KR20140031227A - 지질 나노입자들 및 코르티코스테로이드 또는 비타민 ｄ 유도체를 포함하는 조성물 - Google Patents
지질 나노입자들 및 코르티코스테로이드 또는 비타민 ｄ 유도체를 포함하는 조성물 Download PDFInfo
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- KR20140031227A KR20140031227A KR1020137027812A KR20137027812A KR20140031227A KR 20140031227 A KR20140031227 A KR 20140031227A KR 1020137027812 A KR1020137027812 A KR 1020137027812A KR 20137027812 A KR20137027812 A KR 20137027812A KR 20140031227 A KR20140031227 A KR 20140031227A
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- Prior art keywords
- lipid
- pharmaceutical composition
- skin
- oil
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- Biomedical Technology (AREA)
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- Nutrition Science (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161467192P | 2011-03-24 | 2011-03-24 | |
| US61/467,192 | 2011-03-24 | ||
| PCT/EP2012/055222 WO2012127037A2 (en) | 2011-03-24 | 2012-03-23 | A composition comprising lipid nanoparticles and a corticosteroid or vitamin d derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20140031227A true KR20140031227A (ko) | 2014-03-12 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137027812A Withdrawn KR20140031227A (ko) | 2011-03-24 | 2012-03-23 | 지질 나노입자들 및 코르티코스테로이드 또는 비타민 ｄ 유도체를 포함하는 조성물 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20140079785A1 (enExample) |
| EP (1) | EP2688560A2 (enExample) |
| JP (1) | JP2014508796A (enExample) |
| KR (1) | KR20140031227A (enExample) |
| CN (1) | CN103442700B (enExample) |
| RU (1) | RU2602171C2 (enExample) |
| WO (1) | WO2012127037A2 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180004164A (ko) * | 2015-05-08 | 2018-01-10 | 액티버스 파마 컴퍼니 리미티드 | 글루코코르티코스테로이드의 나노미립자를 함유하는 수성 현탁액제 |
| WO2022203145A1 (ko) * | 2021-03-22 | 2022-09-29 | 주식회사 앱스바이오 | 매스틱검 또는 감마오리자놀로 제조한 지질나노입자 조성물 |
| KR102725138B1 (ko) * | 2023-10-30 | 2024-11-05 | 김윤영 | 나노비타민 복합 조성물 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
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| US9744132B2 (en) | 2010-10-29 | 2017-08-29 | Infirst Healthcare Limited | Solid solution compositions and use in chronic inflammation |
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| US8895537B2 (en) | 2010-10-29 | 2014-11-25 | Infirst Healthcare Ltd. | Compositions and methods for treating cardiovascular diseases |
| US11202831B2 (en) | 2010-10-29 | 2021-12-21 | Infirst Healthcare Limited | Solid solution compositions and use in cardiovascular disease |
| US9504664B2 (en) | 2010-10-29 | 2016-11-29 | Infirst Healthcare Limited | Compositions and methods for treating severe pain |
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| US11224659B2 (en) | 2010-10-29 | 2022-01-18 | Infirst Healthcare Limited | Solid solution compositions and use in severe pain |
| CN104968368B (zh) * | 2013-01-14 | 2018-05-04 | 因佛斯特医疗有限公司 | 固溶体组合物及其在剧痛中的用途 |
| MX2015014701A (es) | 2013-04-24 | 2016-08-08 | Salk Inst For Biological Studi | Circuito genomico del receptor de vitamina d/smad que regula la compuerta de la respuesta fibrotica. |
| CN105451818A (zh) | 2013-06-05 | 2016-03-30 | 萨克生物研究学院 | 治疗涉及cxcl12活性的疾病的维生素d受体激动剂 |
| EP2821077A1 (en) * | 2013-07-04 | 2015-01-07 | Praxis Biopharma Research Institute | Lipid nanoparticles for wound healing |
| CN103417507B (zh) * | 2013-08-23 | 2015-12-02 | 王显著 | 布地奈德药物组合物 |
| TW201636025A (zh) * | 2015-04-15 | 2016-10-16 | Maruho Kk | 皮膚用之醫藥組成物 |
| CZ307681B6 (cs) | 2016-02-29 | 2019-02-13 | Ústav makromolekulární chemie AV ČR, v. v. i. | Fotoaktivovatelná nanočástice pro fotodynamické aplikace, způsob její přípravy, farmaceutická kompozice ji obsahující a jejich použití |
| WO2017194454A1 (en) * | 2016-05-09 | 2017-11-16 | Astrazeneca Ab | Lipid nanoparticles comprising lipophilic anti-inflammatory agents and methods of use thereof |
| CN106265485A (zh) * | 2016-08-22 | 2017-01-04 | 江苏知原药业有限公司 | 一种稳定性改善的卡泊三醇组合物 |
| WO2019023149A1 (en) | 2017-07-24 | 2019-01-31 | Salk Institute For Biological Studies | USE OF BROMODOMAIN-CONTAINING PROTEIN-9 ANTAGONISTS IN ASSOCIATION WITH VITAMIN D RECEPTOR AGONISTS IN THE TREATMENT OF DIABETES |
| CA3085694A1 (en) * | 2017-12-12 | 2019-06-20 | Lead Biotherapeutics Ltd. | Solid lipid nanoparticle for intracellular release of active substances and method for production the same |
| RU2018114533A (ru) * | 2018-04-19 | 2019-10-21 | Общество С Ограниченной Ответственностью "Научно-Исследовательская Компания "Медбиофарм" | Композиция на основе твердых липидных частиц, обладающая свойством направленной доставки для лечения вирусных заболеваний (варианты) |
| CN108904445A (zh) * | 2018-08-06 | 2018-11-30 | 江苏知原药业有限公司 | 钙泊三醇纳米悬浮液 |
| SI3820439T1 (sl) * | 2018-09-11 | 2022-02-28 | Lead Biotherapeutics Ltd. | Sistem mukoadhezivne disperzije nanodelcev in postopek za njegovo izdelavo |
| WO2020231800A1 (en) * | 2019-05-10 | 2020-11-19 | Encube Ethicals Private Limited | Topical antifungal formulation |
| EP3741378A1 (de) | 2019-05-23 | 2020-11-25 | Dimitrios Tsakouridis | Zusammensetzung zur topischen behandlung und pflege der psoriatischen haut |
| CN111588696A (zh) * | 2020-04-28 | 2020-08-28 | 南通华山药业有限公司 | 一种阿法骨化醇口服脂质体药物及其制备方法与应用 |
| CN111494321A (zh) * | 2020-04-28 | 2020-08-07 | 南通华山药业有限公司 | 一种骨化三醇长循环脂质体及其制备方法 |
| CA3182478A1 (en) * | 2020-05-12 | 2021-11-18 | Chemistry Rx | Compositions for treating hair loss |
| RU2749360C1 (ru) * | 2020-10-09 | 2021-06-09 | Федеральное государственное бюджетное военное образовательное учреждение высшего образования "Военно-медицинская академия имени С.М. Кирова" Министерства обороны Российской Федерации (ВМедА) | Способ лечения ладонно-подошвенного пустулеза |
| JP7633712B2 (ja) * | 2023-05-12 | 2025-02-20 | アピ株式会社 | 外用組成物 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU658608B2 (en) * | 1991-03-25 | 1995-04-27 | Astellas Pharma Europe B.V. | Topical preparation containing a suspension of solid lipid particles |
| DE4131562A1 (de) | 1991-09-18 | 1993-03-25 | Medac Klinische Spezialpraep | Arzneistofftraeger aus festen lipidteilchen-feste lipidnanosphaeren (sln) |
| GB9300763D0 (en) | 1993-01-15 | 1993-03-03 | Leo Pharm Prod Ltd | Chemical compound |
| US5785976A (en) * | 1993-03-05 | 1998-07-28 | Pharmacia & Upjohn Ab | Solid lipid particles, particles of bioactive agents and methods for the manufacture and use thereof |
| DK0979654T3 (da) * | 1998-03-04 | 2006-01-02 | Teijin Ltd | Emulsionslotioner med aktivt vitamin D3 |
| US8663692B1 (en) * | 1999-05-07 | 2014-03-04 | Pharmasol Gmbh | Lipid particles on the basis of mixtures of liquid and solid lipids and method for producing same |
| TR200103188T2 (tr) * | 1999-05-07 | 2002-04-22 | Pharmasol Gmbh | Sıvı ve katı lipit karışımları temelli lipid parçacıklar. |
| US7147841B2 (en) * | 2002-06-17 | 2006-12-12 | Ciba Specialty Chemicals Corporation | Formulation of UV absorbers by incorporation in solid lipid nanoparticles |
| JP5777846B2 (ja) * | 2005-06-15 | 2015-09-09 | マサチューセッツ インスティテュート オブ テクノロジー | アミン含有脂質およびその使用 |
| FR2893847B1 (fr) * | 2005-11-30 | 2010-10-29 | Galderma Sa | Composition sous forme de spray comprenant un derive de vitamine d et une phase huileuse |
| JP2010502624A (ja) * | 2006-08-29 | 2010-01-28 | テバ ファーマシューティカル インダストリーズ リミティド | 低ｐＨ親和性を有するコルチコステロイド化合物及びビタミンＤ含有化合物を含む安定な薬理活性組成物 |
| FR2909284B1 (fr) * | 2006-11-30 | 2012-09-21 | Galderma Sa | Nouvelles compositions sous forme d'onguent sans vaseline comprenant un derive de vitamine d et eventuellement un anti-inflammatoire steroidien |
| US10265265B2 (en) * | 2007-03-15 | 2019-04-23 | Drug Delivery Solutions Limited | Topical composition |
| US8470304B2 (en) * | 2009-08-04 | 2013-06-25 | Avidas Pharmaceuticals Llc | Therapeutic vitamin D sun-protecting formulations and methods for their use |
-
2012
- 2012-03-23 RU RU2013147429/15A patent/RU2602171C2/ru not_active IP Right Cessation
- 2012-03-23 US US14/006,890 patent/US20140079785A1/en not_active Abandoned
- 2012-03-23 CN CN201280014897.2A patent/CN103442700B/zh not_active Expired - Fee Related
- 2012-03-23 EP EP12710939.5A patent/EP2688560A2/en not_active Withdrawn
- 2012-03-23 KR KR1020137027812A patent/KR20140031227A/ko not_active Withdrawn
- 2012-03-23 WO PCT/EP2012/055222 patent/WO2012127037A2/en not_active Ceased
- 2012-03-23 JP JP2014500411A patent/JP2014508796A/ja not_active Ceased
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20180004164A (ko) * | 2015-05-08 | 2018-01-10 | 액티버스 파마 컴퍼니 리미티드 | 글루코코르티코스테로이드의 나노미립자를 함유하는 수성 현탁액제 |
| WO2022203145A1 (ko) * | 2021-03-22 | 2022-09-29 | 주식회사 앱스바이오 | 매스틱검 또는 감마오리자놀로 제조한 지질나노입자 조성물 |
| KR102725138B1 (ko) * | 2023-10-30 | 2024-11-05 | 김윤영 | 나노비타민 복합 조성물 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP2014508796A (ja) | 2014-04-10 |
| WO2012127037A3 (en) | 2012-12-27 |
| EP2688560A2 (en) | 2014-01-29 |
| US20140079785A1 (en) | 2014-03-20 |
| CN103442700B (zh) | 2016-04-06 |
| RU2013147429A (ru) | 2015-04-27 |
| RU2602171C2 (ru) | 2016-11-10 |
| WO2012127037A2 (en) | 2012-09-27 |
| CN103442700A (zh) | 2013-12-11 |
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