KR20140099546A - 류코트리엔 b4 길항제 화합물 - Google Patents
류코트리엔 b4 길항제 화합물 Download PDFInfo
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- KR20140099546A KR20140099546A KR1020147018769A KR20147018769A KR20140099546A KR 20140099546 A KR20140099546 A KR 20140099546A KR 1020147018769 A KR1020147018769 A KR 1020147018769A KR 20147018769 A KR20147018769 A KR 20147018769A KR 20140099546 A KR20140099546 A KR 20140099546A
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- 239000003614 peroxisome proliferator Substances 0.000 description 1
- 108091008725 peroxisome proliferator-activated receptors alpha Proteins 0.000 description 1
- 229910052698 phosphorus Inorganic materials 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 description 1
- 102000020233 phosphotransferase Human genes 0.000 description 1
- 239000013612 plasmid Substances 0.000 description 1
- 210000004180 plasmocyte Anatomy 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- DBABZHXKTCFAPX-UHFFFAOYSA-N probenecid Chemical compound CCCN(CCC)S(=O)(=O)C1=CC=C(C(O)=O)C=C1 DBABZHXKTCFAPX-UHFFFAOYSA-N 0.000 description 1
- 229960003081 probenecid Drugs 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002250 progressing effect Effects 0.000 description 1
- 230000000750 progressive effect Effects 0.000 description 1
- 229960002429 proline Drugs 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- DSNYFFJTZPIKFZ-UHFFFAOYSA-N propoxybenzene Chemical group CCCOC1=CC=CC=C1 DSNYFFJTZPIKFZ-UHFFFAOYSA-N 0.000 description 1
- 150000003180 prostaglandins Chemical class 0.000 description 1
- 238000000159 protein binding assay Methods 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002285 radioactive effect Effects 0.000 description 1
- 239000011541 reaction mixture Substances 0.000 description 1
- 239000003642 reactive oxygen metabolite Substances 0.000 description 1
- 210000002254 renal artery Anatomy 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000284 resting effect Effects 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000011808 rodent model Methods 0.000 description 1
- 235000019515 salmon Nutrition 0.000 description 1
- 239000000523 sample Substances 0.000 description 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 1
- 239000013605 shuttle vector Substances 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 238000009987 spinning Methods 0.000 description 1
- 230000002269 spontaneous effect Effects 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 230000004936 stimulating effect Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 description 1
- 230000006103 sulfonylation Effects 0.000 description 1
- 238000005694 sulfonylation reaction Methods 0.000 description 1
- 230000002194 synthesizing effect Effects 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 230000008685 targeting Effects 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000002885 thrombogenetic effect Effects 0.000 description 1
- 230000000451 tissue damage Effects 0.000 description 1
- 231100000827 tissue damage Toxicity 0.000 description 1
- 239000012096 transfection reagent Substances 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 238000000844 transformation Methods 0.000 description 1
- 230000014616 translation Effects 0.000 description 1
- 230000003827 upregulation Effects 0.000 description 1
- 210000001631 vena cava inferior Anatomy 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 230000003313 weakening effect Effects 0.000 description 1
- 229910052727 yttrium Inorganic materials 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/24—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
- C07C233/25—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261584975P | 2012-01-10 | 2012-01-10 | |
| US61/584,975 | 2012-01-10 | ||
| US201261585799P | 2012-01-12 | 2012-01-12 | |
| US61/585,799 | 2012-01-12 | ||
| PCT/US2013/020195 WO2013106238A1 (en) | 2012-01-10 | 2013-01-04 | Leukotriene b4 antagonist compound |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140099546A true KR20140099546A (ko) | 2014-08-12 |
Family
ID=47604162
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020147018769A Withdrawn KR20140099546A (ko) | 2012-01-10 | 2013-01-04 | 류코트리엔 b4 길항제 화합물 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US9187411B2 (https=) |
| EP (1) | EP2802557B1 (https=) |
| JP (1) | JP2015509917A (https=) |
| KR (1) | KR20140099546A (https=) |
| CN (1) | CN104011012B (https=) |
| AU (1) | AU2013208260A1 (https=) |
| BR (1) | BR112014016450A2 (https=) |
| CA (1) | CA2857521C (https=) |
| EA (1) | EA023067B1 (https=) |
| ES (1) | ES2571452T3 (https=) |
| IN (1) | IN2014MN01014A (https=) |
| MX (1) | MX2014008452A (https=) |
| WO (1) | WO2013106238A1 (https=) |
| ZA (1) | ZA201404732B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2017095722A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| WO2017095724A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl sulfonamides as blt1 antagonists |
| WO2017095723A1 (en) | 2015-11-30 | 2017-06-08 | Merck Sharp & Dohme Corp. | Aryl acylsulfonamides as blt1 antagonists |
| EP3383869B1 (en) | 2015-11-30 | 2023-06-28 | Merck Sharp & Dohme LLC | Aryl sulfonamides as blt1 antagonists |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5105017A (en) * | 1983-07-18 | 1992-04-14 | Eli Lilly And Company | Leukotriene antagonist intermediates |
| GB9027023D0 (en) | 1990-12-12 | 1991-01-30 | Wellcome Found | Anti-atherosclerotic aryl compounds |
| PH30449A (en) | 1991-11-25 | 1997-05-28 | Lilly Co Eli | Substituted phenyl phenol leukotriene antagonists |
| CN1035001C (zh) * | 1993-01-02 | 1997-05-28 | 伊莱利利公司 | 取代的苯基苯酚基白三烯拮抗物 |
| EP0743064A1 (en) * | 1995-05-17 | 1996-11-20 | Eli Lilly And Company | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease |
| AU6572298A (en) | 1997-03-21 | 1998-10-20 | Eli Lilly And Company | Leukotriene antagonists useful for treating ischemia reperfusion injury |
| WO2001034135A2 (en) | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| WO2001034198A2 (en) | 1999-11-11 | 2001-05-17 | Eli Lilly And Company | Oncolytic combinations for the treatment of cancer |
| WO2001085166A1 (en) | 2000-05-09 | 2001-11-15 | Creighton University | Methods for inhibiting proliferation and inducing apoptosis in cancer cells |
| WO2001094333A2 (en) * | 2000-06-02 | 2001-12-13 | Eli Lilly & Company | Process for the preparation of benzoyl substituted bicyclic compounds and chiral benzopyran derivatives |
| CN1751037A (zh) | 2003-02-14 | 2006-03-22 | 伊莱利利公司 | 作为ppar调节剂的磺酰胺衍生物 |
-
2013
- 2013-01-04 BR BR112014016450A patent/BR112014016450A2/pt not_active IP Right Cessation
- 2013-01-04 MX MX2014008452A patent/MX2014008452A/es unknown
- 2013-01-04 KR KR1020147018769A patent/KR20140099546A/ko not_active Withdrawn
- 2013-01-04 WO PCT/US2013/020195 patent/WO2013106238A1/en not_active Ceased
- 2013-01-04 CN CN201380004537.9A patent/CN104011012B/zh not_active Expired - Fee Related
- 2013-01-04 AU AU2013208260A patent/AU2013208260A1/en not_active Abandoned
- 2013-01-04 EA EA201491099A patent/EA023067B1/ru not_active IP Right Cessation
- 2013-01-04 JP JP2014552215A patent/JP2015509917A/ja not_active Withdrawn
- 2013-01-04 EP EP13701305.8A patent/EP2802557B1/en active Active
- 2013-01-04 US US14/359,924 patent/US9187411B2/en not_active Expired - Fee Related
- 2013-01-04 CA CA2857521A patent/CA2857521C/en not_active Expired - Fee Related
- 2013-01-04 ES ES13701305T patent/ES2571452T3/es active Active
-
2014
- 2014-05-26 IN IN1014MUN2014 patent/IN2014MN01014A/en unknown
- 2014-06-26 ZA ZA2014/04732A patent/ZA201404732B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EA201491099A1 (ru) | 2014-11-28 |
| ZA201404732B (en) | 2015-11-25 |
| AU2013208260A1 (en) | 2014-06-05 |
| CA2857521A1 (en) | 2013-07-18 |
| JP2015509917A (ja) | 2015-04-02 |
| EA023067B1 (ru) | 2016-04-29 |
| CN104011012A (zh) | 2014-08-27 |
| EP2802557B1 (en) | 2016-04-06 |
| CN104011012B (zh) | 2016-01-20 |
| EP2802557A1 (en) | 2014-11-19 |
| CA2857521C (en) | 2016-03-01 |
| MX2014008452A (es) | 2014-08-27 |
| ES2571452T3 (es) | 2016-05-25 |
| US20140343151A1 (en) | 2014-11-20 |
| US9187411B2 (en) | 2015-11-17 |
| BR112014016450A2 (pt) | 2019-09-24 |
| IN2014MN01014A (https=) | 2015-07-03 |
| WO2013106238A1 (en) | 2013-07-18 |
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