KR20120090034A - 이소폼 선택성 포스포리파제 d 저해제 - Google Patents

이소폼 선택성 포스포리파제 d 저해제 Download PDF

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Publication number
KR20120090034A
KR20120090034A KR1020127004698A KR20127004698A KR20120090034A KR 20120090034 A KR20120090034 A KR 20120090034A KR 1020127004698 A KR1020127004698 A KR 1020127004698A KR 20127004698 A KR20127004698 A KR 20127004698A KR 20120090034 A KR20120090034 A KR 20120090034A
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KR
South Korea
Prior art keywords
optionally substituted
cycloalkyl
alkyl
compound
alkoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
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KR1020127004698A
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English (en)
Korean (ko)
Inventor
에이치. 알렉스 브라운
크레이그 더블유. 린슬리
알렉스 지. 워터슨
세라 에이. 스콧
Original Assignee
벤더르빌트 유니버시티
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Publication of KR20120090034A publication Critical patent/KR20120090034A/ko
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/438—The ring being spiro-condensed with carbocyclic or heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
KR1020127004698A 2009-07-24 2010-07-23 이소폼 선택성 포스포리파제 d 저해제 Withdrawn KR20120090034A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22849209P 2009-07-24 2009-07-24
US61/228,492 2009-07-24

Publications (1)

Publication Number Publication Date
KR20120090034A true KR20120090034A (ko) 2012-08-16

Family

ID=43499428

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020127004698A Withdrawn KR20120090034A (ko) 2009-07-24 2010-07-23 이소폼 선택성 포스포리파제 d 저해제

Country Status (14)

Country Link
US (1) US9127005B2 (cg-RX-API-DMAC7.html)
EP (1) EP2456307B1 (cg-RX-API-DMAC7.html)
JP (1) JP2013500260A (cg-RX-API-DMAC7.html)
KR (1) KR20120090034A (cg-RX-API-DMAC7.html)
CN (1) CN102573474A (cg-RX-API-DMAC7.html)
AU (1) AU2010275526A1 (cg-RX-API-DMAC7.html)
BR (1) BR112012001586A2 (cg-RX-API-DMAC7.html)
CA (1) CA2768940C (cg-RX-API-DMAC7.html)
IL (1) IL217720A0 (cg-RX-API-DMAC7.html)
IN (1) IN2012DN01661A (cg-RX-API-DMAC7.html)
MX (1) MX2012001064A (cg-RX-API-DMAC7.html)
RU (1) RU2012106657A (cg-RX-API-DMAC7.html)
SG (1) SG178102A1 (cg-RX-API-DMAC7.html)
WO (1) WO2011011680A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2010275526A1 (en) 2009-07-24 2012-03-15 Vanderbilt University Isoform selective Phospholipase D inhibitors
CA2850597A1 (en) 2011-09-30 2013-04-04 Vanderbilt University Antiviral therapies with phospholipase d inhibitors
AU2013359311A1 (en) * 2012-12-11 2015-07-23 Vanderbilt University Methods and compositions of treating HIV infection
EP2931277A4 (en) * 2012-12-11 2016-07-27 Univ Vanderbilt PROCEDURE AND COMPOSITIONS WITH ACTIVE INHIBITORS AND / OR PHOSPHOLIPASE D INHIBITORS
CN114778844A (zh) * 2022-03-07 2022-07-22 天津市肿瘤医院（天津医科大学肿瘤医院） Pld1作为评估肿瘤患者对于化疗药物敏感性的分子标志物的用途
CN119365445A (zh) * 2022-06-16 2025-01-24 日本烟草产业株式会社 二氢噁二嗪酮化合物及其药物用途

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1281502B1 (it) 1995-06-13 1998-02-18 Sardinian Antiviral Research C Impiego di un inibitore non nucleosidico della trascrittasi inversa in associazione con inibitori nucleosidici per il trattamento della
US6187559B1 (en) 1997-08-28 2001-02-13 Novartis Ag Phospholipase D gene
US20040029244A1 (en) 2000-05-25 2004-02-12 Ben-Tsion Williger Phospholipase d effectors for therapy and screening
US6482829B2 (en) * 2000-06-08 2002-11-19 Hoffmann-La Roche Inc. Substituted heterocyclic siprodecane compound active as an antagonist of neurokinin 1 receptor
KR101144889B1 (ko) 2002-09-18 2012-05-14 학교법인 포항공과대학교 포스포리파제 ｄ를 포함하는 펩티드 복합체
WO2006071730A1 (en) * 2004-12-27 2006-07-06 Astrazeneca Ab Pyrazolone compounds as metabotropic glutamate receptor agonists for the treatment of neurological and psychiatric disorders
WO2006107451A2 (en) 2005-02-23 2006-10-12 Univ Emory Honokiol derivatives for the treatment of proliferative disorders
CN101448844B (zh) * 2006-05-18 2012-07-25 霍夫曼-拉罗奇有限公司 作为腺苷a2b受体拮抗剂的噻唑并嘧啶/吡啶脲衍生物
US20100009970A1 (en) 2008-03-19 2010-01-14 Combinatorx (Singapore) Pte. Ltd. Compositions and methods for treatment of viral diseases
WO2010037081A1 (en) 2008-09-29 2010-04-01 Palatin Technologies, Inc. Melanocortin receptor-specific spiro-piperidine compounds
WO2010112560A1 (en) 2009-03-31 2010-10-07 Sanofi-Aventis Deutschland Gmbh Drug delivery device body
CA2764038A1 (en) 2009-05-29 2010-12-02 The Trustees Of Columiba University In The City Of New York Modulation of phospholipase d for the treatment of neurodegenerative disorders
AU2010275526A1 (en) 2009-07-24 2012-03-15 Vanderbilt University Isoform selective Phospholipase D inhibitors
US9149445B2 (en) 2009-07-27 2015-10-06 The Trustees Of Princeton University Inhibition of glycerol-3-phosphate acyltransferase (GPAT) and associated enzymes for treatment of viral infections
CA2850597A1 (en) 2011-09-30 2013-04-04 Vanderbilt University Antiviral therapies with phospholipase d inhibitors
AU2013359311A1 (en) 2012-12-11 2015-07-23 Vanderbilt University Methods and compositions of treating HIV infection
EP2931277A4 (en) 2012-12-11 2016-07-27 Univ Vanderbilt PROCEDURE AND COMPOSITIONS WITH ACTIVE INHIBITORS AND / OR PHOSPHOLIPASE D INHIBITORS

Also Published As

Publication number Publication date
SG178102A1 (en) 2012-03-29
IL217720A0 (en) 2012-03-29
IN2012DN01661A (cg-RX-API-DMAC7.html) 2015-06-05
MX2012001064A (es) 2012-07-17
WO2011011680A1 (en) 2011-01-27
EP2456307A4 (en) 2013-01-16
US9127005B2 (en) 2015-09-08
BR112012001586A2 (pt) 2015-09-01
EP2456307B1 (en) 2016-11-02
CA2768940A1 (en) 2011-01-27
EP2456307A1 (en) 2012-05-30
AU2010275526A1 (en) 2012-03-15
JP2013500260A (ja) 2013-01-07
RU2012106657A (ru) 2013-08-27
CA2768940C (en) 2018-03-13
US20120214832A1 (en) 2012-08-23
CN102573474A (zh) 2012-07-11

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Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20120223

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid