KR20110075014A - Ｐ70 ｓ6 키나제 억제제 및 ｍｔｏｒ 억제제 조합 요법 - Google Patents
Ｐ70 ｓ6 키나제 억제제 및 ｍｔｏｒ 억제제 조합 요법 Download PDFInfo
- Publication number
- KR20110075014A KR20110075014A KR1020117010616A KR20117010616A KR20110075014A KR 20110075014 A KR20110075014 A KR 20110075014A KR 1020117010616 A KR1020117010616 A KR 1020117010616A KR 20117010616 A KR20117010616 A KR 20117010616A KR 20110075014 A KR20110075014 A KR 20110075014A
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- KR
- South Korea
- Prior art keywords
- fluoro
- phenyl
- compound
- methyl
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P35/02—Antineoplastic agents specific for leukemia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
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- Hematology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11327908P | 2008-11-11 | 2008-11-11 | |
| US61/113,279 | 2008-11-11 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20110075014A true KR20110075014A (ko) | 2011-07-05 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020117010616A Abandoned KR20110075014A (ko) | 2008-11-11 | 2009-11-04 | Ｐ70 ｓ6 키나제 억제제 및 ｍｔｏｒ 억제제 조합 요법 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20110212977A1 (enExample) |
| EP (1) | EP2355820A1 (enExample) |
| JP (1) | JP2012508239A (enExample) |
| KR (1) | KR20110075014A (enExample) |
| CN (1) | CN102209539B (enExample) |
| AU (1) | AU2009314335B2 (enExample) |
| BR (1) | BRPI0921840A2 (enExample) |
| CA (1) | CA2743242A1 (enExample) |
| EA (1) | EA018824B1 (enExample) |
| MX (1) | MX2011005003A (enExample) |
| WO (1) | WO2010056574A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013116735A1 (en) * | 2012-02-01 | 2013-08-08 | 20/20 Gene Systems, Inc. | Methods for predicting tumor response to targeted therapies |
| HK1218756A1 (zh) * | 2013-03-11 | 2017-03-10 | 默克专利有限公司 | 用作激酶活性调节剂的6-[4-(1h-咪唑-2-基)哌啶-1-基]嘧啶-4-胺衍生物 |
| JP2017502092A (ja) | 2014-01-14 | 2017-01-19 | ミレニアム ファーマシューティカルズ， インコーポレイテッドＭｉｌｌｅｎｎｉｕｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | ヘテロアリール及びその使用 |
| TN2016000270A1 (en) | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
| GB201918815D0 (en) * | 2019-12-19 | 2020-02-05 | Imperial College Innovations Ltd | Treatment of cancer |
| WO2021142305A2 (en) * | 2020-01-10 | 2021-07-15 | Coimmune, Inc. | Methods of treating tumors |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
| JP5213229B2 (ja) * | 2004-04-23 | 2013-06-19 | エグゼリクシス， インコーポレイテッド | キナーゼ調節因子および使用方法 |
| US7994172B2 (en) * | 2004-12-28 | 2011-08-09 | Exelixis, Inc. | [1H-pyrazolo[3, 4-D]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (P70s6k, Atk1 and Atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| EP1946120A2 (en) * | 2005-10-18 | 2008-07-23 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
| UA99284C2 (ru) * | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
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2009
- 2009-11-04 CN CN2009801449528A patent/CN102209539B/zh not_active Expired - Fee Related
- 2009-11-04 MX MX2011005003A patent/MX2011005003A/es not_active Application Discontinuation
- 2009-11-04 JP JP2011535632A patent/JP2012508239A/ja not_active Withdrawn
- 2009-11-04 EP EP09752048A patent/EP2355820A1/en not_active Withdrawn
- 2009-11-04 KR KR1020117010616A patent/KR20110075014A/ko not_active Abandoned
- 2009-11-04 US US13/126,489 patent/US20110212977A1/en not_active Abandoned
- 2009-11-04 CA CA2743242A patent/CA2743242A1/en not_active Abandoned
- 2009-11-04 EA EA201170681A patent/EA018824B1/ru not_active IP Right Cessation
- 2009-11-04 WO PCT/US2009/063188 patent/WO2010056574A1/en not_active Ceased
- 2009-11-04 AU AU2009314335A patent/AU2009314335B2/en not_active Expired - Fee Related
- 2009-11-04 BR BRPI0921840A patent/BRPI0921840A2/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| WO2010056574A1 (en) | 2010-05-20 |
| JP2012508239A (ja) | 2012-04-05 |
| EP2355820A1 (en) | 2011-08-17 |
| AU2009314335B2 (en) | 2013-09-12 |
| US20110212977A1 (en) | 2011-09-01 |
| BRPI0921840A2 (pt) | 2018-10-09 |
| EA201170681A1 (ru) | 2011-10-31 |
| EA018824B1 (ru) | 2013-10-30 |
| CN102209539A (zh) | 2011-10-05 |
| AU2009314335A1 (en) | 2010-05-20 |
| CA2743242A1 (en) | 2010-05-20 |
| CN102209539B (zh) | 2013-06-12 |
| MX2011005003A (es) | 2011-05-25 |
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