KR20140076602A - 항-m-csf 항체를 사용한 염증성 장애의 치료 방법 - Google Patents

항-m-csf 항체를 사용한 염증성 장애의 치료 방법 Download PDF

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Publication number
KR20140076602A
KR20140076602A KR1020147011778A KR20147011778A KR20140076602A KR 20140076602 A KR20140076602 A KR 20140076602A KR 1020147011778 A KR1020147011778 A KR 1020147011778A KR 20147011778 A KR20147011778 A KR 20147011778A KR 20140076602 A KR20140076602 A KR 20140076602A
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South Korea
Prior art keywords
antibody
amino acid
acid sequence
ser
seq
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Ceased
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KR1020147011778A
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English (en)
Korean (ko)
Inventor
마르틴 헤겐
데보라 앤 영
히스 엠. 게이
키리아키 두누시-조아노포울로스
수다카르 스리다란
아넷트 디엘
게일 커머
마고 매리 오'툴
진 엘리자베스 비브
로버트 포겔
마레크 혼차렌코
데이비드 베이들러
파드말라사 순카라 레디
다비드 요하네스 폰 샤크
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화이자 인코포레이티드
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Publication of KR20140076602A publication Critical patent/KR20140076602A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/243—Colony Stimulating Factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
KR1020147011778A 2011-11-08 2012-11-02 항-m-csf 항체를 사용한 염증성 장애의 치료 방법 Ceased KR20140076602A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161557175P 2011-11-08 2011-11-08
US61/557,175 2011-11-08
PCT/IB2012/056125 WO2013068902A1 (en) 2011-11-08 2012-11-02 Methods of treating inflammatory disorders using anti-m-csf antibodies

Publications (1)

Publication Number Publication Date
KR20140076602A true KR20140076602A (ko) 2014-06-20

Family

ID=47216377

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147011778A Ceased KR20140076602A (ko) 2011-11-08 2012-11-02 항-m-csf 항체를 사용한 염증성 장애의 치료 방법

Country Status (14)

Country Link
US (1) US20140286959A1 (enExample)
EP (1) EP2776467A1 (enExample)
JP (1) JP2013100281A (enExample)
KR (1) KR20140076602A (enExample)
CN (1) CN104271599A (enExample)
AU (1) AU2012335247A1 (enExample)
BR (1) BR112014011115A2 (enExample)
CA (1) CA2856149A1 (enExample)
HK (1) HK1205522A1 (enExample)
IL (1) IL232190A0 (enExample)
IN (1) IN2014CN04183A (enExample)
MX (1) MX2014005570A (enExample)
RU (1) RU2014114015A (enExample)
WO (1) WO2013068902A1 (enExample)

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AU2012285875B2 (en) 2011-07-18 2016-11-10 Morphosys Ag Use of c-Fms antagonists
WO2014167088A1 (en) * 2013-04-12 2014-10-16 Morphosys Ag Antibodies targeting m-csf
WO2015160786A1 (en) * 2014-04-14 2015-10-22 Brigham And Women's Hospital, Inc. Method of diagnosing, prognosing, and treating lupus nephritis
CN105985435B (zh) * 2015-01-30 2019-10-15 嘉和生物药业有限公司 全人源her2抗体的突变抗体及其编码基因和应用
CN109071646A (zh) 2016-03-11 2018-12-21 供石公司 TGFβ1-结合免疫球蛋白及其用途
SG10201606949QA (en) 2016-08-19 2018-03-28 Singapore Health Serv Pte Ltd Immunosuppressive composition for use in treating immunological disorders
WO2018129329A1 (en) * 2017-01-06 2018-07-12 Scholar Rock, Inc. ISOFORM-SPECIFIC, CONTEXT-PERMISSIVE TGFβ1 INHIBITORS AND USE THEREOF
WO2018183366A1 (en) 2017-03-28 2018-10-04 Syndax Pharmaceuticals, Inc. Combination therapies of csf-1r or csf-1 antibodies and a t-cell engaging therapy
AU2018269039B2 (en) 2017-05-19 2025-05-15 Syndax Pharmaceuticals, Inc. Combination therapies
US12331320B2 (en) 2018-10-10 2025-06-17 The Research Foundation For The State University Of New York Genome edited cancer cell vaccines

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Publication number Publication date
IN2014CN04183A (enExample) 2015-07-17
AU2012335247A1 (en) 2014-05-29
CN104271599A (zh) 2015-01-07
WO2013068902A1 (en) 2013-05-16
US20140286959A1 (en) 2014-09-25
CA2856149A1 (en) 2013-05-16
BR112014011115A2 (pt) 2017-06-13
MX2014005570A (es) 2014-05-30
RU2014114015A (ru) 2015-12-20
JP2013100281A (ja) 2013-05-23
HK1205522A1 (en) 2015-12-18
IL232190A0 (en) 2014-06-30
EP2776467A1 (en) 2014-09-17

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