KR20140104986A - 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법 - Google Patents

구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법 Download PDF

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Publication number
KR20140104986A
KR20140104986A KR1020147018143A KR20147018143A KR20140104986A KR 20140104986 A KR20140104986 A KR 20140104986A KR 1020147018143 A KR1020147018143 A KR 1020147018143A KR 20147018143 A KR20147018143 A KR 20147018143A KR 20140104986 A KR20140104986 A KR 20140104986A
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Prior art keywords
bicarbonate
carbonate
minutes
pharmaceutical composition
buffer
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KR1020147018143A
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Korean (ko)
Inventor
니크힐레쉬 엔. 싱
Original Assignee
트랜스셉트 파마슈티칼스, 인코포레이티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38102004&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR20140104986(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 트랜스셉트 파마슈티칼스, 인코포레이티드 filed Critical 트랜스셉트 파마슈티칼스, 인코포레이티드
Priority claimed from PCT/US2005/005021 external-priority patent/WO2005079761A1/en
Publication of KR20140104986A publication Critical patent/KR20140104986A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/498—Pyrazines or piperazines ortho- and peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A61K9/0058—Chewing gums
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Anesthesiology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pulmonology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020147018143A 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법 Withdrawn KR20140104986A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US60895704P 2004-02-17 2004-02-17
US60/608,957 2004-02-17
US59862904P 2004-08-03 2004-08-03
US60/598,629 2004-08-03
PCT/US2005/005021 WO2005079761A1 (en) 2004-02-17 2005-02-16 Compositions for delivering hypnotic agents across the oral mucosa and methods of use thereof

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020137025409A Division KR20130116378A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020157007690A Division KR20150038745A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법

Publications (1)

Publication Number Publication Date
KR20140104986A true KR20140104986A (ko) 2014-08-29

Family

ID=38102004

Family Applications (5)

Application Number Title Priority Date Filing Date
KR1020137025409A Withdrawn KR20130116378A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
KR1020127031305A Withdrawn KR20130006523A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
KR1020157007690A Ceased KR20150038745A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
KR1020067018935A Ceased KR20070030178A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법
KR1020147018143A Withdrawn KR20140104986A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법

Family Applications Before (4)

Application Number Title Priority Date Filing Date
KR1020137025409A Withdrawn KR20130116378A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
KR1020127031305A Withdrawn KR20130006523A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
KR1020157007690A Ceased KR20150038745A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의 사용 방법
KR1020067018935A Ceased KR20070030178A (ko) 2004-02-17 2005-02-16 구강 점막을 가로지르는 수면제 전달용 조성물 및 이의사용 방법

Country Status (4)

Country Link
US (6) US7658945B2 (enExample)
EP (1) EP1715853A4 (enExample)
JP (1) JP5179757B2 (enExample)
KR (5) KR20130116378A (enExample)

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US7658945B2 (en) 2010-02-09
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