CN104160038B - 一种用于预测对采用egfr抑制剂的治疗的响应性的方法 - Google Patents

一种用于预测对采用egfr抑制剂的治疗的响应性的方法 Download PDF

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CN104160038B
CN104160038B CN201280067832.4A CN201280067832A CN104160038B CN 104160038 B CN104160038 B CN 104160038B CN 201280067832 A CN201280067832 A CN 201280067832A CN 104160038 B CN104160038 B CN 104160038B
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mir
cancer
growth factor
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CN104160038A (zh
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T·里奥弗里奥
P·劳伦-皮格
S·因班德
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Western Dais Paris, University of
Centre National de la Recherche Scientifique CNRS
Assistance Publique Hopitaux de Paris APHP
Institut National de la Sante et de la Recherche Medicale INSERM
IntegraGen SA
Universite Paris Cite
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France Public Assisted Hosiptal
NATIONAL CENTER FOR SCIENTIFIC RESEARCH
Ying Tegaigen Co
Universite Paris Descartes
National Institute of Health Sciences
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
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  • General Health & Medical Sciences (AREA)
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  • General Engineering & Computer Science (AREA)
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  • Biochemistry (AREA)
  • Molecular Biology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN201280067832.4A 2011-11-25 2012-11-23 一种用于预测对采用egfr抑制剂的治疗的响应性的方法 Expired - Fee Related CN104160038B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP11306568.4 2011-11-25
EP11306568 2011-11-25
EP12306042 2012-08-31
EP12306042.8 2012-08-31
PCT/EP2012/073535 WO2013076282A1 (en) 2011-11-25 2012-11-23 A method for predicting responsiveness to a treatment with an egfr inhibitor

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CN104160038A CN104160038A (zh) 2014-11-19
CN104160038B true CN104160038B (zh) 2018-06-12

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CN201280067832.4A Expired - Fee Related CN104160038B (zh) 2011-11-25 2012-11-23 一种用于预测对采用egfr抑制剂的治疗的响应性的方法

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US (1) US10400284B2 (enExample)
EP (1) EP2783017B1 (enExample)
JP (1) JP6342329B2 (enExample)
KR (1) KR20140104419A (enExample)
CN (1) CN104160038B (enExample)
AU (1) AU2012342397B2 (enExample)
BR (1) BR112014012495A2 (enExample)
CA (1) CA2856594A1 (enExample)
MX (1) MX2014006182A (enExample)
WO (1) WO2013076282A1 (enExample)

Families Citing this family (11)

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Publication number Priority date Publication date Assignee Title
CN105765081A (zh) * 2013-11-26 2016-07-13 英特盖根公司 一种用于预测对采用egfr抑制剂的治疗的响应性的方法
KR101622454B1 (ko) 2014-03-04 2016-05-18 연세대학교 산학협력단 Egfr 티로신 키나아제 억제제에 대한 항암 치료 반응 예측 마커
WO2015160868A1 (en) * 2014-04-16 2015-10-22 Signal Pharmaceuticals, Llc Methods for treating cancer using tor kinase inhibitor combination therapy
EP3000895A1 (en) 2014-09-26 2016-03-30 Integragen A method for predicting responsiveness to a treatment with an EGFR inhibitor
WO2017014694A1 (en) * 2015-07-23 2017-01-26 National University Of Singapore Wbp2 as a co-prognostic factor with her2 for stratification of patients for treatment
CN109072228A (zh) * 2016-04-28 2018-12-21 电化株式会社 判定癌细胞对于表皮细胞生长因子受体抑制剂的耐性的方法
EP3948274A1 (en) * 2019-03-29 2022-02-09 Rakuten Medical, Inc. Methods for photoimmunotherapy and related biomarkers
KR102251864B1 (ko) * 2019-10-18 2021-05-14 지니너스 주식회사 miR-320c를 유효성분으로 포함하는 백금계 항암제에 대한 삼중음성유방암 환자의 약물 반응성 예측용 바이오마커 조성물
CN111798918A (zh) * 2020-05-28 2020-10-20 中山大学孙逸仙纪念医院 一种免疫治疗疗效预测的血肿瘤突变算法及其构建方法
CN111863159B (zh) * 2020-06-01 2022-02-25 中山大学孙逸仙纪念医院 一种肿瘤免疫治疗疗效预测的列线图模型的建立方法
EP4486921A1 (en) * 2022-03-01 2025-01-08 Crown Bioscience (Suzhou) Inc. Methods for determining cetuximab sensitivity in cancer patients

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010121238A2 (en) * 2009-04-17 2010-10-21 Translational Genomics Research Institute (Tgen) Methods and kits to predict therapeutic outcome of tyrosine kinase inhibitors

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JP4808365B2 (ja) 2001-03-02 2011-11-02 ユニバーシティ オブ ピッツバーグ オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション Ｐｃｒ法
RU2010120674A (ru) * 2007-10-22 2011-11-27 Шеринг Корпорейшн (US) Полностью человеческие анти-vegf-антитела и способы их применения
WO2009080437A1 (en) * 2007-12-21 2009-07-02 Exiqon A/S Micro-rna based drug resistance analysis method
WO2010015538A2 (en) * 2008-08-05 2010-02-11 F. Hoffmann-La Roche Ag Predictive marker for egfr inhibitor treatment
WO2011063456A1 (en) * 2009-11-24 2011-06-03 The University Of Western Australia Methods and compositions for increasing sensitivity to tyrosine kinase inhibitors
WO2011135459A2 (en) * 2010-04-29 2011-11-03 Medical Prognosis Institute A/S Methods and devices for predicting treatment efficacy

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010121238A2 (en) * 2009-04-17 2010-10-21 Translational Genomics Research Institute (Tgen) Methods and kits to predict therapeutic outcome of tyrosine kinase inhibitors

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
MicroRNA Profiling Differentiates Colorectal Cancer According to KRAS Status;Neda Mosakhani et al.;《GENES, CHROMOSOMES & CANCER》;20110915;第51卷;第1-9页 *

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US20140370029A1 (en) 2014-12-18
WO2013076282A1 (en) 2013-05-30
MX2014006182A (es) 2014-12-08
BR112014012495A2 (pt) 2017-06-06
EP2783017B1 (en) 2018-12-26
CN104160038A (zh) 2014-11-19
EP2783017A1 (en) 2014-10-01
AU2012342397B2 (en) 2018-04-05
CA2856594A1 (en) 2013-05-30
JP6342329B2 (ja) 2018-06-13
AU2012342397A1 (en) 2014-06-12
US10400284B2 (en) 2019-09-03
JP2014533960A (ja) 2014-12-18
KR20140104419A (ko) 2014-08-28

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