KR20120115348A - 혈관 내피 성장 인자 (ｖｅｇｆ) 수용체의 억제제 및 그의 사용 방법 - Google Patents

혈관 내피 성장 인자 (ｖｅｇｆ) 수용체의 억제제 및 그의 사용 방법 Download PDF

Info

Publication number
KR20120115348A
KR20120115348A KR1020127019855A KR20127019855A KR20120115348A KR 20120115348 A KR20120115348 A KR 20120115348A KR 1020127019855 A KR1020127019855 A KR 1020127019855A KR 20127019855 A KR20127019855 A KR 20127019855A KR 20120115348 A KR20120115348 A KR 20120115348A
Authority
KR
South Korea
Prior art keywords
moiety
vegf receptor
amino acid
domain
antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020127019855A
Other languages
English (en)
Korean (ko)
Inventor
조셉 슐레싱거
얀 양
Original Assignee
예일 유니버시티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 예일 유니버시티 filed Critical 예일 유니버시티
Publication of KR20120115348A publication Critical patent/KR20120115348A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2/00—Peptides of undefined number of amino acids; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/573—Immunoassay; Biospecific binding assay; Materials therefor for enzymes or isoenzymes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Urology & Nephrology (AREA)
  • Biotechnology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Plant Pathology (AREA)
KR1020127019855A 2009-12-29 2010-12-20 혈관 내피 성장 인자 (ｖｅｇｆ) 수용체의 억제제 및 그의 사용 방법 Withdrawn KR20120115348A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US29078909P 2009-12-29 2009-12-29
US61/290,789 2009-12-29

Publications (1)

Publication Number Publication Date
KR20120115348A true KR20120115348A (ko) 2012-10-17

Family

ID=44307462

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127019855A Withdrawn KR20120115348A (ko) 2009-12-29 2010-12-20 혈관 내피 성장 인자 (ｖｅｇｆ) 수용체의 억제제 및 그의 사용 방법

Country Status (14)

Country Link
US (1) US20130071397A1 (https=)
EP (1) EP2519253A4 (https=)
JP (1) JP2013515776A (https=)
KR (1) KR20120115348A (https=)
CN (1) CN102724996A (https=)
AU (1) AU2010343193A1 (https=)
BR (1) BR112012016309A2 (https=)
CA (1) CA2785723A1 (https=)
IL (1) IL220147A0 (https=)
IN (1) IN2012DN05014A (https=)
MX (1) MX2012007745A (https=)
RU (1) RU2012132470A (https=)
SG (1) SG181495A1 (https=)
WO (1) WO2011090648A2 (https=)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101801407B (zh) 2007-06-05 2013-12-18 耶鲁大学 受体酪氨酸激酶抑制剂及其使用方法
US9540443B2 (en) 2011-01-26 2017-01-10 Kolltan Pharmaceuticals, Inc. Anti-kit antibodies
CN104650229A (zh) * 2011-11-02 2015-05-27 埃派斯进有限公司 抗-kdr抗体和使用方法
CN116574185A (zh) 2012-07-25 2023-08-11 塞尔德克斯医疗公司 抗kit抗体及其用途
EP3062740A4 (en) * 2013-11-01 2017-08-02 Atrium Medical Corporation Positioning agent and method of using the same
CN113908269A (zh) 2014-05-23 2022-01-11 塞尔德克斯医疗公司 嗜酸性粒细胞或肥大细胞相关病症的治疗
CN104356226B (zh) * 2014-11-04 2017-03-29 青岛海兰深生物科技有限公司 一种检测血浆免疫标志物‑vegfr1自身抗体的抗原多肽及应用
CN105820244B (zh) * 2015-01-06 2018-03-13 珠海亿胜生物制药有限公司 抗vegf抗体
CN108148133B (zh) * 2015-01-06 2020-04-24 珠海亿胜生物制药有限公司 抗vegf抗体
GB201612520D0 (en) * 2016-07-19 2016-08-31 F-Star Beta Ltd Binding molecules
EP3624811A4 (en) 2017-05-19 2021-03-10 The Regents of The University of California ANTIBODY-BASED CHEMICAL INDUCED DIMERIZER (ABCID) AS A MOLECULAR SWITCH FOR REGULATING CELL THERAPIES
EP3642225A1 (en) 2017-06-23 2020-04-29 Baxalta Incorporated Purification of factor viii subspecies
WO2024155689A1 (en) * 2023-01-17 2024-07-25 Yale University Compounds and methods for inhibiting type-iii receptor tyrosine kinases

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6448077B1 (en) * 1994-02-10 2002-09-10 Imclone Systems, Inc. Chimeric and humanized monoclonal antibodies specific to VEGF receptors
SI1916001T1 (sl) * 2002-03-04 2011-10-28 Imclone Llc Äśloveĺ ka protitelesa specifiäśna za kdr in njihova uporaba
CN101801407B (zh) * 2007-06-05 2013-12-18 耶鲁大学 受体酪氨酸激酶抑制剂及其使用方法
KR100883430B1 (ko) * 2007-06-13 2009-02-12 한국생명공학연구원 혈관내피성장인자 수용체를 중화하는 인간 단클론항체 및그 용도

Also Published As

Publication number Publication date
MX2012007745A (es) 2012-11-23
IN2012DN05014A (https=) 2015-10-02
EP2519253A2 (en) 2012-11-07
WO2011090648A2 (en) 2011-07-28
US20130071397A1 (en) 2013-03-21
WO2011090648A3 (en) 2012-01-05
CN102724996A (zh) 2012-10-10
SG181495A1 (en) 2012-07-30
IL220147A0 (en) 2012-07-31
AU2010343193A1 (en) 2012-06-21
JP2013515776A (ja) 2013-05-09
BR112012016309A2 (pt) 2017-04-18
EP2519253A4 (en) 2013-08-07
CA2785723A1 (en) 2011-07-28
RU2012132470A (ru) 2014-02-10

Similar Documents

Publication Publication Date Title
JP6159760B2 (ja) 受容体型チロシンキナーゼの阻害物質およびその使用方法
KR20120115348A (ko) 혈관 내피 성장 인자 (ｖｅｇｆ) 수용체의 억제제 및 그의 사용 방법
US20120328599A1 (en) Inhibitors of receptor tyrosine kinases (rtk) and methods of use thereof
JP2022104961A (ja) 抗ｃｄ７３抗体を用いた併用療法
KR102218497B1 (ko) 표피 성장 인자 수용체 3 (her3)에 대한 항체
Yeung et al. A therapeutic anti–VEGF antibody with increased potency independent of pharmacokinetic half-life
CN104185681A (zh) C1orf32抗体及其用于治疗癌症的用途
JP7339159B2 (ja) 心疾患の予防および治療方法
CN112135632A (zh) 选择和设计用于癌症疗法的更安全且更有效的抗ctla-4抗体的方法
CN104968679A (zh) 抗h7cr抗体
JP2023532857A (ja) Ｌａｉｒ－１結合剤及びその使用方法
AU2014203645A1 (en) Inhibitors of receptor tyrosine kinases and methods of use thereof
HK1196386A (en) Inhibitors of receptor tyrosine kinases and methods of use thereof
WO2011140295A2 (en) Modulators of notch receptor signaling and methods of use thereof

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20120727

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid