에서 냉각하는 단계; 상기 냉각한 혼합물을 5 내지 15℃에서 3일간 숙성시키는 단계; 상기 숙성시킨 혼합물을 필터로 여과하여 여액을 제조하는 단계; 및 상기 여액을 감압회전증발기에서 용매를 완전히 제거하여 추출물을 제조하는 단계를 포함하는 백련오행차 혼합추출물을 함유하는 아토피 피부 개선 효과를 가지는 화장료 조성물 제조방법이 개시되어 있다.Korean Patent No. 1142977 (registered on Apr. 27, 2012, entitled: Cosmetic Composition Having Atopic Skin Improving Effect Containing Paeonyoung Ochang Tea Mix Extract, Method for Producing the Same, and Cosmetic Containing Same) A method for preparing a cosmetic composition, which comprises mixing 5 to 10 times the volume of dried green tea, white tea, black tea, yellow tea, black tea and white tea with a weight ratio of 2: 1: 1: 0.5: And then heating the mixture at 50 to 100 DEG C for 2 to 20 hours or 5 to 40 DEG C for 1 to 15 days using an extractor equipped with a cooling condenser to extract the mixture; Filtering the extracted mixture using a filter cloth and cooling at 15 to 25 占 폚; Aging the cooled mixture at 5 to 15 占 폚 for 3 days; Filtering the aged mixture with a filter to prepare a filtrate; And a step of completely removing the solvent in the reduced pressure rotary evaporator to prepare an extract. The method for producing a cosmetic composition having an atopic skin-improving effect containing an extract of Paeoniae japonica mixture is disclosed.

이 밖에, 대한민국 등록특허 제136423호(등록일자: 2014. 2. 19., 발명의 명칭: 피부 개선용 약학 조성물, 화장료 조성물 및 그 제조방법) 및 대한민국 등록특허 제1354412호(등록일자: 2014. 1. 15., 발명의 명칭: 두향엽 발효여액을 포함하는 아토피 피부염 개선 및 미백용 화장료 조성물 및 그 제조방법) 등이 개시되어 있으나 이와 같은 모든 발명들은 실제 아토피 피부염의 진정 효과가 주장하고 있으나 이에 대한 근거가 미약한 문제점이 있었다.
In addition, Korean Patent No. 136423 (registered on February 19, 201, entitled "PHARMACEUTICAL COMPOSITION FOR SKIN PURIFICATION, COSMETIC COMPOSITION AND METHOD FOR PRODUCING THE SAME") and Korean Patent No. 1354412 (registered date: 2014. 1. 15, title of the invention: a cosmetic composition for the improvement and whitening of atopic dermatitis comprising a fermented filtrate of bifidobacterium and a method for producing the same, etc.), but all of these inventions claim the sedative effect of atopic dermatitis There is a weak basis for the reason.

상기와 같은 문제점을 해결하고자 창출된 본 발명의 목적은, 천연 성분으로 피부 트러블이 없으며 몰약의 강력한 소염기능을 통한 아토피 진정 효과가 우수한 천연복합물과 성장인자를 함유한 아토피용 화장료 조성물, 이의 제조방법 및 이를 유효성분으로 함유하는 스킨 케어용 조성물을 제공하는 데 있다.
The object of the present invention created to solve the above problems is to provide a cosmetic composition for atopic use containing a natural complex and a growth factor which are free from skin troubles as natural ingredients and have excellent atopy relieving effect through strong anti-inflammatory function of myrrh, And a composition for skin care comprising the same as an active ingredient.

이러한 본 발명의 목적은, 아토피용 화장료 조성물에 있어서, 연 추출액 100 중량부에 대하여, 민들레 발효액 10 ~ 13 중량부, 미나리 추출액 20 ~ 25 중량부, 몰약 농축액 1 ~ 4 중량부 및 표피 성장인자(Epidermal Growth Factor, EGF) 0.1 ~ 3.5 중량부를 더 함유하는 것을 특징으로 하는 천연복합물과 성장인자를 함유한 아토피용 화장료 조성물에 의해 달성될 수 있다.It is an object of the present invention to provide a cosmetic composition for atopic use which comprises 10 to 13 parts by weight of a dandelion fermentation broth, 20 to 25 parts by weight of an extract of Mulberry extract, 1 to 4 parts by weight of a mulberry concentrate, And 0.1 to 3.5 parts by weight of Epidermal Growth Factor (EGF). The cosmetic composition for atopic use containing a natural complex and a growth factor may be used.

