KR20140103985A - 인슐린 아미노산 서열을 포함하는 치료제 - Google Patents
인슐린 아미노산 서열을 포함하는 치료제 Download PDFInfo
- Publication number
- KR20140103985A KR20140103985A KR1020147017232A KR20147017232A KR20140103985A KR 20140103985 A KR20140103985 A KR 20140103985A KR 1020147017232 A KR1020147017232 A KR 1020147017232A KR 20147017232 A KR20147017232 A KR 20147017232A KR 20140103985 A KR20140103985 A KR 20140103985A
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- South Korea
- Prior art keywords
- val pro
- gly
- gly val
- pro gly
- pharmaceutical composition
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- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Substances N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims abstract description 247
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- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 5
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Landscapes
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| WO2017078439A1 (ko) * | 2015-11-03 | 2017-05-11 | 재단법인대구경북과학기술원 | 췌장소도세포 및 엘라스틴 유사 인공 세포외 기질을 포함하는 당뇨병 치료용 약학적 조성물 |
| KR20200131721A (ko) * | 2019-05-14 | 2020-11-24 | 강원대학교산학협력단 | 당뇨병성 합병증의 예방 또는 치료용 약제학적 조성물 |
| US11607445B2 (en) | 2019-05-14 | 2023-03-21 | Amolifescience Co., Ltd. | Pharmaceutical composition for preventing or treating diabetic complications |
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| US11732008B2 (en) | 2016-04-27 | 2023-08-22 | The Regents Of The University Of California | Preparation of functional homocysteine residues in polypeptides and peptides |
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| DE69826705T2 (de) * | 1997-11-12 | 2006-02-23 | Alza Corp., Palo Alto | Verfahren zur dermalen verabreichung von polypeptiden |
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| CN101438158A (zh) * | 2006-03-06 | 2009-05-20 | 阿穆尼克斯股份有限公司 | 遗传包和其应用 |
| CN105727261A (zh) * | 2008-06-27 | 2016-07-06 | 杜克大学 | 包含弹性蛋白样肽的治疗剂 |
| WO2010014689A1 (en) * | 2008-07-29 | 2010-02-04 | Phasebio Pharmaceuticals, Inc. | Pharmaceutical formulations comprising elastin-like proteins |
| NZ597964A (en) * | 2009-07-31 | 2014-04-30 | Sanofi Aventis Deutschland | Long acting insulin composition |
| KR101943420B1 (ko) * | 2009-08-14 | 2019-04-17 | 파세비오 파마수티컬스 인코포레이티드 | 변형된 혈관활성 장 펩티드 |
-
2012
- 2012-11-28 HK HK15102642.1A patent/HK1202067A1/xx unknown
- 2012-11-28 AU AU2012346058A patent/AU2012346058A1/en not_active Abandoned
- 2012-11-28 EP EP12852785.0A patent/EP2785367A4/en not_active Withdrawn
- 2012-11-28 CA CA2856967A patent/CA2856967A1/en not_active Abandoned
- 2012-11-28 SG SG11201402661TA patent/SG11201402661TA/en unknown
- 2012-11-28 BR BR112014012789A patent/BR112014012789A2/pt not_active IP Right Cessation
- 2012-11-28 CN CN201280068260.1A patent/CN104080473A/zh active Pending
- 2012-11-28 WO PCT/US2012/066795 patent/WO2013082116A1/en not_active Ceased
- 2012-11-28 MX MX2014006391A patent/MX2014006391A/es unknown
- 2012-11-28 KR KR1020147017232A patent/KR20140103985A/ko not_active Withdrawn
- 2012-11-28 JP JP2014543618A patent/JP2014534265A/ja active Pending
- 2012-11-28 US US13/687,776 patent/US20130150291A1/en not_active Abandoned
- 2012-11-28 RU RU2014126244A patent/RU2014126244A/ru not_active Application Discontinuation
-
2014
- 2014-05-25 IL IL232781A patent/IL232781A0/en unknown
- 2014-06-13 US US14/304,617 patent/US20140364362A1/en not_active Abandoned
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017078439A1 (ko) * | 2015-11-03 | 2017-05-11 | 재단법인대구경북과학기술원 | 췌장소도세포 및 엘라스틴 유사 인공 세포외 기질을 포함하는 당뇨병 치료용 약학적 조성물 |
| US10813954B2 (en) | 2015-11-03 | 2020-10-27 | Daegu Gyeongbuk Institute Of Science And Technology | Pharmaceutical composition for treating diabetes, comprising pancreatic islet cells and elastin-like artificial extracellular matrix |
| KR20200131721A (ko) * | 2019-05-14 | 2020-11-24 | 강원대학교산학협력단 | 당뇨병성 합병증의 예방 또는 치료용 약제학적 조성물 |
| US11607445B2 (en) | 2019-05-14 | 2023-03-21 | Amolifescience Co., Ltd. | Pharmaceutical composition for preventing or treating diabetic complications |
Also Published As
| Publication number | Publication date |
|---|---|
| US20140364362A1 (en) | 2014-12-11 |
| SG11201402661TA (en) | 2014-08-28 |
| IL232781A0 (en) | 2014-07-31 |
| WO2013082116A1 (en) | 2013-06-06 |
| EP2785367A1 (en) | 2014-10-08 |
| US20130150291A1 (en) | 2013-06-13 |
| MX2014006391A (es) | 2014-09-22 |
| EP2785367A4 (en) | 2015-06-17 |
| RU2014126244A (ru) | 2016-01-27 |
| CN104080473A (zh) | 2014-10-01 |
| BR112014012789A2 (pt) | 2019-09-24 |
| CA2856967A1 (en) | 2013-06-06 |
| JP2014534265A (ja) | 2014-12-18 |
| AU2012346058A1 (en) | 2014-06-12 |
| HK1202067A1 (en) | 2015-09-18 |
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