KR20140104419A - Egfr 억제제를 사용한 치료에 대한 반응을 예측하는 방법 - Google Patents

Egfr 억제제를 사용한 치료에 대한 반응을 예측하는 방법 Download PDF

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Publication number
KR20140104419A
KR20140104419A KR1020147014013A KR20147014013A KR20140104419A KR 20140104419 A KR20140104419 A KR 20140104419A KR 1020147014013 A KR1020147014013 A KR 1020147014013A KR 20147014013 A KR20147014013 A KR 20147014013A KR 20140104419 A KR20140104419 A KR 20140104419A
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South Korea
Prior art keywords
patient
cancer
egfr inhibitor
egfr
hsa
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KR1020147014013A
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English (en)
Korean (ko)
Inventor
토마스 리오 프리오
피에르 로랑 - 푸이그
산드린 임베우드
Original Assignee
인테그라겐
아시스땅스 퍼블리끄-오삐또 드 빠리
위니베르시떼 파리 데카르트
쌩뜨레 나티오날 데 라 르세르쉬 생띠끄 (씨. 엔. 알. 에스)
인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸)
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Application filed by 인테그라겐, 아시스땅스 퍼블리끄-오삐또 드 빠리, 위니베르시떼 파리 데카르트, 쌩뜨레 나티오날 데 라 르세르쉬 생띠끄 (씨. 엔. 알. 에스), 인스티튜트 내셔널 드 라 싼테 에 드 라 리셰르셰 메디칼르 (인 썸) filed Critical 인테그라겐
Publication of KR20140104419A publication Critical patent/KR20140104419A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020147014013A 2011-11-25 2012-11-23 Egfr 억제제를 사용한 치료에 대한 반응을 예측하는 방법 Ceased KR20140104419A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11306568 2011-11-25
EP11306568.4 2011-11-25
EP12306042 2012-08-31
EP12306042.8 2012-08-31
PCT/EP2012/073535 WO2013076282A1 (en) 2011-11-25 2012-11-23 A method for predicting responsiveness to a treatment with an egfr inhibitor

Publications (1)

Publication Number Publication Date
KR20140104419A true KR20140104419A (ko) 2014-08-28

Family

ID=47297187

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147014013A Ceased KR20140104419A (ko) 2011-11-25 2012-11-23 Egfr 억제제를 사용한 치료에 대한 반응을 예측하는 방법

Country Status (10)

Country Link
US (1) US10400284B2 (enExample)
EP (1) EP2783017B1 (enExample)
JP (1) JP6342329B2 (enExample)
KR (1) KR20140104419A (enExample)
CN (1) CN104160038B (enExample)
AU (1) AU2012342397B2 (enExample)
BR (1) BR112014012495A2 (enExample)
CA (1) CA2856594A1 (enExample)
MX (1) MX2014006182A (enExample)
WO (1) WO2013076282A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021075662A1 (ko) * 2019-10-18 2021-04-22 지니너스 주식회사 miR-320c를 유효성분으로 포함하는 백금계 항암제에 대한 삼중음성유방암 환자의 약물 반응성 예측용 바이오마커 조성물

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2931176A1 (en) * 2013-11-26 2015-06-04 Integragen A method for predicting responsiveness to a treatment with an egfr inhibitor
KR101622454B1 (ko) 2014-03-04 2016-05-18 연세대학교 산학협력단 Egfr 티로신 키나아제 억제제에 대한 항암 치료 반응 예측 마커
EP3131552B1 (en) * 2014-04-16 2020-07-15 Signal Pharmaceuticals, LLC Methods for treating cancer using tor kinase inhibitor combination therapy
EP3000895A1 (en) * 2014-09-26 2016-03-30 Integragen A method for predicting responsiveness to a treatment with an EGFR inhibitor
CN107850599B (zh) * 2015-07-23 2021-02-09 新加坡国立大学 Wbp2与her2作为共预后因子对患者分层以进行治疗
EP3450555B1 (en) * 2016-04-28 2020-11-18 Denka Company Limited Method for determining tolerance of cancer cell to epidermal growth factor receptor inhibitor
US12704501B2 (en) 2019-03-29 2026-08-11 Rakuten Medical, Inc. Methods for photoimmunotherapy and related biomarkers
CN111798918A (zh) * 2020-05-28 2020-10-20 中山大学孙逸仙纪念医院 一种免疫治疗疗效预测的血肿瘤突变算法及其构建方法
CN111863159B (zh) * 2020-06-01 2022-02-25 中山大学孙逸仙纪念医院 一种肿瘤免疫治疗疗效预测的列线图模型的建立方法
WO2023165494A1 (en) * 2022-03-01 2023-09-07 Crown Bioscience (Suzhou) Inc. Methods for determining cetuximab sensitivity in cancer patients

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2439402A1 (en) 2001-03-02 2002-09-12 University Of Pittsburgh Of The Commonwealth System Of Higher Education Pcr method
RU2010120674A (ru) * 2007-10-22 2011-11-27 Шеринг Корпорейшн (US) Полностью человеческие анти-vegf-антитела и способы их применения
WO2009080437A1 (en) 2007-12-21 2009-07-02 Exiqon A/S Micro-rna based drug resistance analysis method
WO2010015538A2 (en) * 2008-08-05 2010-02-11 F. Hoffmann-La Roche Ag Predictive marker for egfr inhibitor treatment
EP2419522A4 (en) 2009-04-17 2012-10-31 Glen Weiss METHOD AND KITS FOR THE FORECASTING OF THERAPY RESULTS OF TYROSINE CHINESE INHIBITORS
US9051551B2 (en) * 2009-11-24 2015-06-09 The University Of Western Australia Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
EP2563936B1 (en) * 2010-04-29 2018-03-14 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021075662A1 (ko) * 2019-10-18 2021-04-22 지니너스 주식회사 miR-320c를 유효성분으로 포함하는 백금계 항암제에 대한 삼중음성유방암 환자의 약물 반응성 예측용 바이오마커 조성물

Also Published As

Publication number Publication date
JP2014533960A (ja) 2014-12-18
AU2012342397B2 (en) 2018-04-05
US10400284B2 (en) 2019-09-03
US20140370029A1 (en) 2014-12-18
EP2783017B1 (en) 2018-12-26
BR112014012495A2 (pt) 2017-06-06
MX2014006182A (es) 2014-12-08
JP6342329B2 (ja) 2018-06-13
CA2856594A1 (en) 2013-05-30
CN104160038B (zh) 2018-06-12
AU2012342397A1 (en) 2014-06-12
CN104160038A (zh) 2014-11-19
WO2013076282A1 (en) 2013-05-30
EP2783017A1 (en) 2014-10-01

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