KR20120014769A

KR20120014769A - Anti-acne cosmetic composition

Info

Publication number: KR20120014769A
Application number: KR1020100076942A
Authority: KR
Inventors: 김청택; 한상길
Original assignee: 주식회사 알엔에스
Priority date: 2010-08-10
Filing date: 2010-08-10
Publication date: 2012-02-20

Abstract

PURPOSE: A cosmetic composition for preventing and treating acne is provided to ensure antibacterial effect and safety to human body and to prevent acne. CONSTITUTION: A cosmetic composition for preventing and treating acne contains 0.001-10 wt% of Cudrania tricuspidata extract as an active ingredient. The extract is prepared using water, methanol, ethanol, propanol, butanol, glycerol, propylene glycol, or 1,3-butylene glycol. The cosmetic composition is manufactured in the form of gel, cream, lotion, soap, or liquid cleanser.

Description

Anti-acne cosmetic composition

The present invention relates to a cosmetic composition for preventing and improving acne, and more particularly, excellent antibacterial activity against the causative agent of acne to prevent the occurrence of acne in advance, and to prevent the deterioration of non-inflammatory acne, as well as to the human body It relates to a high safety cosmetic composition.

Skin diseases, commonly referred to as acne, are skin diseases that occur in the hair follicle sebaceous glands that exhibit various skin lesions, such as closed or open cotton, papules, pustules, cysts, and nodules.

Acne causes include increased sebum secretion, abnormal hair follicles in the hair follicle, and colonization of acne bacteria. These factors combine to produce acne lesions. In other words, sebaceous gland function is enhanced by hypersecretion of male hormone, and the resulting sebum causes hyperkeratosis of hair follicle wall and stagnates in hair follicles. As sebum secretion is increased and hair follicles are hyperkeratinized, sebum stagnated in the hair follicles blocks the hair follicles and blocks the circulation of air, which leads to an environment in which acne bacteria, the anaerobic bacteria resident in the hair follicles, can grow well. do. At this time, acne bacteria secrete lipolytic enzymes and chemotactic factors to produce free fatty acids, causing leukocytes to gather around the hair follicles.These non-inflammatory acne causes inflammatory acne as the contents of the hair follicles leak out into the dermis. It will progress to and worsen with purulent acne. As described above, acne bacteria act a lot to aggravate acne lesions.

The microorganism known as the causative agent of acne is Anaerobic Bacterium Propionibacterium (Genus), the human skin Propionibacterium acnes ( Propanibacterium acnes ), Propionibacterium granulosum ( Propionibacterium granulosum) ) And Propionibacterium avidum . There are three types of propionibacterium. Propionobacterium acnes is the main cause of acne.

In general, the treatment of acne is achieved by suppressing its cause. Among them, topical therapies used to treat acne by removing the aforementioned acne bacteria include benzoyl peroxide, azelaic acid, retinoic acid, salicylic acid, Sulfur, topical antibiotics, and the like. However, these preparations do not exhibit sufficient antimicrobial effects against acne bacteria in small amounts, and there are problems such as side effects such as skin redness or dryness of the skin when excessive application occurs.

In addition, in non-medical products such as soaps, body cleansers and deodorants, personal care products such as Triclosan, Triclorocarban, Benzalkonium Chloride, Benzethonium Chloride, and hydrochloric acid Chlorhexidine Hydrochloride, Chlorhexidine Gluconate, Fanesol and Tea tree Oil, Cloves, Fennel, Mint and other plant oils, chitin and derivatives thereof are used.

However, synthetic materials such as triclosan have excellent antibacterial activity, but are not safe from side effects such as skin, and may cause negative thoughts to users because they are synthetic chemicals. In particular, triclosan is an antimicrobial agent widely used in personal care products around the world, but is still defined as a pesticide by the US Environmental Protection Agency (EPA). This problem is being questioned, and due to the seriousness of inducing resistant strains, there is a movement to regulate the use around Europe. As such, there is a growing demand for antimicrobial agents derived from human and environment-friendly natural products that can be applied more safely and effectively to products that can be used in the human body for the purpose of alleviating and preventing microorganism-related diseases.

Therefore, the technical problem to be achieved by the present invention is to solve the above problems, excellent antimicrobial activity against the causative agent of acne prevents the occurrence of acne in advance, and prevents the deterioration of non-inflammatory acne, for the human body It is to provide a high safety cosmetic composition.

The technical problem of the present invention as described above is achieved by the following means.

(1) cosmetic composition for the prevention and improvement of acne, characterized in that it contains Cudrania extract as an active ingredient.

(2) The cosmetic composition for preventing and improving acne according to claim 1, wherein the dry weight of the extract of Cudrania japonica is 0.001 to 10% by weight based on the total weight of the composition.

(3) The method according to claim 1, wherein the Koji mulberry extract is extracted with any one or more solvents selected from the group consisting of water, methanol, ethanol, propanol, butanol, glycerol, propylene glycol and 1,3-butylene glycol. Cosmetic composition for preventing and improving acne.

As described above, the kkujippong tree extract is not only excellent antibacterial effect on the causative bacteria of acne, but also high in the safety of the human body, the cosmetic composition containing it as an active ingredient prevents the occurrence of acne in advance, of non-inflammatory acne It can be used effectively to prevent and improve acne, including preventing aggravation.

The present invention provides a cosmetic composition for preventing and improving acne, characterized in that it contains Cudrania extract as an active ingredient.

EMBODIMENT OF THE INVENTION Hereinafter, this invention is demonstrated in detail.

Cudrania tricuspidata is a shrub belonging to the mulberry family, and it is called as Japonica or Jahuang in China. Stem, stem bark, leaves, fruits, roots when used as a drug, the taste is sweet and bitter, without poison. Cudrania is widely used as a folk remedy for various cancers such as uterine cancer, stomach cancer, and colon cancer.

Such bark extract has been utilized in the development of the composition to which it is applied due to various pharmacological action.

The present inventors repeated the study, found that the extract of the bark is not only excellent antibacterial activity against acne bacteria such as propionibacterium acnes, but also excellent anti-inflammatory effect.

In other words, the Cudrania japonica extract has an excellent antibacterial activity, which essentially eliminates the causative agent of acne, such as propionibacterium acnes, and thus prevents the occurrence of acne, and also the early acne non-inflammatory acne is inflammatory. It also improves acne lesions by preventing further progression to purulent acne. In addition, Cudrania japonica extract is an extract obtained from natural products that have been used as a medicine for a long time, and has high safety for the human body. Therefore, the cosmetic composition comprising the kkujippong extract according to the present invention exhibits an excellent effect on the prevention and improvement of acne, and has a higher safety for the human body than conventional chemical synthetic antimicrobial agents.

It is preferable that the dry weight of the Cudrania japonica extract contained in the cosmetic composition according to the present invention is 0.001 to 10% by weight based on the total weight of the composition. This is because if the content is less than 0.001% by weight, it may be difficult to obtain the expected effect, and if it exceeds 10% by weight, no significant increase in effect may be achieved by the amount added.

The cosmetic composition of the present invention containing such an extract of Cucumber tree may be prepared in the form of gel, cream, lotion, soap, liquid detergent, etc. according to the purpose of use thereof.

Cudrania extract can be obtained, for example, in the following manner.

After crushing Cucumber chopped finely in an extraction solvent, the extract is filtered and concentrated to obtain an extract. At this time, as the extraction solvent, it is preferable to use a solvent such as water, methanol, ethanol, propanol, butanol, glycerol, propylene glycol, 1,3-butylene glycol alone or a mixture of two or more thereof. .

Hereinafter, the present invention will be described in detail with reference to Examples. However, embodiments according to the present invention can be modified in many different forms, the scope of the present invention should not be construed as limited to the embodiments described below. Embodiments of the present invention are provided to more completely explain the present invention to those skilled in the art.

Preparation Example Preparation of Cudrania Extract

After washing the roots of Koji mulberry tree in purified water, finely chopped and chilled for 5 days in 5 times the extraction solvent, the extract was filtered and concentrated to obtain an extract. At this time, ethanol was used as the extraction solvent.

The antimicrobial effect of the obtained Cucumber extract was measured as follows.

Experimental Example 1 Determination of the Antimicrobial Effect of Cudrania japonica Extract

The antimicrobial effect of Cudrania root extract was tested in acne bacteria.

(Public bacteria)

Propionibacterium acnes ATCC 6919, an acne bacterium, was used as the test bacteria.

(Test Methods)

Antimicrobial activity was measured using the Minimum Inhibitory Concentration (MIC). After diluting each sample in a liquid medium at regular concentration intervals, each test strain was inoculated and incubated, and then the minimum concentration of inhibiting bacterial growth was determined by observing the growth of cells by sample concentration. Bacterial growth was determined by adding 1% TTC (2,3,5-Triphenyl Tetrazolium Chloride) solution as positive growth (+) when color changed from colorless to red, and negative growth (-) as non-change. TTC is a dye that turns red when it is reduced from its original oxidized state due to a change in redox potential that occurs when bacteria grow actively, so it is used to easily measure the viability of microorganisms. Since propionibacterium acnes, an acne-causing bacterium, is an anaerobic strain, it was incubated at 37 ° C for 2 days in an anaerobic chamber after inoculation, and then the minimum concentration for inhibiting bacterial growth was selected by observing bacterial growth. The results obtained are shown in Table 1 below.

Antibacterial activity against acne sample MIC (ppm) Cudrania 20

Referring to Table 1, the MIC measurement results for acne bacteria showed that the antimicrobial activity of Cucurbitaceae extract is very excellent.

Hereinafter, the preparation of the face wash composition as a cosmetic composition for preventing and improving acne and examined the effect thereof.

Example 1

According to the ingredients and contents shown in Table 2, the composition was uniformly mixed by stirring, heating, degassing, and cooling in a homo mixer to prepare a face wash composition.

Comparative Example 1

A facial cleanser composition was prepared in the same manner as in Example, except that the extract was not changed to the ingredients and contents shown in Table 2 below.

Examples and Comparative Examples of Facial Wash Preparation Raw material name Example 1 Comparative Example 1 Golgol extract 0.05 - glycerin 5 5 Monoalkyl phosphates 40 40 Myristic acid 5 5 Spices Quantity Quantity Pigment Quantity Quantity Purified water To 100 To 100

Experimental Example 1 Evaluation of Antibacterial Activity

In order to evaluate the antimicrobial activity of the facial cleanser prepared in Example 1 and Comparative Example 1, the experiment was carried out as follows.

After acne bacteria were inoculated in BHI broth and pre-incubated, 100 ml of sterilized BHI broth containing 5% of each cleanser was inoculated at 1% concentration, followed by incubation for 2 days in an anaerobic incubator. It was. The results obtained are shown in Table 2 below.

Bactericidal activity against acne P. acnes Inoculation bacteria concentration (cfu / ml) Bacterial concentration after incubation (cfu / ml) Example 1 2.6 x 10 ⁶ 2.8 x 10 ⁴ Comparative Example 1 2.6 x 10 ⁶ 6.3 x 10 ⁵

As a result, it can be seen that the antibacterial activity against acne bacteria was significantly improved in the case of the face wash containing Cucumber tree extract.

Experimental Example 2 Clinical Trials on the Prevention and Improvement of Acne Treatments

The following experiment was conducted to evaluate the clinical effects of acne prevention and improvement of the cleansing agent (Example 1) and the non-cleansing agent (Comparative Example 1). First, men in their late teens to late 20s (test group: 10, control group 10) were selected as subjects and washed three times a day for one month to evaluate acne prevention and improvement effects. Judging method is rated according to the condition of acne before the start of the experiment, and visual inspection to determine the reduction effect according to the criteria described in Table 4 below, and then the acne grade of the clinical subjects showed a reduction of more than 3 grades excellent effect , 1 ~ 2 grades are shown to be in the middle of the effect, no reduction effect is not shown, and the grade after the test is higher than the grade before the test.

Cotton cloth reduction effect judgment standard Rating condition 0 Normal condition One Very small number or size of cotton cloth or no inflammation 2 Inflammation does not progress moderately in number or size of cotton cloth 3 Scrub with a small number of inflammatory papules 4 Small and widespread nodules and inflammatory scalp 5 Small number and size of papular nodules 6 Moderate inflammatory nodules 7 A large number of inflammatory nodules are present 8 Severe nodular sclera 9 Severe cystic and inflammatory nodules are present

Cotton cloth reduction effect by using face wash Grade Type Excellent effect Effect no effect Worse system Example 1 7 (70%) 3 (30%) 0 0 10 (100%) Comparative Example 1 0 1 (10%) 8 (80%) 1 (10%) 10 (100%)

As shown in Table 5, the facial cleanser of Example 1 containing the kkujippong tree extract was found to have a very good acne prevention and improvement effect than the facial cleanser of Comparative Example 1 does not contain.

Claims

Cosmetic composition for preventing and improving acne, characterized in that it contains Cucumber extract as an active ingredient.

The method of claim 1, wherein the dry weight of the Koji mulberry extract is a cosmetic composition for preventing and improving acne, characterized in that 0.001 to 10% by weight based on the total weight of the composition.

The acne according to claim 1, wherein the Cudrania extract is extracted with any one or more solvents selected from the group consisting of water, methanol, ethanol, propanol, butanol, glycerol, propylene glycol, and 1,3-butylene glycol. Prevention and improvement cosmetic composition.