KR20110044166A - 통증 및 소양증 치료용 방법, 조성물 및 키트 - Google Patents

통증 및 소양증 치료용 방법, 조성물 및 키트 Download PDF

Info

Publication number
KR20110044166A
KR20110044166A KR1020107022652A KR20107022652A KR20110044166A KR 20110044166 A KR20110044166 A KR 20110044166A KR 1020107022652 A KR1020107022652 A KR 1020107022652A KR 20107022652 A KR20107022652 A KR 20107022652A KR 20110044166 A KR20110044166 A KR 20110044166A
Authority
KR
South Korea
Prior art keywords
compound
channels
pain
voltage
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020107022652A
Other languages
English (en)
Korean (ko)
Inventor
브루스 피. 벤
클리포드 제이. 울프
Original Assignee
프레지던트 앤드 펠로우즈 오브 하바드 칼리지
더 제너럴 하스피탈 코포레이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 프레지던트 앤드 펠로우즈 오브 하바드 칼리지, 더 제너럴 하스피탈 코포레이션 filed Critical 프레지던트 앤드 펠로우즈 오브 하바드 칼리지
Publication of KR20110044166A publication Critical patent/KR20110044166A/ko
Withdrawn legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A61K31/24—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group having an amino or nitro group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Emergency Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Neurosurgery (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
KR1020107022652A 2008-03-11 2009-03-11 통증 및 소양증 치료용 방법, 조성물 및 키트 Withdrawn KR20110044166A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6901808P 2008-03-11 2008-03-11
US61/069,018 2008-03-11

Publications (1)

Publication Number Publication Date
KR20110044166A true KR20110044166A (ko) 2011-04-28

Family

ID=41065720

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020107022652A Withdrawn KR20110044166A (ko) 2008-03-11 2009-03-11 통증 및 소양증 치료용 방법, 조성물 및 키트

Country Status (11)

Country Link
US (1) US20110086818A1 (enExample)
EP (1) EP2271329A4 (enExample)
JP (1) JP2011513484A (enExample)
KR (1) KR20110044166A (enExample)
CN (1) CN102112121A (enExample)
AU (1) AU2009223739A1 (enExample)
BR (1) BRPI0909627A2 (enExample)
CA (1) CA2717042A1 (enExample)
IL (1) IL208027A0 (enExample)
MX (1) MX2010009951A (enExample)
WO (1) WO2009114139A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101867779B1 (ko) * 2017-12-08 2018-06-19 서울대학교산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법
KR101877002B1 (ko) * 2017-03-06 2018-07-12 서울대학교 산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2101819B1 (en) 2006-11-20 2013-01-09 President and Fellows of Harvard College Methods, compositions, and kits for treating pain and pruritis
WO2010085589A2 (en) 2009-01-22 2010-07-29 G&H Brands Llc Desensitizing drug product
EP2995303A1 (en) 2009-07-10 2016-03-16 President and Fellows of Harvard College Permanently charged sodium and calcium channel blockers as anti-inflammatory agents
JP5832856B2 (ja) * 2010-12-15 2015-12-16 久光製薬株式会社 局所鎮痛作用増強剤及び局所鎮痛キット
CN103547566B (zh) 2011-02-18 2017-05-31 阿萨纳生物科技有限责任公司 氨基茚满化合物及其治疗疼痛的用途
ES2596215T3 (es) 2011-10-24 2017-01-05 Asana Biosciences, Llc Ciclohexilaminas
US8779003B2 (en) 2011-12-29 2014-07-15 Mackay Memorial Hospital Method and composition for prolonging analgesic effect of local anesthetic
TWI603957B (zh) 2012-08-15 2017-11-01 阿沙納生物科學有限責任公司 胺基氫茚化合物用於治療膀胱過動症及間質性膀胱炎之用途
ES2675215T3 (es) 2013-02-08 2018-07-09 General Mills, Inc. Productos alimentarios reducidos en sodio
AU2015247815A1 (en) * 2014-04-14 2016-11-03 Flex Pharma, Inc. Ion channel activators and methods of use
WO2017024037A1 (en) * 2015-08-03 2017-02-09 President And Fellows Of Harvard College Charged ion channel blockers and methods for use
CN106214678B (zh) * 2016-07-26 2020-12-29 上海璃道医药科技有限公司 苯酮类药物的用途
US11253493B2 (en) 2017-01-23 2022-02-22 Cliff-Cartwright Corporation Compositions and methods affecting exercise performance
WO2019144139A1 (en) * 2018-01-22 2019-07-25 Oregon State University Immunogenic compositions comprising mycobacterium bovis surface proteins and uses thereof
US12023332B2 (en) 2018-03-05 2024-07-02 Wylder Nation Foundation Compositions and methods for activating signaling through the CB1 cannabinoid receptor for treating and preventing diseases and disorders characterized by abnormal cellular accumulation of sphingolipids such as sphingomyelin
KR102954667B1 (ko) * 2018-08-15 2026-04-17 파마실 아베 치환된 벤즈아미드 및 치료법에서 이의 용도
CN109498604A (zh) * 2018-12-24 2019-03-22 复旦大学 香叶醇新用途，预防和治疗非疾病引起的瘙痒症的配制品及方法
BR112021017809A2 (pt) 2019-03-11 2021-11-23 Nocion Therapeutics Inc Bloqueadores de canais iônicos substituídos por éster e métodos para uso
US10786485B1 (en) 2019-03-11 2020-09-29 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10780083B1 (en) 2019-03-11 2020-09-22 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
MA55307A (fr) 2019-03-11 2022-01-19 Nocion Therapeutics Inc Bloqueurs de canaux ioniques chargés et procédés d'utilisation
EP3937945A4 (en) * 2019-03-11 2023-01-04 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
WO2021091585A1 (en) 2019-11-06 2021-05-14 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US10933055B1 (en) 2019-11-06 2021-03-02 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
US20230165812A1 (en) * 2020-02-27 2023-06-01 President And Fellows Of Harvard College Nociceptor neurons control cancer immunosurveillance
JP2023515874A (ja) * 2020-03-04 2023-04-14 ノイキュアズ，インコーポレーテッド Ｔｒｐｖ１調節物質の投与に関連する交感神経興奮を防止するためのｑｘ３１４の使用
US12162851B2 (en) 2020-03-11 2024-12-10 Nocion Therapeutics, Inc. Charged ion channel blockers and methods for use
JP7708777B2 (ja) 2020-03-11 2025-07-15 ノシオン セラピューティクス，インコーポレイテッド 荷電したイオンチャンネル遮断薬および使用方法
CN113509457B (zh) * 2020-09-07 2023-03-21 四川昇嘉科技有限公司 山椒素在制备治疗湿疹的药物中的用途
US11977085B1 (en) 2023-09-05 2024-05-07 Elan Ehrlich Date rape drug detection device and method of using same

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6413961B1 (en) * 1995-12-12 2002-07-02 Omeros Medical Systems, Inc. Irrigation solution and method for inhibition of pain and inflammation
MXPA02006051A (es) * 1999-12-15 2004-08-23 Ucb Farchim Sa Compuestos de amonio cuaternario ciclico.
WO2002089849A1 (en) * 2001-05-07 2002-11-14 Corium International Compositions and delivery systems for administration of a local anesthetic agent
EP1610742B1 (en) * 2003-04-10 2015-01-21 Neurogesx, Inc. Uses and compositions for administration of capsaicin
ES2223277B1 (es) * 2003-06-19 2006-03-01 Fernando Bouffard Fita Composicion anestesica para administracion topica.
EP1713450B1 (en) * 2004-01-30 2021-10-06 Corium, Inc. Rapidly dissolving film for delivery of an active agent
JP5148271B2 (ja) * 2004-06-02 2013-02-20 ニューロジズエックス，インコーポレーテッド 疼痛処置のためのカプサイシノイド、局所麻酔薬および／または鎮痒薬を含有する処方物
EP2101819B1 (en) * 2006-11-20 2013-01-09 President and Fellows of Harvard College Methods, compositions, and kits for treating pain and pruritis

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101877002B1 (ko) * 2017-03-06 2018-07-12 서울대학교 산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법
KR101867779B1 (ko) * 2017-12-08 2018-06-19 서울대학교산학협력단 피라졸 유도체를 유효성분으로 함유하는 소양증의 예방 또는 치료용 약학적 조성물 및 이를 검출하기 위한 스크리닝 방법

Also Published As

Publication number Publication date
US20110086818A1 (en) 2011-04-14
WO2009114139A2 (en) 2009-09-17
AU2009223739A1 (en) 2009-09-17
WO2009114139A3 (en) 2009-12-23
IL208027A0 (en) 2010-12-30
EP2271329A2 (en) 2011-01-12
EP2271329A4 (en) 2013-01-09
JP2011513484A (ja) 2011-04-28
CA2717042A1 (en) 2009-09-17
CN102112121A (zh) 2011-06-29
MX2010009951A (es) 2011-09-01
BRPI0909627A2 (pt) 2018-04-10

Similar Documents

Publication Publication Date Title
US20210186906A1 (en) Methods, compositions, and kits for treating pain and pruritis
US20110086818A1 (en) Methods, compositions, and kits for treating pain and pruritus
JP6530005B2 (ja) 抗炎症剤としての恒久的に荷電したナトリウムおよびカルシウムチャンネルブロッカー
JP7628539B2 (ja) 荷電したイオンチャンネル遮断薬および使用方法
JP7513713B2 (ja) 荷電したイオンチャンネル遮断薬および使用方法
AU2016301282A1 (en) Charged ion channel blockers and methods for use
KR20210143214A (ko) 하전된 이온 채널 차단제 및 사용 방법
CN101610789A (zh) 治疗疼痛和瘙痒的方法、组合物和试剂盒
HK1169953A (en) Methods, compositions, and kits for treating pain and pruritis
HK1159480A (en) Methods, compositions, and kits for treating pain and pruritis

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20101011

Patent event code: PA01051R01D

Comment text: International Patent Application

N231 Notification of change of applicant
PN2301 Change of applicant

Patent event date: 20110316

Comment text: Notification of Change of Applicant

Patent event code: PN23011R01D

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid