EA018824B1 - КОМБИНИРОВАННАЯ ТЕРАПИЯ ИНГИБИТОРОМ КИНАЗЫ p70 S6 И ИНГИБИТОРОМ mTOR - Google Patents
КОМБИНИРОВАННАЯ ТЕРАПИЯ ИНГИБИТОРОМ КИНАЗЫ p70 S6 И ИНГИБИТОРОМ mTOR Download PDFInfo
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- EA018824B1 EA018824B1 EA201170681A EA201170681A EA018824B1 EA 018824 B1 EA018824 B1 EA 018824B1 EA 201170681 A EA201170681 A EA 201170681A EA 201170681 A EA201170681 A EA 201170681A EA 018824 B1 EA018824 B1 EA 018824B1
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- EA
- Eurasian Patent Office
- Prior art keywords
- fluoro
- pyrimidine
- pyrazolo
- piperidin
- methyl
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- 239000000651 prodrug Substances 0.000 description 1
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- ATLPLEZDTSBZQG-UHFFFAOYSA-N propan-2-ylphosphonic acid Chemical compound CC(C)P(O)(O)=O ATLPLEZDTSBZQG-UHFFFAOYSA-N 0.000 description 1
- PAQZWJGSJMLPMG-UHFFFAOYSA-N propylphosphonic anhydride Substances CCCP1(=O)OP(=O)(CCC)OP(=O)(CCC)O1 PAQZWJGSJMLPMG-UHFFFAOYSA-N 0.000 description 1
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Classifications
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
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- Medicinal Chemistry (AREA)
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- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Pulmonology (AREA)
- Oncology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11327908P | 2008-11-11 | 2008-11-11 | |
| PCT/US2009/063188 WO2010056574A1 (en) | 2008-11-11 | 2009-11-04 | P70 s6 kinase inhibitor and mtor inhibitor combination therapy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201170681A1 EA201170681A1 (ru) | 2011-10-31 |
| EA018824B1 true EA018824B1 (ru) | 2013-10-30 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| EA201170681A EA018824B1 (ru) | 2008-11-11 | 2009-11-04 | КОМБИНИРОВАННАЯ ТЕРАПИЯ ИНГИБИТОРОМ КИНАЗЫ p70 S6 И ИНГИБИТОРОМ mTOR |
Country Status (11)
| Country | Link |
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| US (1) | US20110212977A1 (enExample) |
| EP (1) | EP2355820A1 (enExample) |
| JP (1) | JP2012508239A (enExample) |
| KR (1) | KR20110075014A (enExample) |
| CN (1) | CN102209539B (enExample) |
| AU (1) | AU2009314335B2 (enExample) |
| BR (1) | BRPI0921840A2 (enExample) |
| CA (1) | CA2743242A1 (enExample) |
| EA (1) | EA018824B1 (enExample) |
| MX (1) | MX2011005003A (enExample) |
| WO (1) | WO2010056574A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140378500A1 (en) * | 2012-02-01 | 2014-12-25 | 20/20 Gene Systems, Inc. | Methods for predicting tumor reponse to targeted therapies |
| MX370448B (es) | 2013-03-11 | 2019-12-13 | Merck Patent Gmbh | Derivados de 6- [4- (1h-imidazol-2-il) piperidin-1-il] pirimidin-4-amina como moduladores de la actividad de cinasa. |
| WO2015108881A1 (en) | 2014-01-14 | 2015-07-23 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| TN2016000270A1 (en) | 2014-01-14 | 2017-10-06 | Millennium Pharm Inc | Heteroaryls and uses thereof. |
| GB201918815D0 (en) * | 2019-12-19 | 2020-02-05 | Imperial College Innovations Ltd | Treatment of cancer |
| CA3162074A1 (en) * | 2020-01-10 | 2021-07-15 | Joseph HORVATINOVICH | Methods of treating tumors |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117909A2 (en) * | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| WO2006071819A1 (en) * | 2004-12-28 | 2006-07-06 | Exelixis, Inc. | [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| WO2007047754A2 (en) * | 2005-10-18 | 2007-04-26 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| WO2008075109A1 (en) * | 2006-12-21 | 2008-06-26 | Astex Therapeutics Limited | Substituted piperidines having protein kinase inhibiting activity |
| WO2008140947A1 (en) * | 2007-05-11 | 2008-11-20 | Eli Lilly And Company | P70 s6 kinase inhibitors |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA83484C2 (uk) * | 2003-03-05 | 2008-07-25 | Уайт | Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція |
-
2009
- 2009-11-04 CA CA2743242A patent/CA2743242A1/en not_active Abandoned
- 2009-11-04 US US13/126,489 patent/US20110212977A1/en not_active Abandoned
- 2009-11-04 WO PCT/US2009/063188 patent/WO2010056574A1/en not_active Ceased
- 2009-11-04 BR BRPI0921840A patent/BRPI0921840A2/pt not_active IP Right Cessation
- 2009-11-04 EP EP09752048A patent/EP2355820A1/en not_active Withdrawn
- 2009-11-04 MX MX2011005003A patent/MX2011005003A/es not_active Application Discontinuation
- 2009-11-04 CN CN2009801449528A patent/CN102209539B/zh not_active Expired - Fee Related
- 2009-11-04 AU AU2009314335A patent/AU2009314335B2/en not_active Expired - Fee Related
- 2009-11-04 EA EA201170681A patent/EA018824B1/ru not_active IP Right Cessation
- 2009-11-04 KR KR1020117010616A patent/KR20110075014A/ko not_active Abandoned
- 2009-11-04 JP JP2011535632A patent/JP2012508239A/ja not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005117909A2 (en) * | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
| WO2006071819A1 (en) * | 2004-12-28 | 2006-07-06 | Exelixis, Inc. | [1h-pyrazolo[3, 4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-theoronine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases |
| WO2007047754A2 (en) * | 2005-10-18 | 2007-04-26 | George Mason Intellectual Properties, Inc. | Mtor pathway theranostic |
| WO2008075109A1 (en) * | 2006-12-21 | 2008-06-26 | Astex Therapeutics Limited | Substituted piperidines having protein kinase inhibiting activity |
| WO2008140947A1 (en) * | 2007-05-11 | 2008-11-20 | Eli Lilly And Company | P70 s6 kinase inhibitors |
Non-Patent Citations (3)
| Title |
|---|
| BAUMANN P. ET AL.: "Myeloma cell growth inhibition is augmented by synchronous inhibition of the insulin-like growth factor-1 receptor by NVP-AEW541 and inhibition of mammalian target of rapamycin by RadOOl", ANTI-CANCER DRUGS 200904 GB, vol. 20, no. 4, April 2009 (2009-04), pages 259-266, XP8118887, ISSN: 0959-4973, abstract * |
| IKEZOE T. ET AL.: "The antitumor effects of sunitinib (formerly SU11248) against a variety of human hematologic malignancies: Enhancement of growth inhibition via inhibition of mammalian target of rapamcycin signaling", MOLECULAR CANCER THERAPEUTICS 200610 US, vol. 5, no. 10, October 2006 (2006-10), pages 2522-2530, XP002568287, ISSN: 1535-7163, page 2529, right-hand column * |
| VAZQUEZ-MARTIN A. ET AL.: "Low-scale phosphoproteome analyses identify the mTOR effector p70 S6 kinase 1 as a specific biomarker of the dual-HERl/HER2 tyrosine kinase inhibitor lapatinib (Tykerb) in human breast carcinoma cells", ANNALS OF ONCOLOGY: OFFICIAL JOURNAL OF THE EUROPEAN SOCIETY FOR MEDICAL ONCOLOGY/ESMO JUN. 2008, vol. 19, no. 6, June 2008 (2008-06), pages 1097-1109, XP002568286, ISSN: 1569-8041, page 1107, right-hand column * |
Also Published As
| Publication number | Publication date |
|---|---|
| CA2743242A1 (en) | 2010-05-20 |
| AU2009314335B2 (en) | 2013-09-12 |
| CN102209539B (zh) | 2013-06-12 |
| CN102209539A (zh) | 2011-10-05 |
| MX2011005003A (es) | 2011-05-25 |
| AU2009314335A1 (en) | 2010-05-20 |
| BRPI0921840A2 (pt) | 2018-10-09 |
| US20110212977A1 (en) | 2011-09-01 |
| EP2355820A1 (en) | 2011-08-17 |
| JP2012508239A (ja) | 2012-04-05 |
| KR20110075014A (ko) | 2011-07-05 |
| WO2010056574A1 (en) | 2010-05-20 |
| EA201170681A1 (ru) | 2011-10-31 |
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| Date | Code | Title | Description |
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| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ BY KZ KG MD TJ TM RU |