KR20110013450A - 간엽 줄기 세포 및 골-형성 세포 - Google Patents

간엽 줄기 세포 및 골-형성 세포 Download PDF

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KR20110013450A
KR20110013450A KR20107027373A KR20107027373A KR20110013450A KR 20110013450 A KR20110013450 A KR 20110013450A KR 20107027373 A KR20107027373 A KR 20107027373A KR 20107027373 A KR20107027373 A KR 20107027373A KR 20110013450 A KR20110013450 A KR 20110013450A
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cells
bone
msc
forming
cell
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Korean (ko)
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신디 바되어
엔리코 바스티아넬리
사비에 페세쓰
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본 테라퓨틱스 소시에테아노님
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    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
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  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Transplantation (AREA)
  • Pharmacology & Pharmacy (AREA)
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KR20107027373A 2008-05-07 2009-05-07 간엽 줄기 세포 및 골-형성 세포 Ceased KR20110013450A (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP08155764 2008-05-07
EP08155764.7 2008-05-07

Related Child Applications (1)

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KR1020167013649A Division KR20160065213A (ko) 2008-05-07 2009-05-07 간엽 줄기 세포 및 골-형성 세포

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KR20110013450A true KR20110013450A (ko) 2011-02-09

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KR20107027373A Ceased KR20110013450A (ko) 2008-05-07 2009-05-07 간엽 줄기 세포 및 골-형성 세포
KR1020167013649A Ceased KR20160065213A (ko) 2008-05-07 2009-05-07 간엽 줄기 세포 및 골-형성 세포

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US (3) US9371515B2 (enExample)
EP (1) EP2291516B1 (enExample)
JP (2) JP6097479B2 (enExample)
KR (2) KR20110013450A (enExample)
CN (1) CN102016008A (enExample)
AU (1) AU2009245751B2 (enExample)
BE (1) BE1018748A3 (enExample)
CA (1) CA2722625A1 (enExample)
WO (1) WO2009135905A2 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20110013450A (ko) * 2008-05-07 2011-02-09 본 테라퓨틱스 소시에테아노님 간엽 줄기 세포 및 골-형성 세포
US9192695B2 (en) 2008-11-20 2015-11-24 Allosource Allografts combined with tissue derived stem cells for bone healing
WO2011155649A1 (en) * 2010-06-11 2011-12-15 University-Industry Cooperation Group Of Kyunghee University Agent for osteogenesis using substance-p and preparation process thereof
KR102108245B1 (ko) * 2011-11-30 2020-05-08 아스텔라스 인스티튜트 포 리제너러티브 메디슨 중간엽 간질 세포 및 이에 관련된 용도
US8961956B2 (en) 2011-11-30 2015-02-24 Ocata Therapeutics, Inc. Mesenchymal stromal cells and uses related thereto
CN104471059B (zh) 2012-07-12 2018-04-17 珠海横琴爱姆斯坦生物科技有限公司 人胚胎干细胞衍生的间充质样干细胞、方法及其应用
CN102827807B (zh) * 2012-09-19 2014-04-16 北京京蒙高科干细胞技术有限公司 一种间充质干细胞无血清培养基
WO2014113704A2 (en) * 2013-01-18 2014-07-24 Escape Therapeutics, Inc. Enhanced differentiation of mesenchymal stem cells
KR102312720B1 (ko) 2013-03-15 2021-10-13 알로소스 연조직 회복 및 재생을 위한 세포 재배치된 콜라겐 매트릭스
KR101528305B1 (ko) * 2013-06-25 2015-06-11 사회복지법인 삼성생명공익재단 중간엽 줄기세포로부터 유래된, 내피세포의 특성을 포함하는 신규한 줄기세포
DK3083944T3 (da) * 2013-12-19 2021-02-15 Univ Liege Pattedyrsmuskelafledte stamceller
WO2015155777A1 (en) * 2014-04-10 2015-10-15 Bonus Therapeutics Ltd. Bone repair compositions
CA3017772C (en) 2016-03-16 2023-02-21 Cynata Therapeutics Limited Colony forming medium and use thereof
WO2019006328A1 (en) 2017-06-30 2019-01-03 Allosource CELL BONE GRAFTS, AND METHODS OF MAKING AND USING
KR20210076018A (ko) * 2018-09-25 2021-06-23 본 테라퓨틱스 소시에테아노님 체외 분화 세포의 골형성능을 판정하기 위한 방법 및 용도
KR20240089678A (ko) * 2021-11-18 2024-06-20 고쿠리츠 다이가쿠호우징 도쿄이카시카다이가쿠 간엽계 줄기세포를 포함하는 세포 집단, 세포 시트 및 세포 시트의 제조 방법

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5486359A (en) 1990-11-16 1996-01-23 Osiris Therapeutics, Inc. Human mesenchymal stem cells
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5811094A (en) 1990-11-16 1998-09-22 Osiris Therapeutics, Inc. Connective tissue regeneration using human mesenchymal stem cell preparations
CN1104257C (zh) 1993-03-29 2003-04-02 津莫吉尼蒂克斯公司 含pdgf和维生素d的刺激成骨细胞生长的组合物
US5972703A (en) 1994-08-12 1999-10-26 The Regents Of The University Of Michigan Bone precursor cells: compositions and methods
US5736396A (en) 1995-01-24 1998-04-07 Case Western Reserve University Lineage-directed induction of human mesenchymal stem cell differentiation
US5827740A (en) 1996-07-30 1998-10-27 Osiris Therapeutics, Inc. Adipogenic differentiation of human mesenchymal stem cells
WO2000007639A1 (en) 1998-08-07 2000-02-17 Tissue Engineering, Inc. Bone precursor compositions
EP1099754A1 (en) * 1999-11-10 2001-05-16 Universiteit Leiden Mesenchymal stem cells and/or progenitor cells, their isolation and use
US20030032034A1 (en) * 2001-03-05 2003-02-13 Tang Y. Tom Methods and materials relating to stem cell growth factor-like polypeptides and polynucleotides
DE10158680B4 (de) * 2001-11-30 2004-04-08 Universitätsklinikum Hamburg-Eppendorf Verfahren zur ex vivo-Expansion und -Differenzierung von multipotenten Stammzellen
US20050019910A1 (en) * 2001-12-13 2005-01-27 Mutsumi Takagi Human cell culture medium and culture method
US7470538B2 (en) 2002-12-05 2008-12-30 Case Western Reserve University Cell-based therapies for ischemia
US20060205071A1 (en) * 2003-07-17 2006-09-14 Gamida-Cell Ltd. Methods for ex-vivo expanding stem/progenitor cells
US9074190B2 (en) * 2003-10-07 2015-07-07 Biomaster, Inc. Cell differentiation of adipose-derived precursor cells
JP2005287479A (ja) 2004-03-31 2005-10-20 Kazuhisa Maeda 組織幹細胞採取方法及びそれを利用した装置
US20060134781A1 (en) * 2004-12-07 2006-06-22 Bacterin International, Inc. Three-dimensional cell culture system
JP2006230316A (ja) 2005-02-25 2006-09-07 Japan Health Science Foundation 瘢痕のない創傷治癒能を有する細胞およびその調製方法
JPWO2006134951A1 (ja) * 2005-06-13 2009-01-08 株式会社バイオマスター 脂肪由来幹細胞の長期培養増殖法
US7989205B2 (en) * 2005-10-06 2011-08-02 American Cryostem Corporation Cell culture media, kits and methods of use
CZ301148B6 (cs) * 2006-01-25 2009-11-18 Univerzita Karlova V Praze Zpusob pestování lidských mezenchymových kmenových bunek, zejména pro lécbu nehojících se fraktur, a bioreaktor k provádení tohoto zpusobu
US8337827B2 (en) * 2006-02-16 2012-12-25 Universite Libre de Bruxelies Method for osteogenic differentiation of bone marrow stem cells (BMSC) and uses thereof
JP5155530B2 (ja) * 2006-07-25 2013-03-06 株式会社カネカ 成体幹細胞分離・培養システム
WO2008018190A1 (en) * 2006-08-09 2008-02-14 Biomaster, Inc. Fat-derived neural crest cells
KR20110013450A (ko) * 2008-05-07 2011-02-09 본 테라퓨틱스 소시에테아노님 간엽 줄기 세포 및 골-형성 세포

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AU2009245751B2 (en) 2014-09-18
EP2291516A2 (en) 2011-03-09
KR20160065213A (ko) 2016-06-08
JP2017099386A (ja) 2017-06-08
US20170290859A1 (en) 2017-10-12
US20110262404A1 (en) 2011-10-27
CN102016008A (zh) 2011-04-13
US20140093480A1 (en) 2014-04-03
CA2722625A1 (en) 2009-11-12
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US9371515B2 (en) 2016-06-21
AU2009245751A1 (en) 2009-11-12
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