KR20150065709A - 마크로시클릭 뎁시펩티드의 제조를 위한 용액 상 공정 및 신규 중간체 - Google Patents
마크로시클릭 뎁시펩티드의 제조를 위한 용액 상 공정 및 신규 중간체 Download PDFInfo
- Publication number
- KR20150065709A KR20150065709A KR1020157008834A KR20157008834A KR20150065709A KR 20150065709 A KR20150065709 A KR 20150065709A KR 1020157008834 A KR1020157008834 A KR 1020157008834A KR 20157008834 A KR20157008834 A KR 20157008834A KR 20150065709 A KR20150065709 A KR 20150065709A
- Authority
- KR
- South Korea
- Prior art keywords
- formula
- compound
- rti
- prot
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 CN[C@](*)C(O)=O Chemical compound CN[C@](*)C(O)=O 0.000 description 6
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/72—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms
- C07C235/74—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of a saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
- C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
- C07C237/22—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton having nitrogen atoms of amino groups bound to the carbon skeleton of the acid part, further acylated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/02—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length in solution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K11/00—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K11/02—Depsipeptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof cyclic, e.g. valinomycins ; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0819—Tripeptides with the first amino acid being acidic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Analytical Chemistry (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261711284P | 2012-10-09 | 2012-10-09 | |
| US61/711,284 | 2012-10-09 | ||
| PCT/IB2013/059196 WO2014057418A2 (en) | 2012-10-09 | 2013-10-08 | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20150065709A true KR20150065709A (ko) | 2015-06-15 |
Family
ID=49880854
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157008834A Withdrawn KR20150065709A (ko) | 2012-10-09 | 2013-10-08 | 마크로시클릭 뎁시펩티드의 제조를 위한 용액 상 공정 및 신규 중간체 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US9067978B2 (OSRAM) |
| EP (1) | EP2906585A2 (OSRAM) |
| JP (1) | JP2015533156A (OSRAM) |
| KR (1) | KR20150065709A (OSRAM) |
| CN (1) | CN104703997A (OSRAM) |
| AR (1) | AR092948A1 (OSRAM) |
| AU (1) | AU2013328284B2 (OSRAM) |
| BR (1) | BR112015007196A2 (OSRAM) |
| CA (1) | CA2884393A1 (OSRAM) |
| EA (1) | EA201590698A1 (OSRAM) |
| IN (1) | IN2015DN01811A (OSRAM) |
| MX (1) | MX2015004629A (OSRAM) |
| TW (1) | TW201418278A (OSRAM) |
| WO (1) | WO2014057418A2 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CL2008002394A1 (es) | 2007-08-17 | 2009-05-15 | Novartis Ag | Depsipeptido ciclico, o derivados, inhibidores de calicreína 7, obtenidos desde chondromyces crocatus, metodo de obtencion y usos terapeuticos. |
| AR086168A1 (es) | 2011-04-20 | 2013-11-27 | Novartis Ag | Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios |
| US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| US8987413B2 (en) * | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| EP3393499B1 (en) | 2015-12-21 | 2022-05-11 | Texas Tech University System | System and method for solution phase gap peptide synthesis |
| WO2019217116A1 (en) * | 2018-05-06 | 2019-11-14 | Gap Peptides Llc | Method for solution-phase peptide synthesis |
| US12024537B2 (en) | 2018-05-31 | 2024-07-02 | Sederma | Compositions and methods for chemical synthesis |
| US11643438B2 (en) | 2018-07-20 | 2023-05-09 | The Board Of Regents Of The University Of Oklahoma | Antimicrobial peptides and methods of use |
| CA3126705A1 (en) | 2019-02-01 | 2020-08-06 | Gap Peptides Llc | Synthesis strategy for gap protecting group |
| JP7162853B1 (ja) * | 2021-07-02 | 2022-10-31 | ペプチスター株式会社 | 液相ペプチド合成用担体結合ペプチドの分析方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3043252C2 (de) | 1980-11-15 | 1982-12-02 | Degussa Ag, 6000 Frankfurt | Cyclische Acetale von N-Acylglutaminsäure -γ- semialdehyden, Verfahren zu deren Herstellung und ihre Verwendung |
| US5595756A (en) | 1993-12-22 | 1997-01-21 | Inex Pharmaceuticals Corporation | Liposomal compositions for enhanced retention of bioactive agents |
| DE4421113A1 (de) | 1994-06-16 | 1995-12-21 | Biotechnolog Forschung Gmbh | Chondramide, Gewinnungsverfahren, Mittel mit Chondramiden und Mischkultur zur Chondramid-Gewinnung |
| DE19828043A1 (de) | 1998-06-24 | 1999-12-30 | Bayer Ag | Ektoparasitizide Mittel |
| JP2000154198A (ja) | 1998-11-20 | 2000-06-06 | Nisshin Flour Milling Co Ltd | 環状デプシペプチドの固相合成方法及びその中間体 |
| GB0108234D0 (en) | 2001-04-02 | 2001-05-23 | Pharma Mar Sa | Process for producing trunkamide A compounds |
| US20040110228A1 (en) | 2002-04-01 | 2004-06-10 | Mcalpine Shelli R. | Combinatorial organic synthesis of unique biologically active compounds |
| CN101152185B (zh) | 2003-06-06 | 2010-12-08 | 阿里克斯股份公司 | 杂环化合物作为scce抑制剂的用途 |
| GB0322140D0 (en) | 2003-09-22 | 2003-10-22 | Pfizer Ltd | Combinations |
| EP1716248A1 (en) | 2004-02-03 | 2006-11-02 | Bayer HealthCare AG | Diagnostics and therapeutics for diseases associated with kallikrein 7 (klk7) |
| JP2009532664A (ja) | 2006-02-27 | 2009-09-10 | アリゾナ・ボード・オブ・リージェンツ・フォー・アンド・オン・ビハーフ・オブ・アリゾナ・ステイト・ユニバーシティ | 癌の治療のためのノボペプチドの同定および使用 |
| GB0715750D0 (en) | 2007-08-13 | 2007-09-19 | Karus Therapeutics Ltd | Chemical compounds |
| ES2527298T3 (es) | 2007-08-17 | 2015-01-22 | Novartis Ag | Uso de depsipéptidos cíclicos para inhibir calicreína 7 |
| CL2008002394A1 (es) * | 2007-08-17 | 2009-05-15 | Novartis Ag | Depsipeptido ciclico, o derivados, inhibidores de calicreína 7, obtenidos desde chondromyces crocatus, metodo de obtencion y usos terapeuticos. |
| DE102007052391A1 (de) | 2007-10-31 | 2009-05-07 | Henkel Ag & Co. Kgaa | Mattwachs |
| US20110112121A1 (en) | 2009-07-06 | 2011-05-12 | Joerg Berghausen | Pharmaceutical Compositions and Solid Forms |
| KR101004362B1 (ko) | 2010-03-19 | 2010-12-28 | 가톨릭대학교 산학협력단 | 자가 면역 질환 예방 및 치료용 ＴＮＦ－α와 ＴＷＥＡＫ 이중 길항제 |
| US20120064136A1 (en) | 2010-09-10 | 2012-03-15 | Nanobio Corporation | Anti-aging and wrinkle treatment methods using nanoemulsion compositions |
| EP2616037A2 (en) | 2010-09-14 | 2013-07-24 | Trima - Israel Phramaceutical Products Maabarot Ltd. | Foamable topical composition |
| SG193972A1 (en) | 2011-01-24 | 2013-11-29 | Anterios Inc | Nanoparticle compositions, formulations thereof, and uses therefor |
| US20120328702A1 (en) | 2011-01-24 | 2012-12-27 | Anterios, Inc. | Nanoparticle compositions |
| AR086168A1 (es) * | 2011-04-20 | 2013-11-27 | Novartis Ag | Procesos para la elaboracion de depsipeptidos macrociclicos e intermediarios |
| US8680054B2 (en) | 2011-04-20 | 2014-03-25 | Novartis Ag | Suspension type topical formulations comprising cyclic depsipeptide |
| US8987413B2 (en) * | 2012-10-09 | 2015-03-24 | Novartis Ag | Aldehyde acetal based processes for the manufacture of macrocyclic depsipeptides and new intermediates |
| US9067978B2 (en) | 2012-10-09 | 2015-06-30 | Novartis Ag | Solution phase processes for the manufacture of macrocyclic depsipeptides and new intermediates |
-
2013
- 2013-10-04 US US14/045,844 patent/US9067978B2/en active Active
- 2013-10-08 AU AU2013328284A patent/AU2013328284B2/en not_active Ceased
- 2013-10-08 IN IN1811DEN2015 patent/IN2015DN01811A/en unknown
- 2013-10-08 CA CA2884393A patent/CA2884393A1/en not_active Abandoned
- 2013-10-08 CN CN201380051965.7A patent/CN104703997A/zh active Pending
- 2013-10-08 JP JP2015536260A patent/JP2015533156A/ja active Pending
- 2013-10-08 WO PCT/IB2013/059196 patent/WO2014057418A2/en active Application Filing
- 2013-10-08 EA EA201590698A patent/EA201590698A1/ru unknown
- 2013-10-08 MX MX2015004629A patent/MX2015004629A/es unknown
- 2013-10-08 TW TW102136392A patent/TW201418278A/zh unknown
- 2013-10-08 KR KR1020157008834A patent/KR20150065709A/ko not_active Withdrawn
- 2013-10-08 EP EP13812092.8A patent/EP2906585A2/en not_active Withdrawn
- 2013-10-08 BR BR112015007196A patent/BR112015007196A2/pt not_active IP Right Cessation
- 2013-10-09 AR ARP130103654A patent/AR092948A1/es unknown
-
2015
- 2015-04-15 US US14/686,899 patent/US9493512B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CA2884393A1 (en) | 2014-04-17 |
| WO2014057418A2 (en) | 2014-04-17 |
| US9493512B2 (en) | 2016-11-15 |
| AR092948A1 (es) | 2015-05-06 |
| US20140100355A1 (en) | 2014-04-10 |
| JP2015533156A (ja) | 2015-11-19 |
| AU2013328284B2 (en) | 2016-07-14 |
| TW201418278A (zh) | 2014-05-16 |
| MX2015004629A (es) | 2015-07-14 |
| BR112015007196A2 (pt) | 2017-07-04 |
| WO2014057418A3 (en) | 2014-07-10 |
| IN2015DN01811A (OSRAM) | 2015-05-29 |
| EP2906585A2 (en) | 2015-08-19 |
| AU2013328284A1 (en) | 2015-03-12 |
| EA201590698A1 (ru) | 2015-07-30 |
| US20150218224A1 (en) | 2015-08-06 |
| US9067978B2 (en) | 2015-06-30 |
| CN104703997A (zh) | 2015-06-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20150406 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |