KR20110134386A - 단일 세포의 세포독성을 평가하기 위한 조성물 및 방법 - Google Patents

단일 세포의 세포독성을 평가하기 위한 조성물 및 방법 Download PDF

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KR20110134386A
KR20110134386A KR1020117018895A KR20117018895A KR20110134386A KR 20110134386 A KR20110134386 A KR 20110134386A KR 1020117018895 A KR1020117018895 A KR 1020117018895A KR 20117018895 A KR20117018895 A KR 20117018895A KR 20110134386 A KR20110134386 A KR 20110134386A
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cells
cell
hiv
effector
antibody
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Korean (ko)
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존 크리스토퍼 러브
나빈 바라다라잔
보리스 율크
브루스 워커
Original Assignee
메사추세츠 인스티튜트 오브 테크놀로지
더 제너럴 하스피털 코포레이션 두잉 비즈니스 애즈 매사츄세츠 제너럴 하스피털
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Application filed by 메사추세츠 인스티튜트 오브 테크놀로지, 더 제너럴 하스피털 코포레이션 두잉 비즈니스 애즈 매사츄세츠 제너럴 하스피털 filed Critical 메사추세츠 인스티튜트 오브 테크놀로지
Publication of KR20110134386A publication Critical patent/KR20110134386A/ko
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • G01N33/56972—White blood cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
    • G01N33/5047—Cells of the immune system
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52—Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/563—Immunoassay; Biospecific binding assay; Materials therefor involving antibody fragments
    • C—CHEMISTRY; METALLURGY
    • C40—COMBINATORIAL TECHNOLOGY
    • C40B—COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES
    • C40B30/00—Methods of screening libraries
    • C40B30/06—Methods of screening libraries by measuring effects on living organisms, tissues or cells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/005—Assays involving biological materials from specific organisms or of a specific nature from viruses
    • G01N2333/08—RNA viruses
    • G01N2333/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus, feline leukaemia virus, human T-cell leukaemia-lymphoma virus
    • G01N2333/155—Lentiviridae, e.g. visna-maedi virus, equine infectious virus, FIV, SIV
    • G01N2333/16—HIV-1, HIV-2

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Toxicology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
KR1020117018895A 2009-01-21 2009-07-13 단일 세포의 세포독성을 평가하기 위한 조성물 및 방법 Ceased KR20110134386A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US14610609P 2009-01-21 2009-01-21
US61/146,106 2009-01-21

Publications (1)

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KR20110134386A true KR20110134386A (ko) 2011-12-14

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KR1020117018895A Ceased KR20110134386A (ko) 2009-01-21 2009-07-13 단일 세포의 세포독성을 평가하기 위한 조성물 및 방법

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Country Link
US (1) US9244071B2 (https=)
EP (1) EP2389446B1 (https=)
JP (2) JP2012515548A (https=)
KR (1) KR20110134386A (https=)
CN (2) CN104745669A (https=)
AU (1) AU2009338127B2 (https=)
CA (1) CA2689681C (https=)
IL (1) IL213938A0 (https=)
RU (1) RU2532228C2 (https=)
SG (2) SG172889A1 (https=)
WO (1) WO2010085275A1 (https=)

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US9244071B2 (en) 2009-01-21 2016-01-26 Massachusetts Institute Of Technology Compositions and methods for assessing cytotoxicity of single cells
EP2646830B1 (en) * 2010-12-03 2016-04-13 Cellply S.R.L. Rapid screening of monoclonal antibodies
WO2012072822A1 (en) 2010-12-03 2012-06-07 Mindseeds Laboratories Srl Microanalysis of cellular function
CA2856868C (en) 2011-12-13 2020-07-07 Single Cell Technology, Inc. Method of screening a plurality of single secreting cells for functional activity
US20150191772A1 (en) 2012-06-29 2015-07-09 Danmarks Tekniske Universitet Method of charging a test carrier and a test carrier
CN108267581A (zh) * 2012-08-24 2018-07-10 耶鲁大学 用于高通量多重检测的系统、装置和方法
EP3039162B1 (en) * 2013-08-26 2019-01-02 President and Fellows of Harvard College Determination of immune cells and other cells
PT3099172T (pt) 2014-01-31 2021-11-08 Agbiome Inc Agentes modificados de controlo biológico e seus usos
US9877486B2 (en) 2014-01-31 2018-01-30 AgBiome, Inc. Methods of growing plants using modified biological control agents
CN112782140A (zh) 2014-12-03 2021-05-11 伊索普莱西斯公司 细胞分泌特征的分析和筛选
US10488321B2 (en) 2015-03-19 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip
EP4306955B1 (en) 2015-03-26 2025-05-14 University of Houston System Integrated functional and molecular profiling of cells
WO2017124101A2 (en) 2016-01-15 2017-07-20 The Broad Institute Inc. Semi-permeable arrays for analyzing biological systems and methods of using same
US12345708B2 (en) 2016-03-25 2025-07-01 President And Fellows Of Harvard College Microfluidic determination of immune and other cells
US20190106666A1 (en) * 2016-03-30 2019-04-11 Sony Corporation Cell observation device, method for evaluating activity level of immune cells, and method for controlling quality of immune cells
EP3258240B1 (en) 2016-06-14 2023-06-07 Cellply S.R.L. Screening kit and methods
EP3472351B1 (de) 2016-06-15 2020-10-28 Ludwig-Maximilians-Universität München Einzelmolekülnachweis bzw. -quantifizierung durch dna-nanotechnologie
CN106086171A (zh) * 2016-06-15 2016-11-09 广州中大南沙科技创新产业园有限公司 一种抑制肿瘤细胞增殖的药物筛选方法
EP3510398B1 (en) 2016-09-12 2026-02-25 Isoplexis Corporation System and methods for multiplexed analysis of cellular and other immunotherapeutics
AU2017345402A1 (en) * 2016-10-19 2019-05-23 General Automation Lab Technologies Inc. High resolution systems, kits, apparatus, and methods for screening microorganisms and other high throughput microbiology applications
EP4036578A1 (en) * 2016-11-11 2022-08-03 Isoplexis Corporation Compositions and methods for the simultaneous genomic, transcriptomic and proteomic analysis of single cells
US11085912B2 (en) * 2016-12-14 2021-08-10 University Of Cincinnati Methods of diagnosing Clostridium difficile infection or recurrence in a subject
SE543211C2 (en) * 2017-06-29 2020-10-27 Mabtech Production Ab Method and system for analyzing Fluorospot assays
WO2019113457A1 (en) 2017-12-07 2019-06-13 Massachusetts Institute Of Technology Single cell analyses
CN108728356B (zh) * 2018-05-23 2022-02-22 北京科技大学 用于不同三维细胞团配对的装置及共培养方法
EP3911953A4 (en) * 2019-01-16 2022-08-31 Yantai AusBio Laboratories Co., Ltd. AUTOMATED LIQUID HANDLING SYSTEM AND PROCESS FOR SEPARATION OF BIOLOGICAL SAMPLES FOR MICROSCOPIC ANALYZES
WO2020171020A1 (ja) * 2019-02-18 2020-08-27 株式会社エヌビィー健康研究所 細胞の選抜方法、核酸の製造方法、組換え細胞の製造方法、目的物質の製造方法、医薬組成物の製造方法、及び試薬
US12064768B2 (en) 2020-02-21 2024-08-20 Northeastern University Single cell isolation and processing system with reversible well shape
US20240182849A1 (en) 2022-11-07 2024-06-06 Shennon Biotechnologies Inc. Microfluidic Devices for High Throughput Screening of Cell-Cell Interactions

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JP2012515548A (ja) 2012-07-12
JP6017620B2 (ja) 2016-11-02
CN104745669A (zh) 2015-07-01
RU2532228C2 (ru) 2014-10-27
IL213938A0 (en) 2011-07-31
CA2689681A1 (en) 2010-07-21
US9244071B2 (en) 2016-01-26
AU2009338127B2 (en) 2015-11-26
CN102388145A (zh) 2012-03-21
SG172889A1 (en) 2011-08-29
AU2009338127A1 (en) 2011-07-28
RU2011134898A (ru) 2013-02-27
US20120149592A1 (en) 2012-06-14
EP2389446A4 (en) 2012-10-03
JP2015144617A (ja) 2015-08-13
WO2010085275A1 (en) 2010-07-29
SG10201401643PA (en) 2014-08-28
EP2389446A1 (en) 2011-11-30
CA2689681C (en) 2017-08-29
EP2389446B1 (en) 2017-07-05

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