KR20150022362A - Compostie for treating atopic dermatitis - Google Patents

Abstract

The present invention relates to a composition containing a lotus root powder, a buckwheat powder, an onion powder, and N-stearoyl-phytosphingosine in weight ratio of 2:2:2:4 for having excellent moisturizing effect and xeransis preventing effects for xeroderma of atopic dermatitis and improving recuperative power of skin wall.

Description

TECHNICAL FIELD The present invention relates to a composition for improving dry skin resilience of atopic dermatitis and a cosmetic composition containing the same.

The present invention relates to a composition for improving the skin moisturizing function and restoring the barrier function by regulating the formation of the stratum corneum to improve the dry skin of atopic dermatitis and the resilience of damaged skin barrier, and a cosmetic comprising the same. More particularly, the present invention relates to a method for treating atopic dermatitis, comprising the steps of mixing lotion powder, buckwheat powder, onion powder and N-stearoylphytosphingosine of the following structural formula (I) in a weight ratio of 2: 2: And to a composition for improving the skin moisturizing effect and the drying preventing effect and the resilience of damaged skin barrier in dry skin.

(1) What is atopic dermatitis?

The term "atopy" means "strange" or "inappropriate," and the cause of atopic dermatitis has not yet been clarified. Therefore, the symptoms are variously expressed by skin dryness, eczema, and the like. Atopic dermatitis, also known as fever, is a chronic condition of the skin, accompanied by allergic diseases such as asthma and hay fever. This disease is a clinical disease that is called clinical allergic eczema, pediatric eczema, all ovarian eczema, and nerve dermatitis and is a clinical disorder that shows the clinical and histologic progression from infant eczema to typical adolescent dermatitis in adulthood, puberty and adult .

Atopic dermatitis is a chronic recurrent eczematous disease and its cause and pathogenesis is not clear. It is now understood that atopic dermatitis is mainly caused by a unique genetic predisposition, but the cause of the disease is not simple and is caused by multi-factors. Several environmental factors involved in the deterioration of atopic dermatitis are well known. Genetic identification of genetic predisposition and clinical and immunological patterns in patients with atopic dermatitis and their families is currently limited. Immunological abnormalities due to genetic predisposition have been recognized as the main etiologic factors. Immunological abnormalities such as increased serum IgE, increased IL-4 and IL-5, and decreased INF-γ have been suggested. However, clinically most characteristic findings, dry skin and eczema, are not explained by immunologic abnormality and it is not clear whether it is a genetic factor or a secondary change in atopic dermatitis.

(2) Skin abnormalities observed in atopic dermatitis.

- The size of stratum corneum is abnormally reduced.

- The thickness of the epidermal layer is increased.

- Moisture content in the stratum corneum is reduced.

- The ability to contain water in the epidermis is poor.

- The natural moisturizing factor has been reduced.

- Transepidermal water loss is increased.

- The amount of lipid in the stratum corneum is reduced. In particular, the amount of ceramide is reduced due to ceramide synthesis disorder.

- There is an abnormality in lipid metabolism in epidermis.

- Increased lamellar bodies, but they have a defective secretory function.

(3) Why dry skin is a problem in atopic dermatitis

Atopic dermatitis is chronically dry, so it is easily triggered by various stimuli. It has a characteristic of being prone to leaning and recurring repeatedly. These feelings and eczema are repeatedly exacerbated by dry skin, and unless properly managed, they eventually lead to subacute and chronic lesions such as fusiformis, pigmentation, and hyperopia. In addition to immunologic abnormalities, superficial folliculitis, pyritosis forum folliculitis, epidermolysis, superficial dermatophytosis, warts, recurrent herpes simplex are common. Bacterial infections are usually caused by coagulase-positive Staphylococcus aureus, and they appear as folliculitis lesions with a superficial laceration on the arms and legs. They are not accompanied by abscess or ringworm in the deep tissues but are accompanied by severe recurrent follicular eczema The case can cause recurring cellulitis with systemic symptoms. Therefore, the use of moisturizers to improve the skin dryness of atopic dermatitis and the increased resilience of the skin barrier function take an important place in the treatment of atopic dermatitis.

