KR20120102716A - 멜라노코르틴-1 수용체 특이적 선형 펩티드 - Google Patents
멜라노코르틴-1 수용체 특이적 선형 펩티드 Download PDFInfo
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- KR20120102716A KR20120102716A KR20127016182A KR20127016182A KR20120102716A KR 20120102716 A KR20120102716 A KR 20120102716A KR 20127016182 A KR20127016182 A KR 20127016182A KR 20127016182 A KR20127016182 A KR 20127016182A KR 20120102716 A KR20120102716 A KR 20120102716A
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Classifications
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
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- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/68—Melanocyte-stimulating hormone [MSH]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
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- Biophysics (AREA)
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- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
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- Toxicology (AREA)
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- Pharmacology & Pharmacy (AREA)
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- Rheumatology (AREA)
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- Engineering & Computer Science (AREA)
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011063366A1 (en) * | 2009-11-23 | 2011-05-26 | Palatin Technologies, Inc. | Melanocortin-1 receptor-specific cyclic peptides |
| IT1404931B1 (it) * | 2010-06-11 | 2013-12-09 | Medivis S R L | Composizioni oftalmiche per la somministrazione di principi attivi liposolubili . |
| WO2012158960A2 (en) | 2011-05-17 | 2012-11-22 | H. Lee Moffitt Cancer Center & Research Institute, Inc. | Melanocortin 1 receptor ligands and methods of use |
| US9290539B2 (en) | 2011-05-17 | 2016-03-22 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Melanotropin ligands for skin care |
| WO2013067309A1 (en) * | 2011-11-04 | 2013-05-10 | Xion Pharmaceutical Corporation | Methods and compositions for oral administration of melanocortin receptor agonist compounds |
| US9534018B2 (en) | 2012-03-13 | 2017-01-03 | Tensive Controls Inc. | Melanocortin analogs having enhanced activity and transport |
| US9821023B2 (en) | 2014-06-10 | 2017-11-21 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for the treatment of central nervous system (CNS) disorders and mood disorders |
| US20170022252A1 (en) | 2014-06-10 | 2017-01-26 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Novel modulators of melanocortin receptors |
| US9814755B2 (en) | 2014-06-10 | 2017-11-14 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Methods for the treatment of depression and anxiety |
| CN104436159A (zh) * | 2014-12-09 | 2015-03-25 | 天津医科大学眼科医院 | 一种新型滴眼液对治疗干眼的用途 |
| WO2016168388A2 (en) | 2015-04-14 | 2016-10-20 | Palatin Technologies, Inc. | Therapies for obesity, diabetes and related indications |
| AU2016298175B2 (en) | 2015-07-28 | 2022-01-06 | University Of Iowa Research Foundation | Compositions and methods of treating cancer |
| US10550157B2 (en) | 2015-10-16 | 2020-02-04 | Arizona Board Of Regent On Behalf Of The University Of Arizona | Compositions and methods for treating central nervous system (CNS) disorders and mood disorders |
| US11179484B2 (en) | 2016-06-24 | 2021-11-23 | University Of Iowa Research Foundation | Compositions and methods of treating melanoma |
| US11591367B2 (en) | 2016-10-04 | 2023-02-28 | Dsm Ip Assets B.V. | Melanocortin-1-receptor agonists |
| AU2018215619A1 (en) * | 2017-02-01 | 2019-08-08 | Clinuvel Pharmaceuticals Ltd | Alpha-MSH analogues used in the treatment of xeroderma pigmentosum |
| US12364715B2 (en) | 2018-02-23 | 2025-07-22 | Enzyvant Therapeutics Gmbh | Methods of determining the suitability of cultured thymus tissue for implantation into humans and associated methods of use |
| AU2019225151A1 (en) | 2018-02-23 | 2020-08-20 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
| US11819520B2 (en) * | 2018-02-23 | 2023-11-21 | Duke University | Cultured thymus tissue transplantation promotes donor-specific tolerance to allogeneic solid organ transplants |
| US11529335B2 (en) | 2020-07-31 | 2022-12-20 | University Of Iowa Research Foundation | Compositions and methods for treating cancer |
| WO2023091689A1 (en) | 2021-11-19 | 2023-05-25 | University Of Iowa Research Foundation | Combined use of mcr1-directed radiotherapy and immune checkpoint inhibition in the treatment of melanoma |
| WO2024040167A2 (en) * | 2022-08-18 | 2024-02-22 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Selective mc4r ligand for treating obesity and cognitive loss |
| WO2025123055A1 (en) * | 2023-12-07 | 2025-06-12 | Endevica Bio, Inc. | Non-naturally occurring melanocortin analogs and associated methods for modulating weight gain |
| WO2025245252A1 (en) * | 2024-05-21 | 2025-11-27 | Endevica Bio, Inc. | Non-naturally occurring melanocortin receptor agonist analogs for use in pain management and/or substance use disorders |
Family Cites Families (113)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4731408A (en) | 1985-12-20 | 1988-03-15 | Polaroid Corporation | Processable conductive polymers |
| US5674839A (en) | 1987-05-22 | 1997-10-07 | Competitive Technologies, Inc. | Cyclic analogs of alpha-MSH fragments |
| US5683981A (en) | 1987-05-22 | 1997-11-04 | Competitive Technologies, Inc. | Cyclic bridged analogs of α-MSH and methods thereof |
| EP0292291B1 (en) | 1987-05-22 | 1994-08-10 | University Patents, Inc. | Linear and cyclic analogs of alpha-msh fragments with extraordinary potency |
| US5192746A (en) | 1990-07-09 | 1993-03-09 | Tanabe Seiyaku Co., Ltd. | Cyclic cell adhesion modulation compounds |
| US6100048A (en) | 1992-04-10 | 2000-08-08 | Oregon Health Sciences University | Methods and reagents for discovering and using mammalian melanocortin receptor agonists and antagonists to modulate feeding behavior in animals |
| EP0696919B1 (en) | 1993-04-05 | 2002-01-30 | Competitive Technologies, Inc. | Diagnosis and treatment of erectile dysfunction |
| US6054556A (en) | 1995-04-10 | 2000-04-25 | The Arizona Board Of Regents On Behalf Of The University Of Arizona | Melanocortin receptor antagonists and agonists |
| US5731408A (en) | 1995-04-10 | 1998-03-24 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Peptides having potent antagonist and agonist bioactivities at melanocortin receptors |
| US7396814B2 (en) | 1995-06-07 | 2008-07-08 | Palatin Technologies, Inc. | Metallopeptide compositions for treatment of sexual dysfunction |
| CA2158425C (en) | 1995-09-15 | 2003-01-28 | Mac E. Hadley | Diagnostic and treatment of erectile dysfunction |
| US5688489A (en) * | 1995-09-15 | 1997-11-18 | Resolution Pharmaceuticals, Inc. | Non-receptor mediated imaging agents |
| IL118003A0 (en) | 1996-04-23 | 1996-08-04 | Yeda Res & Dev | Novel vip fragments and pharmaceutical compositions comprising them |
| AU5348098A (en) | 1996-12-17 | 1998-07-15 | Quadrant Holdings Cambridge Limited | Melanocortins |
| US5925618A (en) * | 1997-03-06 | 1999-07-20 | American Cyanamid Company | Peptides useful as somatostatin antagonists |
| WO1999021571A1 (en) | 1997-10-27 | 1999-05-06 | Trega Biosciences, Inc. | Melanocortin receptor ligands and methods of using same |
| US20020099003A1 (en) | 1997-10-28 | 2002-07-25 | Wilson Leland F. | Treatment of female sexual dysfunction with vasoactive agents, particularly vasoactive intestinal polypeptide and agonists thereof |
| GB9808229D0 (en) | 1998-04-17 | 1998-06-17 | Quadrant Holdings Cambridge | Melanocortin receptor ligands |
| US6284735B1 (en) | 1998-04-28 | 2001-09-04 | Lion Bioscience Ag | HP-3228 and related peptides to treat sexual dysfunction |
| US6534503B1 (en) | 1998-04-28 | 2003-03-18 | Lion Bioscience Ag | Melanocortin receptor-3 ligands to treat sexual dysfunction |
| US6265162B1 (en) * | 1998-05-05 | 2001-07-24 | Taisei Corporation | Method of identifying, detecting and monitoring microorganisms by an aromatic ring hydroxylase dioxygenase gene |
| SE9801571D0 (sv) | 1998-05-05 | 1998-05-05 | Wapharm Ab | Melanokortin-1-receptorselektiva föreningar |
| SE9804614A0 (en) | 1998-07-06 | 2000-01-07 | A+ Science Invest Ab | New peptides and use thereof |
| GB9816234D0 (en) | 1998-07-24 | 1998-09-23 | William Harvey Research Limite | Compounds for use in the treatment of inflammation |
| CA2622786A1 (en) * | 1998-10-16 | 2000-04-27 | Naoto Oku | Neovascular-specific peptides |
| GB9827500D0 (en) | 1998-12-14 | 1999-02-10 | Wapharm Ab | Compounds for control of eating, growth and body weight |
| EP1140968B9 (en) | 1998-12-23 | 2007-05-09 | Merck & Co., Inc. | Dna molecules encoding splice variants of the human melanocortin 1 receptor protein |
| US6887846B2 (en) | 1999-03-24 | 2005-05-03 | Zengen, Inc. | Antimicrobial amino acid sequences derived from alpha-melanocyte-stimulating hormone |
| TR200102765T2 (tr) | 1999-03-29 | 2002-05-21 | The Procter & Gamble Company | Melanokortin reseptör ligandları |
| US7176279B2 (en) | 2000-06-28 | 2007-02-13 | Palatin Technologies, Inc. | Cyclic peptide compositions and methods for treatment of sexual dysfunction |
| US6579968B1 (en) | 1999-06-29 | 2003-06-17 | Palatin Technologies, Inc. | Compositions and methods for treatment of sexual dysfunction |
| US7235625B2 (en) | 1999-06-29 | 2007-06-26 | Palatin Technologies, Inc. | Multiple agent therapy for sexual dysfunction |
| US6699873B1 (en) | 1999-08-04 | 2004-03-02 | Millennium Pharmaceuticals, Inc. | Melanocortin-4 receptor binding compounds and methods of use thereof |
| US7049398B1 (en) | 1999-08-12 | 2006-05-23 | Palatin Technologies, Inc. | Melanocortin metallopeptide constructs, combinatorial libraries and applications |
| US20030064921A1 (en) | 1999-10-27 | 2003-04-03 | The Regents Of The University Of California | Methods and compounds for modulating melanocortin receptor ligand binding and activity |
| WO2001030808A1 (en) | 1999-10-27 | 2001-05-03 | The Regents Of The University Of California | Methods and compounds for modulating melanocortin receptor-ligand binding |
| EP1251865A1 (en) | 2000-01-18 | 2002-10-30 | Merck & Co., Inc. | Cyclic peptides as potent and selective melanocortin-4 receptor antagonists |
| US6600015B2 (en) | 2000-04-04 | 2003-07-29 | Hoffmann-La Roche Inc. | Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity |
| IL152116A0 (en) * | 2000-04-05 | 2003-05-29 | Vi Technologies Inc | Prion-binding ligands and methods of using same |
| AU2001261363A1 (en) | 2000-05-09 | 2001-11-20 | The Regents Of The University Of California | Methods and compounds for modulating melanocortin receptor ligand binding and activity |
| GB0012370D0 (en) | 2000-05-22 | 2000-07-12 | Quadrant Holdings Cambridge | Peptoids |
| RU2239642C1 (ru) | 2000-08-30 | 2004-11-10 | Ф.Хоффманн-Ля Рош Аг | Селективные циклопептиды |
| AU9631301A (en) | 2000-09-27 | 2002-04-08 | Procter & Gamble | Melanocortin receptor ligands |
| US20030113263A1 (en) | 2001-02-13 | 2003-06-19 | Oregon Health And Sciences University, A Non-Profit Organization | Methods and reagents for using mammalian melanocortin receptor antagonists to treat cachexia |
| ITMI20011057A1 (it) | 2001-05-22 | 2002-11-22 | Bracco Imaging Spa | Preparazione ed uso di peptidi ciclici e ramificati e loro deriati marcati come agenti terapeutici agonisti o antagonisti della colecistochi |
| JP2004534851A (ja) * | 2001-07-11 | 2004-11-18 | パラチン テクノロジーズ インク． | メラノコルチン受容体に特異的な線状および環状ペプチド |
| US7345144B2 (en) | 2001-07-11 | 2008-03-18 | Palatin Technologies, Inc. | Cyclic peptides for treatment of cachexia |
| US7342089B2 (en) | 2001-07-11 | 2008-03-11 | Palatin Technologies, Inc. | Cyclic peptides for treatment for cachexia |
| WO2003006604A2 (en) | 2001-07-12 | 2003-01-23 | Merck & Co., Inc. | Cyclic peptides as potent and selective melanocortin-4 receptor agonists |
| US7328344B2 (en) | 2001-09-28 | 2008-02-05 | Imagitas, Inc. | Authority-neutral certification for multiple-authority PKI environments |
| FR2835528B1 (fr) | 2002-02-01 | 2004-03-12 | Inst Europ Biolog Cellulaire | Nouveaux derives peptidiques, leur preparation et leur application therapeutique et cosmetique |
| US20030186249A1 (en) | 2002-04-01 | 2003-10-02 | Zairen Sun | Human TARPP genes and polypeptides |
| US7034004B2 (en) | 2002-05-07 | 2006-04-25 | University Of Florida | Peptides and methods for the control of obesity |
| US7618788B2 (en) * | 2002-05-10 | 2009-11-17 | Millipore Corporation | Proteome epitope tags and methods of use thereof in protein modification analysis |
| WO2004005318A2 (en) * | 2002-07-03 | 2004-01-15 | Bio Science International, Inc. | Peptides comprising aromatic d-amino acids and methods of use |
| WO2004005324A2 (en) | 2002-07-09 | 2004-01-15 | Palatin Technologies, Inc. | Peptide composition for treatment of sexual dysfunction |
| US7135548B2 (en) | 2002-11-14 | 2006-11-14 | Zengen, Inc. | Modified α-MSH peptides and derivatives thereof |
| AU2003290886A1 (en) | 2002-11-14 | 2004-06-15 | Zengen, Inc. | Modified alpha-msh peptides and derivatives thereof |
| MXPA05011830A (es) | 2003-05-09 | 2006-01-26 | Novo Nordisk As | Peptidos para uso en el tratamiento de la obesidad. |
| EP1625158A2 (en) | 2003-05-09 | 2006-02-15 | Novo Nordisk A/S | Peptides for use in treating obesity |
| US20070105759A1 (en) | 2003-06-19 | 2007-05-10 | Eli Lilly And Company | Melanocortin receptor 4 (mc4) agonists and their uses |
| US20060293223A1 (en) | 2003-06-19 | 2006-12-28 | Eli Lilly And Company Patent Division | Uses of melanocortin-3 receptor (mc3r) agonist peptides |
| US7084111B2 (en) * | 2003-06-23 | 2006-08-01 | University Of Florida Research Foundation, Inc. | Melanocortin receptor templates, peptides, and use thereof |
| US20050026948A1 (en) | 2003-07-29 | 2005-02-03 | Boehringer Ingelheim International Gmbh | Medicaments for inhalation comprising an anticholinergic and a betamimetic |
| ES2286679T3 (es) | 2003-08-20 | 2007-12-01 | Eli Lilly And Company | Compuestos, procedimientos y formulaciones para la liberacion oral de un compuesto de peptido de tipo glucagon (glp)-1 o un peptido agonist a del receptor de melanocortina 4 (mc4). |
| CN100482682C (zh) | 2003-09-30 | 2009-04-29 | 诺沃挪第克公司 | 黑皮素受体激动剂 |
| TWI341835B (en) | 2003-11-12 | 2011-05-11 | Lg Life Sciences Ltd | Melanocortin receptor agonists |
| NZ547383A (en) | 2003-11-24 | 2009-11-27 | Clinuvel Pharmaceuticals Ltd | A method of inducing melanogenesis in humans with MC1R variant alleles |
| WO2005060985A1 (en) | 2003-12-10 | 2005-07-07 | Merck & Co., Inc. | Inhibition of voluntary ethanol consumption with selective melanocortin 4-receptor agonists |
| EP1732586A1 (en) | 2004-03-29 | 2006-12-20 | Eli Lilly And Company | Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continunous infusion |
| CN1563076A (zh) | 2004-04-02 | 2005-01-12 | 西南生物工程产业化中试基地有限公司 | 一种用于治疗性功能障碍的α－MSH类似物及制备方法 |
| US7442693B2 (en) | 2004-05-28 | 2008-10-28 | Smithkline Beecham Corporation | Diazepine compounds as ligands of the melanocortin 1 and/or 4 receptors |
| US7553944B2 (en) * | 2004-07-21 | 2009-06-30 | The University Of Hong Kong | Human virus causing respiratory tract infection and uses thereof |
| JP5208504B2 (ja) | 2004-08-04 | 2013-06-12 | クリヌベール、ファーマスーティカルズ、リミテッド | 対象者でメラニン形成を誘導するための方法 |
| TW200626611A (en) | 2004-09-20 | 2006-08-01 | Lonza Ag | Peptide cyclisation |
| AU2005291862B2 (en) | 2004-10-08 | 2010-07-08 | Clinuvel Pharmaceuticals Limited | Compositions and methods for inducing melanogenesis in a subject |
| US20060105951A1 (en) | 2004-10-25 | 2006-05-18 | Mark Cunningham | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
| JP2008519007A (ja) | 2004-11-04 | 2008-06-05 | ノボ ノルディスク アクティーゼルスカブ | 肥満症の治療に使用するためのペプチド |
| WO2006048449A2 (en) | 2004-11-04 | 2006-05-11 | Novo Nordisk A/S | Mc4r selective peptides and their use in the treatment of obesity |
| EP1809667A1 (en) | 2004-11-04 | 2007-07-25 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| US20080280820A1 (en) | 2004-11-04 | 2008-11-13 | Ulrich Sensfuss | Novel Peptides for Use in the Treatment of Obesity |
| WO2006060873A1 (en) | 2004-12-09 | 2006-06-15 | Prince Henry's Institute Of Medical Research | Method for restoring reproductive function |
| WO2006073771A2 (en) | 2005-01-05 | 2006-07-13 | Eli Lilly And Company | Polyethylene glycol linked mc4r or mc3r agonist peptides |
| WO2006076442A2 (en) | 2005-01-14 | 2006-07-20 | Janssen Pharmaceutica N.V. | Triazolopyrimidine derivatives |
| WO2006086321A2 (en) * | 2005-02-09 | 2006-08-17 | Helix Biomedix Inc. | Antimicrobial hexapeptides |
| WO2006097526A1 (en) | 2005-03-17 | 2006-09-21 | Novo Nordisk A/S | Compounds for use in the treatment of obesity |
| EP1885743A1 (en) | 2005-05-31 | 2008-02-13 | Yissum Research Development Company, of The Hebrew University of Jerusalem | BACKBONE CYCLIZED MELANOCORTIN STIMULATING HORMONE ( alpha S ) ANALOGS |
| EP3925614A3 (en) | 2005-07-08 | 2022-03-23 | Ipsen Pharma | Melanocortin receptor ligands |
| RU2401841C2 (ru) | 2005-07-08 | 2010-10-20 | Ипсен Фарма С.А.С. | Лиганды рецепторов меланокортинов |
| CN1709906A (zh) | 2005-07-15 | 2005-12-21 | 中国科学技术大学 | α－促黑激素的环状类似肽及其应用 |
| MX2007016024A (es) | 2005-07-18 | 2008-03-10 | Novo Nordisk As | Peptidos novedosos para el uso en el tratamiento contra la obesidad. |
| RS52747B (sr) | 2005-08-26 | 2013-08-30 | Abbvie Inc. | Terapeutski aktivni analozi alfa-msh |
| US20080227693A1 (en) | 2005-08-29 | 2008-09-18 | Palatin Technologies, Inc. | Cyclic Peptide Isolation by Spray Drying |
| WO2007035474A2 (en) | 2005-09-15 | 2007-03-29 | Novomed Technologies, Inc. (Shanghai) | Transdermal delivery peptides and method of use thereof |
| TW200745163A (en) * | 2006-02-17 | 2007-12-16 | Syntonix Pharmaceuticals Inc | Peptides that block the binding of IgG to FcRn |
| US8114844B2 (en) | 2006-03-30 | 2012-02-14 | Palatin Technologies, Inc. | Linear and cyclic melanocortin receptor-specific peptidomimetics |
| AU2006350707A1 (en) | 2006-11-08 | 2008-05-15 | Chongxi Yu | Transdermal delivery systems of peptides and related compounds |
| JP2010516654A (ja) | 2007-01-18 | 2010-05-20 | ノボ・ノルデイスク・エー／エス | 肥満の治療に使用される新規ペプチド |
| US20100016237A1 (en) | 2007-01-18 | 2010-01-21 | Novo Nordisk A/S | Novel Peptides for Use in the Treatment of Obesity |
| EP2106406A2 (en) | 2007-01-18 | 2009-10-07 | Novo Nordisk A/S | Novel peptides for use in the treatment of obesity |
| WO2008087187A1 (en) | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Peptides for use in the treatment of obesity |
| WO2008087190A2 (en) | 2007-01-18 | 2008-07-24 | Novo Nordisk A/S | Use of peptides in combination with surgical intervention for the treatment of obesity |
| NZ579056A (en) | 2007-03-16 | 2011-07-29 | Pfizer Ltd | 5-[3-(3-Hydroxy-phenoxy} -azetidin-1-yl]-5-methyl-2,2-diphenyl-hexanoic acid amide hydrochloride salt |
| FR2914646A1 (fr) | 2007-04-04 | 2008-10-10 | Neorphys Soc Par Actions Simpl | Analogues peptidiques des recepteurs des melanocortines |
| WO2008156677A2 (en) | 2007-06-15 | 2008-12-24 | Ipsen Pharma S.A.S. | Cyclic peptide melanocortin receptor ligands |
| EP2197444A1 (en) | 2007-09-12 | 2010-06-23 | Glaxo Group Limited | Novel combination of therapeutic agents |
| DK2214693T3 (en) | 2007-11-05 | 2015-11-30 | Ipsen Pharma Sas | Use of melanocortins in the treatment of insulin sensitivity |
| AR072072A1 (es) | 2008-06-09 | 2010-08-04 | Palatin Technologies Inc | Peptidos especificos del receptor de melanocortina para el tratamiento de la obesidad / 669 |
| AU2009257631B2 (en) | 2008-06-09 | 2014-07-24 | Palatin Technologies, Inc. | Melanocortin receptor-specific peptides for treatment of sexual dysfunction |
| WO2010144341A2 (en) | 2009-06-08 | 2010-12-16 | Palatin Technologies, Inc. | Lactam-bridged melanocortin receptor-specific peptides |
| UY32690A (es) | 2009-06-08 | 2011-01-31 | Astrazeneca Ab | Péptidos específicos para receptores de melanocortina |
| WO2011035205A2 (en) * | 2009-09-18 | 2011-03-24 | Calmune Corporation | Antibodies against candida, collections thereof and methods of use |
| WO2011063366A1 (en) | 2009-11-23 | 2011-05-26 | Palatin Technologies, Inc. | Melanocortin-1 receptor-specific cyclic peptides |
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- 2010-11-23 WO PCT/US2010/057700 patent/WO2011063367A1/en not_active Ceased
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| EP2504351A4 (en) | 2013-10-30 |
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| US10106578B2 (en) | 2018-10-23 |
| CN102712674A (zh) | 2012-10-03 |
| WO2011063367A1 (en) | 2011-05-26 |
| AU2010321739A1 (en) | 2012-05-31 |
| JP2013511554A (ja) | 2013-04-04 |
| ZA201203331B (en) | 2013-07-31 |
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