CN105963695A - 用于调节血管发生和周细胞包裹的基于alk1拮抗剂的方法和组合物 - Google Patents

用于调节血管发生和周细胞包裹的基于alk1拮抗剂的方法和组合物 Download PDF

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Publication number
CN105963695A
CN105963695A CN201610297436.0A CN201610297436A CN105963695A CN 105963695 A CN105963695 A CN 105963695A CN 201610297436 A CN201610297436 A CN 201610297436A CN 105963695 A CN105963695 A CN 105963695A
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alk1
polypeptide
angiogenesis
seq
tumor
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Pending
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CN201610297436.0A
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Chinese (zh)
Inventor
阿斯亚·格林贝格
约翰·克诺夫
拉温德拉·库马尔
罗伯特·斯科特·皮尔索尔
亚斯比尔·西拉
克里斯蒂安·彼得拉斯
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Ludwig Institute for Cancer Research Ltd
Acceleron Pharma Inc
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Ludwig Institute for Cancer Research Ltd
Acceleron Pharma Inc
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Publication of CN105963695A publication Critical patent/CN105963695A/zh
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/32—Fusion polypeptide fusions with soluble part of a cell surface receptor, "decoy receptors"

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CN201610297436.0A 2008-05-02 2009-05-01 用于调节血管发生和周细胞包裹的基于alk1拮抗剂的方法和组合物 Pending CN105963695A (zh)

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Application Number Priority Date Filing Date Title
US5016808P 2008-05-02 2008-05-02
US61/050,168 2008-05-02
US14413109P 2009-01-12 2009-01-12
US61/144,131 2009-01-12
CN200980125712.3A CN102099374B (zh) 2008-05-02 2009-05-01 用于调节血管发生和周细胞包裹的基于alk1拮抗剂的方法和组合物

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CN200980125712.3A Expired - Fee Related CN102099374B (zh) 2008-05-02 2009-05-01 用于调节血管发生和周细胞包裹的基于alk1拮抗剂的方法和组合物

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US (4) US8158584B2 (enExample)
EP (2) EP3398966A1 (enExample)
JP (5) JP5719766B2 (enExample)
KR (8) KR20170012595A (enExample)
CN (2) CN105963695A (enExample)
AU (5) AU2009241755B2 (enExample)
BR (1) BRPI0911853A8 (enExample)
CA (1) CA2723449C (enExample)
MX (2) MX391905B (enExample)
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Cited By (2)

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Publication number Priority date Publication date Assignee Title
CN111344306A (zh) * 2017-11-02 2020-06-26 拜耳股份公司 结合alk-1和bmpr-2的双特异性抗体
CN114028541A (zh) * 2021-05-21 2022-02-11 中山大学 Gdf2在制备改善肿瘤异常血管的药物中的用途

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WO2024153115A1 (zh) * 2023-01-18 2024-07-25 开拓药业(广东)有限公司 抗alk-1抗体及其用途
KR20250168499A (ko) 2023-04-07 2025-12-02 다이애고널 테라퓨틱스 인코포레이티드 액티빈 a 수용체 유사 유형 1(alk1)에 대한 이중 특이적 효현성 항체

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