바람직하게는, 본 발명의 상기 표피 성장인자는 프로필렌 에센스 오일이 주성분인 것을 특징으로 한다.
Preferably, the epidermal growth factor of the present invention is characterized by being a propylene essence oil as a main component.

본 발명의 다른 목적은, 아토피용 화장료 조성물에 있어서, 연 추출액 100 중량부에 대하여, 민들레 발효액 10 ~ 13 중량부, 미나리 추출액 20 ~ 25 중량부, 몰약 농축액 1 ~ 4 중량부 및 표피 성장인자(Epidermal Growth Factor, EGF) 0.1 ~ 3.5 중량부를 더 함유하여 제조되어지되, 상기 연 추출액은, ① 연근, 연잎 및 연자육(연꽃씨) 5 ~ 9 중량부를 세정수를 이용하여 1 ~ 3회 깨끗이 세척한 후 60 ~ 85℃에서 증숙한 후 건조하는 단계와; ② 정제수 100 중량부에 대하여 상기 연근 50 ~ 55 중량부, 상기 연잎 12 ~ 18 중량부 및 상기 연자육 5 ~ 7 중량부를 넣고 90 ~ 120℃ 온도에서 12 ~ 18시간 끓이는 단계와; ③ 구연산 0.02 ~ 0.1 중량부를 더 혼합한 후 180 ~ 220℃ 온도에서 3 ~ 5시간 동안 끓인 후 서냉하는 단계와; ④ 정제수 250 ~ 300 중량부를 더 혼합하여 60 ~ 80℃ 온도에서 18 ~ 22시간 동안 끓인 다음, 여과하여 -5 ~ 0℃ 온도에서 5 ~ 10일간 저온 보관하는 단계로 제조되고, 상기 민들레 발효액은, 발효 용기에 민들레 줄기, 민들레 꽃 및 설탕을 7 ~ 8 : 1 ~ 2 : 10의 중량비로 충전하여 당도 25 ~ 27 브릭스가 되도록 한 후 밀폐하고, 그늘에서 6 ~ 18개월 발효시킨 후 여과하여 제조되고, 상기 미나리 추출액은, ① 뿌리를 제거한 미나리 50kg을 세정수를 이용하여 복수 회 세척하는 단계와; ② 상기 미나리를 압착한 후 5 ~ 10℃ 온도에서 30 ~ 45일간 저온 숙성한 후 여과하는 단계와; ③ 상기 여과된 미나리 100 중량부에 대하여 정제수 200 ~ 350 중량부 및 홍초 식초 0.1 ~ 0.6 중량부를 더 혼합한 다음, 50 ~ 65℃에서 18 ~ 24시간 끓인 후 서냉하는 단계와; ④ 정제수 50 ~ 75 중량부를 더 혼합한 다음, 40 ~ 50℃ 온도에서 3 ~ 5시간 동안 끓인 후 서냉하여 0 ~ 5℃ 온도에서 5 ~ 10일간 저온 보관하여 제조되고, 상기 몰약 농축액은, ① 에틸알코올 100 중량부에 대하여 몰약 10 ~ 15 중량부 및 올리브유 1.5 ~ 2.5 중량부를 혼합한 후 3 ~ 5 시간 교반하는 단계와; ② 45 ~50℃ 온도에서 30 ~ 40분 동안 가열하여 에틸알코올을 휘발시킨 후, 20 ~ 30분 동안 교반하여 여과하는 단계와; ③ 밀폐 용기에 충전한 후 -10 ~ -5℃ 온도에서 10 ~ 15일간 냉동 보관하여 제조되는 것을 특징으로 하는 천연복합물과 성장인자를 함유한 아토피용 화장료 조성물 제조방법에 의해 달성될 수 있다.
Another object of the present invention is to provide a cosmetic composition for atopic use which comprises 10 to 13 parts by weight of a dandelion fermentation broth, 20 to 25 parts by weight of an extract of Mulberry extract, 1 to 4 parts by weight of a mulberry extract, And 0.1 to 3.5 parts by weight of Epidermal Growth Factor (EGF), which is prepared by: 1) washing 5-9 parts by weight of lotus root, leaves and lotus seeds with clean water one to three times Followed by drying at 60 to 85 ° C, followed by drying; (B) adding 50 to 55 parts by weight of the lotus root, 12 to 18 parts by weight of the lotus root, and 5 to 7 parts by weight of the pine nut to 100 parts by weight of purified water, and boiling at 90 to 120 ° C for 12 to 18 hours; (3) 0.02 to 0.1 part by weight of citric acid is further mixed, and the mixture is boiled at a temperature of 180 to 220 DEG C for 3 to 5 hours and then slowly cooled; (D) 250-300 parts by weight of purified water is further mixed and boiled for 18-22 hours at a temperature of 60-80 ° C., filtered, and stored at -5 to 0 ° C. for 5 to 10 days at a low temperature. The dandelion fermentation liquid, Dandelion flower, and sugar at a weight ratio of 7 to 8: 1 to 2:10 to obtain a sugar content of 25 to 27 Bricks, sealing the mixture, fermenting the mixture in the shade for 6 to 18 months, , And the dropwort extract solution is prepared by: (1) washing 50 kg of buttercups with roots removed a plurality of times using washing water; ② squeezing the buttercups, aging at a temperature of 5 to 10 ° C for 30 to 45 days at a low temperature and then filtering; (3) 200 to 350 parts by weight of purified water and 0.1 to 0.6 part by weight of red vinegar are further added to 100 parts by weight of the filtered buttercream, followed by boiling at 50 to 65 ° C for 18 to 24 hours, followed by slow cooling; (4) mixing 50 to 75 parts by weight of purified water, boiling at 40 to 50 ° C for 3 to 5 hours, slowly cooling, and storing at low temperature for 5 to 10 days at 0 to 5 ° C. Mixing 10 to 15 parts by weight of mols and 1.5 to 2.5 parts by weight of olive oil with respect to 100 parts by weight of alcohol, followed by stirring for 3 to 5 hours; ② heating at 45 to 50 ° C for 30 to 40 minutes to volatilize the ethyl alcohol, stirring for 20 to 30 minutes and filtering; (3) filling the container in an airtight container and then storing the mixture at -10 to -5 ° C for 10-15 days.

본 발명의 또 다른 목적은, 스킨 케어 조성물에 있어서, 스킨 케어 베이스 100 중량부에 대하여 천연복합물 20 ~ 33 중량부 및 표피 성장인자 0.3 ~ 0.5 중량부를 더 함유하되, 상기 천연복합물은, 연 추출액 100 중량부에 대하여, 민들레 발효액 10 ~ 13 중량부, 미나리 추출액 20 ~ 25 중량부, 몰약 농축액 1 ~ 4 중량부 및 표피 성장인자(Epidermal Growth Factor, EGF) 0.1 ~ 3.5 중량부인 것을 특징으로 하는 천연복합물과 성장인자를 함유한 스킨 케어용 조성물에 의해 달성될 수 있다.
Another object of the present invention is to provide a skin care composition comprising 20 to 33 parts by weight of a natural complex and 0.3 to 0.5 parts by weight of a skin growth factor per 100 parts by weight of a skin care base, Characterized in that the dandelion fermentation broth (10 to 13 parts by weight), the parsley extract (20 to 25 parts), the myrrh concentrate (1 to 4 parts) and the epidermal growth factor (EGF) And a composition for skin care containing a growth factor.

이상과 같은 본 발명은 천연 성분으로 제조되어 민감성 피부의 트러블 문제가 야기되지 않으며 몰약의 강력한 소염기능으로 아토피 진정 효과가 매우 우수한 특징이 있다.
The present invention as described above is characterized in that it is made of a natural ingredient and does not cause troubles of sensitive skin, and has a strong anti-atopy effect due to strong anti-inflammatory function of myrrh.

