KR20140083039A - 글루카곤 결합형 핵산 - Google Patents
글루카곤 결합형 핵산 Download PDFInfo
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- KR20140083039A KR20140083039A KR1020147013385A KR20147013385A KR20140083039A KR 20140083039 A KR20140083039 A KR 20140083039A KR 1020147013385 A KR1020147013385 A KR 1020147013385A KR 20147013385 A KR20147013385 A KR 20147013385A KR 20140083039 A KR20140083039 A KR 20140083039A
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- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/115—Aptamers, i.e. nucleic acids binding a target molecule specifically and with high affinity without hybridising therewith ; Nucleic acids binding to non-nucleic acids, e.g. aptamers
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- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- C12N2310/00—Structure or type of the nucleic acid
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- C12N2310/16—Aptamers
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- C12N2310/35—Nature of the modification
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- C12N2320/00—Applications; Uses
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| EP11008467.0 | 2011-10-21 | ||
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| EP11008473.8 | 2011-10-21 | ||
| EP11008467 | 2011-10-21 | ||
| EPPCT/EP2012/000089 | 2012-01-10 | ||
| EP12000107.8 | 2012-01-10 | ||
| PCT/EP2012/000089 WO2012095303A1 (en) | 2011-01-10 | 2012-01-10 | Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same |
| EP12000107 | 2012-01-10 | ||
| PCT/EP2012/004421 WO2013056852A1 (en) | 2011-10-21 | 2012-10-22 | Glucagon binding nucleic acids |
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| KR20140083039A true KR20140083039A (ko) | 2014-07-03 |
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| PT2802660T (pt) | 2012-01-10 | 2020-04-21 | Aptarion Biotech Ag | Novos ácidos nucleicos que se ligam a c5a |
| CN103343126B (zh) * | 2013-07-19 | 2015-12-02 | 暨南大学 | 莱克多巴胺适配体与检测莱克多巴胺的适配体电化学生物传感器 |
| US10513536B2 (en) * | 2014-02-03 | 2019-12-24 | Noxxon Pharma Ag | Methods for the preparation of a polyalkoxylated nucleic acid molecule |
| ES2607639B1 (es) * | 2015-09-30 | 2018-02-28 | Urquima, S.A | Sal de ácido maleico de un intermedio de silodosina |
| WO2017062693A1 (en) * | 2015-10-07 | 2017-04-13 | Remd Biotherapeutics, Inc. | Methods for treating rare genetic disorders using glucagon receptor antagonistic antibodies |
| DE17829597T1 (de) | 2016-11-30 | 2019-12-05 | Noxxon Pharma Ag | Verfahren zur polyalkoxylierung von nukleinsäuren zur rückgewinnung und wiederverwendung einer überschüssigen polyalkoxylierungsreagenz |
| JP7418788B2 (ja) * | 2019-10-16 | 2024-01-22 | 国立研究開発法人産業技術総合研究所 | グルカゴン認識ペプチド並びにグルカゴン検出法 |
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| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US6395029B1 (en) | 1999-01-19 | 2002-05-28 | The Children's Hospital Of Philadelphia | Sustained delivery of polyionic bioactive agents |
| US6677136B2 (en) * | 2000-05-03 | 2004-01-13 | Amgen Inc. | Glucagon antagonists |
| US6652886B2 (en) | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| DK1438321T5 (da) | 2001-10-26 | 2011-02-21 | Noxxon Pharma Ag | Modificeret L-nukleinsyre |
| EP1306382A1 (de) | 2001-10-26 | 2003-05-02 | Noxxon Pharma AG | Modifizierte L-Nukleinsäure |
| EP2138575B8 (en) | 2002-02-20 | 2013-07-24 | Mersana Therapeutics, Inc. | Conjugates comprising a biodegradable polymer and uses therefor |
| FI20051017A7 (fi) | 2003-04-13 | 2005-11-28 | Enzon Pharmaceutivals Inc | Polymeeriset oligonukleotidiaihiolääkkeet |
| GB0314472D0 (en) | 2003-06-20 | 2003-07-23 | Warwick Effect Polymers Ltd | Polymer |
| EP1713509A2 (de) | 2004-02-09 | 2006-10-25 | Noxxon Pharma AG | Verfahren zur herstellung von konjugaten aus polysacchariden und polynukleotiden |
| AU2005232371B2 (en) | 2004-03-23 | 2010-10-14 | Complex Biosystems Gmbh | Polymeric prodrug with a self-immolative linker |
| EP1807092B1 (en) | 2004-11-05 | 2016-09-07 | The Children's Hospital of Philadelphia | Biodegradable linkers for molecular therapies |
| WO2006117217A2 (de) * | 2005-05-04 | 2006-11-09 | Noxxon Pharma Ag | Neue verwendung von spiegelmeren |
| JP4706019B2 (ja) * | 2005-07-08 | 2011-06-22 | 国立大学法人東京農工大学 | アプタマーの同定方法 |
| EP2063709A2 (en) | 2006-09-15 | 2009-06-03 | Enzon Pharmaceuticals, Inc. | Hindered ester-based biodegradable linkers for oligonucleotide delivery |
| EP2061901A2 (en) | 2006-10-31 | 2009-05-27 | Noxxon Pharma AG | Methods for detection of a single- or double-stranded nucleic acid molecule |
| EP2663640B1 (en) * | 2011-01-10 | 2020-11-04 | APTARION biotech AG | Nucleic acid molecule having binding affinity to a target molecule and a method for generating the same |
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- 2012-10-22 KR KR1020147013385A patent/KR20140083039A/ko not_active Withdrawn
- 2012-10-22 US US14/351,574 patent/US20150232852A1/en not_active Abandoned
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|---|---|
| EP2768960A1 (en) | 2014-08-27 |
| AU2012325233A2 (en) | 2014-04-24 |
| JP2014533098A (ja) | 2014-12-11 |
| US20150232852A1 (en) | 2015-08-20 |
| CA2852802A1 (en) | 2013-04-25 |
| WO2013056852A1 (en) | 2013-04-25 |
| BR112014009104A2 (pt) | 2017-04-18 |
| SG11201401362TA (en) | 2014-05-29 |
| AU2012325233A1 (en) | 2014-04-24 |
| CN103958682A (zh) | 2014-07-30 |
| MX2014004658A (es) | 2015-08-13 |
| IL231980A0 (en) | 2014-05-28 |
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