KR20120093397A - 선택적 사이토페레시스 장치 및 그와 관련된 방법 - Google Patents
선택적 사이토페레시스 장치 및 그와 관련된 방법 Download PDFInfo
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- KR20120093397A KR20120093397A KR1020127016409A KR20127016409A KR20120093397A KR 20120093397 A KR20120093397 A KR 20120093397A KR 1020127016409 A KR1020127016409 A KR 1020127016409A KR 20127016409 A KR20127016409 A KR 20127016409A KR 20120093397 A KR20120093397 A KR 20120093397A
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Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009525781A (ja) | 2006-02-02 | 2009-07-16 | イノベーティブ バイオ セラピーズ | 細胞をベースとする体外治療装置および送達システム |
| US20090081296A1 (en) * | 2006-02-02 | 2009-03-26 | Humes H David | Extracorporeal cell-based therapeutic device and delivery system |
| ES2581989T3 (es) * | 2007-01-13 | 2016-09-08 | 3M Innovative Properties Company | Dispositivo para la separación de leucocitos de la sangre |
| EP3789056B9 (en) | 2007-08-31 | 2025-09-24 | SeaStar Medical, Inc. | Selective cytopheresis devices |
| WO2009039378A2 (en) | 2007-09-19 | 2009-03-26 | The Charles Stark Draper Laboratory, Inc. | Microfluidic structures for biomedical applications |
| US9138536B2 (en) * | 2008-04-01 | 2015-09-22 | Gambro Lundia Ab | Apparatus and a method for monitoring a vascular access |
| AU2009327485A1 (en) | 2008-06-18 | 2010-06-24 | Cytopherx, Inc. | Methods for propagation of renal precursor cells |
| DE102008045127A1 (de) * | 2008-09-01 | 2010-03-04 | Heinrich, Hans-Werner, Prof. Dr. | Filtersystem zur extrakorporalen Abreicherung von aktivierten Polymorphkernigen Granuloyzten (Polymorphonuclear leukocytes-PMNs) |
| EP2168614B1 (en) * | 2008-09-25 | 2012-02-15 | Gambro Lundia AB | Hybrid bioartificial kidney |
| US20110082563A1 (en) * | 2009-10-05 | 2011-04-07 | The Charles Stark Draper Laboratory, Inc. | Microscale multiple-fluid-stream bioreactor for cell culture |
| CA2776613A1 (en) * | 2009-10-07 | 2011-04-14 | University Of Pittsburgh - Of The Commonwealth System Of Higher Educatio N | Devices, systems and methods for cell modification |
| MY161192A (en) * | 2009-10-08 | 2017-04-14 | Otsuka Pharma Co Ltd | An immunoactivation blood perfusion filter for the treatment of malignant tumors |
| US8425662B2 (en) | 2010-04-02 | 2013-04-23 | Battelle Memorial Institute | Methods for associating or dissociating guest materials with a metal organic framework, systems for associating or dissociating guest materials within a series of metal organic frameworks, and gas separation assemblies |
| US20110250578A1 (en) * | 2010-04-13 | 2011-10-13 | Northern Alberta Institute Of Technology | Ventilator test lung and trigger assembly |
| EP2627369B1 (en) | 2010-10-15 | 2022-01-12 | SeaStar Medical, Inc. | Cytopheresic cartridge and use thereof |
| CA2860158A1 (en) * | 2011-01-07 | 2012-07-12 | Somerset Group Enterprises, Inc. | Modular extracorporeal systems and methods for treating blood-borne diseases |
| US10314594B2 (en) | 2012-12-14 | 2019-06-11 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10307167B2 (en) | 2012-12-14 | 2019-06-04 | Corquest Medical, Inc. | Assembly and method for left atrial appendage occlusion |
| US10813630B2 (en) | 2011-08-09 | 2020-10-27 | Corquest Medical, Inc. | Closure system for atrial wall |
| US20150246169A1 (en) * | 2011-10-14 | 2015-09-03 | Cytopherx, Inc. | Cartridge and method for increasing myocardial function |
| WO2013106109A1 (en) * | 2012-01-09 | 2013-07-18 | Humes, H., David | Cartridge and method for increasing myocardial function |
| CA2897426A1 (en) | 2012-01-09 | 2013-07-18 | Somerset Group Enterprises, Inc. | Modular extracorporeal systems and methods for treating blood-borne diseases |
| CN104349804B (zh) * | 2012-03-01 | 2017-06-06 | 医疗设备工程公司 | 用于监视和控制器官血液灌注的系统 |
| JP2014061285A (ja) * | 2012-08-31 | 2014-04-10 | Asahi Kasei Medical Co Ltd | 臓器炎症抑制用基材及びデバイス |
| US20140142689A1 (en) | 2012-11-21 | 2014-05-22 | Didier De Canniere | Device and method of treating heart valve malfunction |
| WO2014193597A1 (en) * | 2013-05-02 | 2014-12-04 | University Of Vermont And State Agricultural College | Leptin for treating systemic inflammatory response syndrome |
| US9566443B2 (en) | 2013-11-26 | 2017-02-14 | Corquest Medical, Inc. | System for treating heart valve malfunction including mitral regurgitation |
| CN104689403A (zh) * | 2013-12-08 | 2015-06-10 | 杨海龙 | 悬吊式回输血器 |
| WO2015095553A1 (en) * | 2013-12-20 | 2015-06-25 | Nephrogenesis, Llc | Methods and apparatus for kidney dialysis |
| CN103725599B (zh) * | 2014-01-14 | 2015-05-27 | 刘韬 | 一种流体膜过滤细胞分离装置 |
| US10369263B2 (en) | 2014-03-29 | 2019-08-06 | Novaflux Inc. | Blood processing cartridges and systems, and methods for extracorporeal blood therapies |
| US20170165334A1 (en) * | 2015-12-11 | 2017-06-15 | Tianxin Wang | Methods to Treat Diseases with Protein, Peptide, Antigen Modification and Hemopurification |
| US20170266362A1 (en) * | 2014-08-26 | 2017-09-21 | 3M Innovative Properties Company | System for removal of pro-inflammatory mediators as well as granulocytes and monocytes from blood |
| GB201420829D0 (en) * | 2014-11-24 | 2015-01-07 | Imp Innovations Ltd | Lymph node replacement construct |
| US10842626B2 (en) | 2014-12-09 | 2020-11-24 | Didier De Canniere | Intracardiac device to correct mitral regurgitation |
| EP3252164A4 (en) * | 2015-01-26 | 2018-09-26 | UBE Industries, Ltd. | Method for isolating, removing and analyzing cells |
| US10426884B2 (en) | 2015-06-26 | 2019-10-01 | Novaflux Inc. | Cartridges and systems for outside-in flow in membrane-based therapies |
| EP3352888B8 (en) | 2015-09-24 | 2022-01-12 | Princeton Trade and Technology Inc. | Cartridges for hollow fibre membrane-based therapies |
| EP3474922A1 (en) * | 2016-06-23 | 2019-05-01 | New Health Sciences, Inc. | Methods for managing adverse events in patient populations requiring transfusion |
| US11125744B2 (en) | 2016-06-30 | 2021-09-21 | Siemens Healthineers Nederland B.V. | Device, system and method for detecting an analyte in a body fluid sample containing a plurality of cells |
| WO2018145035A1 (en) * | 2017-02-03 | 2018-08-09 | Nxstage Medical, Inc. | Multiple mode treatment devices methods and systems |
| IT201700038389A1 (it) * | 2017-04-07 | 2018-10-07 | In10Sivecare S R L | Apparecchiatura per il trattamento extracorporeo del sangue |
| EP3388140A1 (en) * | 2017-04-10 | 2018-10-17 | Gambro Lundia AB | Extracorporeal blood circuit |
| EP3400976A1 (en) * | 2017-05-12 | 2018-11-14 | Universitat Rovira i Virgili | Device and method for the preparation of platelet rich plasma |
| CN107224624B (zh) * | 2017-06-12 | 2023-12-15 | 谢华南 | 血液透析器、血液透析装置及血液透析方法 |
| EP3427772B1 (en) | 2017-07-10 | 2023-05-03 | B. Braun Avitum AG | Oxygenator unit with a pressure relief valve |
| EP3473327A1 (en) | 2017-10-19 | 2019-04-24 | 3M Innovative Properties Company | Integrated fluid treatment device, and process using such device |
| US11607478B2 (en) | 2017-12-28 | 2023-03-21 | I-Sep | System and method for treating haemorrhagic fluid for autotransfusion |
| CA3086405A1 (en) | 2018-01-05 | 2019-07-11 | Path Ex, Inc. | Device for the capture and removal of disease material from fluids |
| EP3873343A4 (en) * | 2019-03-26 | 2022-01-05 | Nuwellis, Inc. | NEONATAL AND PEDIATRIC BLOOD FILTRATION SYSTEM |
| FR3097770B1 (fr) | 2019-06-27 | 2024-03-01 | I Sep | Système et procédé de traitement de liquide hémorragique pour de l’autotransfusion |
| WO2021022115A1 (en) * | 2019-08-01 | 2021-02-04 | Seastar Medical, Inc. | Device and method for preparing a donor organ for transplantation |
| AU2019474912B2 (en) * | 2019-11-19 | 2022-02-17 | Immunicom, Inc. | System and method for removal of immune inhibitors from biological fluids |
| DE102020104117A1 (de) * | 2020-02-18 | 2021-08-19 | Universität des Saarlandes | Vorrichtung zum Entfernen eines Gases aus einer wässrigen Flüssigkeit |
| CN111939599B (zh) * | 2020-07-14 | 2024-01-12 | 山东中保康医疗器具有限公司 | 富血小板血浆的制备方法及装置 |
| CN113686605B (zh) * | 2021-08-16 | 2023-07-07 | 北京林业大学 | 一种花粉管超薄切片及其制备方法 |
| CN116212121A (zh) * | 2023-04-25 | 2023-06-06 | 四川大学华西医院 | 一种铜氨络合物-多巴胺-肝素抗菌抗凝透析导管及其制备方法 |
Family Cites Families (95)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3489145A (en) | 1966-08-08 | 1970-01-13 | Surgeon General Of The Public | Method and apparatus for continuous separation of blood in vivo |
| GB2018151B (en) | 1978-03-06 | 1982-12-08 | Asahi Chemical Ind | Seperation of leukocytes from leukocyte-containing suspension by filtration |
| US4334993A (en) | 1979-12-05 | 1982-06-15 | Baxter Travenol Laboratories, Inc. | Potted-typed seal with stress relief and method of making same |
| US4500309A (en) | 1982-05-07 | 1985-02-19 | The Kansas University Endowment Association | Method for regional anticoagulation during extracorporeal dialysis |
| US4980068A (en) | 1983-08-15 | 1990-12-25 | Lavender Ardis R | System, apparatus and method for continuously fractionating blood in situ |
| SE441236B (sv) | 1984-06-18 | 1985-09-23 | Gambro Dialysatoren | Forfarande for framstellning av en anordning innefattande en halfiberbunt |
| SE8601891D0 (sv) | 1986-04-24 | 1986-04-24 | Svante Jonsson | Maskin for plasmabytesbehandling och trombocytgivning |
| SE454847B (sv) | 1987-08-31 | 1988-06-06 | Gambro Dialysatoren | Anordning for diffusion och/eller filtrering samt forfarande for tillverkning av denna anordning |
| WO1989001967A1 (en) | 1987-09-03 | 1989-03-09 | Brown University Research Foundation | Blood purification with cultured renal cells |
| CA1325770C (en) | 1988-04-04 | 1994-01-04 | Toru Kuroda | Adsorber module for whole blood treatment and an adsorber apparatus containing the adsorber module |
| US5104373A (en) * | 1988-09-22 | 1992-04-14 | American Immuno Tech, Inc. | Method and apparatus for extracorporeal blood treatment |
| US5344561A (en) | 1989-05-09 | 1994-09-06 | Pall Corporation | Device for depletion of the leucocyte content of blood and blood components |
| US5229012A (en) | 1989-05-09 | 1993-07-20 | Pall Corporation | Method for depletion of the leucocyte content of blood and blood components |
| US5100564A (en) | 1990-11-06 | 1992-03-31 | Pall Corporation | Blood collection and processing system |
| US5032615A (en) | 1989-10-31 | 1991-07-16 | The Regents Of The University Of California | Continuous hemodialysis using citrate |
| US5266219A (en) | 1989-12-28 | 1993-11-30 | Pall Corporation | Device and method for separating plasma from blood |
| DE59109048D1 (de) | 1990-02-14 | 1998-10-15 | Pentapharm Ag | Inhibitoren zur antikoagulierenden Vorbehandung von Blutproben |
| US5383847A (en) * | 1990-03-29 | 1995-01-24 | Therakos, Inc. | Non-specific immune system enhancement |
| US5362406A (en) * | 1990-07-27 | 1994-11-08 | Pall Corporation | Leucocyte depleting filter device and method of use |
| US5217627A (en) | 1990-11-06 | 1993-06-08 | Pall Corporation | System and method for processing biological fluid |
| US5486286A (en) | 1991-04-19 | 1996-01-23 | Althin Medical, Inc. | Apparatus for performing a self-test of kidney dialysis membrane |
| SE502103C2 (sv) | 1991-08-01 | 1995-08-14 | Gambro Dialysatoren | Filterenhet för överföring av massa och/eller värme innehållande hålrumsfibrer |
| US5443743A (en) | 1991-09-11 | 1995-08-22 | Pall Corporation | Gas plasma treated porous medium and method of separation using same |
| CA2074671A1 (en) | 1991-11-04 | 1993-05-05 | Thomas Bormann | Device and method for separating plasma from a biological fluid |
| WO1993009783A1 (en) * | 1991-11-15 | 1993-05-27 | Ss Pharmaceutical Co., Ltd. | Anti-inflammatory and analgesic plaster |
| US5804079A (en) | 1991-12-23 | 1998-09-08 | Baxter International Inc. | Systems and methods for reducing the number of leukocytes in cellular products like platelets harvested for therapeutic purposes |
| JPH0614996A (ja) * | 1992-05-01 | 1994-01-25 | Kawasumi Lab Inc | 吸着モジュ−ル |
| US5403272A (en) | 1992-05-29 | 1995-04-04 | Baxter International Inc. | Apparatus and methods for generating leukocyte free platelet concentrate |
| IL104670A (en) | 1993-02-09 | 1998-04-05 | Travenol Lab Israel Ltd | Leukocyte removal method and filter unit for same |
| ATE204478T1 (de) * | 1993-05-03 | 2001-09-15 | Genentech Inc | Inhibierung von leukozytenadhäsion |
| US5567443A (en) | 1993-08-04 | 1996-10-22 | Japan Immunoresearch Laboratories Co., Ltd. | Method of treating inflammatory diseases |
| US5571418A (en) | 1993-08-20 | 1996-11-05 | Lee; Patrice A. | Hemofiltration of toxic mediator-related disease |
| US5545339A (en) | 1994-02-25 | 1996-08-13 | Pall Corporation | Method for processing biological fluid and treating separated component |
| ES2139783T5 (es) | 1994-07-13 | 2005-10-16 | Fresenius Medical Care Deutschland Gmbh | Preparacion de liquido de sustitucion en un aparato de hemofiltrado o de hemo-dia filtrado. |
| EP0772484B1 (en) | 1994-07-28 | 2008-02-27 | Pall Corporation | Fibrous web and process of preparing same |
| US5582907A (en) | 1994-07-28 | 1996-12-10 | Pall Corporation | Melt-blown fibrous web |
| US5836934A (en) | 1995-06-07 | 1998-11-17 | Baxter International Inc. | Closed system and methods for mixing additive solutions while removing undesired matter from blood cells |
| DE69635205T2 (de) * | 1995-07-10 | 2006-01-26 | Asahi Medical Co. Ltd. | Extrakorporaler blutkreislauf für die heilung entzündlicher krankheiten |
| DE19528907C1 (de) | 1995-08-05 | 1996-11-07 | Fresenius Ag | Vorrichtung zur Ermittlung hämodynamischer Parameter während einer extrakorporalen Blutbehandlung |
| DE19541783C1 (de) | 1995-11-09 | 1997-03-27 | Fresenius Ag | Verfahren zum Betreiben einer Blutbehandlungsvorrichtung zur Ermittlung hämodynamischer Parameter während einer extrakorporalen Blutbehandlung und Vorrichtung zur Ermittlung hämodynamischer Parameter während einer extrakorporalen Blutbehandlung |
| JPH1017493A (ja) * | 1996-07-02 | 1998-01-20 | Masashi Fujii | カルシウムの金属イオン封鎖剤を含む抗炎症性または抗アレルギー性皮膚外用剤 |
| DE69735859T2 (de) | 1996-07-08 | 2006-10-26 | Pall Corp. | Positiv geladene Polymermembranen |
| ATE265882T1 (de) | 1996-07-09 | 2004-05-15 | Pall Corp | Filtervorrichtung für biologische fluide mit einem leukocyten abreichernden medium |
