KR20150022789A - 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 - Google Patents
포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 Download PDFInfo
- Publication number
- KR20150022789A KR20150022789A KR20147033409A KR20147033409A KR20150022789A KR 20150022789 A KR20150022789 A KR 20150022789A KR 20147033409 A KR20147033409 A KR 20147033409A KR 20147033409 A KR20147033409 A KR 20147033409A KR 20150022789 A KR20150022789 A KR 20150022789A
- Authority
- KR
- South Korea
- Prior art keywords
- ethyl
- pyridine
- oxide
- difluoromethoxy
- cyclopropylmethoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 0 *Oc(ccc(C(Cc(c(Cl)cnc1)c1Cl)O)c1)c1O* Chemical compound *Oc(ccc(C(Cc(c(Cl)cnc1)c1Cl)O)c1)c1O* 0.000 description 2
- HXZFQCUQYNKCPJ-AOUTVPPTSA-O C/C(/Cl)=C(/CC(c(cc1)cc(OCC2CC2)c1OC(F)F)O)\C(Cl)=[NH2+] Chemical compound C/C(/Cl)=C(/CC(c(cc1)cc(OCC2CC2)c1OC(F)F)O)\C(Cl)=[NH2+] HXZFQCUQYNKCPJ-AOUTVPPTSA-O 0.000 description 1
- IQPDCQIKZDTKEE-ORLSSACPSA-O C/C(/O)=S(\C)/Nc1c(C(O[C@@H](Cc(c(Cl)c[nH+]c2)c2Cl)c(cc2)cc(OCC3CC3)c2OC(F)F)=O)[s]cc1 Chemical compound C/C(/O)=S(\C)/Nc1c(C(O[C@@H](Cc(c(Cl)c[nH+]c2)c2Cl)c(cc2)cc(OCC3CC3)c2OC(F)F)=O)[s]cc1 IQPDCQIKZDTKEE-ORLSSACPSA-O 0.000 description 1
- TWEQNZZOOFKOER-UHFFFAOYSA-N COC(c([s]cc1)c1N)=O Chemical compound COC(c([s]cc1)c1N)=O TWEQNZZOOFKOER-UHFFFAOYSA-N 0.000 description 1
- JDRDODRTERMXSR-UHFFFAOYSA-N COC(c([s]cc1)c1NS(C)(=O)=O)=O Chemical compound COC(c([s]cc1)c1NS(C)(=O)=O)=O JDRDODRTERMXSR-UHFFFAOYSA-N 0.000 description 1
- NKUCNZKDJQOJFT-UHFFFAOYSA-N CS(Nc1c(C(O)=O)[s]cc1)(=O)=O Chemical compound CS(Nc1c(C(O)=O)[s]cc1)(=O)=O NKUCNZKDJQOJFT-UHFFFAOYSA-N 0.000 description 1
- SFGNNBCWQOIVAZ-UHFFFAOYSA-N O=C(c1ccc[nH]1)Cl Chemical compound O=C(c1ccc[nH]1)Cl SFGNNBCWQOIVAZ-UHFFFAOYSA-N 0.000 description 1
- UWMIIWFIWWXWMI-FQEVSTJZSA-O O=C(c1ccc[nH]1)O[C@@H](Cc(c(Cl)c[nH+]c1)c1Cl)c(cc1)cc(OCC2CC2)c1OC(F)F Chemical compound O=C(c1ccc[nH]1)O[C@@H](Cc(c(Cl)c[nH+]c1)c1Cl)c(cc1)cc(OCC2CC2)c1OC(F)F UWMIIWFIWWXWMI-FQEVSTJZSA-O 0.000 description 1
- WRHZVMBBRYBTKZ-UHFFFAOYSA-N OC(c1ccc[nH]1)=O Chemical compound OC(c1ccc[nH]1)=O WRHZVMBBRYBTKZ-UHFFFAOYSA-N 0.000 description 1
- NAFCBAPMYWHAEB-ZDUSSCGKSA-N O[C@@H](CC(C(Cl)=[N+]=C1)=C1Cl)c(cc1)cc(OCC2CC2)c1OC(F)F Chemical compound O[C@@H](CC(C(Cl)=[N+]=C1)=C1Cl)c(cc1)cc(OCC2CC2)c1OC(F)F NAFCBAPMYWHAEB-ZDUSSCGKSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4436—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12170714.5 | 2012-06-04 | ||
| EP12170714 | 2012-06-04 | ||
| PCT/EP2013/060915 WO2013182451A1 (en) | 2012-06-04 | 2013-05-28 | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20150022789A true KR20150022789A (ko) | 2015-03-04 |
