KR20190081558A - Cosmetic composition comprising liposome for enhancing skin barrier function - Google Patents

Abstract

The present invention relates to a cosmetic composition comprising a liposome excellent in skin barrier strengthening effect. In one embodiment, the cosmetic composition including the liposome comprises a liposome dispersed in an aqueous phase, wherein the liposome comprises a phospholipid layer comprising a lecithin compound and dipotassium glycyrrhizate; and a subject to be carried inside the phospholipid layer and to include a loquat extract.

Description

TECHNICAL FIELD [0001] The present invention relates to a cosmetic composition comprising liposomes excellent in skin barrier strengthening effect. [0002] COSMETIC COMPOSITION COMPRISING LIPOSOME FOR ENHANCING SKIN BARRIER FUNCTION [

The present invention relates to a cosmetic composition comprising a liposome excellent in skin barrier strengthening effect. More particularly, the present invention relates to a cosmetic composition comprising liposomes suitable for use in patients having sensitive skin such as cancer patients and having excellent skin barrier strengthening effect.

Cancer or malignant tumor (Malignant neoplasm) is a disease in which cell cycle is not controlled and cell division continues. Currently, the number of cancer patients in Korea is steadily increasing.

According to the data of National Statistical Office due to the development of diagnostic science and medical technology, 38.3% of males and 35% of females of cancer survive to 78 years of age and 85 years of life expectancy. This is evidence that a cancer patient is a mere illness, not a path to past death, and that the process of treatment is a difficult disease, and that reality is changing into a curable disease.

Cancer is a fearful approach to people because the first treatment period is long, the second lifestyle changes, the third is the high cost of treatment, and the fourth is cancer cells that are rapidly growing due to chemotherapy and radiation therapy. And the daily life itself becomes difficult because of this. In recent years, the trend is increasing in patients who complain that daily life is harder than chemotherapy.

On the other hand, cancer patients are those patients whose immune function has been extremely reduced, and various chemicals and raw materials that are not problematic for the general public may come to a close with severe irritation. They can be grouped into groups with a very sensitive tendency to induce vomiting just by taking an artificial flavor. The number of subjects in this group is higher than that of the domestic group of infants and young children, but there are more subjects than infants.

However, in Korea, due to lack of awareness and indifference, the market for cancer patients has just started. The products such as cosmetics which are marketed to cancer patients are difficult to use due to the use of stimulants when they are used due to severe pain and thus the development of cosmetics suitable for use by extremely sensitive patients whose immune function is extremely decreased like cancer patients It is urgent.

On the other hand, loquat ( Eriobotrya japonica Lindley . ) Is an evergreen broad-leaved tree of Rosaceae and is native to southwestern China. The biha tree has a bloom in autumn, and the fruit ripens from late winter to early spring. The loquat is the fruit of the peach tree, yellow or orange long and round, about 3 ~ 5cm in size.

Prior art relating to the present invention is disclosed in Korean Patent Laid-Open Publication No. 2017-0047515 (published on May 1, 2018, entitled "Cosmetic Composition for Enhancing Skin Vitality and Containing the Antibacterial Extract of Graviola and Method for Producing the Same)".

It is an object of the present invention to provide a cosmetic composition comprising a liposome excellent in skin barrier improvement effect.

Another object of the present invention is to provide a cosmetic composition comprising a liposome which is free from cytotoxicity, is harmless to human body, and has no skin irritation.

Another object of the present invention is to provide a cosmetic composition comprising liposomes excellent in skin antioxidation, moisturizing and skin whitening effect.

Another object of the present invention is to provide a cosmetic composition comprising a liposome excellent in transdermal absorption efficiency and formulation stability.

It is still another object of the present invention to provide a cosmetic composition comprising liposomes excellent in sensory properties such as skin feel and spreadability during use.

One aspect of the present invention relates to a cosmetic composition comprising a liposome. In one embodiment, the cosmetic composition comprising the liposome comprises a liposome dispersed in a water-based component, wherein the liposome comprises a phospholipid layer comprising a lecithin compound and a dipotassium glycyrrhizate; And it is supported on the inside of the phospholipid layer, pidam member comprising a loquat extract; and a (Eriobotrya japonica Lindley.).

In one embodiment, the nonpeak extract may be included in an amount of 0.1 to 5% by weight based on the total weight of the cosmetic composition.

In one embodiment, the lecithin compound and dipotassium glycyrrhizate may be included in a weight ratio of 5: 1 to 30: 1.

In one embodiment, the liposome may have a size of 10 nm to 300 nm.

The delay pidam In one embodiment the carbonate to sodium hyaluronate (sodium hyaluronate), Mayu (horse oil), a non-all-Sabo (bisabolol), ceramide (ceramide), allantoin (allantoin) and Centella asiatica (centella asiatica L. Urbain ) extracts.

In one embodiment, the cosmetic composition may comprise 3 to 10% by weight of sodium hyaluronate, 3 to 10% by weight of maize, 0.05 to 5% by weight of bisabol, 0.05 to 5% by weight of ceramide, 0.05 to 5% And 0.05 to 5% by weight of Centella asiatica extract.

In one embodiment, the cosmetic composition may be in the form of a toner, emulsion, gel, paste, or cream.

The cosmetic composition comprising the liposome according to the present invention is excellent in the skin barrier improvement effect, has no cytotoxicity, is harmless to the human body, has no skin irritation, is suitable for use in patients having extremely sensitive skin And is excellent in skin antioxidation, moisturizing and skin whitening effect, excellent in transdermal absorption efficiency and formulation stability, and excellent in sensory properties such as skin feel and spreadability during use.

FIG. 1 is a graph showing measurement results of skin barrier improvement effect when the embodiment of the present invention is applied.
FIG. 2 is a photograph showing the skin barrier improvement effect when the embodiment of the present invention is applied.

Hereinafter, the present invention will be described in detail. In the following description of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to be exemplary, self-explanatory, allowing for equivalent explanations of the present invention.

Liposomes  Included Cosmetics  Composition

One aspect of the present invention relates to a cosmetic composition comprising a liposome. In one embodiment, the cosmetic composition comprising the liposome comprises a liposome dispersed in a water-based component, wherein the liposome comprises a phospholipid layer comprising a lecithin compound and a dipotassium glycyrrhizate; And it is supported on the inside of the phospholipid layer, pidam member comprising a loquat extract; and a (Eriobotrya japonica Lindley.).

Water component

The aqueous phase component may comprise at least one of glycol, glycerin and water.

The glycol is included in the present invention for the purpose of safely dispersing the liposome and improving the skin moisturizing power. In one embodiment, the glycol may include one or more of propylene glycol, dipropylene glycol, butylene glycol, hexanediol, methylpropanediol, isoprene glycol, pentylene glycol, erythritol, xylitol, and sorbitol. The glycol may be contained in an amount of 3 to 25% by weight based on the total weight of the cosmetic composition. Within the above-mentioned range, the cosmetic composition of the present invention has excellent formulation stability and excellent skin moisturizing effect.

The glycerin is included in the present invention for the purpose of safely dispersing the liposome and improving the skin moisturizing ability. The glycerin may be contained in an amount of 3 to 15% by weight based on the total weight of the cosmetic composition. Within the above-mentioned range, the cosmetic composition of the present invention has excellent formulation stability and excellent skin moisturizing effect.

The water is included for easy mixing and dispersing of the components of the liposome composition. In an embodiment, the water may be included in an amount of 20 to 70% by weight based on the total weight of the cosmetic composition. In the above range, excellent mixing and formulation stability and stable liposome production can be achieved.

Phospholipid layer

The phospholipid layer carries a congestion body therein. The phospholipid layer comprises a lecithin compound and a dipotassium glycyrrhizate. Since the elasticity is increased when the above-mentioned ingredients are contained and the deformation force is excellent, it is possible to effectively penetrate and migrate between the keratin materials, and thus the transdermal absorption efficiency can be excellent.

The lecithin compound has an amphiphatic property and is included in the present invention for the purpose of supporting the antiperspirant. In one embodiment, the lecithin compound may comprise one or more of soy lecithin, egg yolk lecithin, hydrogenated lecithin, hydrogenated lyso lecithin, and hydroxylated lecithin.

For example, the lecithin compound may be fermented. For example, a fermented product obtained by inoculating a strain with the lecithin compound may be used. As the strain, a strain of Bacillus sp. May be used.

In one embodiment, the lecithin compound may be contained in an amount of 0.5 to 6 wt% based on the total weight of the cosmetic composition of the present invention. In this range, the physical properties of the phospholipid layer are not deteriorated, and the stability of the formulation can be excellent.

