KR20150008082A - 수정된 항체 영역 및 그의 용도 - Google Patents

수정된 항체 영역 및 그의 용도 Download PDF

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Publication number
KR20150008082A
KR20150008082A KR1020147030719A KR20147030719A KR20150008082A KR 20150008082 A KR20150008082 A KR 20150008082A KR 1020147030719 A KR1020147030719 A KR 1020147030719A KR 20147030719 A KR20147030719 A KR 20147030719A KR 20150008082 A KR20150008082 A KR 20150008082A
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KR
South Korea
Prior art keywords
region
modified
antibody
numbering
positions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020147030719A
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English (en)
Korean (ko)
Inventor
거하드 프레이
제이 엠. 쇼트
화이 웬 창
Original Assignee
바이오아트라, 엘엘씨
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 바이오아트라, 엘엘씨 filed Critical 바이오아트라, 엘엘씨
Publication of KR20150008082A publication Critical patent/KR20150008082A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020147030719A 2012-04-27 2013-04-26 수정된 항체 영역 및 그의 용도 Ceased KR20150008082A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261639729P 2012-04-27 2012-04-27
US61/639,729 2012-04-27
PCT/US2013/038538 WO2013163630A1 (en) 2012-04-27 2013-04-26 Modified antibody regions and uses thereof

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020207009090A Division KR20200037434A (ko) 2012-04-27 2013-04-26 수정된 항체 영역 및 그의 용도

Publications (1)

Publication Number Publication Date
KR20150008082A true KR20150008082A (ko) 2015-01-21

Family

ID=49483948

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020207009090A Ceased KR20200037434A (ko) 2012-04-27 2013-04-26 수정된 항체 영역 및 그의 용도
KR1020147030719A Ceased KR20150008082A (ko) 2012-04-27 2013-04-26 수정된 항체 영역 및 그의 용도

Family Applications Before (1)

Application Number Title Priority Date Filing Date
KR1020207009090A Ceased KR20200037434A (ko) 2012-04-27 2013-04-26 수정된 항체 영역 및 그의 용도

Country Status (13)

Country Link
US (2) US20150065690A1 (OSRAM)
EP (2) EP2841458A4 (OSRAM)
JP (1) JP6470170B2 (OSRAM)
KR (2) KR20200037434A (OSRAM)
CN (1) CN104428317B (OSRAM)
AU (3) AU2013251309B2 (OSRAM)
BR (1) BR112014026740B1 (OSRAM)
CA (1) CA2871807C (OSRAM)
HK (1) HK1207654A1 (OSRAM)
IN (1) IN2014DN08721A (OSRAM)
MX (2) MX360368B (OSRAM)
RU (1) RU2014147741A (OSRAM)
WO (1) WO2013163630A1 (OSRAM)

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FR3038517B1 (fr) * 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
CA3006462C (en) 2015-12-14 2023-10-31 Macrogenics, Inc. Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof
BR112018067897A2 (pt) * 2016-03-14 2019-04-24 Univ Oslo imunoglobulinas modificadas com ligação de fcrn alterada
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
WO2020092155A1 (en) * 2018-10-31 2020-05-07 Bioatla, Llc Anti-ctla4 antibodies, antibody fragments, their immunoconjugates and uses thereof
WO2019241315A1 (en) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
WO2020086742A1 (en) 2018-10-24 2020-04-30 Obsidian Therapeutics, Inc. Er tunable protein regulation
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CN113966397A (zh) 2019-03-08 2022-01-21 黑曜石疗法公司 人碳酸酐酶2组合物和用于可调调节的方法
EP3966227A1 (en) 2019-05-07 2022-03-16 Voyager Therapeutics, Inc. Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation
EP4014050A1 (en) 2019-08-12 2022-06-22 Voyager Therapeutics, Inc. High-sensitivity immunoassay for the detection of frataxin in biofluids
WO2021040736A1 (en) 2019-08-30 2021-03-04 Obsidian Therapeutics, Inc. Tandem cd19 car-based compositions and methods for immunotherapy
US20220348937A1 (en) 2019-09-06 2022-11-03 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation
JP2023531141A (ja) * 2020-05-21 2023-07-21 ザイダス・ライフサイエンシーズ・リミテッド Ｆｃバリアント及びその調製
US20210363512A1 (en) 2020-05-22 2021-11-25 Formycon Ag ACE2 fusion proteins and uses thereof
JP2023547239A (ja) 2020-10-29 2023-11-09 フォーマイコン アーゲー Ａｃｅ２融合タンパク質及びその使用方法
MX2023009921A (es) 2021-03-03 2023-09-05 Formycon Ag Formulaciones de proteinas de fusion ace2-fc.
EP4437112A1 (en) 2021-11-24 2024-10-02 Formycon AG Improved ace2 fusion proteins
WO2023094571A1 (en) 2021-11-25 2023-06-01 Formycon Ag Stabilization of ace2 fusion proteins
EP4386084A1 (en) 2022-12-14 2024-06-19 Formycon AG Improved ace2 fusion proteins

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US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
DE60334141D1 (de) * 2002-10-15 2010-10-21 Facet Biotech Corp VERÄNDERUNG VON FcRn-BINDUNGSAFFINITÄTEN ODER VON SERUMHALBWERTSZEITEN VON ANTIKÖRPERN MITTELS MUTAGENESE
US7361740B2 (en) * 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
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Also Published As

Publication number Publication date
AU2019202229B2 (en) 2021-02-11
WO2013163630A1 (en) 2013-10-31
MX360368B (es) 2018-10-29
US20150065690A1 (en) 2015-03-05
JP2015515497A (ja) 2015-05-28
MX2014012978A (es) 2015-02-05
EP2841458A1 (en) 2015-03-04
AU2017225111A1 (en) 2017-09-28
EP3470433A1 (en) 2019-04-17
CA2871807A1 (en) 2013-10-31
MX382840B (es) 2025-03-13
US20180186863A1 (en) 2018-07-05
JP6470170B2 (ja) 2019-02-13
BR112014026740A8 (pt) 2021-06-15
IN2014DN08721A (OSRAM) 2015-05-22
EP2841458A4 (en) 2015-09-16
BR112014026740A2 (pt) 2017-06-27
AU2013251309B2 (en) 2017-06-22
BR112014026740B1 (pt) 2022-10-04
US10954288B2 (en) 2021-03-23
KR20200037434A (ko) 2020-04-08
AU2019202229A1 (en) 2019-04-18
CN104428317B (zh) 2018-08-28
AU2013251309A1 (en) 2014-10-30
HK1207654A1 (en) 2016-02-05
AU2017225111B2 (en) 2019-01-03
CN104428317A (zh) 2015-03-18
CA2871807C (en) 2022-10-04
RU2014147741A (ru) 2016-06-20

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