Family
ID=48670496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR20147033409A Withdrawn KR20150022789A (ko) | 2012-06-04 | 2013-05-28 | 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US9440954B2 (https=) |
| EP (1) | EP2855450B1 (https=) |
| KR (1) | KR20150022789A (https=) |
| CN (1) | CN104334542A (https=) |
| AR (1) | AR091261A1 (https=) |
| BR (1) | BR112014029642A2 (https=) |
| CA (1) | CA2875421A1 (https=) |
| HK (1) | HK1205116A1 (https=) |
| IN (1) | IN2014DN10239A (https=) |
| RU (1) | RU2637945C2 (https=) |
| WO (1) | WO2013182451A1 (https=) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2022783A1 (en) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
| EP2216327A1 (en) | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
| CA2838435A1 (en) | 2011-06-06 | 2012-12-13 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| CN103827088B (zh) | 2011-09-26 | 2017-10-13 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1‑苯基‑2‑吡啶基烷基醇的衍生物 |
| HK1212988A1 (zh) | 2012-12-05 | 2016-07-22 | 奇斯药制品公司 | 作为pde-4抑制剂的苯基乙基吡啶衍生物 |
| KR102192739B1 (ko) | 2012-12-05 | 2020-12-18 | 키에시 파르마슈티시 엣스. 피. 에이. | 포스포디에스테라제 억제제로서 1-페닐-2-피리디닐 알킬 알코올의 유도체 |
| CN104837828B (zh) | 2012-12-05 | 2017-07-18 | 奇斯药制品公司 | 作为pde4‑抑制剂的苯基乙基吡啶衍生物 |
| CA2893622A1 (en) | 2012-12-05 | 2014-06-12 | Chiesi Farmaceutici S.P.A. | Novel compounds |
| AR104822A1 (es) * | 2015-06-01 | 2017-08-16 | Chiesi Farm Spa | Derivado de aminoésteres |
| AR104829A1 (es) * | 2015-06-01 | 2017-08-16 | Chiesi Farm Spa | Derivados de aminoésteres |
| CA3125900A1 (en) | 2019-01-08 | 2020-07-16 | Kyorin Pharmaceutical Co., Ltd. | 15-pgdh inhibitor |
| US12304897B2 (en) | 2019-01-31 | 2025-05-20 | Kyorin Pharmaceutical Co., Ltd. | 15-PGDH inhibitors |
| CN116082670B (zh) * | 2023-04-11 | 2023-06-27 | 中国人民解放军军事科学院军事医学研究院 | 一种含有季膦盐的声响应假性共轭聚合物纳米颗粒的制备方法及其在抗菌领域的应用 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ14795A3 (en) | 1992-07-28 | 1996-07-17 | Rhone Poulenc Rorer Ltd | Benzene derivative containing phenyl group bound to aryl or heteroaryl fraction through an aliphatic or hetero atom containing group, process of its preparation and pharmaceutical composition containing thereof |
| US5786354A (en) | 1994-06-21 | 1998-07-28 | Celltech Therapeutics, Limited | Tri-substituted phenyl derivatives and processes for their preparation |
| WO2004096274A1 (ja) | 2003-03-31 | 2004-11-11 | Kyowa Hakko Kogyo Co., Ltd. | 気道内投与剤 |
| DE602007012105D1 (de) * | 2006-07-14 | 2011-03-03 | Chiesi Farma Spa | Derivate von 1-phenyl-2-pyridinylalkylenalkohole als phosphodiesteraseinhibitoren |
