KR20110086101A - 방사선 및 면역사이토카인으로의 암 치료 - Google Patents

방사선 및 면역사이토카인으로의 암 치료 Download PDF

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Publication number
KR20110086101A
KR20110086101A KR1020117011503A KR20117011503A KR20110086101A KR 20110086101 A KR20110086101 A KR 20110086101A KR 1020117011503 A KR1020117011503 A KR 1020117011503A KR 20117011503 A KR20117011503 A KR 20117011503A KR 20110086101 A KR20110086101 A KR 20110086101A
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KR
South Korea
Prior art keywords
immunocytokine
tumor
days
radiation
dose
Prior art date
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Ceased
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KR1020117011503A
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English (en)
Korean (ko)
Inventor
토마스 위컴
울리케 그나트-포그트
슈테판 게 클린츠
실비아 에이 홀덴
칼 요제프 칼렌
Original Assignee
메르크 파텐트 게엠베하
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Publication of KR20110086101A publication Critical patent/KR20110086101A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/2013IL-2
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • A61K38/20Interleukins [IL]
    • A61K38/208IL-12
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/04Immunostimulants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00Radiation therapy
    • A61N5/10X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020117011503A 2008-10-21 2009-10-21 방사선 및 면역사이토카인으로의 암 치료 Ceased KR20110086101A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10714608P 2008-10-21 2008-10-21
US61/107,146 2008-10-21

Publications (1)

Publication Number Publication Date
KR20110086101A true KR20110086101A (ko) 2011-07-27

Family

ID=41510762

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020117011503A Ceased KR20110086101A (ko) 2008-10-21 2009-10-21 방사선 및 면역사이토카인으로의 암 치료

Country Status (12)

Country Link
US (1) US20100330029A1 (https=)
EP (1) EP2337579A1 (https=)
JP (1) JP2012506394A (https=)
KR (1) KR20110086101A (https=)
CN (1) CN102196815A (https=)
AU (1) AU2009306711A1 (https=)
BR (1) BRPI0919857A2 (https=)
CA (1) CA2741130A1 (https=)
EA (1) EA201100626A1 (https=)
MX (1) MX2011004193A (https=)
WO (1) WO2010046097A1 (https=)
ZA (1) ZA201103726B (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230027322A (ko) * 2014-02-19 2023-02-27 메르크 파텐트 게엠베하 암-표적화된 il-12 면역요법

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
US9861833B1 (en) * 2017-03-30 2018-01-09 Norman H. Anderson Methods of treating melanoma
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
WO2020236875A1 (en) 2019-05-20 2020-11-26 Pandion Therapeutics, Inc. Madcam targeted immunotolerance
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector
CN112768029B (zh) * 2020-12-27 2023-10-13 上海市东方医院(同济大学附属东方医院) 一种基于单细胞测序的组合用药推荐设备、方法及介质

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2457701A (en) * 1999-12-28 2001-07-09 Brown University Research Foundation Methods and products for tumor immunotherapy using cytokines
DE60129695T2 (de) * 2000-06-29 2008-06-05 Merck Patent Gmbh Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme
PT1454138E (pt) * 2001-12-04 2012-03-28 Merck Patent Gmbh Imunocitoquinas com seletividade modulada
CA2593648A1 (en) * 2005-01-10 2006-07-13 Research Development Foundation Targeted chimeric molecules for cancer therapy
BRPI0620648B1 (pt) * 2005-12-30 2022-12-20 Merck Patent Gesellschaft Mit Beschrãnkter Haftung Variante de il-12 p40, proteínas il-12, il-23 e de fusão, composição farmacêutica e uso da mesma

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20230027322A (ko) * 2014-02-19 2023-02-27 메르크 파텐트 게엠베하 암-표적화된 il-12 면역요법

Also Published As

Publication number Publication date
WO2010046097A1 (en) 2010-04-29
MX2011004193A (es) 2011-05-24
JP2012506394A (ja) 2012-03-15
BRPI0919857A2 (pt) 2015-12-15
EA201100626A1 (ru) 2011-12-30
CN102196815A (zh) 2011-09-21
ZA201103726B (en) 2012-01-25
US20100330029A1 (en) 2010-12-30
CA2741130A1 (en) 2010-04-29
EP2337579A1 (en) 2011-06-29
AU2009306711A1 (en) 2010-04-29

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