KR20110104196A - Composition for prevention of losing hair or promotion of growing hair - Google Patents

Abstract

The present invention provides a composition comprising at least one extract of Echo extract and ephedra root extract as an active ingredient, the composition has the effect of preventing hair loss or promoting hair growth, and can be used in a variety of fields in medicine, washing and beauty .

Description

Composition for prevention of losing hair or promotion of growing hair}

The present invention relates to a composition for preventing hair loss or promoting hair growth, and more particularly, to a composition containing at least one of the extract of Echo extract or ephedra root.

Hair loss is a problem that occurs through natural processes or is chemically promoted through the use of certain therapeutic drugs designed to alleviate symptoms such as cancer. This hair loss involves the lack of hair regrowth that causes partial or complete baldness.

Recently, as more modern people have alopecia due to environmental pollution, stress, diet, fatigue, and incorrect eating habits, interest in substances that can improve them is increasing. The present inventors have tried to find a substance that suppresses hair loss and promotes hair growth.

An object of one embodiment of the present invention is to provide a composition for preventing hair loss and promoting hair growth.

The present invention provides a composition for preventing hair loss or promoting hair growth, comprising at least one of the extract of Echo and ephedra muscle as an active ingredient.

The composition according to the present invention has an effect of preventing hair loss or promoting hair growth, and can be used in various fields in medicine, washing and beauty.

1 is a photograph taken to compare the hair growth effect of the herbal ingredients according to an embodiment;
Figure 2 is a graph showing the cytotoxicity measurement results of herbal ingredients according to another embodiment.

The composition for preventing hair loss or promoting hair growth according to an embodiment of the present invention contains at least one of choragon extract and ephedra muscle extract as an active ingredient.

Hair growth is caused by an activity cycle involving the growth and rest phases, which are divided into three main stages known as the growth phase, the regression phase, and the resting phase. The growth phase can be characterized by the penetration of hair follicles deep into the skin with rapid proliferation of cells, which is distinct from hair formation. The next phenomenon is the degenerative phase, which is a transitional period in which cell disruption is prominent, during which hair follicles regress through the skin and stop hair growth. In the next phase, the resting phase, the degenerative hair follicles contain germs with densely packed dermal papilla cells. The onset of new growth phase phenomena at rest is induced by rapid cell proliferation in the embryo, swelling of the dermal papilla and the synthesis of basement membrane elements.

Therefore, it is necessary to prevent hair loss by promoting or extending the growth period, that is, to prevent hair loss or to cause regrowth of hair, that is, to promote hair growth, and the composition according to the embodiment of the present invention is to prevent hair from already existing. One or more of an effect of not falling out, an effect of thickening already existing hair, and the like, and an effect of generating new hair. In one embodiment, the composition according to the present invention may exhibit the efficacy of promoting hair growth or hair growth by activating the Wnt / beta-catenin signal (β-catenin) signal (signal).

Choo (바, 바, headpiece, Yakdudu, scientific name: Aconitum jaluense Komarov) is Ranunculaceae (Ranunculaceae) in Choshi (草烏屬, a perennial plant belonging to Aconitum), cultivated in our country is common notjeotgarak herbs (Aconitum of cliliare ), but in one shot is called choo throughout the roots of the same genus plants. In the Choshi pharmacognosy classified into five pulses (烏頭類) called by choohdu it back (草烏頭), cheonohdu (川烏頭), and it has choohdu notjeotgarak herbs (Aconitum cliliare , Hellflower ( Aconitum) jaluense ) and about 40 species, such as Aconitum Kusnezoftii.

Choo is used in the form of external preparations because it contains highly toxic alkaloids. For example, it is used as an analgesic medicine for neuralgia, migraine, toothache, rheumatism and myelomyelitis. Choo is a poisonous poison that is eaten when an old king kills a guilty servant. However, Chou is a poisonous medicinal herb, but also a good herbal medicine to warm and strengthen the body, neuralgia, arthritis, stroke, diabetes, or cold symptoms are great. If you eat a lot of choo addicted to lose lives, but little by little, the energy is increased, the stomach warms, the stomach, intestines, liver, kidneys are strong. Eat 2-4 grams (restricted) per day in the form of drops, pills, powders, etc. When used as an external medicine, powder the unlawful substance and paste it on the base, or call it with vinegar or liquor.

Ephedra with ephedra sinica Stapf .; Ephedra , Ephedra intermedia Schrenk et Mey .; or Ephedra equisetina Bge .;木 賊 麻黃 means root and rhizome. Ephedra muscle is curved in a columnar shape and the surface is maroon or greyish brown with longitudinal wrinkles and side roots. The outer shell is rough and flaky and easily peels off. Root stocks with nodes and transversely long pores on the surface. The vagina is hard, light and brittle, the skin of the cross section is yellowish white, the neck is pale yellow, the diagonal line is radial, and the center is water. Other names are also called warriors, emergencies, and rhinitis. Ephedra muscles are used for cold sweats caused by weak body and insufficiency of skin surface tissues, postpartum fences and sweating in summer heat. Pharmacological action has been reported sweating, body heat lowering action, diuretic action, blood pressure increase action, central nervous system excitement action, cold virus suppression action.

The composition for preventing hair loss or promoting hair growth according to an embodiment of the present invention may include a extract of Ciao. The composition for preventing hair loss or promoting hair growth according to another embodiment of the present invention may include ephedra root extract. In addition, the composition for preventing hair loss or promoting hair growth according to another embodiment of the present invention may include both the extract of chorionic extract and ephedra root. In addition, the preparation method of the cucumber extract and ephedra muscle extract applied to each of the above examples is not particularly limited. In one embodiment, the cho or ephedra extract can be obtained by adjusting the temperature, pressure using an organic solvent containing water or alcohol.

In one embodiment, the organic solvent is not particularly limited, C ₁ ~ C ₅ lower alcohols, such as methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol, glycerol, ethylene glycol Polyhydric alcohols such as propylene glycol, 1,3-butylene glycol, methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether, dichloromethane, hydrocarbon solvents such as chloroform, and petroleum ether, methyl acetate, benzene And non-polar organic solvents such as hexane, chloroform, methylene chloride, dimethyl ether, ethyl acetate, and the like. For example, the composition may be an ethanol extract, more specifically 70% to 100% ethanol extract.

The composition may further comprise a natural plant material component. For example, the composition is white porcelain, ginseng, ginseng, ginger, sugar, Angelica, licorice, red pepper tink, peony, sesao, black beans, black sesame, Baekbongryeong, green tea, camellia, sagejiku, Sangbaekpi, gujeolcho, Cheongung, white paper It further comprises one or more or an extract thereof selected from the group consisting of hyungjak, jaecho, golden, wolfberry, gardenia, turmeric, Astragalus, Dansam, Nasturtium, Schisandra chinensis and mugwort. The natural plant material is not particularly limited unless it is a particular problem in terms of safety of the composition. However, the natural plant ingredients may be formulated to prevent hair loss, promote hair production, or strengthen hair root, and may be prepared through commercially available raw materials.

The content of the myo extract or ephedra muscle extract contained in the composition is not particularly limited, but may be 0.01 to 50% by weight, more specifically 0.05 to 30% by weight based on the total weight of the composition. If the content of the active ingredient is too low, effective hair growth can not be expected. On the contrary, if the content is too high, it may impair the stability of the formulation, and there is a fear that toxicity may occur due to the excessive content of a specific ingredient.

In addition, it may be for preventing or treating alopecia through hair growth prevention or hair growth promotion according to the present invention. In one embodiment, the composition may be a pharmaceutical composition for preventing hair loss or promoting hair growth. When the composition according to an embodiment of the present invention is applied to a mouse from which hair has been removed, the hair growth may be exerted to guide the hair cycle to the growth phase in the resting phase, thereby promoting hair growth. In addition, the composition can prevent hair loss, it was confirmed that the effect of preventing or treating hair loss by promoting hair growth.

The present invention provides a pharmaceutical composition comprising a composition containing any one or more of the extract of Echo and Ephedra. Such pharmaceutical compositions may further contain pharmaceutical adjuvants such as preservatives, stabilizers, hydrating or emulsifying accelerators, salts and / or buffers for controlling osmotic pressure, and other therapeutically useful substances, and may be prepared in various oral forms according to conventional methods. It may be formulated in the form of a dosage form or parenteral dosage form.

The oral dosage forms include, for example, tablets, pills, hard and soft capsules, solutions, suspensions, emulsifiers, syrups, powders, powders, fine granules, granules, pellets, and the like, and these formulations include surfactants in addition to active ingredients. , Diluents such as lactose, dextrose, sucrose, mannitol, sorbitol, cellulose and glycine, and glidants such as silica, talc, stearic acid and its magnesium or calcium salts and polyethylene glycols. . Tablets may also contain binders such as magnesium aluminum silicate, starch paste, gelatin, tragacanth, methylcellulose, sodium carboxymethylcellulose and polyvinylpyrrolidine, optionally starch, agar, alginic acid or its sodium salt Pharmaceutical additives such as disintegrants, absorbents, colorants, flavors, and sweeteners. The tablets can be prepared by conventional mixing, granulating or coating methods.

In addition, the parenteral administration agent may be, for example, formulations such as injections, drops, ointments, lotions, gels, creams, sprays, suspensions, emulsions, suppositories, and patches, but are not limited thereto. no.

The pharmaceutical composition according to an embodiment of the present invention may be administered orally, parenteral, rectal, topical, transdermal, intravenous, intramuscular, intraperitoneal, subcutaneous. Pharmaceutical compositions according to one embodiment of the invention may be administered topically to the scalp, for example.

In addition, the pharmaceutically acceptable dose, ie dosage, of the active ingredient depends on the age, sex, and weight of the subject to be treated, the specific disease or pathology to be treated, the severity of the disease or pathology, the route of administration and the judgment of the prescriber. Will be different. Dosage determination based on these factors is within the level of skill in the art. Typical dosages may be from 0.01 mg / kg / day to 1000 mg / kg / day and from 1 mg / kg / day to 40 mg / kg / day, but the dosage may be in any way It is not intended to limit the scope.

The present invention provides a cleaning or cosmetic composition comprising a composition containing any one or more of the extract of Echo and Ephedra.

The cosmetic composition accordingly may, for example, be a cosmetic, the appearance of which contains a cosmetically or dermatologically acceptable medium or base. These are all formulations suitable for topical application, for example, emulsions, suspensions, microemulsions, microcapsules, microgranules or ionic (liposomes) obtained by dispersing the oil phase in solutions, gels, solids, pasty anhydrous products, aqueous phases, and It may be provided in the form of a nonionic vesicle dispersant or in the form of a cream, skin, lotion, powder, ointment, spray or cone stick. These compositions may be prepared according to conventional methods in the art. The composition according to the invention can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant.

Cosmetic compositions may include fatty substances, organic solvents, solubilizers, thickeners, gelling agents, emollients, antioxidants, suspending agents, stabilizers, foaming agents, fragrances, surfactants, water, ionic or nonionic emulsifiers, fillers Cosmetic or dermatology such as metal ion sequestrants, chelating agents, preservatives, vitamins, blockers, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic actives, lipid vesicles or any other ingredients commonly used in cosmetics It may contain adjuvants commonly used in the art. Such adjuvants are introduced in amounts generally used in the cosmetic or dermatological arts.

The cosmetic composition according to the present invention is not particularly limited in the formulation, for example, supple cosmetics, astringent cosmetics, nourishing cosmetics, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, It may be formulated into cosmetics such as cleansing water, packs, powders, body lotions, body creams, body oils and body essences. The cosmetic composition as described above may be applied in a form applied to the skin, or may be applied in a form that is absorbed into the skin using a microneedle or the like. In addition, the cleaning composition may be formulated in the form of hair tonic, hair nourishing cosmetics, scalp treatment, hair treatment, hair rinse, hair shampoo or hair lotion.

Hereinafter, the present invention will be described in more detail through test examples, but the present invention is not limited thereto.

Test Example 1 Hair Growth Effect Test

The hair growth promoting effect of the active ingredient contained in the composition according to an embodiment of the present invention was tested.

Dorsal hairs were removed from females at 7 weeks of age (C57BL / 6) and 8 animals were selected for each material group. Examples 1, 2 and the control were applied twice daily to 50 μl for 35 days on the dorsal region of each mouse group individual.

Example 1 was a cho extract extract 1% solution, Experimental Example 2 was used ephedra extract 1% solution. Examples 1 and 2 were extracted with choeol or ephedra muscle using 70% ethanol, so that the concentration of the active ingredient is 1% by weight. As a control (vehicle), a mixed solution of water / ethanol / 1,3-butylene glycol (5/3/2) was used.

Photographs of mouse hair growth were taken at weekly intervals from the time of hair removal, and the photographs are shown in FIG. 1.

Referring to FIG. 1, it can be seen that the hair growth rate is significantly increased when the choragonia or ephedra muscle is applied as compared to the control group. Especially, the application of choo was the fastest hair growth rate. From this, it can be expected that the hair growth promoting effect will be very excellent when choo and ephedra muscle are mixed.

Test Example 2 Cytotoxicity Evaluation

One day prior to the experiment, HaCaT was dispensed at 2 × 10 ⁴ per well. At the end of the day, the medium was removed and treated with dichloromyco and ephedra dilutions, respectively. The cho and ephedra muscle diluent was prepared by diluting the cho and ephedra muscle solution prepared at a concentration of 20 mg / ml in a ratio of 1: 1000 and 1: 10000.

After 8 hours of treatment with the chondroitin diluent, MTT (3- (4,5-Dimethyl-2-thiazolyl) -2,5-diphenyl Tetrazolium Bromide) reagent was treated at 8 hours. At this point, DMSO (Dimethyl Sulfoxide) solution was treated. Prior to treatment of the MTT reagent and DMSO solution, each wash once with PBS (Phosphate-Buffered Saline). Cytotoxicity was calculated by measuring the absorbance at 570 nm, the results are shown in FIG.

As can be seen from the results shown in Figure 2, the cytotoxicity was not observed in the chorhea and ephedra muscle according to the present invention.

Examples of the formulation of the composition according to the present invention are described below, but are also applicable to various other formulations, which are intended to explain in detail only and not intended to limit the present invention.

[Formulation Example 1] Ointment in the external preparation for skin

The ointment was prepared in a conventional manner according to the composition described in Table 1 below.

Compounding ingredient Content (% by weight) Choo 0.1 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 15.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 1.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Cetearyl Alcohol 1.0 Beeswax 4.0 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 2 Preparation of Powder

Choo ............... 500 mg

Lactose ................................... 100 mg

Talc ........................ 10 mg

Maintenance ......................................... 5 mg

The above ingredients are mixed and filled in an airtight cloth to prepare a powder.

Formulation Example 3 Preparation of Tablet

Choo and Ephedra ........... 500 mg

Corn starch ........... 100 mg

Lactose ......................................... 100 mg

Magnesium Stearate ............... 2 mg

Vitamin C .................................. 50 mg

After mixing the above components, tablets are prepared by tableting according to a conventional method for preparing tablets.

Formulation Example 4 Preparation of Capsule

Choo ........................ 500 mg

Corn starch ........................ 100 mg

Lactose ......................................... 100 mg

Magnesium Stearate ......................................... 2 mg

Vitamin C ......................................... 50 mg

Serine ...... 50 mg

The above components are mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.

Formulation Example 5 Preparation of Liquid

Choo and Ephedra ............... 5000 mg

Isomerized sugar ......................................... 10 g

Mannitol ........................................ 5 g

Vitamin C ......................................... 50 mg

Serine ......................................... 50 mg

Maintenance ...........................

Purified water ...............

According to the conventional method for preparing a liquid, each component is added and dissolved in purified water, lemon flavor is added, the above components are mixed, purified water is added, the whole is adjusted to 100 ml by adding purified water, and then filled in a brown bottle. The solution is prepared by sterilization.

Formulation Example 6 Preparation of Injection

Choo ......................................... 200 mg

Sterile Distilled Water for Injection ...

pH adjuster ...

According to the conventional method for preparing an injection, the amount of the above ingredient is prepared per ampoule (2 ml).

Formulation Example 7 Flexible Cosmetic (Skin Lotion)

According to the composition described in Table 2 below was prepared a flexible cosmetic water in a conventional manner.