| CA2676933C (en) * | 2007-02-28 | 2015-09-29 | Leo Pharma A/S | Novel phosphodiesterase inhibitors |
| EP2022783A1 (en) | 2007-08-08 | 2009-02-11 | CHIESI FARMACEUTICI S.p.A. | "Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors" |
| EP2070913A1 (en) | 2007-12-14 | 2009-06-17 | CHIESI FARMACEUTICI S.p.A. | Ester derivatives as phosphodiesterase inhibitors |
| EP2110375A1 (en) * | 2008-04-14 | 2009-10-21 | CHIESI FARMACEUTICI S.p.A. | Phosphodiesterase-4 inhibitors belonging to the tertiary amine class |
| EP2216327A1 (en) | 2009-02-06 | 2010-08-11 | CHIESI FARMACEUTICI S.p.A. | Benzoic acid (1-phenyl-2-pyridin-4-yl)ethyl esters as phosphodiesterase inhibitors |
| CA2838435A1 (en) | 2011-06-06 | 2012-12-13 | Chiesi Farmaceutici S.P.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
| CN103827088B (zh) | 2011-09-26 | 2017-10-13 | 奇斯药制品公司 | 作为磷酸二酯酶抑制剂的1‑苯基‑2‑吡啶基烷基醇的衍生物 |
| EP2768822B1 (en) | 2011-10-21 | 2017-12-06 | Chiesi Farmaceutici S.p.A. | Derivatives of 1-phenyl-2-pyridinyl alkyl alcohols as phosphodiesterase inhibitors |
-
2013
- 2013-05-28 RU RU2014148316A patent/RU2637945C2/ru active
- 2013-05-28 BR BR112014029642A patent/BR112014029642A2/pt not_active IP Right Cessation
- 2013-05-28 EP EP13730498.6A patent/EP2855450B1/en active Active
- 2013-05-28 IN IN10239DEN2014 patent/IN2014DN10239A/en unknown
- 2013-05-28 HK HK15105703.0A patent/HK1205116A1/xx unknown
- 2013-05-28 CA CA2875421A patent/CA2875421A1/en not_active Abandoned
- 2013-05-28 CN CN201380029435.2A patent/CN104334542A/zh active Pending
- 2013-05-28 WO PCT/EP2013/060915 patent/WO2013182451A1/en not_active Ceased
- 2013-05-28 KR KR20147033409A patent/KR20150022789A/ko not_active Withdrawn
- 2013-06-03 AR ARP130101959 patent/AR091261A1/es unknown
- 2013-06-04 US US13/909,222 patent/US9440954B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| AR091261A1 (es) | 2015-01-21 |
| US9440954B2 (en) | 2016-09-13 |
| RU2637945C2 (ru) | 2017-12-08 |
| EP2855450A1 (en) | 2015-04-08 |
| WO2013182451A1 (en) | 2013-12-12 |
| RU2014148316A (ru) | 2016-07-27 |
| CN104334542A (zh) | 2015-02-04 |
| WO2013182451A9 (en) | 2014-02-06 |
| CA2875421A1 (en) | 2013-12-12 |
| EP2855450B1 (en) | 2016-07-06 |
| US20130324501A1 (en) | 2013-12-05 |
| BR112014029642A2 (pt) | 2017-06-27 |
| HK1205116A1 (en) | 2015-12-11 |
| IN2014DN10239A (https=) | 2015-08-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PA0105 | International application |
Patent event date: 20141127 Patent event code: PA01051R01D Comment text: International Patent Application |
|
| PG1501 | Laying open of application | ||
| PC1203 | Withdrawal of no request for examination | ||
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |