KR20140043340A - T 세포의 프라이밍을 위한 방법 - Google Patents

T 세포의 프라이밍을 위한 방법 Download PDF

Info

Publication number
KR20140043340A
KR20140043340A KR1020137029247A KR20137029247A KR20140043340A KR 20140043340 A KR20140043340 A KR 20140043340A KR 1020137029247 A KR1020137029247 A KR 1020137029247A KR 20137029247 A KR20137029247 A KR 20137029247A KR 20140043340 A KR20140043340 A KR 20140043340A
Authority
KR
South Korea
Prior art keywords
cells
antigen
cell
specific
viral
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020137029247A
Other languages
English (en)
Korean (ko)
Inventor
알렉스 칼슨-패라
안나-카린 월그렌
벵트 앤더슨
Original Assignee
이뮤니쿰 에이비
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 이뮤니쿰 에이비 filed Critical 이뮤니쿰 에이비
Publication of KR20140043340A publication Critical patent/KR20140043340A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/12Viral antigens
    • A61K39/145Orthomyxoviridae, e.g. influenza virus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/10Cellular immunotherapy characterised by the cell type used
    • A61K40/11T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00Cellular immunotherapy
    • A61K40/40Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/46Viral antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12Antivirals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0634Cells from the blood or the immune system
    • C12N5/0636T lymphocytes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/11Coculture with; Conditioned medium produced by blood or immune system cells
    • C12N2502/1121Dendritic cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16111Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011Details
    • C12N2710/16011Herpesviridae
    • C12N2710/16211Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
    • C12N2710/16234Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011Details
    • C12N2760/16011Orthomyxoviridae
    • C12N2760/16111Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Virology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Mycology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Developmental Biology & Embryology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020137029247A 2011-04-13 2012-04-12 T 세포의 프라이밍을 위한 방법 Withdrawn KR20140043340A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161474892P 2011-04-13 2011-04-13
US61/474,892 2011-04-13
PCT/EP2012/056658 WO2012140127A2 (en) 2011-04-13 2012-04-12 Method for priming of t cells

Publications (1)

Publication Number Publication Date
KR20140043340A true KR20140043340A (ko) 2014-04-09

Family

ID=45953145

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020137029247A Withdrawn KR20140043340A (ko) 2011-04-13 2012-04-12 T 세포의 프라이밍을 위한 방법

Country Status (6)

Country Link
US (2) US9492529B2 (cg-RX-API-DMAC7.html)
EP (1) EP2696894B1 (cg-RX-API-DMAC7.html)
JP (1) JP2014511704A (cg-RX-API-DMAC7.html)
KR (1) KR20140043340A (cg-RX-API-DMAC7.html)
CN (1) CN103533955A (cg-RX-API-DMAC7.html)
WO (1) WO2012140127A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020185056A3 (ko) * 2019-03-08 2020-11-05 신지섭 타가면역세포배양방법, 그 방법으로 얻어진 면역세포배양액 및 이를 포함하는 면역세포치료제

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112015014270B1 (pt) * 2012-12-18 2018-12-04 Immunicum Ab co-diferenciação de monócitos a partir de doadores alogênicos
ES2776698T3 (es) 2012-12-20 2020-07-31 Purdue Research Foundation Células T que expresan un receptor antigénico quimérico como terapia contra el cáncer
DK3268470T3 (da) 2015-03-11 2021-02-22 Univ Texas Transposasepolypeptider og anvendelser deraf
CN108289910A (zh) * 2015-03-26 2018-07-17 宾夕法尼亚大学理事会 在体外人造淋巴结用于治疗和表位作图的t细胞的敏化和扩增
US20180171294A1 (en) * 2015-03-26 2018-06-21 The Trustees Of The University Of Pennsylvania In vitro artificial lymph node method for sensitization and expansion of t cells for therapy and epitope mapping
JP7570080B2 (ja) * 2015-05-07 2024-10-21 ベイラー カレッジ オブ メディスン 樹状細胞免疫療法
ES2824554T3 (es) * 2015-12-16 2021-05-12 Tcer Ab Plataforma de reactividad de células T
CN105543170A (zh) * 2015-12-31 2016-05-04 中山大学 一种可刺激t细胞扩增的组合物
US10888613B2 (en) 2016-02-08 2021-01-12 American Gene Technologies International Inc. Method of producing cells resistant to HIV infection
JP7282521B2 (ja) 2016-04-08 2023-05-29 パーデュー・リサーチ・ファウンデイション Car t細胞療法のための方法および組成物
EP3481418A4 (en) * 2016-07-08 2020-03-11 American Gene Technologies International Inc. PRE-IMMUNIZATION AND IMMUNOTHERAPY OF HIV
US11649288B2 (en) 2017-02-07 2023-05-16 Seattle Children's Hospital Phospholipid ether (PLE) CAR T cell tumor targeting (CTCT) agents
WO2018160622A1 (en) 2017-02-28 2018-09-07 Endocyte, Inc. Compositions and methods for car t cell therapy
US20200345800A1 (en) * 2017-10-03 2020-11-05 Tokyo Metropolitan Institute Of Medical Science Medication for influenza
CN112292138A (zh) 2018-01-22 2021-01-29 西雅图儿童医院(Dba西雅图儿童研究所) Car t细胞的使用方法
SG11202007426XA (en) 2018-02-06 2020-09-29 Seattle Childrens Hospital Dba Seattle Childrens Res Inst Fluorescein-specific cars exhibiting optimal t cell function against fl-ple labelled tumors
WO2019165237A1 (en) 2018-02-23 2019-08-29 Endocyte, Inc. Sequencing method for car t cell therapy
CN109370987A (zh) * 2018-11-23 2019-02-22 见多视光(北京)科技有限公司 外周血ctl细胞改良的培养方法
WO2020219812A1 (en) 2019-04-26 2020-10-29 Allogene Therapeutics, Inc. Methods of manufacturing allogeneic car t cells
WO2021006733A1 (en) * 2019-07-08 2021-01-14 Erasmus University Medical Center Rotterdam Rapid in vitro t cell exhaustion
AU2021397278A1 (en) * 2020-12-09 2023-07-06 Tevogen Bio Inc. Virus specific t-cells and methods of treating and preventing viral infections
CN115877017B (zh) * 2023-03-01 2023-05-05 首都医科大学附属北京地坛医院 预测hiv/aids患者免疫重建的产品和系统

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6821778B1 (en) 1993-12-01 2004-11-23 The Board Of Trustees Of Leland Stanford Junior University Methods for using dendritic cells to activate gamma/delta-T cell receptor-positive T cells
US5827642A (en) 1994-08-31 1998-10-27 Fred Hutchinson Cancer Research Center Rapid expansion method ("REM") for in vitro propagation of T lymphocytes
US6274378B1 (en) 1997-10-27 2001-08-14 The Rockefeller University Methods and compositions for obtaining mature dendritic cells
DK1814580T3 (en) 2004-11-24 2016-12-12 Hutchinson Fred Cancer Res Methods of using il-21 for adoptive immunotherapy and identification of tumor antigens
EP1712634A1 (en) 2005-04-13 2006-10-18 Wittycell SAS Selection of highly efficient antigen presenting cells for regulating immunity and uses thereof
US8476419B2 (en) 2007-09-14 2013-07-02 Vrije Universiteit Brussel Enhancing the T-cells stimulatory capacity of human antigen presenting cells and their use in vaccination
US9211321B2 (en) 2009-10-27 2015-12-15 Immunicum Ab Method for proliferation of antigen-specific T cells

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020185056A3 (ko) * 2019-03-08 2020-11-05 신지섭 타가면역세포배양방법, 그 방법으로 얻어진 면역세포배양액 및 이를 포함하는 면역세포치료제

Also Published As

Publication number Publication date
WO2012140127A2 (en) 2012-10-18
EP2696894B1 (en) 2017-11-01
US10000736B2 (en) 2018-06-19
WO2012140127A3 (en) 2013-01-03
JP2014511704A (ja) 2014-05-19
EP2696894A2 (en) 2014-02-19
US20170152479A1 (en) 2017-06-01
US9492529B2 (en) 2016-11-15
CN103533955A (zh) 2014-01-22
US20140093538A1 (en) 2014-04-03

Similar Documents

Publication Publication Date Title
US10000736B2 (en) Method for priming of T cells
KR102028340B1 (ko) 항원-특이적 t 세포의 증식 방법
CN102597222B (zh) 用于增殖抗原特异性t细胞的方法
JP6081483B2 (ja) T細胞を増殖させるプロセス
CN103898051B (zh) 提高免疫反应性的方法
JP2014511704A5 (cg-RX-API-DMAC7.html)
Hont et al. The generation and application of antigen-specific T cell therapies for cancer and viral-associated disease
JP2020533977A (ja) がん処置における使用のための改良された同種樹状細胞
CA2700942A1 (en) An ex vivo, fast and efficient process to obtain activated antigen-presenting cells that are useful for therapies against cancer and immune system-related diseases
CN101928695A (zh) 生产免疫细胞的方法及诱发产生免疫作用细胞的方法
Zhang et al. Enhanced human T lymphocyte antigen priming by cytokine-matured dendritic cells overexpressing bcl-2 and IL-12
JP2025504109A (ja) Ebv複合抗原、樹状細胞ワクチンおよびその使用
EP3922642A1 (en) Method for t cell activation for cancer treatment
EP1959007A1 (en) Method for providing mature dendritic cells
Li Adoptive Cell Therapy using CD4 T Helper 1-like and CD8 Cytotoxic T Lymphocytes in a Mouse Model of Melanoma
JP2003511419A (ja) ウイルス/抗原処理された樹状細胞による抗原特異的t細胞の活性化
HK40018462A (en) Improved allogeneic dendritic cells for use in cancer treatment
HK1168869A1 (en) Method for proliferation of antigen-specific t cells
HK1168869B (en) Method for proliferation of antigen-specific t cells
WO2004069272A2 (en) Adjuvant combination for use in the immunization of a mamal comprising il2 and il12

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20131104

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid