KR20140049765A - Hair restorer composition and method for manufacturing the same - Google Patents

Abstract

The present invention relates to a hair restorer and a method for preparing the same. The present invention provides a hair restorer comprising: based on 100 parts by weight of a calamus root extract obtained by hot-water extraction of calamus roots, 5-30 parts by weight of a coix extract obtained by hot-water extraction of coix; 0.1-10 parts by weight of a Vitis amurensis extract obtained by solvent extraction of at least one selected from leaves and stems of Vitis amurensis; 5-30 parts by weight of tocopherol; and 2-20 parts by weight of a thiol-based compound having a carboxyl group (-COOH). In addition, the present invention provides a method for preparing a hair restorer, comprising the steps of: obtaining a calamus root extract by hot-water extraction of calamus roots; obtaining a coix extract by hot-water extraction of coix; obtaining a Vitis amurensis extract by solvent extraction of at least one selected from leaves and stems of Vitis amurensis; and mixing 5-30 parts by weight of the coix extract, 0.1-10 parts by weight of the Vitis amurensis extract, 5-30 parts by weight of tocopherol, and 2-20 parts by weight of a thiol-based compound having a carboxyl group (-COOH) based on 100 parts by weight of the obtained calamus root extract. According to the present invention, the hair restorer suppresses bacterial multiplication on the scalp and maintains a clean scalp as well as protects hairs and prevents hair loss, thereby having excellent hair growth promoting activity. Furthermore, the hair restorer has excellent storage stability, and thus can be stored for a long period of time.

Description

[0001] HAIR RESTORER COMPOSITION AND METHOD FOR MANUFACTURING THE SAME [0002]

The present invention relates to a hair growth agent and a method for producing the same, and more particularly, to a hair growth agent having excellent hair growth promoting action and excellent storage stability, and a production method thereof.

The human hair is about 100,000 to 150,000, and is known to be formed in "hair follicles". And hair follicles have nipples, where small blood vessels are distributed to supply nutrients needed for hair growth. Each hair has a different cycle and grows and falls through the anagen, catagen and telogen phases. This cycle repeats over 3 to 6 years, with an average of 50 to 100 hairs dropping normally on a daily basis.

In general, alopecia refers to an abnormally high number of hairs falling out due to shortening of the growth phase hairs and more degenerative or resting hairs during these cycles.

The causes of hair loss are discussed, such as hyperthermia of male hormone action, excessive sebum secretion, poor blood circulation, hypoxia caused by peroxide, bacteria, genetic factors, aging, stress. Generally, it has been reported that testosterone, which is a male hormone, is activated by dehydrotestoserone (DHT) by an enzyme, and DHT binds to a specific receptor and induces a protein that causes hair loss, resulting in hair loss have. In addition, this mechanism causes excessive production of sebum, and acne and seborrheic dermatitis are caused, resulting in hair loss accompanied by inflammation in the scalp.

In recent years, various studies have been conducted to promote the prevention of hair loss and hair growth, and in Korea, a method using mainly oriental medicine or natural extract has been mainstream.

Korean Patent Laid-Open Publication No. 10-2000-0031349, for example, discloses a hair growth inhibitor composition using herbal medicine extracts such as ginseng, astragalus, Hanhyuncho, Bogolji, Angelica gigas, The present invention relates to a composition for promoting hair growth and a method for producing the same, which comprises using as an essential ingredient ogga, ginseng and apple juice.

Korean Patent Laid-Open Publication No. 10-2012-0038585 discloses a herbal extract for preventing hair loss, which is prepared by mixing and extracting Rhodiola, Hwangbyeong, Golden, Hwangjeong, Hwanggi, Baekji, Korean chrysanthemum, Licorice and Ginger.

As described above, most of the conventional hair growth promoting agents are based on herbal extracts such as ginseng which are known to be effective for hair damage and hair loss prevention, and other natural materials are added.

Hair loss is caused not only by degeneration of scalp cells caused by aging, lack of nutrients supplied to hair follicles, but also by inflammation due to lipid, foreign body or scalp disease and clogging of pores. In particular, hair loss caused by stress or environmental factors as well as genetic factors is increasing recently, it is most important to keep the scalp clean.

However, the hair growth inhibitor according to the prior art has little function to suppress the bacterium of the scalp and to manage the scalp cleanly. In addition, the conventional hair growth inhibitor has a problem in that it is difficult to store the hair growth agent for a long time because of low storage stability.

Korean Patent Publication No. 10-2000-0031349 Korean Patent Publication No. 10-2002-0076834 Korean Patent Publication No. 10-2012-0038585

Accordingly, it is an object of the present invention to provide a hair growth agent having excellent hair growth (and wool) promoting action while suppressing the bacterium of the scalp and keeping it clean and having excellent storage stability, and a method for producing the hair growth agent.

According to an aspect of the present invention,

With respect to 100 parts by weight of the extract of Xiangfang root obtained by hot water extraction of iris root,

5 to 30 parts by weight of an extract of wool obtained by hot water extraction of Nadin;

0.1 to 10 parts by weight of an extract of Solanum tuberosum obtained by solvent extraction of at least one selected from the mouth and stem of a hairless hair;

5-30 parts by weight of tocopherol; And

And 2 to 20 parts by weight of a thiol compound having a carboxyl group (COOH-).

Further, according to the present invention,

Extracting the root of iris by hot water extraction to obtain an extract of spore root;

Extracting a nutrient solution by hot water extraction to obtain a nutrient solution;

Extracting at least one selected from the mouth and the stem of the hairless hair to obtain an extract of a hairy loam; And

5 to 30 parts by weight of an extract of Wuin extract, 0.1 to 10 parts by weight of a bamboo hair extract, 5 to 30 parts by weight of tocopherol and 2 to 20 parts by weight of a thiol compound having a carboxyl group (COOH-) And a step of mixing the mixture.

In this case, the thiol compound is preferably selected from compounds represented by the following formulas.

[Chemical Formula]

(In the above formula, R is H, OH, COOH or CH ₂ -COOH.)

According to the present invention, it is possible to protect hair and prevent hair loss, as well as inhibit bacterial growth of the scalp and keep the scalp clean and have excellent hair growth (and wool) promoting action. In addition, it has an excellent storage stability and can be stored for a long period of time.

Hereinafter, the present invention will be described in detail.

The hair growth inhibitory composition according to the present invention is a hair growth composition for preventing hair loss and promoting hair growth (and wool). The hair growth inhibitory composition according to the present invention is a hair growth composition for promoting hair growth (and wool) 5 to 30 parts by weight of the extract of wool obtained by extraction; 0.1 to 10 parts by weight of a bladder extract obtained by solvent extraction of at least one selected from the mouths and stalks of Vitis amurensis; 5-30 parts by weight of tocopherol; And 2 to 20 parts by weight of a thiol compound having a carboxyl group (COOH-) as an active ingredient.

In addition, the method for preparing a hair growth agent according to the present invention comprises the steps of: extracting Acrysaceae root with hot water to obtain a root extract; Extracting Coicis semen with hot water to obtain a nutrient solution; A step of solvent extraction of at least one selected from the mouth and the stem of Vitis amurensis to obtain a blight extract; And 5 to 30 parts by weight of tocopherol, and 2 to 20 parts by weight of a thiol compound having a carboxyl group (COOH-), based on 100 parts by weight of the obtained crude muscle extract, And mixing the components. Hereinafter, a hair growth agent according to a specific embodiment of the present invention and a method for producing the hair growth agent will be described together.

One. Changshou  Extract

The iris (Acdrus asiaticus) is a perennial herb of iris, which is about 1m long, and around June to July, there is a pedicel between the leaves and a pale yellow or rusty white small flower blooms. Iris is known to have effects such as skin ulceration, dandruff removal, and itching inhibition. The active ingredients are, for example, oegenol, carrageenan, and the like. It is said that iris is shiny on its head when hair is wrapped around roots and leaves in May,

The hair growth agent according to the present invention includes the above-mentioned Xanthomonas extract. Specifically, it includes a root extract obtained by hot water extraction of iris root. These extracts act as active ingredients to protect hair and prevent hair loss.

The extract may be prepared by adding water, for example, 2 to 8 times the weight of iris root, and heating the extract at a temperature of 80 to 100 ° C for 24 hours or more. After the extraction, it is possible to use, for example, a solid content of 60 to 85% by weight through concentration under reduced pressure. In addition, the extract can be used after being extracted with hot water and then added with an alkaline agent such as triethanolamine (TEA), and then neutralized to pH 7 by mixing oleic acid and the like.

2. Wisdom  Extract

Coicis semen (薏苡仁) is an annual herbaceous herbaceous plant belonging to the Hwangbong family. It is a seed of yulmu which reduces heat, removes sweat, strengthens the spleen, protects the lungs, inhibits cholesterol , Prevention of arteriosclerosis, thrombolysis, hypotension, and peripheral vasodilation.

In addition, Nyin includes myristric acid, beta-sitosterol, campesterol and stigmasterol as main components, and myristric acid ) And beta-sitosterol have been reported to inhibit 5-alpha-reductase causing hair loss.

The hair growth agent according to the present invention includes the above-described extract. Specifically, it includes a nutrient extract obtained by hot water extraction of Nuyin. These nutrient extracts help prevent hair loss while feeding nutrients to hair follicle cells, helping oxygen supply, and promoting hair growth (and wool).

The above-described extract can be obtained by adding water, for example, 2 to 8 times the weight of the nutrient (seeds) and heating and extracting the same at a temperature of 80 to 100 DEG C for 1 hour or more. In addition, the nutrient solution may be extracted with hot water and concentrated under reduced pressure, for example, having a solid content of 60 to 85% by weight.

The nutrient solution is contained in an amount of 5 to 30 parts by weight based on 100 parts by weight of the extract. At this time, when the content of the nutrient extract is less than 5 parts by weight, the hair loss prevention and the nutrient supply to the hair follicle cells or the oxygen supply effect may be insignificant. When the content of the nutrient extract is more than 30 parts by weight, the synergistic effect with the excessive content is not so large, and the content of other components such as the extracts of the root extract and the extract of the royal family is relatively low, have.

3. Blond hair extract

Vitis amurensis is a vine-bearing wood belonging to the broad-leaved grape, which contains about 10 times the components of normal grapes such as calcium, phosphorus, iron, ash and anthocyanin. Such hair follicles are known to have medicinal effects such as antioxidant activity, anti-inflammatory activity and anticancer activity. Also, it has been reported that blond hair has a blood-collecting tonic and nourishing effect.

The hair growth agent according to the present invention includes the above-described hair dough extract. Specifically, it includes a bladder extract obtained by solvent extraction of at least one selected from the mouth and the stem of the hairless hair. This blond hair extract inhibits bacterial growth causing scalp disease and keeps scalp clean. Specifically, according to the present invention, the bark extract has excellent antimicrobial activity against pathogenic bacteria such as Staphylococcus aureus , which causes atopic diseases causing scalp disease, and inhibits bacterial proliferation of scalp And keep scalp clean to prevent hair loss while promoting hair growth (and wool).

In the present invention, the extract can be obtained by using various extraction methods. For example, one or a mixture of two or more selected from water, anhydrous or hydrous lower alcohol (methanol, ethanol, propanol, butanol, etc.) And extracted and extracted with an extraction solvent can be used. The above-described blond hair extract is included in the present invention as long as it exhibits substantially the same effect using not only the above-mentioned extraction solvent but also other extraction solvents. The extraction solvent preferably contains ethanol.

