KR20130109000A - 세포 배양 장치 및 방법 - Google Patents

세포 배양 장치 및 방법 Download PDF

Info

Publication number
KR20130109000A
KR20130109000A KR1020127032214A KR20127032214A KR20130109000A KR 20130109000 A KR20130109000 A KR 20130109000A KR 1020127032214 A KR1020127032214 A KR 1020127032214A KR 20127032214 A KR20127032214 A KR 20127032214A KR 20130109000 A KR20130109000 A KR 20130109000A
Authority
KR
South Korea
Prior art keywords
carrier
bioreactor
carriers
open space
adjacent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020127032214A
Other languages
English (en)
Korean (ko)
Inventor
디디어 카레란가보
줄리엔 카돈
곤잘레스 호세 안토니오 카스틸로
Original Assignee
아르텔리스 에스에이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB1007863.2A external-priority patent/GB201007863D0/en
Priority claimed from GBGB1007861.6A external-priority patent/GB201007861D0/en
Priority claimed from GBGB1007855.8A external-priority patent/GB201007855D0/en
Application filed by 아르텔리스 에스에이 filed Critical 아르텔리스 에스에이
Publication of KR20130109000A publication Critical patent/KR20130109000A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M3/00Tissue, human, animal or plant cell, or virus culture apparatus
    • C12M3/04Tissue, human, animal or plant cell, or virus culture apparatus with means providing thin layers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/06Plates; Walls; Drawers; Multilayer plates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M1/00Apparatus for enzymology or microbiology
    • C12M1/14Apparatus for enzymology or microbiology with means providing thin layers or with multi-level trays
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/02Form or structure of the vessel
    • C12M23/04Flat or tray type, drawers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/22Transparent or translucent parts
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00Constructional details, e.g. recesses, hinges
    • C12M23/44Multiple separable units; Modules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02Membranes; Filters
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/46Means for regulation, monitoring, measurement or control, e.g. flow regulation of cellular or enzymatic activity or functionality, e.g. cell viability
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02PCLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00Technologies relating to chemical industry
    • Y02P20/50Improvements relating to the production of bulk chemicals
    • Y02P20/582Recycling of unreacted starting or intermediate materials

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Clinical Laboratory Science (AREA)
  • Cell Biology (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020127032214A 2010-05-11 2011-05-11 세포 배양 장치 및 방법 Withdrawn KR20130109000A (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GBGB1007863.2A GB201007863D0 (en) 2010-05-11 2010-05-11 Bioreactor for cell culture
GB1007855.8 2010-05-11
GB1007863.2 2010-05-11
GBGB1007861.6A GB201007861D0 (en) 2010-05-11 2010-05-11 Dynamic bioreactor for cell culture
GB1007861.6 2010-05-11
GBGB1007855.8A GB201007855D0 (en) 2010-05-11 2010-05-11 Bioreactor for the culture of cells
PCT/EP2011/057621 WO2011141512A2 (en) 2010-05-11 2011-05-11 Apparatus and methods for cell culture

Publications (1)

Publication Number Publication Date
KR20130109000A true KR20130109000A (ko) 2013-10-07

Family

ID=44914753

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127032214A Withdrawn KR20130109000A (ko) 2010-05-11 2011-05-11 세포 배양 장치 및 방법

Country Status (9)

Country Link
US (3) US9399755B2 (https=)
EP (1) EP2516618B1 (https=)
JP (2) JP5988962B2 (https=)
KR (1) KR20130109000A (https=)
CN (1) CN102947438B (https=)
AU (1) AU2011252063A1 (https=)
BR (1) BR112012028786A2 (https=)
SG (2) SG10201503666UA (https=)
WO (1) WO2011141512A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200118416A (ko) * 2017-12-20 2020-10-15 유니버셀스 테크놀로지스 에스.에이. 생물반응기 및 관련 방법

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5939650B2 (ja) * 2013-01-07 2016-06-22 賽宇細胞科技股▲ふん▼有限公司 充填ベッド培養装置のための大規模な細胞採取方法
CN103146578B (zh) * 2013-03-29 2014-11-05 东北农业大学 转基因细胞培养装置
KR20150117599A (ko) * 2014-04-09 2015-10-20 에스케이이노베이션 주식회사 바이오매스의 연속당화 반응기
AU2016397306B2 (en) * 2016-03-14 2022-02-03 Omnibrx Biotechnologies Private Limited A bioreactor system and method thereof
EP3484997A4 (en) * 2016-07-12 2020-07-29 California Institute of Technology SUBSTRATES FOR HIGH-DENSITY CELL GROWTH AND METABOLITE EXCHANGE
JP6942448B2 (ja) * 2016-08-08 2021-09-29 株式会社カネカ 細胞培養容器、これを用いた細胞培養システム、および細胞培養方法
AU2017316545B2 (en) 2016-08-21 2022-12-08 Adva Biotechnology Ltd. Bioreactor and methods of use thereof
BE1024733B1 (fr) * 2016-11-09 2018-06-14 Univercells Sa Matrice de croissance cellulaire
DE102017128489B4 (de) * 2017-09-26 2025-08-14 Elmos Semiconductor Se Selbsttestfähiges Bussystem und Verwendung dieser Selbsttestfähigkeit zur Vergabe von Busknotenadressen mit einer Erkennung der Vertauschung von Eingängen und Ausgängen
EP3493479B1 (de) * 2017-11-30 2020-12-02 Elmos Semiconductor SE Verfahren zum einspeisen von adressierungsströmen durch busknoten eines seriellen datenbussystems und busknoten für ein derartiges datenbussystem
US10367782B2 (en) * 2017-12-05 2019-07-30 Elmos Semiconductor Ag Serial bus auto-addressing
US20190233787A1 (en) * 2018-01-30 2019-08-01 The Trustees Of Indiana University Bioreactor
BE1026108B1 (fr) * 2018-03-16 2019-10-14 Univercells S.A. Échantillonneur à lit fixe et procédés associés
US12351793B2 (en) 2018-07-27 2025-07-08 Univercells Technologies S.A. System and method for the production of biomolecules
US10647954B1 (en) * 2018-11-15 2020-05-12 Flaskworks, Llc Dendritic cell generating apparatus and method
GB2579673A (en) 2018-12-12 2020-07-01 Haemair Ltd Cell washing apparatus
WO2020223556A1 (en) * 2019-04-30 2020-11-05 Pbs Biotech, Inc. Macrocarriers for cell growth in bioreactors
CN117701496A (zh) * 2019-05-28 2024-03-15 阿普赛德食品公司 制备可食用肉制品的方法
WO2021003188A1 (en) * 2019-07-01 2021-01-07 Ology Bioservices, Inc. Method for cultivation of adherent cells in a multiparallel bioreactor
CN114729292A (zh) * 2019-10-24 2022-07-08 奥克泰生物科技股份有限公司 具有经改进的细胞接触表面的细胞培养室
WO2021084077A1 (en) 2019-10-30 2021-05-06 Minaris Regenerative Medicine Gmbh Bioreactor for adherent cells
AU2020386085B2 (en) 2019-11-20 2022-08-11 Upside Foods, Inc. Apparatuses and systems for preparing a meat product
KR102417445B1 (ko) * 2019-11-29 2022-07-06 주식회사 아모그린텍 세포배양장치
IL294920A (en) 2020-01-20 2022-09-01 Adva Biotechnology Ltd Apparatus and method for controlling a bioreactor
CN113861296A (zh) * 2020-06-30 2021-12-31 广州凌腾生物医药有限公司 一种使用环轨摇晃式生物反应器制备双特异性抗体的方法
US20240052283A1 (en) * 2021-01-26 2024-02-15 Hitachi High-Tech Corporation Aseptic Sampling Apparatus and Aseptic Sampling Method
CN114276927B (zh) * 2021-12-29 2024-05-10 上海日泰医药设备工程有限公司 一种用于生物反应器的折叠式载体柱
US11981884B2 (en) 2022-10-17 2024-05-14 Upside Foods, Inc. Pipe-based bioreactors for producing comestible meat products and methods of using the same
CN115369036B (zh) * 2022-10-21 2023-07-04 天信和(苏州)生物科技有限公司 细胞培养载体组件及生物反应器
CN117070451B (zh) * 2023-10-13 2024-01-30 北京中卫医正科技有限公司 一种间充质干细胞的传代培养方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5299284A (en) 1976-02-13 1977-08-19 Toray Ind Inc Cell culturing device
US4307193A (en) 1978-06-09 1981-12-22 Toray Industries, Inc. Method of producing interferon
US4654308A (en) 1985-06-19 1987-03-31 La Corporation De L'ecole Polytechnique Bioreactor
US4734373A (en) * 1986-06-24 1988-03-29 Bartal Arie H Apparatus for enhancing cell growth, preservation and transport
US5079161A (en) * 1988-06-27 1992-01-07 Snow Brand Milk Products Co., Ltd. Method and apparatus for cell culture with immobilizing carriers
DE3923279A1 (de) * 1989-07-14 1990-01-18 Will W Prof Dr Minuth Minusheets ist ein neues produkt, um zellen in beliebigen behaeltnissen in hochdifferenzierter form auf einer moeglichst natuerlichen unterlage zu kultivieren
DE4206585C2 (de) * 1992-03-03 1994-11-24 Augustinus Dr Med Bader Vorrichtung zur Massenkultur von Zellen
US5776748A (en) 1993-10-04 1998-07-07 President And Fellows Of Harvard College Method of formation of microstamped patterns on plates for adhesion of cells and other biological materials, devices and uses therefor
JP3049183B2 (ja) * 1994-02-15 2000-06-05 石川島播磨重工業株式会社 光合成生物の培養装置
GB2338243A (en) 1998-06-11 1999-12-15 Nicholas George Maroudas Macro carrier for cell culture
US6572830B1 (en) * 1998-10-09 2003-06-03 Motorola, Inc. Integrated multilayered microfludic devices and methods for making the same
ATE328618T1 (de) * 1998-10-28 2006-06-15 Cellon S A Strukturierter und poröser silikonkautschuk
WO2000078920A1 (en) * 1999-06-21 2000-12-28 The General Hospital Corporation Methods and devices for cell culturing and organ assist systems
US6569675B2 (en) 2000-06-16 2003-05-27 Corning Incorporated Cell cultivating flask and method for using the cell cultivating flask
DE60014410T2 (de) 2000-12-20 2006-03-02 Corning Incorporated Verfahren unter Verwendung eines monolithischen Stapelreaktors
DE60233542D1 (de) 2001-03-29 2009-10-15 Canon Kk Träger für Zellkulturen, seine Herstellung, Methode zur Kultivierung von Zellen
JP2003093041A (ja) * 2001-09-25 2003-04-02 Hamamatsu Photonics Kk 培養試料観察装置
EP1451584B1 (en) * 2001-11-09 2011-05-11 3dbiosurfaces Technologies, LLC High surface area substrates for microarrays and methods to make same
JP4049263B2 (ja) * 2003-05-20 2008-02-20 株式会社ハイロックス 多段式培養容器内に培養された細胞の観察装置
CN101120083B (zh) 2003-10-08 2013-03-27 威尔森沃尔夫制造公司 利用透气性材料进行细胞培养的方法及装置
US7078228B2 (en) 2003-12-31 2006-07-18 Corning Incorporated Cell cultivating flask
JP4456393B2 (ja) * 2004-03-26 2010-04-28 大日本印刷株式会社 細胞培養基板の製造方法および細胞培養基板製造装置
US20070218554A1 (en) 2004-04-26 2007-09-20 Dai Nippon Printing Co., Ltd. Cell Culture Patterning Substrate And Method For Manufacturing The Same
WO2006089354A1 (en) 2005-02-23 2006-08-31 M.B.T.L. Limited Culture device
US7745209B2 (en) 2005-07-26 2010-06-29 Corning Incorporated Multilayered cell culture apparatus
BE1016793A4 (fr) 2005-10-04 2007-06-05 Artelis Procede de culture de cellules et dispositif permettant sa mise en oeuvre.
JP5157139B2 (ja) * 2006-11-28 2013-03-06 大日本印刷株式会社 細胞移植用部材
AU2007332869B2 (en) * 2006-12-07 2012-10-11 Wilson Wolf Manufacturing, LLC Highly efficient gas permeable devices and methods for culturing cells
JP2009124977A (ja) 2007-11-21 2009-06-11 Ulvac Japan Ltd 細胞接着又は培養用基板およびその製造方法
KR100946643B1 (ko) * 2007-11-30 2010-03-09 코아스템(주) 세포배양장치 및 이를 구비한 대용량 자동화 세포배양기
US8216828B2 (en) * 2008-05-30 2012-07-10 Corning Incorporated Assembly of cell culture vessels
WO2010014902A1 (en) 2008-07-31 2010-02-04 Reitzel John S Horizontal plate microbial support media
EP2344622B1 (en) * 2008-10-08 2017-12-20 Agency for Science, Technology And Research Apparatus for culturing anchorage dependent cells
EP2698425B1 (en) 2009-02-25 2015-09-09 Corning Incorporated Cell culture system with collector

