JP6470170B2 - 改変抗体領域およびその使用 - Google Patents

改変抗体領域およびその使用 Download PDF

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Publication number
JP6470170B2
JP6470170B2 JP2015509206A JP2015509206A JP6470170B2 JP 6470170 B2 JP6470170 B2 JP 6470170B2 JP 2015509206 A JP2015509206 A JP 2015509206A JP 2015509206 A JP2015509206 A JP 2015509206A JP 6470170 B2 JP6470170 B2 JP 6470170B2
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antibody
modified
polypeptide
parent
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Japanese (ja)
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JP2015515497A5 (OSRAM
JP2015515497A (ja
Inventor
ショート、ジェイ、エム.
チャン、ファイ、ウェン
フレイ、ガーハード
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バイオアトラ、エルエルシー
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52Constant or Fc region; Isotype
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2015509206A 2012-04-27 2013-04-26 改変抗体領域およびその使用 Active JP6470170B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261639729P 2012-04-27 2012-04-27
US61/639,729 2012-04-27
PCT/US2013/038538 WO2013163630A1 (en) 2012-04-27 2013-04-26 Modified antibody regions and uses thereof

Publications (3)

Publication Number Publication Date
JP2015515497A JP2015515497A (ja) 2015-05-28
JP2015515497A5 JP2015515497A5 (OSRAM) 2016-10-13
JP6470170B2 true JP6470170B2 (ja) 2019-02-13

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
JP2015509206A Active JP6470170B2 (ja) 2012-04-27 2013-04-26 改変抗体領域およびその使用

Country Status (13)

Country Link
US (2) US20150065690A1 (OSRAM)
EP (2) EP3470433B1 (OSRAM)
JP (1) JP6470170B2 (OSRAM)
KR (2) KR20150008082A (OSRAM)
CN (1) CN104428317B (OSRAM)
AU (3) AU2013251309B2 (OSRAM)
BR (1) BR112014026740B1 (OSRAM)
CA (1) CA2871807C (OSRAM)
HK (1) HK1207654A1 (OSRAM)
IN (1) IN2014DN08721A (OSRAM)
MX (2) MX382840B (OSRAM)
RU (1) RU2014147741A (OSRAM)
WO (1) WO2013163630A1 (OSRAM)

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FR3038517B1 (fr) 2015-07-06 2020-02-28 Laboratoire Francais Du Fractionnement Et Des Biotechnologies Utilisation de fragments fc modifies en immunotherapie
SG11201804839WA (en) 2015-12-14 2018-07-30 Macrogenics Inc Bispecific molecules having immunoreactivity with pd-1 and ctla-4, and methods of use thereof
KR102895909B1 (ko) * 2016-03-14 2025-12-05 유니버시티에트 이 오슬로 변경된 FcRn 결합을 갖는 조작된 면역글로불린
US11542332B2 (en) 2016-03-26 2023-01-03 Bioatla, Inc. Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof
WO2019241315A1 (en) 2018-06-12 2019-12-19 Obsidian Therapeutics, Inc. Pde5 derived regulatory constructs and methods of use in immunotherapy
US20210386788A1 (en) 2018-10-24 2021-12-16 Obsidian Therapeutics, Inc. Er tunable protein regulation
IL321750A (en) * 2018-10-31 2025-08-01 Bioatla Llc Anti-ctla4 antibodies, antibody fragments, immunoconjugates thereof and their uses
CN120005022A (zh) * 2019-01-03 2025-05-16 因外泰克斯公司 用于增加治疗剂在犬中的半衰期的组合物及使用方法
CN113966397A (zh) 2019-03-08 2022-01-21 黑曜石疗法公司 人碳酸酐酶2组合物和用于可调调节的方法
WO2020227515A1 (en) 2019-05-07 2020-11-12 Voyager Therapeutics, Inc. Compositions and methods for the vectored augmentation of protein destruction, expression and/or regulation
WO2021030303A1 (en) 2019-08-12 2021-02-18 Voyager Therapeutics, Inc. High-sensitivity immunoassay for the detection of frataxin in biofluids
US20230092895A1 (en) 2019-08-30 2023-03-23 Obsidian Therapeutics, Inc. Tandem cd19 car-based compositions and methods for immunotherapy
WO2021046451A1 (en) 2019-09-06 2021-03-11 Obsidian Therapeutics, Inc. Compositions and methods for dhfr tunable protein regulation
CN115515975A (zh) * 2020-05-21 2022-12-23 兹杜斯生命科学有限公司 Fc变体及其制备
JP2023526540A (ja) 2020-05-22 2023-06-21 フォーマイコン アーゲー Ace2融合タンパク質及びその使用方法
JP2023547239A (ja) 2020-10-29 2023-11-09 フォーマイコン アーゲー Ace2融合タンパク質及びその使用方法
US20240139296A1 (en) 2021-03-03 2024-05-02 Formycon Ag Formulations of ace2 fc fusion proteins
WO2023094507A1 (en) 2021-11-24 2023-06-01 Formycon Ag Improved ace2 fusion proteins
WO2023094571A1 (en) 2021-11-25 2023-06-01 Formycon Ag Stabilization of ace2 fusion proteins
EP4386084A1 (en) 2022-12-14 2024-06-19 Formycon AG Improved ace2 fusion proteins

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AU2003286467B2 (en) * 2002-10-15 2009-10-01 Abbvie Biotherapeutics Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7217797B2 (en) 2002-10-15 2007-05-15 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
US7361740B2 (en) * 2002-10-15 2008-04-22 Pdl Biopharma, Inc. Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis
AU2003280247A1 (en) 2002-11-05 2004-06-07 Affinium Pharmaceuticals, Inc. Essential novel bacterial polypeptides
WO2004063351A2 (en) * 2003-01-09 2004-07-29 Macrogenics, Inc. IDENTIFICATION AND ENGINEERING OF ANTIBODIES WITH VARIANT Fc REGIONS AND METHODS OF USING SAME
US7960512B2 (en) * 2003-01-09 2011-06-14 Macrogenics, Inc. Identification and engineering of antibodies with variant Fc regions and methods of using same
US20090010920A1 (en) * 2003-03-03 2009-01-08 Xencor, Inc. Fc Variants Having Decreased Affinity for FcyRIIb
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Also Published As

Publication number Publication date
MX2014012978A (es) 2015-02-05
BR112014026740B1 (pt) 2022-10-04
CA2871807C (en) 2022-10-04
BR112014026740A2 (pt) 2017-06-27
US10954288B2 (en) 2021-03-23
AU2017225111A1 (en) 2017-09-28
IN2014DN08721A (OSRAM) 2015-05-22
WO2013163630A1 (en) 2013-10-31
KR20200037434A (ko) 2020-04-08
EP3470433B1 (en) 2025-12-03
EP2841458A1 (en) 2015-03-04
HK1207654A1 (en) 2016-02-05
AU2013251309B2 (en) 2017-06-22
AU2019202229A1 (en) 2019-04-18
CA2871807A1 (en) 2013-10-31
RU2014147741A (ru) 2016-06-20
AU2019202229B2 (en) 2021-02-11
EP2841458A4 (en) 2015-09-16
US20150065690A1 (en) 2015-03-05
BR112014026740A8 (pt) 2021-06-15
CN104428317B (zh) 2018-08-28
MX360368B (es) 2018-10-29
AU2017225111B2 (en) 2019-01-03
CN104428317A (zh) 2015-03-18
JP2015515497A (ja) 2015-05-28
EP3470433A1 (en) 2019-04-17
US20180186863A1 (en) 2018-07-05
MX382840B (es) 2025-03-13
KR20150008082A (ko) 2015-01-21
AU2013251309A1 (en) 2014-10-30

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