In addition, in the present invention, the bluestoon extract includes not only an extract by an extraction solvent, but also an extract after purification and purification. Concretely, in the case of the hair dough extract used in the present invention, the liquid extract of the extracting solvent is used as it is or after the extraction, the separation process such as ultrafiltration membrane having a certain molecular weight cut-off value, And a separation process such as separation by filtration (separation for separation according to size, charge, hydrophobicity or affinity). In addition, the bluestone extract is obtained by concentrating the extract obtained by concentrating the extract as described above under reduced pressure; A dilute solution obtained by obtaining a powder through an additional process such as vacuum distillation and drying (freezing, spray drying, etc.), and diluting the powder in a solvent may be used.

According to a preferred embodiment, the above-described blond hair extract can be obtained by extracting the extract obtained by solvent extraction (for example, ethanol solvent extraction) or a concentrated solution thereof by fractionation. Specifically, the extract or the concentrate may be separated and extracted into a single compound or a mixture of two or more compounds by using ethyl acetate or the like. The solvent of the bluestone extract may be extracted from the solvent and concentrated under reduced pressure, for example, having a solid content of 60 to 85% by weight.

According to the present invention, it has been found that the above-described blond hair extract contains compounds having excellent antimicrobial activity against bacterium causing scalp disease (for example, atopic pathogens, etc.). Specifically, bluestone extracts contain several kinds of single compounds, and among various kinds of single compounds, piceatannol, trans-resveratrol, trans-epsilon-Viniferin, Ampelopsin A, Ampelopsin F, Amuresin G, and 2-y-Viniferin, which are used in the present invention, And it has excellent antimicrobial activity.

Therefore, the bark extract may contain at least one selected from the seven listed single compounds. In the following Formulas 1 to 5, several structural formulas of the single compounds are shown. According to a more preferred embodiment, the bark extract has three kinds of single compounds represented by the following formulas (1) to (3), namely, piceatannol represented by the following formula (1), trans-resveratrol represented by the following formula Resveratrol) represented by the following formula (3) and trans-epsilon-Viniferin represented by the following formula (3). These three compounds are highly antimicrobial against bacterium causing scalp disease.

[Chemical Formula 1]

Piceatannol

(2)

  trans-Resveratrol

(3)

trans-ε-Viniferin

[Chemical Formula 4]

(+) - Ampelopsin A

[Chemical Formula 5]

(+) - Ampelopsin F

The bluestone extract is contained in an amount of 0.1 to 10 parts by weight based on 100 parts by weight of the extract. At this time, when the content of the bladder extract is less than 0.1 part by weight, the suppressing effect (antibacterial activity) of the scalp bacteria and the cleansing effect of the scalp depending on the content thereof may be insignificant. If the content of the blond hair extract is more than 10 parts by weight, the synergistic effect due to the excessive content is not so large, and it may give stimulation to the scalp.

The bluestone extract preferably contains 0.1 to 20% by weight of piceatannol represented by the above formula, based on the total weight of the bladder extract, containing the single compounds as described above. Such Piceatannol is very effective for suppression of scalp bacteria.

4. Tocopherol

Tocopherol can be selected from natural or synthetic compounds, which are commonly known as tocols or vitamin E. Tocopherol is used in conventional hair growth promoting compositions (hair growth promoting compositions), which nourishes hair and promotes hair growth (and wool).

The tocopherol may be a commonly used one, and one or more selected from alpha, beta, gamma, and delta-tocopherol may be used. The tocopherol is preferably selected from? -Tocopherol.

The tocopherol may be included in an amount of 5 to 30 parts by weight based on 100 parts by weight of the extract. At this time, when the content of tocopherol is less than 5 parts by weight, nutritional supply and hair growth (and wool) promoting effects may be insignificant. When the content of tocopherol is more than 30 parts by weight, the synergistic effect with the excessive content is not so large and the content of the other components may be undesirably low.

5. Thiol  compound

Generally, a thiol-based compound is a compound having at least one thiol group (SH-) in a molecule, which is known to have antioxidant and immune functions.

In the present invention, a thiol compound having at least one carboxyl group (COOH-) in the molecule together with a thiol group (SH-) is used. The thiol compound is preferably selected from compounds represented by the following formula (6).

[Chemical Formula 6]

(In the above formula, R is H, OH, COOH or CH ₂ -COOH.)

According to the present invention, the thiol compound increases the storage stability of the hair growth agent by antioxidative action, and it also prevents deterioration while improving the miscibility of each of the above components, such as the elongated extract, .

The thiol compound is contained in an amount of 2 to 20 parts by weight based on 100 parts by weight of the extract. At this time, if the content of the thiol compound is less than 2 parts by weight, the effect of improving the storage stability may be insignificant. When the content of the thiol compound is more than 20 parts by weight, the synergistic effect with the excessive content is not so large, and the stimulation can be given to the scalp.

On the other hand, the hair growth agent according to the present invention is prepared by mixing each of the components as described above, namely, Janghak Root Extract, Wuyin Extract, Wangharu Extract, Tocopherol and Thiol compounds. At this time, when mixing, one or more diluents selected from water (distilled water) and an organic solvent may be further mixed. Such diluents, such as water / or container solvents, may be included (diluted), for example, from 1 to 80% by weight, based on the total weight of the hair growth agent.

The organic solvent may be selected from the group consisting of C 1 -C 4 lower alcohols such as ethanol, isopropyl alcohol, and acetone, alkylene glycols such as ethylene glycol and propylene glycol, ethylene glycol monomethyl, monoethyl or monobutyl ether, Monoethyl ether of ethyl ether and dipropylene glycol, and polytetrahydrofuran ether.

In addition, the hair growth agent according to the present invention may further include an additional component capable of improving hair loss prevention and hair growth (wool) promotion in addition to the above components. These additional ingredients are commonly used, for example, herbal medicine extracts such as ginseng, and chloramphenic chloride, minoxidil, paraffin wax, and the like.

In addition, the hair growth agent according to the present invention may have formulations such as, for example, liquid, suspension, spray, aerosol, paste and cream. The hair growth agent according to the present invention can be applied to hair products such as shampoo and hair spray.

In addition, the hair growth agent according to the present invention may optionally contain at least one additive selected from flavoring agents, pH adjusting agents, foaming agents (surfactants), preservatives and humectants, and such additives may be selected from those conventionally used .

For example, the perfume can be dissolved in a solvent such as a solubilizer or ethanol to be included in the hair growth promoter of the present invention. Examples of the perfume oil include peppermint oil, menthol, spearmint oil, carbohydrate, anise oil, , Eucalyptus oil system, eucalyptol (1,8-cineol), clove oil system, eugenol, wintergreen oil system, methyl silicate, cinnamon oil system, cinnamic aldehyde and other perfume ingredients. Such a perfume can be contained in an amount of 0.001 to 5.0% by weight based on the total weight of the hair growth inhibitor.

The pH adjusting agent may be at least one selected from the group consisting of sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, citric acid, sodium citrate and tartaric acid, 0.001 to 2.0% by weight, so as to have a pH of 6 to 8.

The foaming agent (surfactant) may be selected from the group consisting of sodium lauryl sulfate, sodium N-lauroylsalicylate, N-long chain acyl glutamate, sucrose fatty acid ester, polyoxyethylene hydrogenated castor oil, sorbitan fatty acid ester, polyoxyethylene and polyoxypropylene , And the like. These foaming agents may be contained in an amount of 0.1 to 10.0 wt%, preferably 0.5 to 5.0 wt%, based on the total weight of the hair growth agent.

The preservative may be at least one selected from the group consisting of p-hydroxybenzoic acid methyl, p-hydroxybenzoic acid, paraoxybenzoic acid ester, benzoic acid, sodium benzoate and DMDM Hydantoin, By weight, preferably 0.01 to 10.0% by weight, more preferably 0.05 to 5.0% by weight.

The moisturizing agent imparts moisturization to the hair, which may be selected from, for example, glycols and oils. Such a humectant may be contained in an amount of 0.01 to 10.0% by weight, preferably 0.2 to 5.0% by weight, based on the total weight of the hair growth inhibitor.

