KR20100119768A - 아이에이피 억제제 - Google Patents
아이에이피 억제제 Download PDFInfo
- Publication number
- KR20100119768A KR20100119768A KR1020107018102A KR20107018102A KR20100119768A KR 20100119768 A KR20100119768 A KR 20100119768A KR 1020107018102 A KR1020107018102 A KR 1020107018102A KR 20107018102 A KR20107018102 A KR 20107018102A KR 20100119768 A KR20100119768 A KR 20100119768A
- Authority
- KR
- South Korea
- Prior art keywords
- compound
- alkyl
- mmol
- hydroxy
- pharmaceutically acceptable
- Prior art date
Links
- 0 *c([n](*)c1c2c(*)c(*)c(*)c1*[O-])c2S Chemical compound *c([n](*)c1c2c(*)c(*)c(*)c1*[O-])c2S 0.000 description 16
- CSXNJPHCILPDOJ-TZHYSIJRSA-N CC(C)(C)OC(N(CC1)[C@H](Cc(c2ccccc2[nH]2)c2Br)C1OC(C)=O)=O Chemical compound CC(C)(C)OC(N(CC1)[C@H](Cc(c2ccccc2[nH]2)c2Br)C1OC(C)=O)=O CSXNJPHCILPDOJ-TZHYSIJRSA-N 0.000 description 1
- HOHWFCNJXYVGSR-DHIUTWEWSA-N CC(C)(C)OC(N(CC1)[C@H](Cc2c(-c(cc3)ccc3F)[nH]c3c2cccc3)[C@@H]1OC(C)=O)=O Chemical compound CC(C)(C)OC(N(CC1)[C@H](Cc2c(-c(cc3)ccc3F)[nH]c3c2cccc3)[C@@H]1OC(C)=O)=O HOHWFCNJXYVGSR-DHIUTWEWSA-N 0.000 description 1
- RNDKWDBMRLWZAH-MSOLQXFVSA-N CC(C)(C)OC(N(CC1)[C@H](Cc2c[nH]c3cc(F)ccc23)[C@H]1OC(C)=O)=O Chemical compound CC(C)(C)OC(N(CC1)[C@H](Cc2c[nH]c3cc(F)ccc23)[C@H]1OC(C)=O)=O RNDKWDBMRLWZAH-MSOLQXFVSA-N 0.000 description 1
- PNAWEOXRFOVEMS-KPQWGBOZSA-N CC(N(C[C@H](CC(CC(C1)OC(C)=O)N1C(OCc1ccccc1)=O)c1c2)c1ccc2Br)=O Chemical compound CC(N(C[C@H](CC(CC(C1)OC(C)=O)N1C(OCc1ccccc1)=O)c1c2)c1ccc2Br)=O PNAWEOXRFOVEMS-KPQWGBOZSA-N 0.000 description 1
- WTPQHHYDMGLQLG-UHFFFAOYSA-N CC(OC(CC1CC2c3ccccc3NC2)CN1C(OCc1ccccc1)=O)=O Chemical compound CC(OC(CC1CC2c3ccccc3NC2)CN1C(OCc1ccccc1)=O)=O WTPQHHYDMGLQLG-UHFFFAOYSA-N 0.000 description 1
- NYBHGFGAQZKRNG-JBAPVGOWSA-N CC(O[C@@H]1[C@@H](Cc2c[nH]c(C3)c2C=CC3F)NCC1)=O Chemical compound CC(O[C@@H]1[C@@H](Cc2c[nH]c(C3)c2C=CC3F)NCC1)=O NYBHGFGAQZKRNG-JBAPVGOWSA-N 0.000 description 1
- GVLCHSFBYQUNRB-MRVPVSSYSA-N CC[C@@H](C)NCN(C)C=C Chemical compound CC[C@@H](C)NCN(C)C=C GVLCHSFBYQUNRB-MRVPVSSYSA-N 0.000 description 1
- PUJDIJCNWFYVJX-UHFFFAOYSA-N NC(OCc1ccccc1)=O Chemical compound NC(OCc1ccccc1)=O PUJDIJCNWFYVJX-UHFFFAOYSA-N 0.000 description 1
- UCWCGSYNBBBXBA-KRWDZBQOSA-N O=C(N1[C@H](Cc2c[nH]c3ncccc23)CCC1)OCc1ccccc1 Chemical compound O=C(N1[C@H](Cc2c[nH]c3ncccc23)CCC1)OCc1ccccc1 UCWCGSYNBBBXBA-KRWDZBQOSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Transplantation (AREA)
- Diabetes (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2323708P | 2008-01-24 | 2008-01-24 | |
| US61/023,237 | 2008-01-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100119768A true KR20100119768A (ko) | 2010-11-10 |
Family
ID=40901405
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107018102A KR20100119768A (ko) | 2008-01-24 | 2009-01-15 | 아이에이피 억제제 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20110288116A1 (es) |
| EP (1) | EP2242362A4 (es) |
| JP (1) | JP2011520770A (es) |
| KR (1) | KR20100119768A (es) |
| CN (1) | CN101951766A (es) |
| AU (1) | AU2009206588A1 (es) |
| BR (1) | BRPI0906785A2 (es) |
| CA (1) | CA2712604A1 (es) |
| IL (1) | IL207066A0 (es) |
| MX (1) | MX2010007948A (es) |
| WO (1) | WO2009094287A1 (es) |
| ZA (1) | ZA201005618B (es) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8283372B2 (en) | 2009-07-02 | 2012-10-09 | Tetralogic Pharmaceuticals Corp. | 2-(1H-indol-3-ylmethyl)-pyrrolidine dimer as a SMAC mimetic |
| NZ600608A (en) | 2009-12-18 | 2015-01-30 | Idenix Pharmaceuticals Inc | 5,5-fused arylene or heteroarylene hepatitis c virus inhibitors |
| UY33236A (es) | 2010-02-25 | 2011-09-30 | Novartis Ag | Inhibidores dimericos de las iap |