| US6045899A (en) | 1996-12-12 | 2000-04-04 | Usf Filtration & Separations Group, Inc. | Highly assymetric, hydrophilic, microfiltration membranes having large pore diameters |
| US6595943B1 (en) | 1997-02-14 | 2003-07-22 | Nxstage Medical, Inc. | Systems and methods for controlling blood flow and waste fluid removal during hemofiltration |
| US6830553B1 (en) | 1997-02-14 | 2004-12-14 | Nxstage Medical, Inc. | Blood treatment systems and methods that maintain sterile extracorporeal processing conditions |
| DE19712298C2 (de) | 1997-03-24 | 1999-05-20 | Fresenius Ag | Vorrichtung und Verfahren zum Trennen von Blut in Blutkomponenten |
| US6889082B2 (en) | 1997-10-09 | 2005-05-03 | Orqis Medical Corporation | Implantable heart assist system and method of applying same |
| JP4197545B2 (ja) * | 1997-12-01 | 2008-12-17 | 旭化成クラレメディカル株式会社 | 特異的細胞除去材料 |
| US6123859A (en) | 1998-04-22 | 2000-09-26 | Hemasure Inc. | Method for in-line filtering biological liquid |
| US6287516B1 (en) | 1998-07-10 | 2001-09-11 | Immunocept, L.L.C. | Hemofiltration systems, methods, and devices used to treat inflammatory mediator related disease |
| JP3640824B2 (ja) * | 1999-01-07 | 2005-04-20 | テルモ株式会社 | 白血球除去フィルターおよびその製造方法 |
| WO2000055621A2 (en) | 1999-03-17 | 2000-09-21 | Japan Immunoresearch Laboratories Co., Ltd. | Blood leucocyte apheresis for treatment of disease |
| US6561997B1 (en) | 1999-04-23 | 2003-05-13 | The Regents Of The University Of Michigan | Extracorporeal fluid circuit and related methods |
| US6736972B1 (en) | 2000-03-24 | 2004-05-18 | Immunocept, L.L.C. | Method and system for providing therapeutic agents with hemofiltration for reducing inflammatory mediator related diseases |
| JP2001276217A (ja) * | 2000-04-04 | 2001-10-09 | Dountsuendorufaa Udo | 単一又は複数の疾患のある患者での組織、血漿又は血液透析用のバイオコートされた吸着剤 |
| WO2001089513A1 (en) | 2000-05-24 | 2001-11-29 | Uab Research Foundation | Use of citrate-containing dialysate for renal dialysis treatment |
| US20020107469A1 (en) | 2000-11-03 | 2002-08-08 | Charles Bolan | Apheresis methods and devices |
| DE10114283C2 (de) | 2000-12-22 | 2003-04-24 | Fresenius Medical Care De Gmbh | Verfahren zur Ermittlung der Ionenkonzentration des Blutes eines Patienten bei der citrat-antikoagulierten Hämodialyse und/oder Hämofiltration; Dialysegerät |
| US6706274B2 (en) * | 2001-01-18 | 2004-03-16 | Scimed Life Systems, Inc. | Differential delivery of nitric oxide |
| US6582386B2 (en) | 2001-03-06 | 2003-06-24 | Baxter International Inc. | Multi-purpose, automated blood and fluid processing systems and methods |
| US6706008B2 (en) | 2001-03-06 | 2004-03-16 | Baxter International Inc. | Automated system and method for withdrawing compounds from blood |
| US6653131B2 (en) | 2001-08-30 | 2003-11-25 | The Regents Of The University Of Michigan | Method of treating systemic inflammatory response syndrome |
| US8986944B2 (en) * | 2001-10-11 | 2015-03-24 | Aviva Biosciences Corporation | Methods and compositions for separating rare cells from fluid samples |
| US7442546B2 (en) | 2002-03-15 | 2008-10-28 | The Regents Of The University Of Michigan | Method of modulating inflammatory response |
| US7531133B2 (en) * | 2002-09-10 | 2009-05-12 | Pulmonox Technologies Corporation | Use of nitric oxide gas in an extracorporeal circuitry to treat blood plasma |
| CA2501965C (en) | 2002-09-11 | 2012-04-10 | The Regents Of The University Of Michigan | Ultrafiltration membrane, device, bioartificial organ, and methods |
| JP5030383B2 (ja) * | 2002-10-21 | 2012-09-19 | アルヴィヴォ インコーポレイテッド | 生物活性化合物を含む表面コーティング |
| EP1582228B2 (en) * | 2002-12-02 | 2019-03-13 | Asahi Kasei Medical Co., Ltd. | Method of removing leukocytes, leukocyte-removing filter and utilization thereof |
| US7351218B2 (en) | 2002-12-20 | 2008-04-01 | Gambro Lundia Ab | Device and process for extracorporeal treatment by citrate anticoagulant |
| JP2004243048A (ja) | 2003-02-10 | 2004-09-02 | Besutekku:Kk | 電位治療装置制御方法、電位治療装置及び白血球分画の顆粒球とリンパ球との比率を調整する方法 |
| US7201730B2 (en) | 2003-03-17 | 2007-04-10 | Hemavation, Llc | Device and method for reducing inflammatory mediators in blood |
| US7297270B2 (en) | 2003-04-04 | 2007-11-20 | Chf Solutions, Inc. | Hollow fiber filter for extracorporeal blood circuit |
| US20070148772A1 (en) | 2003-06-21 | 2007-06-28 | Lifeforce Group Plc | Leukocyte cell banks |
| EP1518573B1 (en) | 2003-09-23 | 2006-08-23 | Fresenius Hemocare Italia S.r.l. | Filter, purification device and method for the removal of substances from blood products |
| US7029456B2 (en) | 2003-10-15 | 2006-04-18 | Baxter International Inc. | Medical fluid therapy flow balancing and synchronization system |
| EP1718603A4 (en) * | 2004-02-09 | 2009-09-23 | Noxilizer Inc | MOLECULES RELEASING NITROGEN MONOXIDE |
| US20050281809A1 (en) | 2004-02-23 | 2005-12-22 | Roberts Craig P | Plasma detoxification and volume control system and methods of use |
| US20050215937A1 (en) | 2004-03-05 | 2005-09-29 | Spinale Francis G | System and method for filtering leukocytes in cardiac surgery |
| WO2005107802A2 (en) * | 2004-04-30 | 2005-11-17 | Biopheresis Technologies, Llc | Method and system to remove soluble tnfr1, tnfr2, and il2 in patients |
| JP4854083B2 (ja) | 2004-06-09 | 2012-01-11 | 旭化成メディカル株式会社 | 白血球除去方法およびその方法に用いられるフィルター |
| WO2006008906A1 (ja) | 2004-07-22 | 2006-01-26 | Asahi Kasei Medical Co., Ltd. | 手術部位感染の抑制方法およびそれに使用するカラム |
| WO2006083322A2 (en) * | 2004-07-29 | 2006-08-10 | Ligocyte Pharmaceuticals, Inc. | Methods for the treatment and prevention of infection using anti-selectin agents |
| CN101098704B (zh) * | 2005-01-06 | 2011-07-13 | 旭化成医疗株式会社 | 白血球除去方法 |
| KR100972702B1 (ko) | 2005-03-31 | 2010-07-27 | 도레이 카부시키가이샤 | 흡착재 및 체외 순환용 칼럼 |
| DE602006017713D1 (de) | 2005-08-31 | 2010-12-02 | Gambro Lundia Ab | Verfahren und gerät zur entfernung von immunzellen |
| KR101256363B1 (ko) | 2005-09-09 | 2013-04-25 | 멤브라나 게엠베하 | 혈액으로부터 백혈구의 제거방법 |
| US7874998B2 (en) | 2005-11-04 | 2011-01-25 | The Regents Of The University Of Michigan | Filtration devices and related methods thereof |
| US7527737B2 (en) * | 2006-05-09 | 2009-05-05 | Wang Xiangyu | Hemodialysis apparatus and methods |
| CN101583722A (zh) | 2006-07-14 | 2009-11-18 | 阿维瓦生物科学股份有限公司 | 从生物学样品检测稀有细胞的方法和组合物 |
| US7410583B2 (en) * | 2006-08-10 | 2008-08-12 | East Bay Municipal Utility District | Process of treating organic waste for anaerobic digestion |
| ES2581989T3 (es) * | 2007-01-13 | 2016-09-08 | 3M Innovative Properties Company | Dispositivo para la separación de leucocitos de la sangre |
| EP3789056B9 (en) | 2007-08-31 | 2025-09-24 | SeaStar Medical, Inc. | Selective cytopheresis devices |
| DE102008045127A1 (de) | 2008-09-01 | 2010-03-04 | Heinrich, Hans-Werner, Prof. Dr. | Filtersystem zur extrakorporalen Abreicherung von aktivierten Polymorphkernigen Granuloyzten (Polymorphonuclear leukocytes-PMNs) |
| JP2012525403A (ja) | 2009-04-28 | 2012-10-22 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | PKCθ阻害薬による免疫学的疾患のEX−VIVO治療 |
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