KR20120063475A - 항-ｔｇｆ-베타 수용체 타입 ⅱ 단일 도메인 항체 - Google Patents
항-ｔｇｆ-베타 수용체 타입 ⅱ 단일 도메인 항체 Download PDFInfo
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- KR20120063475A KR20120063475A KR1020127005555A KR20127005555A KR20120063475A KR 20120063475 A KR20120063475 A KR 20120063475A KR 1020127005555 A KR1020127005555 A KR 1020127005555A KR 20127005555 A KR20127005555 A KR 20127005555A KR 20120063475 A KR20120063475 A KR 20120063475A
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Ophthalmology & Optometry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
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- Biomedical Technology (AREA)
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| US22933409P | 2009-07-29 | 2009-07-29 | |
| US61/229,334 | 2009-07-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20120063475A true KR20120063475A (ko) | 2012-06-15 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020127005555A Ceased KR20120063475A (ko) | 2009-07-29 | 2010-07-27 | 항-ｔｇｆ-베타 수용체 타입 ⅱ 단일 도메인 항체 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9109031B2 (enExample) |
| EP (1) | EP2459593A2 (enExample) |
| JP (2) | JP2013500030A (enExample) |
| KR (1) | KR20120063475A (enExample) |
| CN (1) | CN102574922A (enExample) |
| AU (1) | AU2010277629B2 (enExample) |
| BR (1) | BR112012001977A2 (enExample) |
| CA (1) | CA2768981A1 (enExample) |
| EA (1) | EA026097B1 (enExample) |
| IL (1) | IL217458A0 (enExample) |
| IN (1) | IN2012DN00412A (enExample) |
| MX (1) | MX2012001278A (enExample) |
| SG (1) | SG178135A1 (enExample) |
| WO (1) | WO2011012609A2 (enExample) |
| ZA (1) | ZA201200372B (enExample) |
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| CN103443126B (zh) * | 2011-01-06 | 2016-11-23 | 葛兰素集团有限公司 | 结合TGFβ受体II的配体 |
| KR20180131557A (ko) * | 2016-04-05 | 2018-12-10 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | 면역요법에서의 tgf베타의 억제 |
| GB201608052D0 (en) * | 2016-05-09 | 2016-06-22 | Univ Oslo Hf | T-cell receptors which recognise frameshift mutants of TGF-beta RII |
| JP2020501510A (ja) * | 2016-09-20 | 2020-01-23 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 目の表面で使用するためのアンカードメインを含む繋留タンパク質に基づく薬物 |
| US11713487B2 (en) | 2017-07-14 | 2023-08-01 | The Regents Of The University Of California | Methods of predicting transplant rejection risk |
| JP2021516966A (ja) | 2018-03-09 | 2021-07-15 | ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション | 組織への生物学的薬物の送達 |
| GB201807693D0 (en) * | 2018-05-11 | 2018-06-27 | Autolus Ltd | Cell |
| IL305181A (en) | 2021-02-15 | 2023-10-01 | Takeda Pharmaceuticals Co | Cell therapy compositions and methods for modulating tgf-b signaling |
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| WO1994026087A2 (en) | 1993-05-14 | 1994-11-24 | Connor Kim C O | Recombinant protein production and insect cell culture and process |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| JP2001206899A (ja) * | 1999-11-18 | 2001-07-31 | Japan Tobacco Inc | ＴＧＦ−βＩＩ型受容体に対するヒトモノクローナル抗体及びその医薬用途 |
| US20050053973A1 (en) | 2001-04-26 | 2005-03-10 | Avidia Research Institute | Novel proteins with targeted binding |
| US20050089932A1 (en) | 2001-04-26 | 2005-04-28 | Avidia Research Institute | Novel proteins with targeted binding |
| CA2447851C (en) | 2001-06-28 | 2012-08-28 | Domantis Limited | Dual-specific ligand and its use |
| US20030028905A1 (en) * | 2001-07-31 | 2003-02-06 | Petra Knaus | Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms |
| WO2003076567A2 (en) | 2002-03-05 | 2003-09-18 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
| US9321832B2 (en) | 2002-06-28 | 2016-04-26 | Domantis Limited | Ligand |
| US7696320B2 (en) | 2004-08-24 | 2010-04-13 | Domantis Limited | Ligands that have binding specificity for VEGF and/or EGFR and methods of use therefor |
| US20060002935A1 (en) | 2002-06-28 | 2006-01-05 | Domantis Limited | Tumor Necrosis Factor Receptor 1 antagonists and methods of use therefor |
| DK1517921T3 (da) | 2002-06-28 | 2006-10-09 | Domantis Ltd | Immunglobulin-enkeltvariable antigen-bindende domæner og dobbeltspecifikke konstruktioner deraf |
| JP2004121001A (ja) * | 2002-08-07 | 2004-04-22 | Japan Tobacco Inc | ＴＧＦ−βＩＩ型受容体に対する高親和性モノクローナル抗体 |
| EP3299393A1 (en) | 2002-11-08 | 2018-03-28 | Ablynx N.V. | Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor |
| AU2003290330A1 (en) | 2002-12-27 | 2004-07-22 | Domantis Limited | Dual specific single domain antibodies specific for a ligand and for the receptor of the ligand |
| AU2004239065B2 (en) | 2003-05-14 | 2008-05-15 | Domantis Limited | A process for recovering polypeptides that unfold reversibly from a polypeptide repertoire |
| AU2004220325B2 (en) | 2003-06-30 | 2011-05-12 | Domantis Limited | Polypeptides |
| EP1675878A2 (en) | 2003-10-24 | 2006-07-05 | Avidia, Inc. | Ldl receptor class a and egf domain monomers and multimers |
| EP1729795B1 (en) | 2004-02-09 | 2016-02-03 | Human Genome Sciences, Inc. | Albumin fusion proteins |
| EP1737962B1 (en) | 2004-03-24 | 2010-09-01 | Domantis Limited | Gas1 universal leader |
| US7563443B2 (en) * | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| CA2636854A1 (en) | 2006-01-24 | 2007-08-02 | Domantis Limited | Ligands that bind il-4 and/or il-13 |
| GB0724331D0 (en) | 2007-12-13 | 2008-01-23 | Domantis Ltd | Compositions for pulmonary delivery |
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2010
- 2010-07-27 EA EA201290028A patent/EA026097B1/ru not_active IP Right Cessation
- 2010-07-27 MX MX2012001278A patent/MX2012001278A/es not_active Application Discontinuation
- 2010-07-27 CA CA2768981A patent/CA2768981A1/en not_active Abandoned
- 2010-07-27 US US13/387,376 patent/US9109031B2/en not_active Expired - Fee Related
- 2010-07-27 WO PCT/EP2010/060867 patent/WO2011012609A2/en not_active Ceased
- 2010-07-27 BR BR112012001977A patent/BR112012001977A2/pt not_active Application Discontinuation
- 2010-07-27 CN CN2010800450323A patent/CN102574922A/zh active Pending
- 2010-07-27 EP EP10735014A patent/EP2459593A2/en not_active Withdrawn
- 2010-07-27 JP JP2012522147A patent/JP2013500030A/ja active Pending
- 2010-07-27 IN IN412DEN2012 patent/IN2012DN00412A/en unknown
- 2010-07-27 SG SG2012006029A patent/SG178135A1/en unknown
- 2010-07-27 AU AU2010277629A patent/AU2010277629B2/en not_active Ceased
- 2010-07-27 KR KR1020127005555A patent/KR20120063475A/ko not_active Ceased
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2012
- 2012-01-10 IL IL217458A patent/IL217458A0/en unknown
- 2012-01-17 ZA ZA2012/00372A patent/ZA201200372B/en unknown
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2015
- 2015-10-09 JP JP2015201067A patent/JP2016053039A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2012001278A (es) | 2012-03-16 |
| AU2010277629A1 (en) | 2012-02-16 |
| US20120129778A1 (en) | 2012-05-24 |
| CN102574922A (zh) | 2012-07-11 |
| IL217458A0 (en) | 2012-02-29 |
| JP2013500030A (ja) | 2013-01-07 |
| WO2011012609A3 (en) | 2011-09-15 |
| ZA201200372B (en) | 2013-06-26 |
| CA2768981A1 (en) | 2011-02-03 |
| EA026097B1 (ru) | 2017-03-31 |
| JP2016053039A (ja) | 2016-04-14 |
| EP2459593A2 (en) | 2012-06-06 |
| IN2012DN00412A (enExample) | 2015-05-22 |
| BR112012001977A2 (pt) | 2017-01-31 |
| EA201290028A1 (ru) | 2012-08-30 |
| AU2010277629B2 (en) | 2016-05-19 |
| WO2011012609A2 (en) | 2011-02-03 |
| SG178135A1 (en) | 2012-03-29 |
| US9109031B2 (en) | 2015-08-18 |
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