(4) Why physiological lipid combination is important for dry skin of atopic dermatitis

As described above, the amount of lipid in the stratum corneum is reduced with abnormalities of lipid metabolism in the epidermis. In particular, the amount of ceramide is reduced due to ceramide cholestasis. Non-physiological lipids such as vaseline and mineral oil are left in the stratum corneum primarily as a skin barrier after skin barrier damage, whereas physiological lipids such as ceramides penetrate into the epidermis and enter into keratinocytes through intracellular entry, Of the world's population. Therefore, a physiological lipid mixture such as sphingolipids (ceramides) contained in the present formulation, rather than a non-physiological lipid such as Vaseline or mineral oil and a simple moisturizing component such as glycerin, which are used commercially, Improvement plays an important role in restoring skin barrier function in skin barrier damage diseases as well.

So far, allergy-type moisturizers have been used for relieving dry skin symptoms observed in atopic dermatitis. However, the effect was temporary due to the increase of moisture by the applied moisturizing ingredient, and it was not effective for improving resilience of skin barrier function .

The present invention relates to a skin moisturizing agent which is excellent in moisturizing effect, dryness prevention effect, sterilization effect for reducing itching, and skin barrier recovery ability damaged in atopic dermatitis, It is an object of the present invention to provide a mixture of active ingredients which is effective for increasing the prevention effect and increasing the resilience of the skin barrier and the germicidal effect for relieving itching. In order to achieve the above object, the present invention provides a cosmetic composition for preventing and treating skin such as buckwheat powder, lotion powder, and onion powder having excellent sterilizing effect against itching, -Stearoyl-phytosphingosine is used in combination, it is possible to enhance the moisturizing effect, the sterilization effect and the prevention of drying, as well as the recovery ability of the skin barrier.

Accordingly, it is an object of the present invention to provide a composition and a cosmetic comprising the same, which have an effect of increasing the moisturizing ability, the prevention of drying, the inhibition of itching, and the resilience of damaged skin barrier against atopic dermatitis.

In order to achieve the above object, the present invention provides a composition for improving the itching effect of atopic dermatitis, improving dryness of skin and repairing damaged skin barrier, and a cosmetic composition containing the same, comprising lotus root powder, buckwheat powder, onion powder, -Stearoyl-phytosphingosine in a weight ratio of 2: 2: 2: 4.

As described above, the cosmetic composition provided by the present invention is prepared by mixing lotus root powder, buckwheat powder, onion powder and N-stearoyl-phytosphingosine (formula II) in a weight ratio of 2: 2: 2: 4 Has a synergistic effect in improving the dryness of the skin of atopic dermatitis and in improving the resilience of damaged skin barrier than when using either alone or in combination with other two compounds.

Hereinafter, the present invention will be described in more detail.

The composition of the present invention contains onion powder, lotus root powder and buckwheat powder.

The onion powder is prepared by the following method. 1) Remove the outer skin of the onion, wash it with clean water to remove water, and dry it in the shade for 48 hours. 2) After putting it in a hot water bath, 10 times as much water is added and steam is applied at 90 ° C for 1 hour in a state in which the cooling condenser is attached and the effective ingredient is prevented from evaporating. 3) After thoroughly cooling, take out and dry in a well-ventilated shade for 24 hours. 4) Repeat steps 2) and 3) eight more times. 5) Finely pulverize to a size of 5-10 micrometer using a jet mill. 5) Store in 4C refrigerator.

Lotus root powder is prepared by the following method. 1) After washing the lotion thoroughly, cut it to 5cm size and dry it in the shade for 48 hours. 2) After putting in a hot water bath, it is steamed for 2 hours in the same manner as above. 3) The rest of the process is the same as the above-mentioned process of producing the onion powder.

Buckwheat powder is prepared by the following method. 1) Wash the buckwheat thoroughly and dry in the shade for 48 hours. 2) After putting in a hot water bath, it is steamed for 4 hours in the same manner as above. 3) The rest of the process is the same as the above-mentioned process of producing the onion powder.

The composition of the present invention contains N-stearoyl-phytosphingosine. N-stearoyl-4Dhydroxysphinganine or (2S, 3S, 3S, 4S) -dialkylglycine was used in place of N-octadecanoyl-phytospingosine, Molecular Weight of 584.0, 4R) -2-stearoylamido-1,3,4-octadecanetriol (also referred to as (2S, 3S, 4R) -2-Stearoylamido-1,3,4-octadecanetriol).

The composition for improving the skin barrier recovery ability in atopic dermatitis, irritative dermatitis, skin barrier damage diseases such as allergic dermatitis, laryngeal gland, psoriasis, etc. is not particularly limited in the formulation of the present invention for improving the itching of atopic dermatitis, . For example, it may be a cosmetic composition having a formulation of softening agent, nutritional lotion, massage cream, nutritional cream, pack, gel or adhesive type. In the composition for external application for each formulation, 0.01 to 10.00% by weight of the lotus root powder, 0.01 to 10.00% by weight of buckwheat powder, 0.01 to 10.00% by weight of onion powder and / or N-stearoyl-phytosphingosine (N -stearoyl-p hytosphingosine) can be selected and mixed by the inventor without difficulty according to the formulation or purpose of use of other cosmetic compositions.

Hereinafter, the present invention will be described in more detail with reference to the following examples, but it should be understood that the invention is not construed as being limited thereto.

≪ Comparative Examples 1 to 4 and Examples 1 to 4 >

Components 19, 12, 13 and 14 were mixed and the temperature was adjusted to 70 ° C (Sample 1). The components 1, 2, 3, 4, 5, 6, 7, 8, 9, and 10 were mixed, and in Comparative Example 5 of Table 1 and Component 11 in the Examples, the temperature was adjusted to 70 캜 (Sample 2). Sample 2 was added to Sample 1 and emulsified at 3600 rpm for 3 minutes. The temperature of the sample was lowered to 50 캜 with cooling water. In Comparative Example 2 and Example, Component 16 was included. In Comparative Example 3 and Example, Component 17 In the case of Comparative Example 4 and Example, only Component 15 was added except that Component 18 was added. After stirring well, the mixture was cooled to 30 占 폚. The composition ratios of Comparative Examples 1 to 5 and Examples 1 to 4 are summarized in Table 1.

[Table 1]

≪ Test Example 1 > Effect of resilience test after skin barrier damage in reared mice [

Acetone was applied as a method of skin barrier damage. When transepidermal water loss (TEWL) reached 4.0 g / m < 2 > / h, the sample containing the composition of Table 1 was applied to an area of 5 cm2. TEWL was measured by Tewameter 210, an evaporimeter from CK (Courage + Khazaka, Cologne, Germany). After 6 hours of application, TEWL was measured to evaluate the degree of reduction of TEWL to evaluate the extent to which the skin barrier function was restored. The recovery rate used in the efficacy evaluation was calculated as shown in Equation 1 below and the results are shown in Table 2.

(Equation 1)

(Bt = 6 - Bt = 0) / (Bt = d - Bt = 0)) * 100

Bt = 6: TEWL measurement value after 6 hours after skin barrier damage

Bt = 0: TEWL measurement before skin barrier damage

Bt = d: TEWL measured immediately after skin barrier damage

[Table 2]

<Experimental Results>

The results of Table 2 show that skin barrier damage (Examples 1, 2, 3 and 4) in which these components are mixed (Examples 1, 2, 3 and 4) The recovery effect was increased.

&Lt; Test Example 2 >

In order to induce skin irritation and hypersensitivity in 8- to 12-week-old reared mice, 100 μl of oleic acid was applied once a day. In the control group, only oleic acid was applied for 7 days. In the test group, oleic acid was applied for 7 days, and then 100 μl of each of Comparative Examples 1 to 4 and Examples 1 to 4 was applied for 7 days. On the 7th day after the start of the study, the outer stratum corneum was separated from D-squamer tape at the apical portion of the posterior dorsal rats and the D-squame was recorded with CCD camera. Then, the image was analyzed by BMI's image analyzer program BMI The amount of keratin was quantitated to evaluate the extent of induction. The percent inhibitory rate used for the efficacy evaluation was calculated as Equation 2 in relative amounts with the amount of keratin produced by oleic acid as 100 after calculating the amount of each keratin. The results are shown in FIG. 1 and Table 3.

(Equation 2)

Stratum Corneum (Sc) = Sn * Sa

Sn: number of keratin per unit area

Sa: Average area of individual keratin

Excessive inhibition rate = (1 - (Si / So)) * 100

Si: horny amount of each test group

So: Exfoliation by oleic acid application

[Table 3]

<Experimental Results>

The results of Table 3 show that when the components are mixed (Examples 1, 2, 3 and 4), the effect of inhibiting the peroxidation is higher than that of the case where each component is used as the active ingredient (Comparative Examples 2, .

<Test Example 3 Measurement of Skin Moisture Power through Human Body Experiment>

The skin moisturizing power of the cosmetics prepared according to Table 1 was compared. The skin moisturizing ability was measured in 10 normal 20 - 30 adults. The test method is as follows. The skin conductivity was measured using a corneometer (CM820 Courage + Khazaka, Cologne, Germany) under the constant temperature and humidity conditions (24 ° C, 40% The skin moisturizing effect of the sample was measured by measuring changes in skin conductivity after 2, 4, and 8 hours after applying the uncoated region, Comparative Examples 1 to 4, and Examples 1 to 4, And the moisture amount changed with respect to the initial value was calculated as shown in Equation 3. The results are shown in Table 4.

(Equation 3)

Moisturization = ((Mt = i - Mt = 0) / Mt = 0) * 100

Mt = i: water content measured at t = i time

Mt = 0: Moisture measured immediately before the start of the test at the uncoated region (t = 0)

[Table 4]

<Experimental Results>

As shown in Table 4, the effect of the mixed composition of Example 4 in skin moisture increase was the highest.

EXPERIMENTAL EXAMPLE 4 Measurement of Dry Skin Symptoms of Atopic Dermatitis and Improvement of Recovery Ability of Damaged Skin Barrier [

The cosmetic compositions prepared according to Example 4 and Comparative Example 1 of Table 1 were tested on 20 patients who had atopic dermatitis and the effect of improving skin dryness and damaged skin barrier recovery was evaluated. The test method is as follows.

The subjects were randomly divided into two groups. Each group was given Example 4 and Comparative Example 5, and applied to the dry region (limb or face) twice a day for one month. Before and after the start of the test, the skin conductivity was measured at the test site, and 5 regions were selected before and after the application to measure changes in skin conductivity, and the effect of improving the skin dryness of the samples was evaluated. The effect of improving skin dryness was calculated using the change in water content of Equation 4. Also, histological examination was performed before the start of the test and 4 weeks after the application, and the change of calcium ion distribution was observed by an electron microscope. The results are shown in FIG. In addition, before and after the start of the test, the outermost horny layer was separated from the dry area with D-squame tape. D-squame was stored with a CCD camera, and the amount of horny material was measured by BMI image analyzer program BMI The percent inhibition of peroxidation used in the evaluation is shown in equations (5) and (6).

(Equation 4)

Skin dryness improvement effect = ((Mn-Mn) / Mn) * 100

Ma: Moisture content measured at the application site after 4 weeks of application

Mn: Moisture content measured at the uncoated region after 4 weeks of application

[Table 5]

(Equation 5)

Stratum Corneum (Sc) = Sn * Sa

Sn: number of keratin per unit area

Sa: Average area of individual keratin

Excessive inhibition rate = (1 - (Ai / Ao)) * 100

Ai: Horny amount of each test group

Ao: Initial horny amount of substance not shown

[Table 6]

<Experimental Results>

In Table 5, it can be seen that the application of the mixed composition of Example 4 is excellent in improving the dryness of skin in dry skin of atopic dermatitis. In FIG. 2, abnormalities in the distribution of calcium ions in the dry skin area of atopic dermatitis can be observed, and the distribution of calcium ions is restored to the normal calcium slope by the application of the mixed composition of Example 4. As shown in Example 4 It can be seen that the mixed composition is excellent in improving the skin barrier restoring force. Table 6 also shows that the mixed composition of Example 4 has an excellent inhibitory effect on the hyperkeratosis phenomenon in dry skin.

Claims (1)

Containing lotus root powder, buckwheat powder, onion powder and N-stearoyl-phytosphingosine in a weight ratio of 2: 2: 2: 4 improves skin dryness of atopic dermatitis and promotes resilience of damaged skin barrier Wherein the composition exhibits a synergistic effect.