KR20190010482A - Phlorotannin composition having inhibitory effect on induction of gray hair and promoting effect on induction of dark hair - Google Patents

Abstract

The present invention relates to a composition for the scalp, capable of preventing and improving discoloration of hair. More particularly, the present invention relates to a use of a composition and related products, wherein the composition includes phlorotannin as an active ingredient and is applied to the scalp in a form of soap, shampoo, or hair tonic to prevent and improve discoloration of hair.

Description

[0001] The present invention relates to a composition and a product for promoting prevention of white hair and promoting the prevention of white hair, which comprises phlorotannin as an active ingredient,

The present invention relates to a composition for promoting anti-whitening and anti-whitening agents comprising a fluorotannin compound and an article containing the same.

Human hair color is determined by the combination of eumelanin and pheomelanin synthesized in melanocytes (melanocytes) present in hair follicles.

Degradation of melanocyte site leads to deterioration of melanin synthesis and causes gray hair. The main causes of melanocyte dysfunction are genetic defects, hormone abnormalities, aging, stress, exposure to toxins and chemicals. Lack of nutrients such as protein, iron, copper, zinc, and biotin can also cause baldness.

In normal hair follicles, melanocyte stem cells are activated to form melanocytes and function normally, whereas when senescence occurs, melanocyte stem cells are reduced, resulting in melanocyte deterioration and cell loss. On the other hand, due to environmental pollution, job stress, and shortage of essential nutrients due to an increase in instant food intake, the graying of young people is increasingly occurring. In addition, metabolic syndrome is increasing due to excessive intake of nutrients. The occurrence of metabolic syndrome induces abnormalities of blood flow in the body, deteriorates functions such as feeding of nutrients and elimination of waste products, thereby adversely affecting cells and inducing baldness .

When gray hair grows, it looks older than its age, it is difficult to style, and it lowers the individual's appearance and satisfaction. As a complementary means for this, wig, dyeing, taking medicines and the like can be utilized, but there are drawbacks such as high cost, inconvenience and side effects. In particular, hair dyeing may not only worsen the health of the hair, but may also cause allergic or inflammatory reactions caused by chemicals, and hair loss. In addition, there is a disadvantage that it is required to be performed periodically, and often an unnatural color is produced.

Korean Patent Publication No. 10-2015-0124193

1. Inhibitory Effect of Phlorotannins Isolated from Ecklonia cava on Mushroom Tyrosinase Activity and Melanin Formation in Mouse B16F10 Melanoma Cells, J. Agric. Food Chem., 2009, 57 (10), pp4124-4129, NY Yoon et al., 2. Phlorotannins as bioactive agents from brown algae, 2011, Process Biochemistry 46, pp2219-2224, YX Li et al.

The problems caused by chemical agents used for hair dyeing, the cost of dyeing and the burden of time are eliminated, and natural ingredients for maintaining and restoring the natural hair color are provided. Thus, hair coloring or hair- To solve the problem of

In order to accomplish the above object, the present invention provides a composition for preventing hair loss and for promoting hair loss comprising Florotannin as an active ingredient.

The present invention also provides a scalp application product for preventing white hair and for promoting hair loss comprising the composition.

The composition and the product containing the phlorotannin of the present invention as an effective ingredient exhibit an effect of being easy to use as a natural origin material and blacking out of gray hair, and thus can be usefully used for the improvement of gray hair.

The composition and the product containing the fluorotannine of the present invention as an effective ingredient have the advantage that they can be used without adverse effects as natural origin materials.

Fig. 1 is a graph showing the improvement effect of the composition-added soap of the present invention.
2 is a graph showing an improvement effect of the composition-containing shampoo of the present invention.
FIG. 3 is a graph showing an improvement effect of tonic added with the composition of the present invention. FIG.
4 is a comparative photograph before and after use of the composition 1 additive soap of the present invention.
5 is a comparative photograph before and after using the composition 4-added shampoo of the present invention.
6 is a comparative photograph before and after use of the composition 3-added tonic of the present invention.

Hereinafter, the present invention will be described in detail.

Phlorotannin is a polyphenolic substance, and according to a number of prior arts, phlorotannin is known to have the action of inhibiting melanin production. (References: 1. Inhibitory Effect of Phlorotannins Isolated from Ecklonia cava on Mushroom Tyrosinase Activity and Melanin Formation in Mouse B16F10 Melanoma Cells, J. Agric . Food Chem ., 2009, 57 (10), pp4124-4129, NY Yoon et al Nevertheless, the present inventors have found that when fluorotannine is accidentally applied to normal skin, it inhibits the production of melanin. When applied to the scalp and hair, the formation of melanin in the hair is promoted, and the hair that was discolored in white is changed from the hair root to the original color. On the other hand, when florotannin is used as an active ingredient The present invention has been completed by developing a scalp application composition and a product.

The composition for improving gray matter comprising the present fluorotannine as an active ingredient prevents gray hair formation and promotes dark hair formation.

The composition for prevention and improvement of gray hair according to the present invention may contain 20-100 wt% of a float tannin compound.

The above-mentioned phlorotannin can be obtained by any conventional method as a naturally occurring component. That is, it may be synthesized using a commercially available reagent, or may be obtained by extraction and separation from natural products, particularly seaweeds.

The phlorotannin can be extracted from seaweeds, especially brown algae. Specifically, the phlorotannine can be extracted from seaweeds, especially brown algae, and specifically includes Eisenia bicyclis, Eisenia arborea, Eisenia desmarestioides, Eisenia galapagensis, Eisenia masonii, Ecklonia kurome, Ecklonia cava, Ecklonia stolonifera, Ecklonia maxima, Ecklonia radiata, For example, Ecklonia bicyclis, Ecklonia biruncinate, Ecklonia buccinalis, Ecklonia caepaestipes, Ecklonia exasperta, , Ecklonia fastigiata, Ecklonia brevipes, Ecklonia arborea, Ecklonia latipia, ifolia, Ecklonia muratii, Ecklonia radicosa, Ecklonia richardiana, and Ecklonia wrightii. In the present invention,

In addition to phlorotannin, the composition of the present invention may further contain 0 to 80% by weight of a component composed of mannitol, alginic acid, fucoidan, laminaran, and fucosterol, fucosanthin and the like as lipid components.

The composition of the present invention may contain at least one phlorotannin selected from compounds having the following general formulas (1) to (12) as an active ingredient.

[Chemical Formula 1]

(2)

(3)

[Chemical Formula 4]

[Chemical Formula 5]

[Chemical Formula 6]

(7)

[Chemical Formula 8]

[Chemical Formula 9]

[Chemical formula 10]

(11)

[Chemical Formula 12]

The composition of the present invention may contain at least one kind of phlorotannin selected from the above-mentioned formulas (2), (4), (5) and (8) as an effective ingredient.

The composition of the present invention may contain two or more kinds of phlorotannines selected from the above-mentioned formulas (2), (4), (5) and (8) as effective ingredients.

The composition of the present invention comprises 1-60% by weight of a fluorotannin of the formula (2), 0.3-20% by weight of a fluorotannin of the formula (4), 0.1-10% by weight of a fluorotannin of the formula (5) 0.1 to 5% by weight of tannin.

The composition of the present invention may contain 1-65 wt% of fluorotannine of Formula 2 and 0.3-45 wt% of fluorotannin of Formula 4, based on the total weight.

The composition of the present invention may contain 1-45 wt% of fluorotannine of Formula 5 and 0.3-45 wt% of fluorotannine of Formula 8, based on the total weight.

The composition of the present invention comprises 0.1 to 3% by weight of a fluorotannine of the formula (1), 5 to 21% by weight of a fluorotannine of the formula (2), 1 to 3% by weight of a fluorotannin of the formula (3) 0.1 to 7% by weight of phlorotannin of formula (5), 0.5 to 8% by weight of phlorotannin of formula (6), 0.1 to 1% by weight of phlorotannin of formula (7), 0.1 to 8% 0.1 to 2% by weight of phlorotannin of formula (9), 0.1 to 7% by weight of phlorotannin of formula (10), 0.1 to 3% by weight of phlorotannin of formula (11) and 0.1 to 4% by weight of phlorotannin of formula can do.

The composition of the present invention comprises 20 to 100% by weight of phlorotannin, 0 to 30% by weight of mannitol, 0 to 25% by weight of alginic acid, 0 to 25% by weight of fucoidan, 0 to 10% by weight of fucosterol, 0 to 10% , And 0 to 10% by weight of laminaran.

The composition of the present invention comprises 20 to 97% by weight of phlorotannin, 1 to 30% by weight of mannitol, 1 to 25% by weight of alginic acid, 0.5 to 25% by weight of fucoidan, 0.1 to 10% by weight of fucosterol, 0.1 to 10% And 0.1 to 10% by weight of the laminate.

The present invention provides a product for improving gray hair comprising the above-mentioned flurotanin composition.

The product may be in the form of a soap, a tonic, a shampoo, or the like.

The product may contain 0.01 to 5% by weight, preferably 0.02 to 4% by weight, more preferably 0.03 to 3% by weight based on the total weight of the product. When the content of phlorotannin is included in the above amount, the effect of improving the gray hair is excellent.

The product of the present invention may further contain 0.01 to 0.5% by weight of ascorbic acid.

The soap of the present invention can be used in combination with the above-described fluro tannin composition and a composition containing at least one selected from the group consisting of palm, coconut, castor, caster, olive, canola, evening primrose, camellia, peanut, corn, flaxseed, red palm, rose hip, macadamia nut, cottonseed, Bauxite, baobab, citron, sunflower, ham, jojoba, safflower seed, argan and the like, lanolin, and lard. The tonic of the present invention may contain at least one selected from the above-mentioned fluorotannine composition, purified water, and ethanol, glycerin, salicylic acid and menthol. The shampoos of the present invention can be used in combination with the above-mentioned fluorotannine composition, purified water, and glycerin, natural vitamin E, sodium laureth sulfate, cocamidopropyl betaine, propylene glycol, glycol distearate, Polyquaternium-7, citric acid, and fragrance.

The daily use amount of phlorotannin contained in the composition for preventing and improving hair bleaching of the present invention is preferably about 0.1 to 50 mg, but the amount used is not limited to the above range. When the daily dose is in the above range, the effect of improving the gray hair is excellent.

Hereinafter, the present invention will be described in more detail by way of examples. However, the following examples are intended to further illustrate the present invention, and the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Example 1. Preparation of a composition containing fluorotannine

In order to prepare a composition containing the phlorotannin of the present invention as an active ingredient, the brown algae of the present invention were extracted by the following method.

Ecklonia cava was washed with distilled water to remove foreign matter, dried in shade, and then shattered. 500 g of the above menthol was added to the extraction container, 20 times of 30 wt% aqueous solution of menthol was added thereto, and the mixture was refluxed at 75 to 80 ° C for 4 hours to obtain an extract. The extract was filtered through a filter net of 10 mu m, and the filtered extract was concentrated under reduced pressure to obtain a primary extract concentrate. The primary extract concentrate was dried with a vacuum drier and pulverized to obtain 170 g of Composition 1.

The composition 1 was dissolved in hot water at 50 캜, adsorbed on an adsorption resin, washed with water, and eluted with a solvent to obtain a fluorotannine eluant. The eluate was filtered through a 1 탆 filter net, and the filtered extract was concentrated under reduced pressure to obtain a second extract concentrate. The second extraction concentrate was dried with a vacuum drier and pulverized to obtain 30 g of Composition 2.

Then, the composition 2 was suspended in 20 times as much distilled water and extracted three times with the same amount of ethyl acetate solvent to obtain an ethyl acetate fraction. The ethyl acetate fraction was concentrated under reduced pressure, and the concentrate was dried with a vacuum drier and pulverized to obtain 10 g of Composition 3.

Composition 3 was dissolved in 30% methanol and then compositions 4 and 5 were separated using reverse phase chromatography. Separation was carried out by using a 15 to 80% methanol aqueous solution. The solution separated by 15 to 30% aqueous methanol solution was concentrated to obtain 4 2 g of the composition. The separated solution was concentrated in a 30 to 80% aqueous methanol solution, 7 g.

Each of the compositions 1 to 5 obtained above was loaded onto liquid chromatography to proceed with compound separation. The compounds thus obtained were identified as the compounds of the formulas (1) to (12) using the NMR spectroscopic analysis apparatus. Each of the compositions 1 to 5 prepared above was dissolved in 60% methanol, filtered through a 0.2 μm membrane filter, and loaded onto high performance liquid chromatography. In high performance liquid chromatography, HP ODS Hypersil was used as the column, distilled water and methanol were used as the solvent, and the solvent supply was linearly gradient from methanol 15% to 70% over a period of 30 minutes at a flow rate of 1.0 ml / And the presence of the compounds of the above formulas (1) to (12) was confirmed. The chemical compositions of the above-mentioned compositions 1 to 5 are shown in Table 1 below.

sample Composition of sample Composition 1 20% by weight of total fluorotannine containing 2% by weight of the formula 2, 1% by weight of the formula 4, 0.5% by weight of the formula 5, 0.3% by weight of the formula 8 and 16.2% by weight of the single compound of the formula 1-12, , 20% by weight of alginic acid, 20% by weight of fucoidan, 5% by weight of fucosterol, 5% by weight of fucoxanthin, 5% Composition 2 70% by weight of total fluorotannine, 10% by weight of mannitol, 3% by weight of the compound of formula (2), 3% by weight of the compound of formula (4) , 6% by weight of alginic acid, 6% by weight of fucoidan, 3% by weight of fucosterol, 3% by weight of fucozanthin, 2% Composition 3 100% by weight of total fluorotannin including 17% by weight of Formula 2, 5% by weight of Formula 4, 5% by weight of Formula 5, 3% by weight of Formula 8, and 70% Composition 4 100% by weight of total fluorotannin including 50% by weight of the formula (5), 46% by weight of the formula (8) and 4% by weight of the single compound of the formula (1-12) Composition 5 100% by weight of total fluorotannin containing 63% by weight of the formula (2), 34% by weight of the formula (4) and 3% by weight of the single compound of the formula (1-12)

Example 2. Production of soap using the composition

125 g of caustic soda is dissolved in 264 g of distilled water, heated to 65 ° C, and 300 g of palm oil, 300 g of coconut oil and 200 g of castor oil are heated to 65 ° C and mixed. When the mixture is kneaded, the top is wrapped in plastic, bound with rubber band, sealed and heated. 164 g of glycerin and 278 g of alcohol are added to the solution and stirred well. 4 g of the composition 1 of Example 1 is added to the above solution, and the mixture is heated with hot water for about 30 minutes. The pH of the soap is suitably adjusted using stearic acid, and 135 g of sugar is dissolved in 52 g of hot water. After adding 8g of pigment and 8g of essential oil, pour it into a soap frame and harden for more than 24 hours. Cut it to a suitable size and dry it for 2 ~ 3 weeks.

Soaps were prepared in the same manner using 0.8 g, 0.4 g, 0.4 g and 0.4 g of Composition 2 and Composition 3, Composition 4 and Composition 5, respectively, instead of Composition 1.

For the evaluation of activity, a placebo soap having the same amount of the components other than the composition was also prepared and used for evaluation of the composition.

Example 3: Tonic production utilizing the composition

Using the composition of the present invention, a tonic was prepared as shown in Table 2. Of the components contained, ascorbic acid acts to improve the efficacy when used in combination with the composition of the present invention. When preparing the tonic using the composition, a mixture solution of ethanol in purified water was prepared and the remaining ingredients were added and mixed until completely dissolved.

Component (% by weight) Placebo tonic Composition 1 Additive tonic Composition 2 Additive tonic Composition 3 Additive tonic Composition 4 Additive tonic Composition 5 Additive tonic ethanol 50.00 50.00 50.00 50.00 50.00 50.00 Composition - 3.00 0.60 0.30 0.30 0.30 glycerin 3.00 3.00 3.00 3.00 3.00 3.00 Salicylic acid 0.05 0.05 0.05 0.05 0.05 0.05 menthol 0.02 0.02 0.02 0.02 0.02 0.02 Ascorbic acid 0.03 0.03 0.03 0.03 0.03 0.03 1,2-hexanediol 0.03 0.03 0.03 0.03 0.03 0.03 Rhodiola root extract 0.03 0.03 0.03 0.03 0.03 0.03 Green tea extract 0.02 0.02 0.02 0.02 0.02 0.02 Purified water 46.82 43.82 46.32 46.52 46.52 46.52 Total 100.00 100.00 100.00 100.00 100.00 100.00

Example 4. Preparation of shampoo using composition

Using the composition of the present invention, a shampoo was prepared as shown in Table 3. Of the components contained, ascorbic acid acts to improve the efficacy when used in combination with the composition of the present invention. The shampoo using the composition was prepared by mixing the purified water with the remaining ingredients except for the oil until completely dissolved. Then, the two kinds of oils were blended until thoroughly mixed to prepare a shampoo.

Component name (% by weight) Placebo shampoo Composition 1 Additive Shampoo Composition 2 Additive Shampoo Composition 3 Additive Shampoo Composition 4 Additive Shampoo Composition 5 Additive Shampoo Purified water 51.82 50.32 51.52 51.67 51.67 51.67 Composition - 1.50 0.30 0.15 0.15 0.15 Olive surfactant 34.50 34.50 34.50 34.50 34.50 34.50 Coco Betaine 10.30 10.30 10.30 10.30 10.30 10.30 Poly quota 0.30 0.30 0.30 0.30 0.30 0.30 glycerin 1.70 1.70 1.70 1.70 1.70 1.70 Natural Vitamin E 0.30 0.30 0.30 0.30 0.30 0.30 Ascorbic acid 0.03 0.03 0.03 0.03 0.03 0.03 Grapefruit seed extract 0.30 0.30 0.30 0.30 0.30 0.30 Di-panthenol (provitamin B5) 0.70 0.70 0.70 0.70 0.70 0.70 1,2-hexanediol 0.03 0.03 0.03 0.03 0.03 0.03 Citric acid 0.01 0.01 0.01 0.01 0.01 0.01 Niacinamide 0.01 0.01 0.01 0.01 0.01 0.01 Total 100.00 100.00 100.00 100.00 100.00 100.00 Tea tree essential oil 2drops 2drops 2drops 2drops 2drops 2drops Peppermint Essential Oil 2drops 2drops 2drops 2drops 2drops 2drops

Example 5. Activity Evaluation Experiment of Products Containing Composition 1 to Composition 5

5-1: Evaluation of color improvement effect at hair-growing site

For the products of Examples 2, 3 and 4 containing Composition 1 to Composition 5, the color improvement effect of newly produced hair was evaluated as follows.

To 12 male subjects who have 20% or more hair discoloration by visual inspection, let the product use for 4 weeks. After randomly selecting 30 pieces of hair decolorized before and after use, 10 each from the left, right and top parts of the head Respectively. Before and after the use of the product, 30 of the decolorized hairs were compared to the upper part of the hair, and the number of the areas close to the scalp was thicker. From the scalp, the number of hairs that were darker on the lower side was recorded by comparing the darkness with the 1 cm portion along the hair length. During the 4 weeks of the test, the hair was not allowed to be removed. The evaluation results are shown in Table 4 and Figs.

Before use After 4 weeks of use Improvement rate (%) Composition 1 Additive Soap 1.3 4.7 262 Composition 2 Additive soap 1.8 5.1 283 Composition 1 Additive Shampoo 2.2 5.3 141 Composition 3 Additive Shampoo 1.5 8.3 453 Composition 4 Additive Shampoo 1.6 8.0 500 Composition 5 Additive Shampoo 1.5 7.4 493 Composition 3 Additive tonic 1.2 10.7 792 Composition 4 Additive tonic 1.1 9.9 900 Composition 5 Additive tonic 1.4 11.4 814 Placebo soap 1.4 1.3 -7 Placebo shampoo 2.0 2.2 10 Placebo tonic 1.7 1.5 -12

5-2: Satisfaction evaluation for overall hair color improvement

For the products of Examples 2, 3 and 4 containing Composition 1 to Composition 5, degree of hair color improvement by visual observation was performed as follows.

Twenty four male subjects aged 20 to 70 years who had cosmetic anxiety due to usual gray hair were allowed to use the product containing the composition of the present invention for 4 weeks and the subjective satisfaction degree of the cosmetic improvement after use was 1 (not improved) , 2 (slightly improved), 3 (somewhat improved), 4 (fairly improved), and 5 (satisfactory improvement). The evaluation results are shown in Table 5. The results showed that all products were more satisfied with the placebo than with the placebo, and the use of soap or shampoo and tonic was more satisfactory.

Satisfaction (1 ~ 5) Composition 1 Additive Soap 3 Composition 2 Additive soap 3 Composition 1 Additive Shampoo 2 Composition 3 Additive Shampoo 4 Composition 4 Additive Shampoo 4 Composition 5 Additive Shampoo 4 Composition 3 Additive tonic 5 Composition 4 Additive tonic 5 Composition 5 Additive tonic 5 Placebo soap One Placebo shampoo One Placebo tonic One

5-3: Comparison of overall hair color change photographs

For the products of Examples 2, 3 and 4 containing Composition 1 to Composition 5, the degree of hair color improvement was compared by photographing before and after use, and the results are shown in FIG. 4 to FIG. It can be seen from the above that the use of a product comprising the fluorotannine composition of the present invention improves gray matter. That is, the generation of gray hair was prevented and the generation of dark hair was promoted.

Claims (15)

A composition for preventing white hair and for promoting intestinal pigment containing phlorotannin as an active ingredient The composition of claim 1, wherein the fluorotannine is at least one compound selected from the group consisting of compounds represented by the following formulas (1) to (12):
[Chemical Formula 1]

(2)

(3)

[Chemical Formula 4]

[Chemical Formula 5]

[Chemical Formula 6]

(7)

[Chemical Formula 8]

[Chemical Formula 9]

[Chemical formula 10]

(11)

[Chemical Formula 12]

The composition of claim 1, wherein the composition comprises 20-100% by weight of total fluorotannin. The composition according to claim 1, wherein the composition comprises at least one kind of fluorotannine selected from the following formulas (2), (4), (5) The composition of claim 4, wherein the composition comprises 1-60 wt% of a fluorotannine of Formula 2, 0.3-20 wt% of a fluorotannine of Formula 4, 0.1-10 wt% of a fluorotannin of Formula 5, 0.1 to 5% by weight based on the total weight of the composition. [4] The composition of claim 4, wherein the composition comprises 1-65% by weight of phlorotannin of formula (2) and 0.3-45% by weight of phlorotannin of formula (4) The composition according to claim 4, wherein the composition comprises 1-45% by weight of phlorotannin of formula (5) and 0.3-45% by weight of phlorotannin of formula (8) [4] The composition of claim 4, wherein the composition comprises 0.1 to 3% by weight of a fluorotannine of Formula 1, 5 to 63% by weight of a fluorotannine of Formula 2, 1 to 3% by weight of a fluorotannin of Formula 3, 0.5 to 8% by weight of fluorotannin of formula (6), 0.1 to 1% by weight of fluorotannine of formula (7), 0.1 to 1% by weight of fluorotannine of formula (8) 0.1 to 3% by weight of phlorotannin of formula (11), 0.1 to 4% by weight of phlorotannin of formula (12), 0.1 to 2% % ≪ tb > The method of claim 3, wherein the composition comprises 20 to 100% by weight of fluorotannine, 0 to 30% by weight of mannitol, 0 to 25% by weight of alginic acid, 0 to 25% by weight of fucoidan, 0 to 10% by weight of fucosterol, 0 to 10% , And 0 to 10% by weight of laminaran. [4] The method of claim 3, wherein 20 to 97 wt% of fluorotannine, 1 to 30 wt% of mannitol, 1 to 25 wt% of alginic acid, 0.5 to 25 wt% of fucoidan, 0.1 to 10 wt% of fucosterol, 0.1 to 10 wt% , And 0.1 to 10% by weight of laminaran. The method of claim 1, wherein the fluorotannine compound is selected from the group consisting of Eisenia bicyclis, Eisenia arborea, Eisenia desmarestioides, Eisenia galapagensis, (Ecklonia radiata), Eclonia bacillus (Ecklonia spp.), Ecklonia cava, Ecklonia stolonifera, Sea bamboo (Ecklonia maxima), Ecklonia radiata, Ecklonia bicyclis), Ecklonia biruncinate, Ecklonia buccinalis, Ecklonia caepaestipes, Ecklonia exasperta, Ecologia pasty, Ecklonia fastigiata, Ecklonia brevipes, Ecklonia arborea, Ecklonia latifolia, Ecklonia latifolia, characterized in that it is extracted from at least one member selected from the group consisting of lonia muratii, Ecklonia radicosa, Ecklonia richardiana and Ecklonia wrightii. Composition Anti-whitening and anti-irritant products comprising the composition of claim 1 The anti-whitening and black hair promoting product according to claim 12, wherein the product is in the form of soap, shampoo or tonic [12] The anti-whorl and anti-whorl product according to claim 12, wherein the content of florotannin is 0.01 to 5% by weight based on the total weight of the product. [12] The anti-whitening and black hair promoting product according to claim 12, wherein the composition is used in an amount of 0.1 to 50 mg per day

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