KR20110031908A - 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물 - Google Patents

혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물 Download PDF

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KR20110031908A
KR20110031908A KR1020107027046A KR20107027046A KR20110031908A KR 20110031908 A KR20110031908 A KR 20110031908A KR 1020107027046 A KR1020107027046 A KR 1020107027046A KR 20107027046 A KR20107027046 A KR 20107027046A KR 20110031908 A KR20110031908 A KR 20110031908A
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alk1
polypeptide
seq
mammal
antibody
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Korean (ko)
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아시아 그린버그
존 크노프
라빈드라 쿠마르
로버트 스콧 퍼살
자스비르 씨라
크리스티안 피에트라스
Original Assignee
악셀레론 파마 인코포레이티드
루드비히 인스티튜트 포우 캔써 리써치 엘티디.
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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KR1020107027046A 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물 Ceased KR20110031908A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US5016808P 2008-05-02 2008-05-02
US61/050,168 2008-05-02
US14413109P 2009-01-12 2009-01-12
US61/144,131 2009-01-12

Related Child Applications (1)

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KR1020177002063A Division KR20170012595A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물

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KR20110031908A true KR20110031908A (ko) 2011-03-29

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KR1020107027046A Ceased KR20110031908A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020187006926A Ceased KR20180029111A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020197008836A Withdrawn KR20190037355A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020217028926A Ceased KR20210113446A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020217003129A Withdrawn KR20210014224A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020177002063A Ceased KR20170012595A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020197032900A Withdrawn KR20190128254A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020207018412A Withdrawn KR20200079567A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물

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KR1020187006926A Ceased KR20180029111A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020197008836A Withdrawn KR20190037355A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020217028926A Ceased KR20210113446A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020217003129A Withdrawn KR20210014224A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020177002063A Ceased KR20170012595A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020197032900A Withdrawn KR20190128254A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물
KR1020207018412A Withdrawn KR20200079567A (ko) 2008-05-02 2009-05-01 혈관신생 및 혈관주위세포 적용범위의 조정을 위한 ａｌｋ１ 길항제 기재의 방법 및 조성물

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US (4) US8158584B2 (enExample)
EP (2) EP3398966A1 (enExample)
JP (5) JP5719766B2 (enExample)
KR (8) KR20110031908A (enExample)
CN (2) CN105963695A (enExample)
AU (5) AU2009241755B2 (enExample)
BR (1) BRPI0911853A8 (enExample)
CA (1) CA2723449C (enExample)
MX (2) MX2010011998A (enExample)
TW (3) TWI586364B (enExample)
WO (1) WO2009134428A2 (enExample)

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US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
CN105658672A (zh) * 2013-08-22 2016-06-08 阿塞勒隆制药公司 TGF-β受体II型变体及其用途
JP2016036322A (ja) * 2014-08-11 2016-03-22 日本化薬株式会社 血管新生因子と結合するキメラタンパク質
HK1250373A1 (zh) * 2015-04-06 2018-12-14 Acceleron Pharma Inc. Alk7:actriib异多聚体和其用途
MD3280727T2 (ro) * 2015-04-06 2021-06-30 Acceleron Pharma Inc Proteine de fuziune ale receptorului de tip I și de tip II cu un singur braț și utilizările acestora
CN110498851B (zh) * 2015-11-10 2022-10-11 孙嘉琳 一种抗肿瘤蛋白内皮抑素的衍生物及应用
RU2748278C2 (ru) 2016-07-15 2021-05-21 Акселерон Фарма Инк. Композиции и способы лечения легочной гипертензии
JP7280182B2 (ja) 2016-10-05 2023-05-23 アクセルロン ファーマ インコーポレイテッド バリアントＡｃｔＲＩＩＢタンパク質およびその使用
CN111344306A (zh) * 2017-11-02 2020-06-26 拜耳股份公司 结合alk-1和bmpr-2的双特异性抗体
CN114028541A (zh) * 2021-05-21 2022-02-11 中山大学 Gdf2在制备改善肿瘤异常血管的药物中的用途
WO2024153115A1 (zh) * 2023-01-18 2024-07-25 开拓药业(广东)有限公司 抗alk-1抗体及其用途
KR20250168499A (ko) 2023-04-07 2025-12-02 다이애고널 테라퓨틱스 인코포레이티드 액티빈 a 수용체 유사 유형 1(alk1)에 대한 이중 특이적 효현성 항체

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