| UY33794A (es) | 2010-12-13 | 2012-07-31 | Novartis Ag | Inhibidores diméricos de las iap |
| GB201106817D0 (en) | 2011-04-21 | 2011-06-01 | Astex Therapeutics Ltd | New compound |
| NZ704554A (en) * | 2012-08-01 | 2015-12-24 | Tetralogic Pharm Corp | Combination therapy of a smac mimetic and gm-csf |
| GB201218862D0 (en) * | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218864D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| US9980973B2 (en) | 2012-10-19 | 2018-05-29 | Astex Therapeutics Limited | Bicyclic heterocycle compounds and their uses in therapy |
| GB201218850D0 (en) | 2012-10-19 | 2012-12-05 | Astex Therapeutics Ltd | Bicyclic heterocycle compounds and their uses in therapy |
| HUE056297T2 (hu) | 2013-12-20 | 2022-02-28 | Astex Therapeutics Ltd | Biciklikus heterociklusos vegyületek és ezek terápiában történõ alkalmazása |
| US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
| WO2019091492A1 (zh) | 2017-11-13 | 2019-05-16 | 南京明德新药研发股份有限公司 | 用作iap抑制剂的smac模拟物及其用途 |
| US20220175917A1 (en) * | 2019-03-07 | 2022-06-09 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Combination of iap inhibitor and immune checkpoint inhibitor |
| DK3967702T3 (da) * | 2019-05-10 | 2024-04-15 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Krystallisering af smac-mimic anvendt som iap-inhibitor og fremgangsmåde til fremstilling deraf |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2553871A1 (en) * | 2004-01-16 | 2005-08-04 | The Regents Of The University Of Michigan | Smac peptidomimetics and the uses thereof |
| AR048927A1 (es) * | 2004-04-07 | 2006-06-14 | Novartis Ag | Compuestos heterociclicos como inhibidores de proteinas de apoptosis (iap); composiciones farmaceuticas que los contienen y su uso en el tratamiento de una enfermedad proliferativa |
| US7674787B2 (en) * | 2004-07-09 | 2010-03-09 | The Regents Of The University Of Michigan | Conformationally constrained Smac mimetics and the uses thereof |
| US7517906B2 (en) * | 2005-02-25 | 2009-04-14 | Tetralogic Pharmaceuticals Corporation | Dimeric IAP inhibitors |
| US20070203749A1 (en) * | 2005-08-09 | 2007-08-30 | Sri Chunduru | Business methods for compounds for treatment of proliferative disorders |
-
2009
- 2009-01-15 JP JP2010544375A patent/JP2011520770A/ja not_active Abandoned
- 2009-01-15 US US12/863,375 patent/US20110288116A1/en not_active Abandoned
- 2009-01-15 MX MX2010007948A patent/MX2010007948A/es not_active Application Discontinuation
- 2009-01-15 KR KR1020107018102A patent/KR20100119768A/ko not_active Application Discontinuation
- 2009-01-15 CA CA2712604A patent/CA2712604A1/en not_active Abandoned
- 2009-01-15 AU AU2009206588A patent/AU2009206588A1/en not_active Abandoned
- 2009-01-15 WO PCT/US2009/031093 patent/WO2009094287A1/en active Application Filing
- 2009-01-15 BR BRPI0906785-0A patent/BRPI0906785A2/pt not_active IP Right Cessation
- 2009-01-15 CN CN200980106206XA patent/CN101951766A/zh active Pending
- 2009-01-15 EP EP09703244A patent/EP2242362A4/en not_active Withdrawn
-
2010
- 2010-07-18 IL IL207066A patent/IL207066A0/en unknown
- 2010-08-05 ZA ZA2010/05618A patent/ZA201005618B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2242362A4 (en) | 2012-04-11 |
| AU2009206588A1 (en) | 2009-07-30 |
| BRPI0906785A2 (pt) | 2015-07-14 |
| IL207066A0 (en) | 2010-12-30 |
| WO2009094287A1 (en) | 2009-07-30 |
| JP2011520770A (ja) | 2011-07-21 |
| CA2712604A1 (en) | 2009-07-30 |
| CN101951766A (zh) | 2011-01-19 |
| US20110288116A1 (en) | 2011-11-24 |
| MX2010007948A (es) | 2010-10-04 |
| EP2242362A1 (en) | 2010-10-27 |
| ZA201005618B (en) | 2011-04-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| WITN | Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid |