KR20150108640A - Antidandruff Composition - Google Patents

Abstract

The present invention relates to an anti-dandruff composition and, more specifically, to an anti-dandruff composition which is characterized by containing non-ionic surfactant, anti-dandruff agent, a glycerin/glyceryl polyacrylate gel and a mixed solvent consisting of gel and water. The anti-dandruff composition of the present invention has excellent usability, and conveniently used by not needing additional water when being used, easily carried, and has excellent anti-dandruff effect event with a small among of anti-dandruff component, and has safety to a human body like the skin.

Description

Antidandruff Composition

The present invention relates to a composition for preventing dandruff which is excellent in use feeling, easy to use, easy to carry, excellent in dandruff prevention effect, and safe for skin.

Dandruff prevention products have been developed since the development of various materials and shampoos, and various products have been developed all over the world. The main products are dandruff-resistant shampoo. Many dandruff-preventing products have been launched in Korea since 1980's.

These anti-dandruff products are designed to be suited to normal use habits, but they are difficult to deliver to the scalp due to the limitation of the wash type. Therefore, development of high-efficacy ingredients, high adsorption Development of formulation technology was the focus of dandruff prevention product development. However, such a high-efficacy component and a high-adsorptive formulation are adsorbed not only on the scalp but also on the surface of other skin such as face, arm, and the like, and safety may be a problem.

On the other hand, the aging society and the importance of individual welfare have increased the necessity of products for elderly people / patients who are uncomfortable to move. However, since the conventional dandruff-resistant shampoo requires rinsing with water, it is inconvenient to use in the case of an elderly person or patient who is uncomfortable with the body.

There is a patent on a cleaning substrate (see US Patent No. 6,338,855) that focuses on portability as a prior art related to the related art. However, this is an invention relating to a general cleaning substrate, There have been no inventions that have improved their appearance. In addition, although not water-rinse formulations are known (see U.S. Patent No. 5,826,546), it is not easy to use because it emits foams for pets and has a similar effect to that of general shampoos.

Accordingly, it is an object of the present invention to provide a dandruff preventive composition which is excellent in the dandruff prevention effect and at the same time has excellent human safety, because it does not require any water or rinse during use and is easy to use, easy to carry, will be.

In order to accomplish the above object, the present invention provides a composition comprising: (a) 0.1 to 5% by weight of a nonionic surfactant represented by the following formula (1), a nonionic surfactant represented by the following formula (2) (b) 0.01 to 5% by weight of at least one anti-dandruff agent selected from the group consisting of flavonoids, tea tree oil, pylontonol amine, chlorophenoxyimidazole ylidmethylbutanone and urethropropyl butylcarbamate; (c) 0.1 to 50% by weight of a glycerin / glyceryl polyacrylate gel; And (d) a residual solvent mixture of water and ethanol.

[Chemical Formula 1]

In Formula ^1, R 1 is a C5-alkyl group or alkenyl group of 21, a, b, c and d are each independently 0 to 80, a, b, c and d the sum (a + b + c of + d) < / RTI >

(2)

CH ₃ (CH ₂ ) ₇ CH = CH (CH ₂ ) ₇ CH ₂ (OCH ₂ CH ₂ ) _n OH

In the above formula (2), n is 10 to 30.

More preferably, the present invention provides a dandruff preventing composition, wherein the mixed solvent of water and ethanol (water: ethanol, v / v) is 10: 1 to 1: 5.

Hereinafter, the dandruff preventive composition of the present invention will be described in more detail.

The present invention relates to an anti-dandruff agent for solubilizing components such as anti-dandruff agent and perfume, including a low-foaming nonionic surfactant, and for imparting anti-dandruff effect, and has a glycerin / glyceryl Which comprises a polyacrylate gel and a mixed solvent composed of ethanol and water for increasing the volatility after use, is provided.

The anti-dandruff composition of the present invention is a nonionic surfactant comprising a polyoxyethylene sorbitan fatty acid ester represented by the following formula (1), Oleth represented by the following formula (2), or a mixture thereof.

≪ Formula 1 >

In Formula ^1, R 1 is a C5-alkyl group or alkenyl group of 21, a, b, c and d are each independently 0 to 80, a, b, c and d the sum (a + b + c of + d) < / RTI >

(2)

CH ₃ (CH ₂ ) ₇ CH = CH (CH ₂ ) ₇ CH ₂ (OCH ₂ CH ₂ ) _n OH

In the above formula (2), n is 10 to 30.

Examples of the polyoxyethylene sorbitan fatty acid ester of Formula 1 include polysorbate 20, polysorbate 40, polysorbate 60 and polysorbate 80, which are widely used as a fluidizing agent, and Oleth of Formula 2 Olecs 16, Olecs 20 and the like are more preferable for ease of mixing with the dandruff preventive, feeling for use, safety and the like. The anti-dandruff composition of the present invention includes such a nonionic surfactant to solubilize the dandruff-preventing active ingredient, fragrance and the like, and facilitates the massage feeling.

In the anti-dandruff composition of the present invention, the content of the nonionic surfactant is preferably 0.1 to 5% by weight, more preferably 0.2 to 2% by weight based on the total weight of the composition. If the content of the nonionic surfactant is less than 0.1% by weight, the solubilizing power is deteriorated to lose its function as a solubilizing agent. If the content is more than 5% by weight, a residual feeling may remain in the hair after use.

The anti-dandruff composition of the present invention is a dandruff preventing agent which imparts a function of preventing dandruff, and is a dandruff preventing agent which is selected from the group consisting of flavonoids, tea tree oil, Piroctone Olamine (for example, Octopirox (Hoechst)), chlorophenoxyimidazolyldimethylbutanone , Urethropropyl butylcarbamate, and the like.

The flavonoid is a plant pigment having a flavone as a basic structure and is also called vitamin P (permeable vitamin) or vitamin C ₂ (a synergist of vitamin C). Such flavonoids include all of anthoxanthins, anthocyanins, and catechins.

The tea tree oil is an oil component of a plant whose chemical name is Melaleuca alternifolia, and is an α-Thujene, α-Pinene, α-Terpinene, 1,8-cineole,? -Terpinolene,? -Terpinene, terpinene-4-ol, etc. Has been used as a natural preservative and bactericide for about 60 years in Australia and has been reported to have the ability to inhibit and remove bacteria and fungi in particular.

The above-mentioned antioxidant function is also known, such as Piroctone Olamine (trade name: Octopirox (Hoechst)), chlorophenoxyimidazolyldimethylbutanone, and urethropropyl butylcarbamate.

The dandruff preventive composition of the present invention can exhibit excellent dandruff prevention effect, dandruff treatment effect and scalp itching removal effect even when a small amount of anti-dandruff ingredient is used in the characteristics of the formulation and the method of use.

The content of the anti-dandruff agent contained in the anti-dandruff composition of the present invention is preferably 0.01 to 5% by weight based on the total weight of the composition. If the amount is less than 0.01% by weight, the effect is insignificant. If the amount is more than 5% by weight, the stimulation on the scalp may be too high.

The anti-dandruff composition of the present invention includes a glycerin / glyceryl polyacrylate gel for ease of application to the scalp and ease of massaging. The content of the glycerin / glyceryl polyacrylate gel is preferably 0.1 to 50% by weight based on the total weight of the composition. When the amount is less than 0.1% by weight, the feeling of application is insignificant and flows down from the scalp. When the amount is more than 50% by weight, the viscosity is too high,

The dandruff preventive composition of the present invention is also used as a solvent by mixing a large amount of volatile alcohol with water in order to solve the problem that the residual component flows in the hair when the hair is not dried quickly, thereby causing discomfort. In the mixed solvent of ethanol and water, the mixing ratio of water to ethanol is preferably 10: 1 to 1: 5. When more than 10 times the volume of ethanol is added, the natural drying time becomes longer and the residual composition after use is lowered. When ethanol exceeding 5 times the volume of water is used, the ethanol is very irritating, .

As described above, the anti-dandruff composition of the present invention comprises a low-foaming nonionic surfactant, and includes a dandruff agent to impart anti-dandruff effect and a glycerin / glyceryl polyacrylate gel for ease of application and massage And a mixed solvent in which ethanol and water are mixed to increase the volatility after use. Thus, it can be used easily both indoors and outdoors without water, excellent in dandruff prevention effect, and excellent in safety of skin and the like.

The dandruff preventive composition of the present invention may contain preservatives, thickeners, viscosity regulators, pH adjusters, perfumes, dyes, and the like, which are conventionally usefully used in cosmetic compositions to the extent that they do not impair the object of the present invention, , A conditioning agent, and the like.

As the preservative, methyl paraoxybenzoate, a mixture of methyl chloroisothiazolinone and methyl isothiazolinone (trade name: Kathon CG, manufactured by Rohm & Haas Company, USA) are preferably used. Examples of the thickening agent and viscosity adjusting agent include hydroxypropylmethylcellulose, Hydroxymethylcellulose, sodium chloride, ammonium chloride, propylene glycol, hexylene glycol and the like are preferable. Citric acid, sodium hydroxide, triethanolamine and the like are preferable as the pH adjusting agent. The dye is preferably a water-soluble tar pigment and the like. Is preferably polyquaternium-7, polyquaternium-10, polyoxyethylene lanolin, lanolin alcohol, methylpolysiloxane, dimethicone copolyol, hydrolyzed animal protein, ethylene glycol monostearate and the like.

The present invention provides a dandruff preventive composition which is excellent in use sensation, does not require rinsing with water, is easy to use and easy to carry, and is excellent in dandruff preventing effect while using a small amount of dandruff preventing ingredient and safe for skin.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail with reference to the following examples. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

≪ Preparation of Example 1-6 and Comparative Example 1-7 >

In a composition ratio shown in Table 1 below, a mixed solvent of ethanol and water was added with 20 parts of polysorbate 20, olex-20, octopirox, flavonoid, tea trioyl, chlorophenoxyimidazolyldimethylbutanone, , Glycerin / glyceryl polyacrylate gel, polyoxyethylene laurylsulfate (30%) and p-hydroxybenzoate were added thereto, followed by heating to 40 ° C and stirring for 30 minutes to prepare the following compositions.

Raw material
(Unit: wt%) Example Comparative Example One 2 3 4 5 6 One 2 3 4 5 6 7 Ethanol (95%) ^{1 )} 20 20 20 20 20 20 20 20 0 0 0 0 0 Polysorbate 20 ²⁾ 2 - 2 2 2 2 - - 2 2 2 2 2 Orrath-20 ³⁾ - 2 - - - - 2 2 - - - - - Octopirox ^{4 )} 0.1 0.1 - - - - - 0.1 1.0 - - - - Flavonoids ^{5 )} - - 0.5 - - - - - - 2.0 - - - Tea trioyl ^{6 )} - - - 0.5 - - - - - - 2.0 - - Chlorophenoxyimidazolylidimethylbutanone ^{7 ) < RTI ID = 0.0 >} - - - - 0.1 - - - - - - 0.5 - Urethropropyl butylcarbamate ^{8 )} - - - - - 0.1 - - - - - - 0.5 Glycerin / glyceryl polyacrylate gel ^{9 )} 10 10 10 10 10 10 10 - - - - - - Sodium polyoxyethylene lauryl sulfate (30%) - - - - - - - 50 50 50 50 50 50 incense 0.5 Color (Blue No. 1) 0.0001 Paraoxybenzoic acid ester 0.2 water Balance

In Table 1, ¹⁾ is Ethanol (95%), ²⁾ PL-64, ³⁾ Konion OA-20 (Green Soft Chem.), ⁴⁾ Octopirox (Clariant), ⁵⁾ is Flavonoid (ririseu Chemicals, Japan), ⁶⁾ Tea Tree Oil (RIFM G), ⁷⁾ Crinipan AD (Symrize), ⁸⁾ is Glycasil 2000 (Lonza, Inc.), ⁹⁾ Hispagel 50 (Clariant) was used.

In Comparative Examples of Table 1, Comparative Example 1 is a composition that does not contain a dandruff-preventing ingredient, and Comparative Examples 2 to 7 are shampoo-type compositions that contain the same or an excessive amount of an anti-dandruff agent.

<Dandruff prevention effect evaluation>

The compositions of Examples 1-6 and 1-7 were evaluated for anti-dandruff effect in the following manner.

130 persons were selected as subjects to be tested by 10 persons each having a relatively large number of dandruff, and the composition of Table 1 was tested for 1 month. Before starting the test, the weight of the dandruff collected by collecting the dandruff accumulated with the ordinary shampoo for 3 days and the composition shown in Table 1 were tested once every three days, and the weight of the dandruff accumulated for 3 days after completion of the test was compared Respectively.

In Example 1-6 and Comparative Example 1, since there was no cleanser, the hair was first shaved with a conventional shampoo prior to the start of the test, and after 1 hour had passed, the composition was applied to a dry scalp and massaged. Since there is a detergent, it was used in the same way as shampoo.

The accumulated dandruff was collected directly from the scalp using a vacuum suction device, and the dandruff reduction rate was calculated according to the following equation (1). The dandruff prevention effect was judged to be effective only when the dandruff reduction rate was 30% or more.

In addition, as shown in Table 2 below, a questionnaire was conducted on the dandruff prevention effect of the subject.

division Test evaluation result Results of the questionnaire survey on dandruff prevention effectiveness (unit: persons) Average reduction rate (%) Be effective Ineffective I do not know Example 1 63.2 9 - One Example 2 68.7 9 - One Example 3 52.5 8 - 2 Example 4 56.4 9 - One Example 5 71.1 9 - One Example 6 73.3 8 - 2 Comparative Example 1 1.1 2 5 3 Comparative Example 2 10.5 4 3 3 Comparative Example 3 46.8 7 - 3 Comparative Example 4 38.5 7 One 2 Comparative Example 5 36.4 6 One 3 Comparative Example 6 48.9 7 - 3 Comparative Example 7 50.1 7 - 3

<Safety evaluation>

A cytotoxicity test was carried out by the safety evaluation method of the composition. 50-2000 ㎍ / ㎖ of each sample was added to 10 ⁴ fibroblasts and cultured for 24 hours. Then, the concentration of 50% inhibition of fibroblast growth (EC ₅₀ ) Was obtained and the result was regarded as cytotoxicity. The larger the EC ₅₀ , the better the safety. The results are shown in Table 3.

division Example Comparative Example One 2 3 4 5 6 One 2 3 4 5 6 7 EC ₅₀ ([mu] g / ml) 680 630 750 645 570 538 880 622 120 220 195 80 94

As shown in Tables 2 and 3, the anti-dandruff compositions according to the present invention are superior in safety against dandruff, as compared with the compositions of the comparative examples, but have high EC _{50 in} cytotoxicity, one of the skin safety measures.

Claims (2)

(a) 0.1 to 5% by weight of a nonionic surfactant represented by the following formula (1), a nonionic surfactant represented by the following formula (2), or a mixture thereof;
(b) 0.01 to 5% by weight of at least one anti-dandruff agent selected from the group consisting of flavonoids, tea tree oil, pylontonol amine, chlorophenoxyimidazole ylidmethylbutanone and urethropropyl butylcarbamate;
(c) 0.1 to 50% by weight of a glycerin / glyceryl polyacrylate gel; And
(d) a mixed solvent balance consisting of water and ethanol;
Wherein the dandruff prevention composition comprises:
&Lt; Formula 1 >

In Formula ^1, R 1 is 5 - alkyl group or alkenyl group of 21, a, b, c and d are each independently 0 to 80, a, b, c, and the sum of d (a + b + c + d) is from 3 to 80.
(2)
CH ₃ (CH ₂ ) ₇ CH = CH (CH ₂ ) ₇ CH ₂ (OCH ₂ CH ₂ ) _n OH
In the above formula (2), n is 10 to 30. The method according to claim 1,
(Water: ethanol, v / v) of the mixed solvent is 10: 1 to 1: 5.