Compounding ingredient Content (% by weight) Choo 0.1 glycerin 3.0 Butylene glycol 2.0 Propylene glycol 2.0 Carboxy Vinyl Polymer 0.1 Fiji-12 nonylphenyl ether 0.2 Polysorbate 80 0.4 ethanol 10.0 Triethanolamine 0.1 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 8 Nutrients (Milk Lotion)

Nutritional longevity was prepared according to the conventional composition described in Table 3 below.

Compounding ingredient Content (% by weight) Choo and Ephedra 0.1 glycerin 3.0 Butylene glycol 3.0 Propylene glycol 3.0 Carboxy Vinyl Polymer 0.1 Beeswax 4.0 Polysorbate 60 1.5 Caprylic / Capric Triglycerides 5.0 Squalane 5.0 Sorbitassquioleate 1.5 Liquid paraffin 0.5 Cetearyl Alcohol 1.0 Triethanolamine 0.2 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 9 Nutrition Cream

Nutritional cream was prepared in a conventional manner according to the composition shown in Table 4.

Compounding ingredient Content (% by weight) Choo 0.1 glycerin 3.0 Butylene glycol 3.0 Liquid paraffin 7.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Squalane 5.0 Cetearyl Glucoside 1.5 Sorbitan stearate 0.4 Polysorbate 60 1.2 Triethanolamine 0.1 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 10 Massage Cream

To prepare a massage cream in a conventional manner according to the composition described in Table 5.

Compounding ingredient Content (% by weight) Ephedra 0.1 glycerin 8.0 Butylene glycol 4.0 Liquid paraffin 45.0 Beta Glucan 7.0 Carbomer 0.1 Caprylic / Capric Triglycerides 3.0 Beeswax 4.0 Cetearyl Glucoside 1.5 Sesqui oleic acid sorbitan 0.9 Vaseline 3.0 paraffin 1.5 Preservative, coloring, fragrance Quantity Purified water Balance

Formulation Example 11 Pack

To prepare a pack in a conventional manner according to the composition described in Table 6.

Compounding ingredient Content (% by weight) Choo 0.1 glycerin 4.0 Polyvinyl alcohol 15.0 Hyaluronic acid extract 5.0 Beta Glucan 7.0 Allantoin 0.1 Nonyl Phenyl Ether 0.4 Polysorbate 60 1.2 ethanol 6.0 Preservative, coloring, fragrance Quantity Purified water Balance

The above examples and formulations are provided only for the purpose of understanding the present invention, but the scope of the present invention is not limited thereto.

Claims (7)

A composition for preventing hair loss or promoting hair growth comprising at least one of choochuchu extract and ephedra root extract as an active ingredient. The method of claim 1,
The choo extract or ephedra extract is water; Lower alcohols of methanol, ethanol, isopropyl alcohol, n-propyl alcohol, n-butanol and isobutanol; Polyhydric alcohols of glycerol, ethylene glycol, propylene glycol and 1,3-butylene glycol; Methyl acetate, ethyl acetate, benzene, n-hexane, diethyl ether, dichloromethane, chloroform hydrocarbon solvents; And at least one solvent extract selected from nonpolar organic solvents of petroleum ether, methyl acetate, benzene, hexane, chloroform, methylene chloride, dimethyl ether, and ethyl acetate. The method of claim 1,
The cho extract or ephedra extract is a composition for preventing hair loss or promoting hair growth is an ethanol extract. The method of claim 1,
The composition, white porcelain, ginseng, ginseng, ginger, medicinal herbs, Angelica, licorice, red pepper tink, peony, sesuo, black beans, black sesame, baekbongnyeong, green tea, camellia, sukjiwang, baekbaekpi, gujeolcho, cheongung, baekji, hyeonggae, A composition for preventing hair loss or promoting hair growth further comprising at least one selected from the group consisting of golden, wolfberry, gardenia, turmeric, yellow, dansam, nasturtium, schisandra and wormwood. The method of claim 1,
The content of the cho extract or ephedra extract, the composition for preventing hair loss or promoting hair growth is 0.01 to 50% by weight based on the total weight of the composition. A pharmaceutical composition for preventing hair loss or promoting hair growth comprising the composition of claim 1. A cleaning or cosmetic composition comprising the composition of claim 1.

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