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200118416A (ko) * 2017-12-20 2020-10-15 유니버셀스 테크놀로지스 에스.에이. 생물반응기 및 관련 방법
US12415978B2 (en) 2017-12-20 2025-09-16 Univercells Technologies S.A. Bioreactor and related methods

Also Published As

Publication number Publication date
US20130059339A1 (en) 2013-03-07
JP2013526269A (ja) 2013-06-24
US20170015967A1 (en) 2017-01-19
SG10201503666UA (en) 2015-06-29
EP2516618B1 (en) 2020-07-08
WO2011141512A3 (en) 2012-03-15
AU2011252063A1 (en) 2012-11-29
EP2516618A2 (en) 2012-10-31
WO2011141512A2 (en) 2011-11-17
JP5988962B2 (ja) 2016-09-07
CN102947438B (zh) 2017-01-18
JP2016144464A (ja) 2016-08-12
SG185434A1 (en) 2012-12-28
BR112012028786A2 (pt) 2015-11-24
CN102947438A (zh) 2013-02-27
US20220380711A1 (en) 2022-12-01
US9399755B2 (en) 2016-07-26

Similar Documents

Publication Publication Date Title
KR20130109000A (ko) 세포 배양 장치 및 방법
KR102641877B1 (ko) 생물 반응기 시스템 및 그 방법
JP6474616B2 (ja) 細胞を保持し再循環させるための一方向分離器
CN101316925A (zh) 细胞培养方法以及进行该方法的设备
JP7696340B2 (ja) 改善された細胞接触面を有する細胞培養チャンバ
US20230348834A1 (en) Fixed bed bioreactor vessel and methods of using the same
CN109689853A (zh) 生物反应器
WO2010063845A1 (en) Liquid substance circulation device comprising a compartment for an impeller having a sloped upper portion
KR20230018437A (ko) 생체분자 생산 시스템 및 방법
JP2025523768A (ja) 細胞収量を増加させる細胞培養チャンバ
MX2008004419A (es) Metodo de cultivos celulares y dispositivo para implementar este

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20121210

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid