BRPI0911853A8 - composições e métodos para a modulação de angiogênese e composição de pericito - Google Patents

composições e métodos para a modulação de angiogênese e composição de pericito Download PDF

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Publication number
BRPI0911853A8
BRPI0911853A8 BRPI0911853A BRPI0911853A BRPI0911853A8 BR PI0911853 A8 BRPI0911853 A8 BR PI0911853A8 BR PI0911853 A BRPI0911853 A BR PI0911853A BR PI0911853 A BRPI0911853 A BR PI0911853A BR PI0911853 A8 BRPI0911853 A8 BR PI0911853A8
Authority
BR
Brazil
Prior art keywords
pericyte
compositions
composition
methods
angiogenesis modulation
Prior art date
Application number
BRPI0911853A
Other languages
English (en)
Inventor
Grinberg Asya
Seehra Jasbir
Knopf John
Pietras Kristian
Kumar Ravindra
Scott Pearsall Robert
Original Assignee
Acceleron Pharma Inc
Ludwig Inst For Cancer Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc, Ludwig Inst For Cancer Res Ltd filed Critical Acceleron Pharma Inc
Publication of BRPI0911853A2 publication Critical patent/BRPI0911853A2/pt
Publication of BRPI0911853A8 publication Critical patent/BRPI0911853A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/45—Transferases (2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"
BRPI0911853A 2008-05-02 2009-05-01 composições e métodos para a modulação de angiogênese e composição de pericito BRPI0911853A8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5016808P 2008-05-02 2008-05-02
US14413109P 2009-01-12 2009-01-12
PCT/US2009/002699 WO2009134428A2 (en) 2008-05-02 2009-05-01 Methods and compositions for modulating angiogenesis and pericyte composition

Publications (2)

Publication Number Publication Date
BRPI0911853A2 BRPI0911853A2 (pt) 2016-06-14
BRPI0911853A8 true BRPI0911853A8 (pt) 2018-03-06

Family

ID=41055305

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0911853A BRPI0911853A8 (pt) 2008-05-02 2009-05-01 composições e métodos para a modulação de angiogênese e composição de pericito

Country Status (11)

Country Link
US (4) US8158584B2 (pt)
EP (2) EP3398966A1 (pt)
JP (5) JP5719766B2 (pt)
KR (8) KR20190128254A (pt)
CN (2) CN102099374B (pt)
AU (5) AU2009241755B2 (pt)
BR (1) BRPI0911853A8 (pt)
CA (1) CA2723449C (pt)
MX (1) MX2010011998A (pt)
TW (3) TWI672151B (pt)
WO (1) WO2009134428A2 (pt)

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EP3181580A1 (en) * 2006-11-02 2017-06-21 Acceleron Pharma Inc. Alk1 receptor and ligand antagonists and uses thereof
CA2703099A1 (en) 2007-11-09 2009-05-14 Genentech, Inc. Activin receptor-like kinase-i compositions and methods of use
TWI672151B (zh) * 2008-05-02 2019-09-21 艾西利羅製藥公司 調節血管新生與周圍細胞組成的方法與組合物
CA2724525A1 (en) * 2008-05-15 2009-11-19 Acceleron Pharma, Inc. Antagonists of bmp9, bmp10, alk1 and other alk1 ligands, and uses thereof
KR20140123558A (ko) * 2012-02-02 2014-10-22 악셀레론 파마 인코포레이티드 Alk1 길항제 및 신세포 암종 치료에서의 그의 용도
US9809636B2 (en) 2012-04-06 2017-11-07 Acceleron Pharma Inc. Methods for increasing red blood cell levels comprising administering BMP9
CN116655801A (zh) * 2013-08-22 2023-08-29 阿塞勒隆制药公司 TGF-β受体II型变体及其用途
JP2016036322A (ja) * 2014-08-11 2016-03-22 日本化薬株式会社 血管新生因子と結合するキメラタンパク質
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EA037293B1 (ru) 2015-04-06 2021-03-05 Акселерон Фарма Инк. Гетеромультимеры рецепторов типа i и типа ii белков суперсемейства tgf-бета
CN110498851B (zh) * 2015-11-10 2022-10-11 孙嘉琳 一种抗肿瘤蛋白内皮抑素的衍生物及应用
EP3496739B1 (en) 2016-07-15 2021-04-28 Acceleron Pharma Inc. Compositions comprising actriia polypeptides for use in treating pulmonary hypertension
CN110036025B (zh) 2016-10-05 2024-03-22 阿塞勒隆制药公司 变体ActRIIB蛋白及其用途
EP3704153A2 (en) * 2017-11-02 2020-09-09 Bayer Aktiengesellschaft Bispecific antibodies binding alk-1 and bmpr-2
CN114028541A (zh) * 2021-05-21 2022-02-11 中山大学 Gdf2在制备改善肿瘤异常血管的药物中的用途

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CA2703099A1 (en) * 2007-11-09 2009-05-14 Genentech, Inc. Activin receptor-like kinase-i compositions and methods of use
TWI672151B (zh) * 2008-05-02 2019-09-21 艾西利羅製藥公司 調節血管新生與周圍細胞組成的方法與組合物
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Also Published As

Publication number Publication date
CN102099374B (zh) 2016-06-08
TWI672151B (zh) 2019-09-21
EP2283040A2 (en) 2011-02-16
AU2018200237A1 (en) 2018-02-01
JP5719766B2 (ja) 2015-05-20
KR20190037355A (ko) 2019-04-05
KR20190128254A (ko) 2019-11-15
JP2017101068A (ja) 2017-06-08
WO2009134428A2 (en) 2009-11-05
AU2018200237B2 (en) 2019-10-03
KR20180029111A (ko) 2018-03-19
CA2723449C (en) 2020-01-21
KR20110031908A (ko) 2011-03-29
CN105963695A (zh) 2016-09-28
KR20170012595A (ko) 2017-02-02
AU2016200018A1 (en) 2016-01-28
US8158584B2 (en) 2012-04-17
JP6194302B2 (ja) 2017-09-06
US20130039910A1 (en) 2013-02-14
AU2021286240A1 (en) 2022-01-06
EP3398966A1 (en) 2018-11-07
TW201737947A (zh) 2017-11-01
WO2009134428A3 (en) 2010-03-04
US20090311272A1 (en) 2009-12-17
BRPI0911853A2 (pt) 2016-06-14
TWI586364B (zh) 2017-06-11
AU2009241755B2 (en) 2015-10-01
JP2021183652A (ja) 2021-12-02
US20180179293A1 (en) 2018-06-28
JP2015042680A (ja) 2015-03-05
MX2010011998A (es) 2011-04-11
US20210388104A1 (en) 2021-12-16
AU2019232838A1 (en) 2019-10-10
AU2019232838B2 (en) 2021-09-16
CA2723449A1 (en) 2009-11-05
TW201609138A (zh) 2016-03-16
JP2019210298A (ja) 2019-12-12
KR20210014224A (ko) 2021-02-08
JP2011520793A (ja) 2011-07-21
CN102099374A (zh) 2011-06-15
KR20200079567A (ko) 2020-07-03
KR20210113446A (ko) 2021-09-15
TW200950806A (en) 2009-12-16
AU2009241755A1 (en) 2009-11-05

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