도 1 내지 도 3은 본 발명의 스킨 케어의 사용 전 및 사용 4주 후를 병변부위를 나타내는 사진들이다.Figs. 1 to 3 are photographs showing lesion sites before and 4 weeks after use of the skin care of the present invention. Fig.

이하, 본 발명의 실시예를 참조하여 설명하기로 한다.Hereinafter, embodiments of the present invention will be described.

본 실시예에 적용된 천연복합물과 성장인자를 함유한 아토피용 화장료 조성물은 연 추출액 100 중량부에 대하여, 민들레 발효액 10 ~ 13 중량부, 미나리 추출액 20 ~ 25 중량부, 몰약 농축액 1 ~ 4 중량부 및 표피 성장인자(Epidermal Growth Factor, EGF) 0.1 ~ 3.5 중량부를 함유한다.The cosmetic composition for atopic use containing the natural complex and the growth factor according to the present invention is characterized in that it comprises 10 to 13 parts by weight of a dandelion fermentation broth, 20 to 25 parts by weight of a cinnabar extract, 1 to 4 parts by weight of a myrrh concentrate, And 0.1 to 3.5 parts by weight of Epidermal Growth Factor (EGF).

여기서, 실시예에 적용된 표피 성장인자(EGF)는 프로필렌 에센스 오일 (Propylene Essential Oils)이 주성분인 것을 사용한다.
Herein, the epidermal growth factor (EGF) used in the examples is one having propylene essential oil as a main component.

천연복합물 제조Manufacture of natural composites

(가) 연 추출액 (A) Kite extract

1. 연근, 연잎 및 연자육(연꽃씨)을 세정수를 이용하여 1 ~ 3회 깨끗이 세척한다. 1. Wash the lotus root, the lotus leaf and the lotus seeds cleanly 1 ~ 3 times using the washing water.

2. 연근, 연잎 및 연자육을 60 ~ 85℃에서 증숙한 후 건조한다. 이와 같은 증숙 건조 공정을 3 ~ 5회 반복한다.2. Dried lotus root, kelp leaf and pineal gland at 60 ~ 85 ℃. Repeat this steam drying process 3 to 5 times.

3. 정제수 100 중량부에 대하여 연근 50 ~ 55 중량부, 연잎 12 ~ 18 중량부 및 연자육 5 ~ 7 중량부를 넣고 90 ~ 120℃ 온도에서 12 ~ 18시간 끓인다.3. 50 to 55 parts by weight of a lotus root, 12 to 18 parts by weight of a lotus root and 5 to 7 parts by weight of a pine nut are added to 100 parts by weight of purified water, and the mixture is boiled at 90 to 120 ° C for 12 to 18 hours.

4. 구연산 0.02 ~ 0.1 중량부를 더 혼합한 후 180 ~ 220℃ 온도에서 3 ~ 5시간 동안 끓인 후 서냉한다.4. Add 0.02 to 0.1 part by weight of citric acid, boil at 180 to 220 ° C for 3 to 5 hours, and slowly cool.

5. 정제수 250 ~ 300 중량부를 더 혼합하여 60 ~ 80℃ 온도에서 18 ~ 22시간 동안 끓인 다음, 여과하여 -5 ~ 0℃ 온도에서 5 ~ 10일간 저온 보관한다.
5. 250-300 parts by weight of purified water is further mixed and boiled at a temperature of 60 to 80 ° C for 18 to 22 hours, filtered, and stored at -5 to 0 ° C for 5 to 10 days.

(나) 민들레 발효액 (B) Dandelion fermentation liquid

발효 용기에 민들레 줄기, 민들레 꽃 및 설탕을 7 ~ 8 : 1 ~ 2 : 10의 중량비로 충전하여 당도 25 ~ 27 브릭스가 되도록 한 후 밀폐한다. 그런 다음, 상온의 그늘에서 6 ~ 18개월 발효시킨 후 여과한다.
Fill the fermentation vessel with dandelion stem, dandelion flower and sugar at a weight ratio of 7 ~ 8: 1 ~ 2: 10 to make the sugar content 25 ~ 27 Bricks. Then, it is fermented in shade at room temperature for 6 to 18 months and then filtered.

(다) 미나리 추출액 (C) Buttercup extract

1. 뿌리를 제거한 미나리 50kg을 세정수를 이용하여 1 ~ 3회 세척한다.1. Remove 50 kg of rootstock and wash it once or three times with washing water.

2. 미나리를 15 ~ 17 kg/cm2의 압력으로 압착한 후 5 ~ 10℃ 온도에서 30 ~ 45일간 저온 숙성한 후 여과한다.2. Pressurize the buttercups at a pressure of 15 to 17 kg / cm 2 , mature at 5 to 10 ° C for 30 to 45 days, and then filter.

3. 여과된 미나리 100 중량부에 대하여 정제수 200 ~ 350 중량부 및 홍초 식초 0.1 ~ 0.6 중량부를 더 혼합한 다음, 50 ~ 65℃에서 18 ~ 24시간 끓인 후 서냉한다.3. 200 to 350 parts by weight of purified water and 0.1 to 0.6 part by weight of red vinegar are further mixed with 100 parts by weight of filtered buttercream, boiled at 50 to 65 ° C for 18 to 24 hours, and slowly cooled.

4. 정제수 50 ~ 75 중량부를 더 혼합한 다음, 40 ~ 50℃ 온도에서 3 ~ 5시간 동안 끓인 후 서냉하여 0 ~ 5℃ 온도에서 5 ~ 10일간 저온 보관한다.
4. 50 to 75 parts by weight of purified water is further mixed and boiled at a temperature of 40 to 50 ° C for 3 to 5 hours, followed by gradual cooling and stored at 0 to 5 ° C for 5 to 10 days.

(라) 몰약 농축액 (D) Myrrh concentrate

1. 에틸알코올 100 중량부에 대하여 몰약 10 ~ 15 중량부 및 올리브유 1.5 ~ 2.5 중량부를 혼합한 후 3 ~ 5 시간 교반한다.1. 10-15 parts by weight of mols and 1.5-2.5 parts by weight of olive oil are mixed with 100 parts by weight of ethyl alcohol, followed by stirring for 3 to 5 hours.

2. 그런 다음, 45 ~50℃ 온도에서 30 ~ 40분 동안 가열하여 에틸알코올을 휘발시킨 후, 20 ~ 30분 동안 교반하여 여과한다.2. Then, the mixture is heated at 45 to 50 ° C for 30 to 40 minutes to volatilize the ethyl alcohol, and then the mixture is stirred for 20 to 30 minutes.

3. 마지막, 밀폐 용기에 충전한 후 -10 ~ -5℃ 온도에서 10 ~ 15일간 냉동 보관한다.
3. Finally, after filling in sealed container, keep frozen at -10 ~ -5 ℃ for 10 ~ 15 days.

(바) 천연복합물 및 성장인자를 함유한 스킨 케어 조성물 (F) Skins containing natural complexes and growth factors Care composition

본 실시예는 스킨 케어 베이스(로션) 100 중량부에 대하여 천연복합물 20 ~ 33 중량부 및 표피 성장인자 0.3 ~ 0.5 중량부를 첨가하여 제조된다.
This embodiment is prepared by adding 20 to 33 parts by weight of a natural complex and 0.3 to 0.5 parts by weight of a skin growth factor to 100 parts by weight of a skin care base (lotion).

(사) 천연복합물 및 성장인자를 함유한 스킨 케어 조성물 제조방법 (G) Skins containing natural complexes and growth factors Method for manufacturing care composition

본 실시예의 제조방법은 스킨 케어 베이스 100 중량부에 대하여 천연복합물 20 ~ 33 중량부 및 표피 성장인자 0.3 ~0.5 중량부를 첨가한 다음 4 ~ 6시간 교반한 후 -5 ~ 0℃ 온도에서 10 ~ 60일 저온 보관하여 제조하는 방법을 제공한다.
20 to 33 parts by weight of the natural complex and 0.3 to 0.5 part by weight of the epidermal growth factor were added to 100 parts by weight of the skin care base, and then the mixture was stirred for 4 to 6 hours, Which is stored at a low temperature for one day.

(아) 스킨 케어(로션) 제조(A) Skin care (lotion) manufacturing

Figure pat00001
Figure pat00001

여기서, 본 실시예에 적용된 스킨 케어는 스킨 케어 베이스 100 중량부에 대하여 20 ~33 중량부 및 표피 성장인자 0.3 ~ 0.5 중량부를 혼합하여 20 ~ 25℃에서 4 ~ 8시간 교반하여 제조된다. 스킨 케어 베이스는 표 1에서 천연복합물 및 표피 성장인자를 제외한 성분을 나타낸다.
Here, the skin care applied to the present embodiment is prepared by mixing 20 to 33 parts by weight of the skin care base with 0.3 to 0.5 parts by weight of the epidermal growth factor and stirring at 20 to 25 캜 for 4 to 8 hours. The skin-care base represents the components in Table 1, excluding the natural complex and epidermal growth factor.

아토피 진정 효과실험Atopy calming effect experiment

① 실험 대상자 - 35명 선정① Test subject - selected 35 persons

만성 질환이 없는 민감성 피부를 가진 10 ~ 30대 여성을 선정한다.Women in their 10s and 30s with sensitive skin without chronic disease are selected.

② 실험 방법 및 결과② Experimental methods and results

실험 조건은 바람이 잘 통하는 실내온도 25℃, 상대습도 23% 조건하에서 이루어졌다.The experimental conditions were as follows: windy room temperature 25 ℃, relative humidity 23%.

병변부위를 깨끗히 씻은 후 물기를 제거하고 10분 후 천연복합물 및 표피 성장인자를 함유하는 스킨 케어(표 1)을 아토피 환부에 발랐다. 여기서, 피험자들은 본 실시예의 스킨 케어를 4주 동안 하루에 두 번씩 병변부위에 도포하도록 하였으며, 제품 사용 전과 사용 4주 후의 병변부위를 활영한 사진으로부터 아토피 증상이 개선되는 것을 확인하였다.After the lesion was cleaned, the water was removed, and 10 minutes later, a skin care containing natural complex and epidermal growth factor (Table 1) was applied to the atopic lesion. Here, the subjects were allowed to apply the skin care of the present example to the lesion twice a day for 4 weeks, and the atopic symptoms were improved from the photograph of the lesion area before use and after 4 weeks of use.

피험자들은 4주 후의 방문에서 병변 부위의 호전을 보였고, 피험자의 주관적인 평가와 가려움증 정도, 아토피 피부증상 등이 모두 호전 또는 개선되었음을 도 1 내지 도 3와 같이 확인할 수 있었다.
The subjects showed improvement in the lesion site after 4 weeks' visit, and the subjective evaluation of the subject, the degree of itching, and the atopic skin symptoms were both improved or improved as shown in FIGS. 1 to 3.

이상과 같은 본 발명은 일 실시예에 한정되어 설명되었으나, 이에 한정되지 않고 본 발명의 기술적 사상을 토대로 변형되는 실시예들은 모두 본 발명의 권리범위에 속함이 분명하다.While the present invention has been described with reference to exemplary embodiments, it is to be understood that the invention is not limited to the disclosed exemplary embodiments.

Claims (4)

아토피용 화장료 조성물에 있어서,
연 추출액 100 중량부에 대하여, 민들레 발효액 10 ~ 13 중량부, 미나리 추출액 20 ~ 25 중량부, 몰약 농축액 1 ~ 4 중량부 및 표피 성장인자(Epidermal Growth Factor, EGF) 0.1 ~ 3.5 중량부를 더 함유하는 것을 특징으로 하는 천연복합물과 성장인자를 함유한 아토피용 화장료 조성물.
A cosmetic composition for atopic use,
Further comprising 10 to 13 parts by weight of a dandelion fermentation broth, 20 to 25 parts by weight of an extract of Mulberry extract, 1 to 4 parts by weight of a myrrh concentrate and 0.1 to 3.5 parts by weight of an epidermal growth factor (EGF) Wherein the at least one cosmetic composition contains at least one natural compound and a growth factor.
제 1 항에 있어서,
상기 표피 성장인자는 프로필렌 에센스 오일이 주성분인 것을 특징으로 하는 천연복합물과 성장인자를 함유한 아토피용 화장료 조성물.
The method according to claim 1,
Wherein the epidermal growth factor comprises a propylene essential oil as a main component, and a natural composition and a growth factor-containing atopic cosmetic composition.
아토피용 화장료 조성물에 있어서,
연 추출액 100 중량부에 대하여, 민들레 발효액 10 ~ 13 중량부, 미나리 추출액 20 ~ 25 중량부, 몰약 농축액 1 ~ 4 중량부 및 표피 성장인자(Epidermal Growth Factor, EGF) 0.1 ~ 3.5 중량부를 더 함유하여 제조되어지되,
상기 연 추출액은, ① 연근, 연잎 및 연자육(연꽃씨) 5 ~ 9 중량부를 세정수를 이용하여 1 ~ 3회 깨끗이 세척한 후 60 ~ 85℃에서 증숙한 후 건조하는 단계와; ② 정제수 100 중량부에 대하여 상기 연근 50 ~ 55 중량부, 상기 연잎 12 ~ 18 중량부 및 상기 연자육 5 ~ 7 중량부를 넣고 90 ~ 120℃ 온도에서 12 ~ 18시간 끓이는 단계와; ③ 구연산 0.02 ~ 0.1 중량부를 더 혼합한 후 180 ~ 220℃ 온도에서 3 ~ 5시간 동안 끓인 후 서냉하는 단계와; ④ 정제수 250 ~ 300 중량부를 더 혼합하여 60 ~ 80℃ 온도에서 18 ~ 22시간 동안 끓인 다음, 여과하여 -5 ~ 0℃ 온도에서 5 ~ 10일간 저온 보관하는 단계로 제조되고,
상기 민들레 발효액은, 발효 용기에 민들레 줄기, 민들레 꽃 및 설탕을 7 ~ 8 : 1 ~ 2 : 10의 중량비로 충전하여 당도 25 ~ 27 브릭스가 되도록 한 후 밀폐하고, 그늘에서 6 ~ 18개월 발효시킨 후 여과하여 제조되고,
상기 미나리 추출액은, ① 뿌리를 제거한 미나리 50kg을 세정수를 이용하여 복수 회 세척하는 단계와; ② 상기 미나리를 압착한 후 5 ~ 10℃ 온도에서 30 ~ 45일간 저온 숙성한 후 여과하는 단계와; ③ 상기 여과된 미나리 100 중량부에 대하여 정제수 200 ~ 350 중량부 및 홍초 식초 0.1 ~ 0.6 중량부를 더 혼합한 다음, 50 ~ 65℃에서 18 ~ 24시간 끓인 후 서냉하는 단계와; ④ 정제수 50 ~ 75 중량부를 더 혼합한 다음, 40 ~ 50℃ 온도에서 3 ~ 5시간 동안 끓인 후 서냉하여 0 ~ 5℃ 온도에서 5 ~ 10일간 저온 보관하여 제조되고,
상기 몰약 농축액은, ① 에틸알코올 100 중량부에 대하여 몰약 10 ~ 15 중량부 및 올리브유 1.5 ~ 2.5 중량부를 혼합한 후 3 ~ 5 시간 교반하는 단계와; ② 45 ~50℃ 온도에서 30 ~ 40분 동안 가열하여 에틸알코올을 휘발시킨 후, 20 ~ 30분 동안 교반하여 여과하는 단계와; ③ 밀폐 용기에 충전한 후 -10 ~ -5℃ 온도에서 10 ~ 15일간 냉동 보관하여 제조되는 것을 특징으로 하는 천연복합물과 성장인자를 함유한 아토피용 화장료 조성물 제조방법.
A cosmetic composition for atopic use,
Further comprising 10 to 13 parts by weight of a dandelion fermentation broth, 20 to 25 parts by weight of an extract of Mulberry extract, 1 to 4 parts by weight of a myrrh concentrate and 0.1 to 3.5 parts by weight of an epidermal growth factor (EGF) ≪ / RTI >
The kite extract solution is prepared by: 1) thoroughly washing 5 to 9 parts by weight of a lotus root, a lotus leaf and a lotus seed with 1 to 3 times of washing water using a washing water, (B) adding 50 to 55 parts by weight of the lotus root, 12 to 18 parts by weight of the lotus root, and 5 to 7 parts by weight of the pine nut to 100 parts by weight of purified water, and boiling at 90 to 120 ° C for 12 to 18 hours; (3) 0.02 to 0.1 part by weight of citric acid is further mixed, and the mixture is boiled at a temperature of 180 to 220 DEG C for 3 to 5 hours and then slowly cooled; (4) 250-300 parts by weight of purified water is further mixed and boiled at a temperature of 60 to 80 ° C for 18 to 22 hours, followed by filtration and kept at -5 to 0 ° C for 5 to 10 days.
The dandelion fermentation broth is prepared by filling dandelion stem, dandelion flower and sugar at a weight ratio of 7 to 8: 1 to 2:10 in a fermentation vessel to obtain a sugar content of 25 to 27 Bricks, sealing it, and fermenting it in shade for 6 to 18 months After filtration,
The dropwort extract solution is prepared by: (1) washing 50 kg of buttercups with roots removed a plurality of times using washing water; ② squeezing the buttercups, aging at a temperature of 5 to 10 ° C for 30 to 45 days at a low temperature and then filtering; (3) 200 to 350 parts by weight of purified water and 0.1 to 0.6 part by weight of red vinegar are further added to 100 parts by weight of the filtered buttercream, followed by boiling at 50 to 65 ° C for 18 to 24 hours, followed by slow cooling; (4) 50 to 75 parts by weight of purified water is further mixed, then boiled at a temperature of 40 to 50 ° C for 3 to 5 hours, slowly cooled and stored at 0 to 5 ° C for 5 to 10 days,
(1) mixing 10 to 15 parts by weight of mols and 1.5 to 2.5 parts by weight of olive oil with respect to 100 parts by weight of ethyl alcohol, followed by stirring for 3 to 5 hours; ② heating at 45 to 50 ° C for 30 to 40 minutes to volatilize the ethyl alcohol, stirring for 20 to 30 minutes and filtering; (3) filling the container in an airtight container, and then cryopreserving at -10 to -5 ° C for 10 to 15 days, thereby producing a cosmetic composition for atopic use containing a natural complex and a growth factor.
스킨 케어 조성물에 있어서,
스킨 케어 베이스 100 중량부에 대하여 천연복합물 20 ~ 33 중량부 및 표피 성장인자 0.3 ~ 0.5 중량부를 더 함유하되,
상기 천연복합물은, 연 추출액 100 중량부에 대하여, 민들레 발효액 10 ~ 13 중량부, 미나리 추출액 20 ~ 25 중량부, 몰약 농축액 1 ~ 4 중량부 및 표피 성장인자(Epidermal Growth Factor, EGF) 0.1 ~ 3.5 중량부인 것을 특징으로 하는 천연복합물과 성장인자를 함유한 스킨 케어용 조성물.
In a skin care composition,
20 to 33 parts by weight of the natural complex and 0.3 to 0.5 part by weight of the epidermal growth factor with respect to 100 parts by weight of the skin care base,
The natural complex comprises 10 to 13 parts by weight of a dandelion fermentation broth, 20 to 25 parts by weight of an extract of Mulberry Extract, 1 to 4 parts by weight of a myrrh concentrate and 0.1 to 3.5 parts by weight of Epidermal Growth Factor (EGF) By weight of a natural compound and a growth factor.
KR1020140033077A 2014-03-21 2014-03-21 Cosmetic composition for atopic care product that contains natural conjugated materials and growth factors, and manufacturing method thereof, and skin care composition with it KR20150109783A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180098796A (en) 2017-02-27 2018-09-05 (주)더화이트넷 Anti-itching cosmetic composition

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20180098796A (en) 2017-02-27 2018-09-05 (주)더화이트넷 Anti-itching cosmetic composition

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