According to the present invention described above, it is possible to protect the hair from damages and prevent hair loss by incorporating each of the components as described above, that is, the extracts of Janghak Root Extract, Waiin Extract, Tumor Extract, Tocopherol and Thiol- , It suppresses the bacterial growth of the scalp and keeps the scalp clean and has an excellent hair growth promoting effect. It has excellent storage stability and can be stored for a long time.

Hereinafter, examples and comparative examples of the present invention will be exemplified. The following examples are provided to illustrate the present invention in order to facilitate understanding of the present invention, and thus the technical scope of the present invention is not limited thereto.

[Example]

≪ Preparation of bamboo hair extract &

First, leaves and stalks of powdered dried blonde hair (Vitis amurensis) were pulverized, and 2 kg of the powder was added to 10 L of 70 wt% aqueous ethanol solution, followed by solvent extraction for 3 hours. The filtrate was concentrated under reduced pressure to obtain a concentrated solution. The concentrate was fractionated with ethyl acetate to extract and separate seven kinds of single compounds as shown in Table 1 below.

Antibacterial Experiment (1)

Antimicrobial experiments were carried out on the seven single compounds extracted and separated from the hair follicles (leaves and stems) by the disk diffusion method. At this time, Staphylococcus aureus was used as an atopic pathogen known to cause scalp disease as a bacterium. The results are shown in Table 1 below.

  <Antimicrobial Test Results of Single Compounds Extracted and Separated from Bangaloo (1), Unit: mm>
Staphylococcus aureus (占 퐂 / disk) 50 100 200 400 600 Fisethanol
(Piceatannol) 16 21 24 33 37 (+) - Ampelopathine A
(Ampelopsin) - 9 12 14 16 (+) - ameloprostine F
(Ampelopsin F) - 11 16 21 24 Trans-Resveratrol
(trans-Resveratrol) 9 11 18 24 28 Amoresin G
(Amuresin G) - 9 10 11 14 Trans-ε-Vinipelin
(trans-ε-Viniferin) 11 15 18 20 23 2-y-binipiperine
(2-y-Viniferin) - 10 11 12 15

As shown in the above Table 1, it was found that the extract of Solanaceae has antimicrobial activity against the atopic pathogen Staphylococcus aureus . Particularly, among the single compounds isolated from the bamboo shoot extract, three single compounds, namely Piceatannol, trans-Resveratrol and trans-epsilon-Viniferin, Piceatannol was found to have a very strong antimicrobial activity.

Antibacterial experiment (2)

MIC, MBC and TBAI tests on Staphylococcus aureus were performed on the above-mentioned blight extract (concentrate) using a conventional liquid medium dilution method. At this time, the bluestone extract solution was allowed to stand at room temperature for 30 days, and 0.1 ml of the extract was applied to a retinol agar medium (liquid medium) and cultured at 25 ° C for 72 hours to confirm the presence of bacteria. In addition, as the control group, trichloroacid, which is usually added to the shampoo composition as a sterilizing agent, was used instead of the bluestone extract. The results are shown in Table 2 below.

(1) MIC (Minimum Inhibitory Concentration) - Minimum growth inhibition concentration, the minimum concentration at which bacteria can not grow.

(2) MBC (Minimum Bactericidal Concentration) - Minimum bactericidal concentration, the minimum concentration required to completely inhibit and kill bacterial growth.

(3) Total Bacterial Adherence Inhibition (TBAI) - When the inhibition value is determined at a concentration lower than the minimum growth inhibition concentration (MIC), the antibacterial activity is good.

                 <Antibacterial Test Results of Bambalu Extract (2)>
Remarks Staphylococcus aureus MIC
(쨉 g / mL) MBC
(쨉 g / mL) TBAI
(쨉 g / mL) Bluestone extract 0.60 0.10 0.55 Control group <1.5 <1.5 6.25

As shown in the above Table 2, it was found that the extract of Wangharu had an excellent antibacterial effect even in the results of MIC, MBC and TBAI measurement.