The dipotassium glycyrrhizate may impart flexibility and elasticity to the lipid membrane of the liposome. In one embodiment, the dipotassium glycyrrhizate may be included in an amount of 0.05 to 3% by weight based on the total weight of the cosmetic composition. Since the phospholipid layer has excellent elasticity and excellent deformability in the above-mentioned range, it can effectively penetrate and migrate between the keratin layers, and the transdermal absorption efficiency can be excellent.

In one embodiment, the lecithin compound and dipotassium glycyrrhizate may be included in a weight ratio of 5: 1 to 30: 1. When included at the above weight ratio, the formulation stability of the present invention is excellent, and the transdermal absorption efficiency can be excellent at the same time.

Congestion

The concealed body is supported inside the phospholipid layer of the liposome. In one embodiment, the concealer comprises a non-pea extract.

The loquat extract may be extracted using one or more of the leaves, flesh and seeds of loquat ( Eriobotrya japonica Lindley . ). For example, extraction can be performed using a method such as distillation, supercritical extraction, solvent extraction, and compression. For example, a supernatant extraction can be used to obtain a nonpeak extract.

In one embodiment, the nonpeak extract may be included in an amount of 0.1 to 5% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability of the present invention is excellent, and skin barrier improvement and strengthening effect and antioxidation effect can be excellent. For example, 0.3 to 3% by weight.

The delay pidam In one embodiment the carbonate to sodium hyaluronate (sodium hyaluronate), Mayu (horse oil), a non-all-Sabo (bisabolol), ceramide (ceramide), allantoin (allantoin) and Centella asiatica (centella asiatica L. Urbain ) extracts. For example, the cosmetic composition may contain 3 to 10% by weight of sodium hyaluronate, 3 to 10% by weight of maize, 0.05 to 5% by weight of bisabol, 0.05 to 5% by weight of ceramide, 0.05 to 5% And 0.05 to 5% by weight of Centella asiatica extract.

The sodium hyaluronate is a sodium salt of hyaluronic acid and may be included for skin barrier enhancement, skin moisturization and wrinkle improvement.

In one embodiment, the sodium hyaluronate may be contained in an amount of 3 to 10% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability of the cosmetic composition of the present invention, skin barrier enhancement, skin moisturizing and wrinkle reducing effect can be excellent.

Horse oil is oil extracted from horses and contains unsaturated fatty acids and proteins such as linolenic and linolenic acid. It is excellent in skin soothing, moisturizing and anti-inflammatory effect. It is similar to human fat and ingredients. The absorption efficiency can be excellent.

In one embodiment, the hemp oil may be contained in an amount of 3 to 10% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability of the cosmetic composition of the present invention and the skin soothing and moisturizing effect can be excellent.

The bisabolol may be alpha-bisabolol. The unsorbol is a colorless viscous substance of molecular formula C ₁₅ H ₂₆ O, which naturally exists in chamomile and can be chemically synthesized or extracted from plants. The non-saponin inhibits the activity of tyrosinase, an enzyme that forms melanin, thereby blocking the production of melanin. Thus, it has an excellent whitening effect, inhibits the collagenase activity of collagenase and promotes collagen synthesis There is an effect of improving the wrinkles through the mechanism. In addition, non-saponin has no irritation to the skin and can have a good anti-inflammatory effect because it is truly effective.

In one embodiment, the non-saponin may be included in an amount of 0.05 to 5% by weight based on the total weight of the cosmetic composition. When it is included in the above amount, the formulation stability of the present invention is excellent, and wrinkle improvement and anti-inflammatory effect can be excellent.

The ceramide is a compound containing sphingosine and fatty acid and may be included in the present invention for the purpose of moisturizing skin and strengthening skin barrier. In one embodiment, the ceramide may include at least one of cerrebrocide, ceramide 1, ceramide 2, ceramide 3, ceramide 3B, ceramide 4, and ceramide 5.

In one embodiment, the ceramide may be included in an amount of 0.05 to 5% by weight based on the total weight of the cosmetic composition. When included in the above range, the stability of the congestion retardant, the skin moisturizing effect and the skin barrier strengthening effect can be excellent.

The allantoin may be included for skin moisturizing, soothing and conditioning purposes. The allantoin can be extracted from oak, wheat, and the like.

In one embodiment, the allantoin may be included in an amount of 0.05 to 5% by weight based on the total weight of the cosmetic composition. When the content is in the above range, the stability of the concealment and the skin moisturizing effect can be excellent.

The Centella asiatica Urban (centella asiatica L. Urbain ) extracts may be included for the purpose of skin barrier improvement, skin elasticity increase, antibacterial and skin soothing. The Centella asiatica Urban extract, using a method such as the Centella asiatica Urban (centella asiatica L. Urbain) distillation, supercritical extraction and solvent extraction may be used an extract obtained.

In one embodiment of the present invention, the centella aspirate may be included in an amount of 0.05 to 5% by weight based on the total weight of the cosmetic composition. When included in the above range, the formulation stability, barrier improvement and skin soothing effect of the concealed body of the present invention can be excellent.

In one embodiment, the liposome may have a size of 10 nm to 300 nm. As used herein, the term " size " may mean the " maximum diameter " or " maximum length " of the liposome. In this size, the congestion component can be easily absorbed from the dermis layer to the dermis layer, and the formulation stability can be excellent. For example, it may be 30 to 100 nm.

In one embodiment, the liposome may be contained in an amount of 0.01 to 50% by weight based on the total weight of the cosmetic composition. When the pH is within the above range, the formulation stability is excellent, the transdermal absorption effect of the active ingredient is excellent, the skin moisturizing and antioxidative effect, the skin barrier improving and strengthening effect are excellent, the skin irritation is not caused and the human body stability is excellent.

In one embodiment of the present invention, the cosmetic composition may further comprise shea butter ( Butyrospermum Parkii , shea butter). The shea butter is an oil or fat extracted from the fruit of a shea tree inhabited in Africa and can impart excellent skin elasticity and moisturizing effect when applied to skin while improving the formulation stability of the cosmetic composition.

In one embodiment, the sheer butter may be included in an amount of 0.5 to 25% by weight based on the total weight of the cosmetic composition. When it is included in the above range, stability of formulation and elasticity and moisturizing effect when applied to skin can be excellent. For example, 5 to 15% by weight.

In one embodiment, the cosmetic composition may further comprise ingredients that can be formulated into conventional cosmetic compositions. It may further comprise water, a solubilizer, a surfactant, a pH adjuster, a preservative, an antioxidant, a sequestering agent, a bactericide, an anti-inflammatory agent, an antimicrobial agent, a solubilizing agent or a flavoring agent, a dye and a pigment.

Surfactants that can be included in the cosmetic composition according to the present invention include anionic surfactants such as ammonium laurylsulfosuccinate and ammonium lauryl sulfate and nonionic surfactants such as polyoxyethylene alkyl ether and polyoxyethylene fatty acid ester This is possible. Also, cationic surfactants such as tertiary aliphatic amine salts, alkyltrimethylammonium chloride and the like and amphoteric surfactants such as betaine, amide betaine and the like can be used.

Specific examples of the pH adjuster include citric acid, sodium hydroxide, triethanolamine, sodium citrate, phosphoric acid, sodium phosphate, lactic acid, and the like.

The preservative may be benzoic acid, paraoxybenzoic acid ester, a mixture of methylchloroisothiazolinone, phenoxyethanol, DMDM, and the like. Specific examples of the antioxidant include dibutylhydroxytoluene and ascorbic acid .

The metal ion sequestrant may be ethylenediaminetetraacetic acid dipotassium, ethylenediaminetetraacetate disodium, ethylenediaminetetraacetate tetrasodium, and the fungicide may be specifically chlorhexidine gluconate, quaternary ammonium salt, pyrrothonol amine, zinc pyrite On suspension, urethropropyl butylcarbamate, salicylic acid, and the like.

Examples of the anti-inflammatory component include monoammonium glycyrrhizinate, dipotassium glycyrrhizinate, allantoin, and mixtures thereof. The antibacterial (antimicrobial) component specifically includes phenoxyethanol, chlorhexidine, chlorhexidine gluconate, benzoic acid and its salts, benzyl Alcohols, salicylic acid, trichlorocarbane, zinc pyrithione suspensions, and mixtures thereof.

The solubilizing agent may specifically be a phage 60-hydrogenated castor oil or the like, and the flavoring agent may be a conventional ingredient used in the cosmetic composition field of the present invention.

The cosmetic composition may further comprise a cosmetically acceptable ingredient. The components contained in the cosmetic composition may include water, oil, wax, fatty acid, fatty acid alcohol, fatty acid ester, surfactant, humectant, thickening agent, antioxidant, viscosity stabilizer, viscosity stabilizers, chelating agents, buffers and lower alcohols, and the like.

In one embodiment, the cosmetic composition may be in the form of a toner, emulsion, gel, paste, or cream. Examples of the formulations of the cosmetic composition include a skin lotion, a skin softener, a skin toner, an astringent, a lotion, a milk lotion, a moisturizing lotion, a nutrition lotion, a massage cream, But are not limited to, nourishing essence, pack, soap, shampoo, cleansing foam, cleansing lotion, cleansing cream, body lotion, body cleanser, press powder, loose powder, eye shadow.

In one embodiment, the cosmetic composition comprises at least one of an oil-in-water (O / W), a water-in-oil (W / O), a water-in- / S), Oil-in-Water-in-Oil (O / W / O) or Water-in-Oil-in-Water (W / O / W) .

The cosmetic composition comprising the liposome according to the present invention is excellent in the skin barrier improvement effect, has no cytotoxicity, is harmless to the human body, has no skin irritation, is suitable for use in patients having extremely sensitive skin And is excellent in skin antioxidation, moisturizing and skin whitening effect, excellent in transdermal absorption efficiency and formulation stability, and excellent in sensory properties such as skin feel and spreadability during use.

Hereinafter, the configuration and operation of the present invention will be described in more detail with reference to preferred embodiments of the present invention. It is to be understood, however, that the same is by way of illustration and example only and is not to be construed in a limiting sense.

Example  1 to 2 and Comparative Example

A cosmetic composition comprising liposomes was prepared using the ingredients of Table 1 below and other ingredients. Among the components shown in Table 1, fermented hydrogenated lecithin was used as the lecithin compound, and the non- pea extract was obtained by solvent extraction of the loquat seed pulverized from the loquat seed, asiatica L. Urbain ) was used.

The mixture containing the components and contents in the following Table 1 was stirred using a homomixer and treated with microfluidizer three times at a pressure of 800 to 1200 bar at room temperature to prepare a cosmetic composition containing liposomes . The average sizes of the liposomes in the Examples and Comparative Examples measured using an optical microscope were found to be 50 to 80 nm.

Using the cosmetic compositions comprising the liposomes prepared in the above Examples and Comparative Examples, cream form cosmetic compositions were prepared by a conventional method.

Test Example  1: Evaluation of skin barrier improvement

Representative examples of the examples and comparative examples were evaluated for improving the damaged skin barrier of the cosmetic composition of Example 2 (cream formulation). Twenty-one 19- to 59-year-old women were evaluated by applying the above example and comparative example to a full-bodied area for two weeks. Specifically, 1% SLS (Sodium Lauryl Sulfate) was applied for 24 hours and the skin barrier was temporarily weakened by dividing the unused portion of the cosmetic composition and the use site of the cosmetic composition on the entire area of the test subjects, Only the cosmetic composition of Example 2 was used, and was applied once a day for two weeks.

The skin barrier improvement effect of the cosmetic composition of Example 2, which was damaged by external stimuli, was measured using a Vapometer before the test product was used (before the SLS patch), after removing the patch, 1 day after using the test product, , And 14 days later, the amount of water loss of the scalp was measured. The results are shown in Table 2, Fig. 1 and Fig. 2.

At this time, for the instrumental skin measurement, the subject is firstly rinsed with the prepared detergent and then the skin is stabilized for 30 minutes in the space of constant temperature and humidity condition (temperature 20 ~ 24 ℃, humidity 40 ~ 60% To adapt. The measured value was used as the data on the water loss of the hard surface, and the measured value was g / m ² · h. The measurement value of the light skin skin moisture loss is proportional to the degree of skin damage due to external stimuli, so that the lower the measured value, the better the skin barrier damaged by external stimuli. SPSS 23.0, a statistical analysis program, was used to determine the significance of the changes in skin measurements between the test site use site and the unused site. Statistical significance was confirmed at p <0.05 at 95% confidence interval.

* Rate of change ^a (%) = [(Measured value after use of Example 2 - measured value before use of Example 2) / (measured value before use of Example 2)] x 100

* Probability ^b ( p value) # = p &lt; 0.05 by Independent T-test

FIG. 1 is a graph showing an improvement effect of skin barrier according to time according to the second embodiment of the present invention. FIG. 2 is a graph showing the improvement of skin barrier over time according to the second embodiment of the present invention. This is a photograph showing the effect. Referring to the results shown in Table 2, FIG. 1 and FIG. 2, the region to which the Example 2 was applied had a statistically significant difference And it was found that the effect of strengthening and improving the skin barrier damaged by external stimuli was excellent.

Test Example  2: Formulation stability evaluation

In order to measure the stability against the separation and discoloration degree of the above Examples 1 to 2 and Comparative Example cosmetic (cream), the inside of the thermostat kept constant at 50 ° C, 45 ° C and 25 ° C, In a refrigerator maintained and under daylight conditions, the examples 1 to 2 and the comparative cosmetic composition were placed in a sample container, respectively, and stored for 8 weeks, and the degree of separation and discoloration was comparatively measured. The results are shown in Table 3 below. The degree of separation and discoloration of the product was classified into the following six grades and evaluated.

* Separation and discoloration evaluation criteria:

4: Severely separated (discolored), 5: Severely separated (discolored), 2: slightly separated (discolored), 3: slightly separated (discolored)

Referring to Table 3, it was found that the cosmetic compositions of Examples 1 and 2 exhibited less discoloration and separation phenomenon, and thus were superior in stable formulation stability. On the other hand, in the case of the comparative example in which the nonpeak extract of the present invention was not included, the formulation stability was lowered than in Examples 1 and 2.

Test Example  3: Sensory evaluation test

The skin barrier improvement test of Test Example 1 was carried out in the same manner as in Example 2, except that immediately after use, and after 1 day, 7 days, and 14 days after use, The results are shown in Table 4 below.

Referring to the results of Table 4, it was found that the skin cosmetic composition of Example 2 did not have skin irritation.

Test Example  4: Sensory evaluation

The test subjects who participated in the skin barrier improvement test of the above Test Example 1 were evaluated for the feeling of use such as spreadability, degree of fragrance, and the like of the cosmetic composition, Physicians, purchasing physicians, and overall satisfaction, and the results are shown in Table 5 below.

* 5: very satisfied, 4: satisfied, 3: normal, 2: unsatisfied, 1: very dissatisfied

* Percentage of respondents who answered with a positive response rate (%) = 3 or higher (normal, satisfactory, highly satisfied)

Referring to the results of Table 5, it was found that the cosmetic composition of Example 2 of the present invention was excellent in feeling and flavor, such as dripping, and excellent in overall satisfaction.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the invention as defined by the appended claims.

Claims (7)

A liposome dispersed in the aqueous phase component,
The liposome may contain,
A phospholipid layer comprising a lecithin compound and a dipotassium glycyrrhizate; And
Wherein the liposome comprises a liposome supported on the inside of the phospholipid layer and containing a lipoprotein ( Eriobotrya japonica Lindley . ) Extract.
[Claim 2] The cosmetic composition according to claim 1, wherein the non-lipase extract is contained in an amount of 0.1-5 wt% based on the total weight of the cosmetic composition.
The cosmetic composition according to claim 1, wherein the lecithin compound and dipotassium glycyrrhizate are contained in a weight ratio of 5: 1 to 30: 1.
The cosmetic composition according to claim 1, wherein the liposome has a size of 10 nm to 300 nm.
The method of claim 1, wherein the delay is pidam carbonate to sodium hyaluronate (sodium hyaluronate), Mayu (horse oil), a non-all-Sabo (bisabolol), ceramide (ceramide), allantoin (allantoin) and Centella asiatica (centella asiatica L. Urbain ) extract. &lt; RTI ID = 0.0 &gt; 11. &lt; / RTI &gt;
The cosmetic composition according to claim 5, which comprises 3 to 10% by weight of sodium hyaluronate, 3 to 10% by weight of maize, 0.05 to 5% by weight of bisabol, 0.05 to 5% by weight of ceramide, 5% by weight, and 0.05 to 5% by weight of Centella asiatica extract.
The cosmetic composition according to claim 1, wherein the cosmetic composition is a toner, an emulsion, a gel, a paste, or a cream.

Images