CN102196815A - 使用辐射和免疫细胞因子的癌症治疗 - Google Patents

使用辐射和免疫细胞因子的癌症治疗 Download PDF

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Publication number
CN102196815A
CN102196815A CN2009801417993A CN200980141799A CN102196815A CN 102196815 A CN102196815 A CN 102196815A CN 2009801417993 A CN2009801417993 A CN 2009801417993A CN 200980141799 A CN200980141799 A CN 200980141799A CN 102196815 A CN102196815 A CN 102196815A
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CN
China
Prior art keywords
immunocytokine
tumor
days
radiation
dose
Prior art date
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Pending
Application number
CN2009801417993A
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English (en)
Chinese (zh)
Inventor
T·威克姆
U·格纳德-福格特
S·G·克林兹
S·A·霍尔登
K·J·卡伦
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Merck Patent GmbH
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Merck Patent GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Patent GmbH filed Critical Merck Patent GmbH
Publication of CN102196815A publication Critical patent/CN102196815A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/2013—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
    • A61K38/208—IL-12
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/10—X-ray therapy; Gamma-ray therapy; Particle-irradiation therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN2009801417993A 2008-10-21 2009-10-21 使用辐射和免疫细胞因子的癌症治疗 Pending CN102196815A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US10714608P 2008-10-21 2008-10-21
US61/107,146 2008-10-21
PCT/EP2009/007533 WO2010046097A1 (en) 2008-10-21 2009-10-21 Cancer treatments with radiation and immunocytokines

Publications (1)

Publication Number Publication Date
CN102196815A true CN102196815A (zh) 2011-09-21

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ID=41510762

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2009801417993A Pending CN102196815A (zh) 2008-10-21 2009-10-21 使用辐射和免疫细胞因子的癌症治疗

Country Status (12)

Country Link
US (1) US20100330029A1 (https=)
EP (1) EP2337579A1 (https=)
JP (1) JP2012506394A (https=)
KR (1) KR20110086101A (https=)
CN (1) CN102196815A (https=)
AU (1) AU2009306711A1 (https=)
BR (1) BRPI0919857A2 (https=)
CA (1) CA2741130A1 (https=)
EA (1) EA201100626A1 (https=)
MX (1) MX2011004193A (https=)
WO (1) WO2010046097A1 (https=)
ZA (1) ZA201103726B (https=)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105992590A (zh) * 2014-02-19 2016-10-05 默克专利股份公司 靶定癌症的il-12免疫疗法
CN112768029A (zh) * 2020-12-27 2021-05-07 上海市东方医院（同济大学附属东方医院） 一种基于单细胞测序的组合用药推荐设备、方法及介质

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112019018915A2 (pt) 2017-03-15 2020-04-14 Pandion Therapeutics Inc imunotolerância direcionada
US9861833B1 (en) * 2017-03-30 2018-01-09 Norman H. Anderson Methods of treating melanoma
JP2020521452A (ja) 2017-05-24 2020-07-27 パンディオン・セラピューティクス・インコーポレイテッド 標的化免疫寛容
US10174091B1 (en) 2017-12-06 2019-01-08 Pandion Therapeutics, Inc. IL-2 muteins
US10946068B2 (en) 2017-12-06 2021-03-16 Pandion Operations, Inc. IL-2 muteins and uses thereof
USRE50550E1 (en) 2017-12-06 2025-08-26 Pandion Operations, Inc. IL-2 muteins and uses thereof
WO2020236875A1 (en) 2019-05-20 2020-11-26 Pandion Therapeutics, Inc. Madcam targeted immunotolerance
US11981715B2 (en) 2020-02-21 2024-05-14 Pandion Operations, Inc. Tissue targeted immunotolerance with a CD39 effector

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186804B2 (en) * 2001-12-04 2007-03-06 Emd Lexigen Research Center Corp. IL-2 fusion proteins with modulated selectivity

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2457701A (en) * 1999-12-28 2001-07-09 Brown University Research Foundation Methods and products for tumor immunotherapy using cytokines
DE60129695T2 (de) * 2000-06-29 2008-06-05 Merck Patent Gmbh Steigerung von durch antikörper-zytokin-fusionsproteine mediierten immunantworten durch eine kombinierte behandlung mit mitteln zur erhöhung der immunzytokinaufnahme
CA2593648A1 (en) * 2005-01-10 2006-07-13 Research Development Foundation Targeted chimeric molecules for cancer therapy
BRPI0620648B1 (pt) * 2005-12-30 2022-12-20 Merck Patent Gesellschaft Mit Beschrãnkter Haftung Variante de il-12 p40, proteínas il-12, il-23 e de fusão, composição farmacêutica e uso da mesma

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7186804B2 (en) * 2001-12-04 2007-03-06 Emd Lexigen Research Center Corp. IL-2 fusion proteins with modulated selectivity

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEVERLY A.T. ET AL.: "IN VIVO studies with interleukin-12 alone and in combination with monocyte colony-stimulating factor and/or fractionated radiation treatment.", 《INT.J.CANCER》 *
刘世喜 等: "细胞因子基因联合放射治疗小鼠头颈部鳞状细胞癌的实验研究", 《中华耳鼻咽喉科杂志》 *
姬舒荣: "IL-12抗肿瘤免疫治疗及其基因治疗的研究进展", 《国外医学（免疫学分册）》 *
孙蒙: "应用IL- 12 进行肿瘤免疫治疗的新进展", 《国外医学（免疫学分册）》 *
魏道严 等: "病毒载体介导mIL-12基因治疗联合放射治疗小鼠肝癌的研究", 《中华放射医学与防护杂志》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105992590A (zh) * 2014-02-19 2016-10-05 默克专利股份公司 靶定癌症的il-12免疫疗法
CN105992590B (zh) * 2014-02-19 2019-12-31 默克专利股份公司 靶定癌症的il-12免疫疗法
CN112768029A (zh) * 2020-12-27 2021-05-07 上海市东方医院（同济大学附属东方医院） 一种基于单细胞测序的组合用药推荐设备、方法及介质
CN112768029B (zh) * 2020-12-27 2023-10-13 上海市东方医院（同济大学附属东方医院） 一种基于单细胞测序的组合用药推荐设备、方法及介质

Also Published As

Publication number Publication date
WO2010046097A1 (en) 2010-04-29
MX2011004193A (es) 2011-05-24
JP2012506394A (ja) 2012-03-15
BRPI0919857A2 (pt) 2015-12-15
EA201100626A1 (ru) 2011-12-30
ZA201103726B (en) 2012-01-25
US20100330029A1 (en) 2010-12-30
CA2741130A1 (en) 2010-04-29
EP2337579A1 (en) 2011-06-29
AU2009306711A1 (en) 2010-04-29
KR20110086101A (ko) 2011-07-27

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Application publication date: 20110921