< Changshou  Preparation of Extracts>

100 g of iris root was washed thoroughly, finely chopped and placed in 1 L of water, heated at a high temperature in a hot water bath at 100 캜 for about 36 hours, and then filtered to obtain a root extract (solid content 75% by weight). Triethanolamine was added to the extract to alkalize it, followed by mixing with oleic acid to neutralize it to pH 7. [

< Wisdom  Extract preparation>

And then the mixture was washed 6 times with water and then extracted with hot water for about 1 hour and 30 minutes and then filtered and concentrated under reduced pressure to prepare an extract of Uinin (solid content 65% by weight).

&Lt; Preparation of hair growth inhibitor composition >

The compositions of hair growth (shampoo formulation) according to each of the examples were prepared by using the above-obtained blush extract, Changmaokin extract, and Uinin extract as shown in Table 3 below. At this time, the concentrated solution obtained by extracting ethanol solvent, followed by filtration and concentration under reduced pressure, was used. The thiol compound was used in which R was CH ₂ -COOH in the above formula (6).

[Comparative Example]

Compared with the above examples, those which did not use the bluestone extract and the thiol compound were used as the test piece according to the present comparative example. Further, trichloroacid was added as a fungicide. The composition and content of the hair extender composition according to this Comparative Example are shown in Table 3 below.

                  &Lt; Component and content of hair growth inhibitor composition, unit: weight part > Remarks Example 1 Example 2 Comparative Example Changsha extract 100 100 100 Nutrient Extract 20 20 20 Bluestone extract 1.0 5.0 - ? -tocopherol 10 10 10 Thiol compounds 10 3 - Aqueous ethanol solution (95 wt%) 50 50 50 Silk amino acid 5 5 5 Surfactants
Ammonium lauryl sulfate 5 5 5 Cocoamidopropyl betaine 10 10 10 pH adjusting agent Citric acid 0.2 0.2 0.2 antiseptic Paraoxybenzoic acid methyl 0.1 0.1 0.1 disinfectant Trichloroacid - - 2.0 Moisturizer Propylene glycol 3 3 3 Incrementer Zen sword 2 2 2 Spices Peppermint 2 2 2 Purified water 100 100 100

For the hair growth inhibitor composition (shampoo) according to each of the examples and the comparative examples, the following customer satisfaction and hair restraining ability were evaluated.

<Evaluation of Preference>

(Shampoo) according to each of Examples (1) and (2) and Comparative Example was used for 20 times (20 days, once a day) for 30 persons to be tested to evaluate the cleaning ability, itching, Hygiene status, amount of foam, and freshness after rinsing. At this time, the evaluation criteria were evaluated as 5 out of the following values, and the average value is shown in Table 4 below.

<Evaluation Criteria>

1 point: very bad

2 points: Bad

3 points: Normal

4 points: Good

5 points: Very satisfied

              <Results of Preference Evaluation> Remarks Example 1 Example 2 Comparative Example Cleaning ability 3.5 3.2 3.2 Itching 3.2 4.2 2.4 Hygienic condition of hair 3.4 3.8 2.0 Amount of bubbles 2.8 2.4 2.8 Refreshing after rinsing 3.5 3.8 2.6

As shown in the above Table 4, all the hair growth inhibitory compositions according to the examples of the present invention showed better results than the comparative example in all five preference evaluations. In particular, it was found that the case of Example 2, in which the amount of the bluestone extract was large, showed very good results in terms of itching, hair hygiene and freshness compared to Example 1 and Comparative Example.

<Evaluation of wool and hair loss intelligence>

An adult male having hair loss symptoms was used to evaluate the hair wool effect and hair loss prevention effect by using the hair growth agent composition according to each of the above Examples and Comparative Examples. At this time, 20 adult men aged 40 to 50 years, who had an average hair loss number of 100 or more per day, were selected, and the hair growth agent composition according to each of the Examples and Comparative Examples was used. About 2 ~ 3 times a day about 3 ㎖ of the finger was applied properly and then rubbed to be absorbed sufficiently. After six months, the evaluation of wool and hair loss was evaluated according to the following three points. The average values of the wool and hair loss were shown in Table 5 below.

<Evaluation Criteria>

1 point: No effect

2 points: Medium

3 points: Good

        <Results of wit and hair loss intelligence evaluation> Example 1 Example 2 Comparative Example 2.5 2.8 2.1

As shown in Table 5, it was found that the hair growth inhibitory composition according to the examples of the present invention is superior in the wool and hair loss preventing ability compared with the comparative example. It was also found that the case of Example 2 in which the addition amount of the hair dough extract was high was also excellent in the wool and hair loss preventing ability.

<Storage stability evaluation>

The hair growth inhibitor composition according to each of the Examples and Comparative Examples was placed in an aluminum container and stored at a high temperature of 60% and a temperature of 80 캜 for 5 days and then at a low temperature of 4 캜 for 2 days. Then, the sample was further stored for 3 days under a high temperature condition of 60% relative humidity and 80 ° C, and then poured onto a glass plate to evaluate the fluidity (flow-down). At this time, the fluidity was evaluated according to the following evaluation criteria, and the results are shown in Table 6 below.

<Evaluation Criteria>

+: Damp and not fluid

++: Low liquidity, but liquidity

+++: high liquidity due to rippling

 <Storage stability (fluidity) evaluation result> Example 1 Example 2 Comparative Example +++ ++ +

As shown in Table 6, the hair growth inhibitor compositions according to the examples of the present invention have excellent storage stability due to fluidity even after storage under severe conditions of high temperature / low temperature / high temperature. It was also found that the storage stability of Example 1, in which the amount of the thiol compound was increased, was much better than that of Example 2 and Comparative Example.

As can be seen from the above examples, the hair growth inhibitory composition according to the present invention can be used as an effective ingredient to inhibit bacterial proliferation of the scalp, prevent hair loss, Hair (and wool) can be promoted. It can be seen that it suppresses itching, keeps hair and scalp clean, has excellent storage stability and can be stored for a long time.

Claims (5)

(Acdrus asiaticus) 100 parts by weight of the extract of Root Extract obtained by hot water extraction of roots,
5 to 30 parts by weight of an extract which is a wool obtained by hot water extraction of {Coicis semen};
0.1 to 10 parts by weight of an extract of Solanum tuberosum obtained by solvent extraction of at least one selected from the mouths and stalks of a hairy loaf {Vitis amurensis};
5-30 parts by weight of tocopherol; And
Hair repellent, comprising 2 to 20 parts by weight of a thiol compound having a carboxyl group (COOH-).
The method of claim 1,
The thiol-based compound is a compound represented by the following formula.
[Chemical Formula]

(In the above formula, R is H, OH, COOH or CH ₂ -COOH.)
3. The method according to claim 1 or 2,
The hair dyestuff extract according to claim 1, wherein the hair flower extract contains 0.1-20% by weight of fichethanol represented by the following formula based on the total weight of the hair dough extract.
[Chemical Formula 1]

(Acdrus asiaticus) roots extracted with hot water to obtain a root extract;
Extracting Coicis semen with hot water to obtain a nutrient solution;
A step of solvent extraction of at least one selected from the mouth and the stem of the hair follicle {Vitis amurensis} to obtain a hair dough extract; And
5 to 30 parts by weight of Euiin extract, 0.1 to 10 parts by weight of Wangeru extract, 5 to 30 parts by weight of tocopherol, and 2 to 20 parts by weight of a thiol compound having a carboxyl group (COOH-) Method of producing a hair regrowth agent comprising the step of mixing.
5. The method of claim 4,
Wherein the thiol compound is a compound represented by the following formula.
[Chemical Formula]

(In the above formula, R is H, OH, COOH or CH ₂ -COOH.)