KR20100097098A

KR20100097098A - 레티놀 관련 질환을 치료하기 위한 방법 및 화합물

레티놀 관련 질환을 치료하기 위한 방법 및 화합물 Download PDF

Info

Publication number: KR20100097098A
Authority: KR; South Korea
Prior art keywords: alkyl; compound; optionally substituted; formula; butyl
Prior art date: 2007-09-27
Legal status : Withdrawn

Application number

KR1020107009129A

Other languages

English (en)

Korean (ko)

Inventor

나탄 엘 마타

킴 비 판

탐 브이 부이

무스타파 하다치

Original Assignee

리비젼 쎄러퓨틱스, 인크.

Priority date

2007-09-27

Filing date

2008-09-16

Publication date

2010-09-02

2008-09-16 Application filed by 리비젼 쎄러퓨틱스, 인크. filed Critical 리비젼 쎄러퓨틱스, 인크.

2010-09-02 Publication of KR20100097098A publication Critical patent/KR20100097098A/ko

Status Withdrawn legal-status Critical Current

Links

150000001875 compounds Chemical class 0.000 title claims abstract description 328
FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 title claims abstract description 308
FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 title claims abstract description 173
239000011607 retinol Substances 0.000 title claims abstract description 149
229960003471 retinol Drugs 0.000 title claims abstract description 149
238000000034 method Methods 0.000 title claims abstract description 137
235000020944 retinol Nutrition 0.000 title claims abstract description 135
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims description 60
201000010099 disease Diseases 0.000 title claims description 56
239000000203 mixture Substances 0.000 claims abstract description 103
208000002780 macular degeneration Diseases 0.000 claims abstract description 71
210000002966 serum Anatomy 0.000 claims abstract description 66
230000000007 visual effect Effects 0.000 claims abstract description 12
-1 methylenecyclopropyl Chemical group 0.000 claims description 155
125000000217 alkyl group Chemical group 0.000 claims description 116
108091000053 retinol binding Proteins 0.000 claims description 115
102000029752 retinol binding Human genes 0.000 claims description 115
241000124008 Mammalia Species 0.000 claims description 107
239000008194 pharmaceutical composition Substances 0.000 claims description 94
125000000592 heterocycloalkyl group Chemical group 0.000 claims description 91
102000009190 Transthyretin Human genes 0.000 claims description 77
108010071690 Prealbumin Proteins 0.000 claims description 76
150000003839 salts Chemical class 0.000 claims description 75
150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 68
239000000651 prodrug Substances 0.000 claims description 68
229940002612 prodrug Drugs 0.000 claims description 68
125000004404 heteroalkyl group Chemical group 0.000 claims description 65
239000002207 metabolite Substances 0.000 claims description 65
125000003342 alkenyl group Chemical group 0.000 claims description 63
125000001072 heteroaryl group Chemical group 0.000 claims description 63
229910052760 oxygen Inorganic materials 0.000 claims description 59
125000003107 substituted aryl group Chemical group 0.000 claims description 59
229910052717 sulfur Inorganic materials 0.000 claims description 58
125000004366 heterocycloalkenyl group Chemical group 0.000 claims description 57
239000012453 solvate Substances 0.000 claims description 57
UZFMOKQJFYMBGY-UHFFFAOYSA-N 4-hydroxy-TEMPO Chemical compound CC1(C)CC(O)CC(C)(C)N1[O] UZFMOKQJFYMBGY-UHFFFAOYSA-N 0.000 claims description 53
230000000694 effects Effects 0.000 claims description 48
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 46
102100038246 Retinol-binding protein 4 Human genes 0.000 claims description 45
125000005843 halogen group Chemical group 0.000 claims description 43
229910052736 halogen Inorganic materials 0.000 claims description 39
125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 39
125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 38
125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 34
230000027455 binding Effects 0.000 claims description 33
125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 33
206010064930 age-related macular degeneration Diseases 0.000 claims description 32
125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 32
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 32
239000000546 pharmaceutical excipient Substances 0.000 claims description 27
208000001072 type 2 diabetes mellitus Diseases 0.000 claims description 26
206010067584 Type 1 diabetes mellitus Diseases 0.000 claims description 25
125000004169 (C1-C6) alkyl group Chemical group 0.000 claims description 23
108090000623 proteins and genes Proteins 0.000 claims description 23
125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims description 22
RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims description 21
102000004169 proteins and genes Human genes 0.000 claims description 21
230000007850 degeneration Effects 0.000 claims description 18
239000003937 drug carrier Substances 0.000 claims description 18
125000003118 aryl group Chemical group 0.000 claims description 17
239000003795 chemical substances by application Substances 0.000 claims description 17
229910052799 carbon Inorganic materials 0.000 claims description 15
108091008695 photoreceptors Proteins 0.000 claims description 15
230000005764 inhibitory process Effects 0.000 claims description 13
206010003694 Atrophy Diseases 0.000 claims description 12
102000018832 Cytochromes Human genes 0.000 claims description 12
108010052832 Cytochromes Proteins 0.000 claims description 12
230000037444 atrophy Effects 0.000 claims description 12
230000002829 reductive effect Effects 0.000 claims description 12
238000011282 treatment Methods 0.000 claims description 12
230000009918 complex formation Effects 0.000 claims description 11
206010012601 diabetes mellitus Diseases 0.000 claims description 11
229910052757 nitrogen Inorganic materials 0.000 claims description 11
208000018127 Idiopathic intracranial hypertension Diseases 0.000 claims description 10
125000004104 aryloxy group Chemical group 0.000 claims description 10
125000000753 cycloalkyl group Chemical group 0.000 claims description 10
229910052739 hydrogen Inorganic materials 0.000 claims description 10
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 10
208000001381 pseudotumor cerebri Diseases 0.000 claims description 10
125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims description 9
125000006650 (C2-C4) alkynyl group Chemical group 0.000 claims description 9
102000004190 Enzymes Human genes 0.000 claims description 9
108090000790 Enzymes Proteins 0.000 claims description 9
208000008069 Geographic Atrophy Diseases 0.000 claims description 9
239000003963 antioxidant agent Substances 0.000 claims description 9
235000006708 antioxidants Nutrition 0.000 claims description 9
125000003710 aryl alkyl group Chemical group 0.000 claims description 9
206010020718 hyperplasia Diseases 0.000 claims description 9
125000004433 nitrogen atom Chemical group N* 0.000 claims description 9
208000035719 Maculopathy Diseases 0.000 claims description 8
150000002367 halogens Chemical class 0.000 claims description 8
208000024827 Alzheimer disease Diseases 0.000 claims description 7
206010012689 Diabetic retinopathy Diseases 0.000 claims description 7
CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims description 7
206010038910 Retinitis Diseases 0.000 claims description 7
206010038933 Retinopathy of prematurity Diseases 0.000 claims description 7
206010002022 amyloidosis Diseases 0.000 claims description 6
208000000208 Wet Macular Degeneration Diseases 0.000 claims description 5
208000011580 syndromic disease Diseases 0.000 claims description 5
GQZJXCWWWICSNA-UHFFFAOYSA-N 3-[(2-tert-butyl-4-chlorophenoxy)methyl]cyclohexane-1-carboxylic acid Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCC1CC(C(O)=O)CCC1 GQZJXCWWWICSNA-UHFFFAOYSA-N 0.000 claims description 4
ZKKJLUXXPYMLBL-UHFFFAOYSA-N 4-[[3-[(2-tert-butyl-4-chlorophenoxy)methyl]cyclopentanecarbonyl]amino]benzoic acid Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCC1CC(C(=O)NC=2C=CC(=CC=2)C(O)=O)CC1 ZKKJLUXXPYMLBL-UHFFFAOYSA-N 0.000 claims description 4
MWUXSHHQAYIFBG-UHFFFAOYSA-N Nitric oxide Chemical compound O=[N] MWUXSHHQAYIFBG-UHFFFAOYSA-N 0.000 claims description 4
235000021466 carotenoid Nutrition 0.000 claims description 4
150000001747 carotenoids Chemical class 0.000 claims description 4
238000009792 diffusion process Methods 0.000 claims description 4
239000000539 dimer Substances 0.000 claims description 4
238000004519 manufacturing process Methods 0.000 claims description 4
150000003904 phospholipids Chemical class 0.000 claims description 4
238000013518 transcription Methods 0.000 claims description 4
230000035897 transcription Effects 0.000 claims description 4
NQPDZGIKBAWPEJ-UHFFFAOYSA-N valeric acid Chemical compound CCCCC(O)=O NQPDZGIKBAWPEJ-UHFFFAOYSA-N 0.000 claims description 4
NCYCYZXNIZJOKI-IOUUIBBYSA-N 11-cis-retinal Chemical compound O=C/C=C(\C)/C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-IOUUIBBYSA-N 0.000 claims description 3
OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical group [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 claims description 3
QNVSXXGDAPORNA-UHFFFAOYSA-N Resveratrol Natural products OC1=CC=CC(C=CC=2C=C(O)C(O)=CC=2)=C1 QNVSXXGDAPORNA-UHFFFAOYSA-N 0.000 claims description 3
LUKBXSAWLPMMSZ-OWOJBTEDSA-N Trans-resveratrol Chemical compound C1=CC(O)=CC=C1\C=C\C1=CC(O)=CC(O)=C1 LUKBXSAWLPMMSZ-OWOJBTEDSA-N 0.000 claims description 3
229910052698 phosphorus Inorganic materials 0.000 claims description 3
239000011574 phosphorus Substances 0.000 claims description 3
235000021283 resveratrol Nutrition 0.000 claims description 3
229940016667 resveratrol Drugs 0.000 claims description 3
COBGWVGXUVRBBY-UHFFFAOYSA-N 2-[3-[(2-tert-butyl-4-chlorophenoxy)methyl]cyclopentyl]acetic acid Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCC1CC(CC(O)=O)CC1 COBGWVGXUVRBBY-UHFFFAOYSA-N 0.000 claims description 2
OPGXIVOGSNQWAY-UHFFFAOYSA-N 3-[(2-tert-butyl-4-chlorophenoxy)methyl]cyclopentane-1-carboxylic acid Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCC1CC(C(O)=O)CC1 OPGXIVOGSNQWAY-UHFFFAOYSA-N 0.000 claims description 2
WLNCCKQPRPEHGG-UHFFFAOYSA-N 4-(2-tert-butyl-4-chlorophenoxy)butanoic acid Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCCCC(O)=O WLNCCKQPRPEHGG-UHFFFAOYSA-N 0.000 claims description 2
USAYISRQNIQXKN-UHFFFAOYSA-N 4-[5-(2-tert-butyl-4-chlorophenoxy)pentanoylamino]benzoic acid Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCCCCC(=O)NC1=CC=C(C(O)=O)C=C1 USAYISRQNIQXKN-UHFFFAOYSA-N 0.000 claims description 2
UVSNIHJFKAQJTI-UHFFFAOYSA-N 5-(2-tert-butyl-4-chlorophenoxy)-n-(4-hydroxyphenyl)pentanamide Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCCCCC(=O)NC1=CC=C(O)C=C1 UVSNIHJFKAQJTI-UHFFFAOYSA-N 0.000 claims description 2
KDUSFSMSZCTCFC-UHFFFAOYSA-N 5-(2-tert-butyl-4-chlorophenoxy)pentanoic acid Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCCCCC(O)=O KDUSFSMSZCTCFC-UHFFFAOYSA-N 0.000 claims description 2
WILYQPHCMRMJCA-UHFFFAOYSA-N 7-(2-tert-butyl-4-chlorophenoxy)heptanoic acid Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCCCCCCC(O)=O WILYQPHCMRMJCA-UHFFFAOYSA-N 0.000 claims description 2
229940121710 HMGCoA reductase inhibitor Drugs 0.000 claims description 2
SHGAZHPCJJPHSC-NUEINMDLSA-N Isotretinoin Chemical compound OC(=O)C=C(C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-NUEINMDLSA-N 0.000 claims description 2
208000001140 Night Blindness Diseases 0.000 claims description 2
102100040756 Rhodopsin Human genes 0.000 claims description 2
108090000820 Rhodopsin Proteins 0.000 claims description 2
PJANXHGTPQOBST-VAWYXSNFSA-N Stilbene Natural products C=1C=CC=CC=1/C=C/C1=CC=CC=C1 PJANXHGTPQOBST-VAWYXSNFSA-N 0.000 claims description 2
229940121369 angiogenesis inhibitor Drugs 0.000 claims description 2
239000004037 angiogenesis inhibitor Substances 0.000 claims description 2
239000002260 anti-inflammatory agent Substances 0.000 claims description 2
229940121363 anti-inflammatory agent Drugs 0.000 claims description 2
XRLDSWLMHUQECH-UHFFFAOYSA-N cyclopentanecarboxamide Chemical compound NC(=O)C1CCCC1 XRLDSWLMHUQECH-UHFFFAOYSA-N 0.000 claims description 2
239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 claims description 2
229910052500 inorganic mineral Inorganic materials 0.000 claims description 2
229960005280 isotretinoin Drugs 0.000 claims description 2
239000003771 matrix metalloproteinase inhibitor Substances 0.000 claims description 2
229940121386 matrix metalloproteinase inhibitor Drugs 0.000 claims description 2
239000011707 mineral Substances 0.000 claims description 2
230000008929 regeneration Effects 0.000 claims description 2
238000011069 regeneration method Methods 0.000 claims description 2
101000665882 Homo sapiens Retinol-binding protein 4 Proteins 0.000 claims 2
BURKQRZKFCTWJX-UHFFFAOYSA-N 7-(2-tert-butyl-4-chlorophenoxy)-n-(4-hydroxyphenyl)heptanamide Chemical compound CC(C)(C)C1=CC(Cl)=CC=C1OCCCCCCC(=O)NC1=CC=C(O)C=C1 BURKQRZKFCTWJX-UHFFFAOYSA-N 0.000 claims 1
239000000411 inducer Substances 0.000 claims 1
230000003902 lesion Effects 0.000 claims 1
PJANXHGTPQOBST-UHFFFAOYSA-N trans-Stilbene Natural products C=1C=CC=CC=1C=CC1=CC=CC=C1 PJANXHGTPQOBST-UHFFFAOYSA-N 0.000 claims 1
230000008569 process Effects 0.000 abstract description 9
208000024891 symptom Diseases 0.000 abstract description 8
238000012261 overproduction Methods 0.000 abstract description 2
239000002699 waste material Substances 0.000 abstract 1
235000002639 sodium chloride Nutrition 0.000 description 61
101710137011 Retinol-binding protein 4 Proteins 0.000 description 43
FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 36
235000019155 vitamin A Nutrition 0.000 description 36
239000011719 vitamin A Substances 0.000 description 36
229940045997 vitamin a Drugs 0.000 description 36
238000009472 formulation Methods 0.000 description 32
NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 30
210000001508 eye Anatomy 0.000 description 26
238000007910 systemic administration Methods 0.000 description 26
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 25
239000000243 solution Substances 0.000 description 25
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 24
239000000725 suspension Substances 0.000 description 24
239000008203 oral pharmaceutical composition Substances 0.000 description 23
210000001519 tissue Anatomy 0.000 description 22
210000004027 cell Anatomy 0.000 description 21
238000012360 testing method Methods 0.000 description 21
241000699670 Mus sp. Species 0.000 description 20
239000004480 active ingredient Substances 0.000 description 20
239000002552 dosage form Substances 0.000 description 19
229920001577 copolymer Polymers 0.000 description 18
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 18
235000018102 proteins Nutrition 0.000 description 17
239000002904 solvent Substances 0.000 description 17
239000003981 vehicle Substances 0.000 description 17
102000004877 Insulin Human genes 0.000 description 15
108090001061 Insulin Proteins 0.000 description 15
239000003814 drug Substances 0.000 description 15
239000007924 injection Substances 0.000 description 15
238000002347 injection Methods 0.000 description 15
229940125396 insulin Drugs 0.000 description 15
230000015572 biosynthetic process Effects 0.000 description 14
239000000839 emulsion Substances 0.000 description 14
235000019441 ethanol Nutrition 0.000 description 14
239000003755 preservative agent Substances 0.000 description 14
125000004432 carbon atom Chemical group C* 0.000 description 13
230000004438 eyesight Effects 0.000 description 13
239000008273 gelatin Substances 0.000 description 13
229920000159 gelatin Polymers 0.000 description 13
229940014259 gelatin Drugs 0.000 description 13
229920000642 polymer Polymers 0.000 description 13
239000000843 powder Substances 0.000 description 13
NCYCYZXNIZJOKI-OVSJKPMPSA-N retinal group Chemical group C\C(=C/C=O)\C=C\C=C(\C=C\C1=C(CCCC1(C)C)C)/C NCYCYZXNIZJOKI-OVSJKPMPSA-N 0.000 description 13
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 12
108010010803 Gelatin Proteins 0.000 description 12
229920002472 Starch Polymers 0.000 description 12
125000004429 atom Chemical group 0.000 description 12
210000004369 blood Anatomy 0.000 description 12
239000008280 blood Substances 0.000 description 12
230000007423 decrease Effects 0.000 description 12
238000001514 detection method Methods 0.000 description 12
235000019322 gelatine Nutrition 0.000 description 12
235000011852 gelatine desserts Nutrition 0.000 description 12
239000011159 matrix material Substances 0.000 description 12
229920001223 polyethylene glycol Polymers 0.000 description 12
239000008107 starch Substances 0.000 description 12
229940032147 starch Drugs 0.000 description 12
235000019698 starch Nutrition 0.000 description 12
239000000126 substance Substances 0.000 description 12
NCYCYZXNIZJOKI-UHFFFAOYSA-N vitamin A aldehyde Natural products O=CC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-UHFFFAOYSA-N 0.000 description 12
201000004569 Blindness Diseases 0.000 description 11
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 11
239000002253 acid Substances 0.000 description 11
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 11
239000002775 capsule Substances 0.000 description 11
239000003085 diluting agent Substances 0.000 description 11
229940079593 drug Drugs 0.000 description 11
239000000499 gel Substances 0.000 description 11
235000011187 glycerol Nutrition 0.000 description 11
210000000056 organ Anatomy 0.000 description 11
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 11
229920000036 polyvinylpyrrolidone Polymers 0.000 description 11
239000001267 polyvinylpyrrolidone Substances 0.000 description 11
239000003826 tablet Substances 0.000 description 11
201000003883 Cystic fibrosis Diseases 0.000 description 10
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 10
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 10
239000002202 Polyethylene glycol Substances 0.000 description 10
229930002945 all-trans-retinaldehyde Natural products 0.000 description 10
239000011230 binding agent Substances 0.000 description 10
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 10
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 10
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 10
239000007788 liquid Substances 0.000 description 10
210000002381 plasma Anatomy 0.000 description 10
238000006722 reduction reaction Methods 0.000 description 10
235000020945 retinal Nutrition 0.000 description 10
239000011604 retinal Substances 0.000 description 10
230000002207 retinal effect Effects 0.000 description 10
239000000600 sorbitol Substances 0.000 description 10
229960002920 sorbitol Drugs 0.000 description 10
235000010356 sorbitol Nutrition 0.000 description 10
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 9
239000005977 Ethylene Substances 0.000 description 9
239000000872 buffer Substances 0.000 description 9
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
238000013270 controlled release Methods 0.000 description 9
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 9
230000035772 mutation Effects 0.000 description 9
239000003921 oil Substances 0.000 description 9
230000009467 reduction Effects 0.000 description 9
210000001525 retina Anatomy 0.000 description 9
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 description 8
101000801643 Homo sapiens Retinal-specific phospholipid-transporting ATPase ABCA4 Proteins 0.000 description 8
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 8
229920000663 Hydroxyethyl cellulose Polymers 0.000 description 8
239000004354 Hydroxyethyl cellulose Substances 0.000 description 8
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 8
208000008589 Obesity Diseases 0.000 description 8
102100033617 Retinal-specific phospholipid-transporting ATPase ABCA4 Human genes 0.000 description 8
230000002159 abnormal effect Effects 0.000 description 8
238000004458 analytical method Methods 0.000 description 8
239000007891 compressed tablet Substances 0.000 description 8
GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 8
201000001727 diffuse idiopathic skeletal hyperostosis Diseases 0.000 description 8
229940071826 hydroxyethyl cellulose Drugs 0.000 description 8
235000019447 hydroxyethyl cellulose Nutrition 0.000 description 8
230000001965 increasing effect Effects 0.000 description 8
239000008101 lactose Substances 0.000 description 8
239000002502 liposome Substances 0.000 description 8
235000020824 obesity Nutrition 0.000 description 8
229920002451 polyvinyl alcohol Polymers 0.000 description 8
235000019422 polyvinyl alcohol Nutrition 0.000 description 8
239000003381 stabilizer Substances 0.000 description 8
229920002153 Hydroxypropyl cellulose Polymers 0.000 description 7
206010022489 Insulin Resistance Diseases 0.000 description 7
206010025421 Macule Diseases 0.000 description 7
239000004698 Polyethylene Substances 0.000 description 7
239000004372 Polyvinyl alcohol Substances 0.000 description 7
239000012491 analyte Substances 0.000 description 7
230000033115 angiogenesis Effects 0.000 description 7
239000002585 base Substances 0.000 description 7
230000004071 biological effect Effects 0.000 description 7
210000004204 blood vessel Anatomy 0.000 description 7
239000001768 carboxy methyl cellulose Substances 0.000 description 7
238000007906 compression Methods 0.000 description 7
239000008103 glucose Substances 0.000 description 7
230000012010 growth Effects 0.000 description 7
230000002209 hydrophobic effect Effects 0.000 description 7
235000010977 hydroxypropyl cellulose Nutrition 0.000 description 7
239000001863 hydroxypropyl cellulose Substances 0.000 description 7
238000001727 in vivo Methods 0.000 description 7
239000008297 liquid dosage form Substances 0.000 description 7
VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 7
239000012071 phase Substances 0.000 description 7
239000000049 pigment Substances 0.000 description 7
229920000573 polyethylene Polymers 0.000 description 7
239000002243 precursor Substances 0.000 description 7
241000894006 Bacteria Species 0.000 description 6
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 6
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
229930195725 Mannitol Natural products 0.000 description 6
241001465754 Metazoa Species 0.000 description 6
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 6
NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 6
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
229920002125 Sokalan® Polymers 0.000 description 6
208000027073 Stargardt disease Diseases 0.000 description 6
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 6
229930006000 Sucrose Natural products 0.000 description 6
229920001615 Tragacanth Polymers 0.000 description 6
238000009825 accumulation Methods 0.000 description 6
238000003556 assay Methods 0.000 description 6
230000008901 benefit Effects 0.000 description 6
239000000969 carrier Substances 0.000 description 6
239000000460 chlorine Substances 0.000 description 6
230000006835 compression Effects 0.000 description 6
239000006071 cream Substances 0.000 description 6
239000002270 dispersing agent Substances 0.000 description 6
239000003995 emulsifying agent Substances 0.000 description 6
239000000796 flavoring agent Substances 0.000 description 6
239000012530 fluid Substances 0.000 description 6
239000008187 granular material Substances 0.000 description 6
238000000338 in vitro Methods 0.000 description 6
JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
210000004185 liver Anatomy 0.000 description 6
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
239000000594 mannitol Substances 0.000 description 6
235000010355 mannitol Nutrition 0.000 description 6
239000000463 material Substances 0.000 description 6
235000019198 oils Nutrition 0.000 description 6
239000002674 ointment Substances 0.000 description 6
238000007911 parenteral administration Methods 0.000 description 6
230000001105 regulatory effect Effects 0.000 description 6
239000011734 sodium Substances 0.000 description 6
239000011780 sodium chloride Substances 0.000 description 6
239000005720 sucrose Substances 0.000 description 6
238000011200 topical administration Methods 0.000 description 6
241000416162 Astragalus gummifer Species 0.000 description 5
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 5
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 5
102000014914 Carrier Proteins Human genes 0.000 description 5
229920000858 Cyclodextrin Polymers 0.000 description 5
229920003171 Poly (ethylene oxide) Polymers 0.000 description 5
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 5
102000005789 Vascular Endothelial Growth Factors Human genes 0.000 description 5
108010019530 Vascular Endothelial Growth Factors Proteins 0.000 description 5
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 5
OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 5
239000007864 aqueous solution Substances 0.000 description 5
235000013734 beta-carotene Nutrition 0.000 description 5
239000011648 beta-carotene Substances 0.000 description 5
TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 5
229960002747 betacarotene Drugs 0.000 description 5
210000000988 bone and bone Anatomy 0.000 description 5
235000010980 cellulose Nutrition 0.000 description 5
229920002678 cellulose Polymers 0.000 description 5
229920002301 cellulose acetate Polymers 0.000 description 5
239000006184 cosolvent Substances 0.000 description 5
LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 5
239000007884 disintegrant Substances 0.000 description 5
239000000975 dye Substances 0.000 description 5
230000003628 erosive effect Effects 0.000 description 5
235000003599 food sweetener Nutrition 0.000 description 5
210000003494 hepatocyte Anatomy 0.000 description 5
238000004128 high performance liquid chromatography Methods 0.000 description 5
239000000314 lubricant Substances 0.000 description 5
239000012528 membrane Substances 0.000 description 5
210000004379 membrane Anatomy 0.000 description 5
229920000609 methyl cellulose Polymers 0.000 description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 5
235000010981 methylcellulose Nutrition 0.000 description 5
239000001923 methylcellulose Substances 0.000 description 5
229960002900 methylcellulose Drugs 0.000 description 5
210000003097 mucus Anatomy 0.000 description 5
230000003204 osmotic effect Effects 0.000 description 5
239000002953 phosphate buffered saline Substances 0.000 description 5
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 5
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 5
229920000053 polysorbate 80 Polymers 0.000 description 5
108090000765 processed proteins & peptides Proteins 0.000 description 5
239000000523 sample Substances 0.000 description 5
239000008299 semisolid dosage form Substances 0.000 description 5
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 5
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 5
239000007787 solid Substances 0.000 description 5
239000007921 spray Substances 0.000 description 5
239000003765 sweetening agent Substances 0.000 description 5
239000006188 syrup Substances 0.000 description 5
235000020357 syrup Nutrition 0.000 description 5
239000006216 vaginal suppository Substances 0.000 description 5
229940117958 vinyl acetate Drugs 0.000 description 5
230000004393 visual impairment Effects 0.000 description 5
201000005932 Alstrom Syndrome Diseases 0.000 description 4
QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 4
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 4
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 4
229920002134 Carboxymethyl cellulose Polymers 0.000 description 4
108010079245 Cystic Fibrosis Transmembrane Conductance Regulator Proteins 0.000 description 4
239000001856 Ethyl cellulose Substances 0.000 description 4
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 4
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 4
201000007737 Retinal degeneration Diseases 0.000 description 4
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 4
QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 4
XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 description 4
150000007513 acids Chemical class 0.000 description 4
239000000443 aerosol Substances 0.000 description 4
235000010443 alginic acid Nutrition 0.000 description 4
229920000615 alginic acid Polymers 0.000 description 4
235000001014 amino acid Nutrition 0.000 description 4
229940024606 amino acid Drugs 0.000 description 4
150000001413 amino acids Chemical group 0.000 description 4
239000008135 aqueous vehicle Substances 0.000 description 4
108091008324 binding proteins Proteins 0.000 description 4
239000003086 colorant Substances 0.000 description 4
235000012343 cottonseed oil Nutrition 0.000 description 4
239000002385 cottonseed oil Substances 0.000 description 4
230000006378 damage Effects 0.000 description 4
230000008021 deposition Effects 0.000 description 4
238000011161 development Methods 0.000 description 4
230000018109 developmental process Effects 0.000 description 4
239000008121 dextrose Substances 0.000 description 4
235000014113 dietary fatty acids Nutrition 0.000 description 4
208000035475 disorder Diseases 0.000 description 4
235000019325 ethyl cellulose Nutrition 0.000 description 4
229920001249 ethyl cellulose Polymers 0.000 description 4
229930195729 fatty acid Natural products 0.000 description 4
239000000194 fatty acid Substances 0.000 description 4
239000000945 filler Substances 0.000 description 4
235000011167 hydrochloric acid Nutrition 0.000 description 4
239000000017 hydrogel Substances 0.000 description 4
229920001477 hydrophilic polymer Polymers 0.000 description 4
230000003914 insulin secretion Effects 0.000 description 4
210000004153 islets of langerhan Anatomy 0.000 description 4
239000010410 layer Substances 0.000 description 4
239000007937 lozenge Substances 0.000 description 4
210000004072 lung Anatomy 0.000 description 4
239000002609 medium Substances 0.000 description 4
235000010270 methyl p-hydroxybenzoate Nutrition 0.000 description 4
239000000693 micelle Substances 0.000 description 4
239000004005 microsphere Substances 0.000 description 4
102000004196 processed proteins & peptides Human genes 0.000 description 4
239000000047 product Substances 0.000 description 4
235000010232 propyl p-hydroxybenzoate Nutrition 0.000 description 4
239000006215 rectal suppository Substances 0.000 description 4
230000004258 retinal degeneration Effects 0.000 description 4
YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 4
210000003786 sclera Anatomy 0.000 description 4
235000015424 sodium Nutrition 0.000 description 4
229910052708 sodium Inorganic materials 0.000 description 4
238000007920 subcutaneous administration Methods 0.000 description 4
235000000346 sugar Nutrition 0.000 description 4
239000004094 surface-active agent Substances 0.000 description 4
239000000375 suspending agent Substances 0.000 description 4
238000013268 sustained release Methods 0.000 description 4
239000012730 sustained-release form Substances 0.000 description 4
239000000454 talc Substances 0.000 description 4
229910052623 talc Inorganic materials 0.000 description 4
235000012222 talc Nutrition 0.000 description 4
231100000331 toxic Toxicity 0.000 description 4
230000002588 toxic effect Effects 0.000 description 4
235000010487 tragacanth Nutrition 0.000 description 4
229940116362 tragacanth Drugs 0.000 description 4
150000003626 triacylglycerols Chemical class 0.000 description 4
210000002700 urine Anatomy 0.000 description 4
239000000080 wetting agent Substances 0.000 description 4
OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 description 4
AKJHMTWEGVYYSE-AIRMAKDCSA-N 4-HPR Chemical compound C=1C=C(O)C=CC=1NC(=O)/C=C(\C)/C=C/C=C(C)C=CC1=C(C)CCCC1(C)C AKJHMTWEGVYYSE-AIRMAKDCSA-N 0.000 description 3
206010068783 Alstroem syndrome Diseases 0.000 description 3
YDNKGFDKKRUKPY-JHOUSYSJSA-N C16 ceramide Natural products CCCCCCCCCCCCCCCC(=O)N[C@@H](CO)[C@H](O)C=CCCCCCCCCCCCCC YDNKGFDKKRUKPY-JHOUSYSJSA-N 0.000 description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 3
102000008186 Collagen Human genes 0.000 description 3
108010035532 Collagen Proteins 0.000 description 3
102000012605 Cystic Fibrosis Transmembrane Conductance Regulator Human genes 0.000 description 3
229920002307 Dextran Polymers 0.000 description 3
241000196324 Embryophyta Species 0.000 description 3
229920002907 Guar gum Polymers 0.000 description 3
208000032843 Hemorrhage Diseases 0.000 description 3
235000010643 Leucaena leucocephala Nutrition 0.000 description 3
240000007472 Leucaena leucocephala Species 0.000 description 3
VVQNEPGJFQJSBK-UHFFFAOYSA-N Methyl methacrylate Chemical compound COC(=O)C(C)=C VVQNEPGJFQJSBK-UHFFFAOYSA-N 0.000 description 3
229920000168 Microcrystalline cellulose Polymers 0.000 description 3
229920000881 Modified starch Polymers 0.000 description 3
SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 3
CRJGESKKUOMBCT-VQTJNVASSA-N N-acetylsphinganine Chemical compound CCCCCCCCCCCCCCC[C@@H](O)[C@H](CO)NC(C)=O CRJGESKKUOMBCT-VQTJNVASSA-N 0.000 description 3
208000017442 Retinal disease Diseases 0.000 description 3
229920001800 Shellac Polymers 0.000 description 3
241000251539 Vertebrata <Metazoa> Species 0.000 description 3
229930003427 Vitamin E Natural products 0.000 description 3
HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
238000010521 absorption reaction Methods 0.000 description 3
235000011054 acetic acid Nutrition 0.000 description 3
NIXOWILDQLNWCW-UHFFFAOYSA-N acrylic acid group Chemical group C(C=C)(=O)O NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 3
210000001789 adipocyte Anatomy 0.000 description 3
210000000577 adipose tissue Anatomy 0.000 description 3
150000001336 alkenes Chemical class 0.000 description 3
150000001345 alkine derivatives Chemical group 0.000 description 3
229910000147 aluminium phosphate Inorganic materials 0.000 description 3
150000001408 amides Chemical class 0.000 description 3
239000004599 antimicrobial Substances 0.000 description 3
238000013459 approach Methods 0.000 description 3
239000008346 aqueous phase Substances 0.000 description 3
235000010323 ascorbic acid Nutrition 0.000 description 3
229960004853 betadex Drugs 0.000 description 3
230000000740 bleeding effect Effects 0.000 description 3
239000001913 cellulose Substances 0.000 description 3
229940106189 ceramide Drugs 0.000 description 3
ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 description 3
235000015165 citric acid Nutrition 0.000 description 3
229960004106 citric acid Drugs 0.000 description 3
229920001436 collagen Polymers 0.000 description 3
239000008139 complexing agent Substances 0.000 description 3
235000005687 corn oil Nutrition 0.000 description 3
239000002285 corn oil Substances 0.000 description 3
125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 3
230000003247 decreasing effect Effects 0.000 description 3
230000003412 degenerative effect Effects 0.000 description 3
229960002086 dextran Drugs 0.000 description 3
235000013870 dimethyl polysiloxane Nutrition 0.000 description 3
239000008298 dragée Substances 0.000 description 3
LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
239000000284 extract Substances 0.000 description 3
239000003925 fat Substances 0.000 description 3
235000019197 fats Nutrition 0.000 description 3
229950003662 fenretinide Drugs 0.000 description 3
235000019634 flavors Nutrition 0.000 description 3
239000006260 foam Substances 0.000 description 3
235000013355 food flavoring agent Nutrition 0.000 description 3
230000006870 function Effects 0.000 description 3
WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 3
235000010417 guar gum Nutrition 0.000 description 3
239000000665 guar gum Substances 0.000 description 3
229960002154 guar gum Drugs 0.000 description 3
229920000591 gum Polymers 0.000 description 3
BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 3
238000000265 homogenisation Methods 0.000 description 3
208000015181 infectious disease Diseases 0.000 description 3
230000002401 inhibitory effect Effects 0.000 description 3
230000003993 interaction Effects 0.000 description 3
238000001990 intravenous administration Methods 0.000 description 3
FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 description 3
239000007951 isotonicity adjuster Substances 0.000 description 3
235000014655 lactic acid Nutrition 0.000 description 3
239000004310 lactic acid Substances 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
230000007246 mechanism Effects 0.000 description 3
QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 description 3
229910052753 mercury Inorganic materials 0.000 description 3
229940041669 mercury Drugs 0.000 description 3
208000030159 metabolic disease Diseases 0.000 description 3
230000004060 metabolic process Effects 0.000 description 3
235000019813 microcrystalline cellulose Nutrition 0.000 description 3
239000002480 mineral oil Substances 0.000 description 3
235000010446 mineral oil Nutrition 0.000 description 3
VVGIYYKRAMHVLU-UHFFFAOYSA-N newbouldiamide Natural products CCCCCCCCCCCCCCCCCCCC(O)C(O)C(O)C(CO)NC(=O)CCCCCCCCCCCCCCCCC VVGIYYKRAMHVLU-UHFFFAOYSA-N 0.000 description 3
239000002687 nonaqueous vehicle Substances 0.000 description 3
239000004006 olive oil Substances 0.000 description 3
235000008390 olive oil Nutrition 0.000 description 3
239000002357 osmotic agent Substances 0.000 description 3
230000011164 ossification Effects 0.000 description 3
208000001040 ossification of the posterior longitudinal ligament of the spine Diseases 0.000 description 3
239000002245 particle Substances 0.000 description 3
235000019271 petrolatum Nutrition 0.000 description 3
239000000825 pharmaceutical preparation Substances 0.000 description 3
235000011007 phosphoric acid Nutrition 0.000 description 3
210000000608 photoreceptor cell Anatomy 0.000 description 3
229920000435 poly(dimethylsiloxane) Polymers 0.000 description 3
229940068886 polyethylene glycol 300 Drugs 0.000 description 3
229920000139 polyethylene terephthalate Polymers 0.000 description 3
239000005020 polyethylene terephthalate Substances 0.000 description 3
229920001282 polysaccharide Polymers 0.000 description 3
239000005017 polysaccharide Substances 0.000 description 3
150000004804 polysaccharides Chemical class 0.000 description 3
229920002689 polyvinyl acetate Polymers 0.000 description 3
239000011118 polyvinyl acetate Substances 0.000 description 3
229920000915 polyvinyl chloride Polymers 0.000 description 3
239000004800 polyvinyl chloride Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
230000002335 preservative effect Effects 0.000 description 3
QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 3
150000004492 retinoid derivatives Chemical class 0.000 description 3
229920006395 saturated elastomer Polymers 0.000 description 3
239000008159 sesame oil Substances 0.000 description 3
235000011803 sesame oil Nutrition 0.000 description 3
ZLGIYFNHBLSMPS-ATJNOEHPSA-N shellac Chemical compound OCCCCCC(O)C(O)CCCCCCCC(O)=O.C1C23[C@H](C(O)=O)CCC2[C@](C)(CO)[C@@H]1C(C(O)=O)=C[C@@H]3O ZLGIYFNHBLSMPS-ATJNOEHPSA-N 0.000 description 3
229940113147 shellac Drugs 0.000 description 3
239000004208 shellac Substances 0.000 description 3
235000013874 shellac Nutrition 0.000 description 3
229920002379 silicone rubber Polymers 0.000 description 3
150000003384 small molecules Chemical class 0.000 description 3
HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 3
229940001584 sodium metabisulfite Drugs 0.000 description 3
235000010262 sodium metabisulphite Nutrition 0.000 description 3
239000007901 soft capsule Substances 0.000 description 3
150000008163 sugars Chemical class 0.000 description 3
239000000829 suppository Substances 0.000 description 3
230000001225 therapeutic effect Effects 0.000 description 3
239000002562 thickening agent Substances 0.000 description 3
230000000699 topical effect Effects 0.000 description 3
239000000196 tragacanth Substances 0.000 description 3
230000032258 transport Effects 0.000 description 3
229940088594 vitamin Drugs 0.000 description 3
229930003231 vitamin Natural products 0.000 description 3
235000013343 vitamin Nutrition 0.000 description 3
239000011782 vitamin Substances 0.000 description 3
239000011709 vitamin E Substances 0.000 description 3
235000019165 vitamin E Nutrition 0.000 description 3
229940046009 vitamin E Drugs 0.000 description 3
239000008136 water-miscible vehicle Substances 0.000 description 3
229920001285 xanthan gum Polymers 0.000 description 3
235000010493 xanthan gum Nutrition 0.000 description 3
239000000230 xanthan gum Substances 0.000 description 3
229940082509 xanthan gum Drugs 0.000 description 3
229910052725 zinc Inorganic materials 0.000 description 3
239000011701 zinc Substances 0.000 description 3
PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 2
DUUCJSJYISFGCI-WBPXWQEISA-N (2r,3r)-2,3-dihydroxybutanedioic acid;2-(dimethylamino)ethanol Chemical compound CN(C)CCO.OC(=O)[C@H](O)[C@@H](O)C(O)=O.OC(=O)[C@H](O)[C@@H](O)C(O)=O DUUCJSJYISFGCI-WBPXWQEISA-N 0.000 description 2
125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 description 2
BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 2
ICLYJLBTOGPLMC-KVVVOXFISA-N (z)-octadec-9-enoate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCC\C=C/CCCCCCCC(O)=O ICLYJLBTOGPLMC-KVVVOXFISA-N 0.000 description 2
DHKHKXVYLBGOIT-UHFFFAOYSA-N 1,1-Diethoxyethane Chemical compound CCOC(C)OCC DHKHKXVYLBGOIT-UHFFFAOYSA-N 0.000 description 2
IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 2
VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
OEPOKWHJYJXUGD-UHFFFAOYSA-N 2-(3-phenylmethoxyphenyl)-1,3-thiazole-4-carbaldehyde Chemical compound O=CC1=CSC(C=2C=C(OCC=3C=CC=CC=3)C=CC=2)=N1 OEPOKWHJYJXUGD-UHFFFAOYSA-N 0.000 description 2
HZAXFHJVJLSVMW-UHFFFAOYSA-N 2-Aminoethan-1-ol Chemical compound NCCO HZAXFHJVJLSVMW-UHFFFAOYSA-N 0.000 description 2
MJKVTPMWOKAVMS-UHFFFAOYSA-N 3-hydroxy-1-benzopyran-2-one Chemical compound C1=CC=C2OC(=O)C(O)=CC2=C1 MJKVTPMWOKAVMS-UHFFFAOYSA-N 0.000 description 2
FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 description 2
229920001817 Agar Polymers 0.000 description 2
101710141544 Allatotropin-related peptide Proteins 0.000 description 2
239000005995 Aluminium silicate Substances 0.000 description 2
NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 2
102000001049 Amyloid Human genes 0.000 description 2
108010094108 Amyloid Proteins 0.000 description 2
102000013455 Amyloid beta-Peptides Human genes 0.000 description 2
108010090849 Amyloid beta-Peptides Proteins 0.000 description 2
239000004475 Arginine Substances 0.000 description 2
208000035143 Bacterial infection Diseases 0.000 description 2
239000004322 Butylated hydroxytoluene Substances 0.000 description 2
NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
SOGAXMICEFXMKE-UHFFFAOYSA-N Butylmethacrylate Chemical compound CCCCOC(=O)C(C)=C SOGAXMICEFXMKE-UHFFFAOYSA-N 0.000 description 2
101150029409 CFTR gene Proteins 0.000 description 2
229920000623 Cellulose acetate phthalate Polymers 0.000 description 2
DQEFEBPAPFSJLV-UHFFFAOYSA-N Cellulose propionate Chemical compound CCC(=O)OCC1OC(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C1OC1C(OC(=O)CC)C(OC(=O)CC)C(OC(=O)CC)C(COC(=O)CC)O1 DQEFEBPAPFSJLV-UHFFFAOYSA-N 0.000 description 2
229920001661 Chitosan Polymers 0.000 description 2
108010062745 Chloride Channels Proteins 0.000 description 2
102000011045 Chloride Channels Human genes 0.000 description 2
239000004709 Chlorinated polyethylene Substances 0.000 description 2
208000005590 Choroidal Neovascularization Diseases 0.000 description 2
206010060823 Choroidal neovascularisation Diseases 0.000 description 2
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
229920002261 Corn starch Polymers 0.000 description 2
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 2
KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
LVGKNOAMLMIIKO-UHFFFAOYSA-N Elaidinsaeure-aethylester Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC LVGKNOAMLMIIKO-UHFFFAOYSA-N 0.000 description 2
241000792859 Enema Species 0.000 description 2
IMROMDMJAWUWLK-UHFFFAOYSA-N Ethenol Chemical compound OC=C IMROMDMJAWUWLK-UHFFFAOYSA-N 0.000 description 2
229920000896 Ethulose Polymers 0.000 description 2
239000001859 Ethyl hydroxyethyl cellulose Substances 0.000 description 2
239000001116 FEMA 4028 Substances 0.000 description 2
208000002705 Glucose Intolerance Diseases 0.000 description 2
244000043261 Hevea brasiliensis Species 0.000 description 2
SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 description 2
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 2
QIGBRXMKCJKVMJ-UHFFFAOYSA-N Hydroquinone Chemical compound OC1=CC=C(O)C=C1 QIGBRXMKCJKVMJ-UHFFFAOYSA-N 0.000 description 2
208000032578 Inherited retinal disease Diseases 0.000 description 2
108010044467 Isoenzymes Proteins 0.000 description 2
WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 description 2
TWRXJAOTZQYOKJ-UHFFFAOYSA-L Magnesium chloride Chemical compound [Mg+2].[Cl-].[Cl-] TWRXJAOTZQYOKJ-UHFFFAOYSA-L 0.000 description 2
CSNNHWWHGAXBCP-UHFFFAOYSA-L Magnesium sulfate Chemical compound [Mg+2].[O-][S+2]([O-])([O-])[O-] CSNNHWWHGAXBCP-UHFFFAOYSA-L 0.000 description 2
244000246386 Mentha pulegium Species 0.000 description 2
235000016257 Mentha pulegium Nutrition 0.000 description 2
235000004357 Mentha x piperita Nutrition 0.000 description 2
AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 2
241000699666 Mus <mouse, genus> Species 0.000 description 2
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 2
239000004677 Nylon Substances 0.000 description 2
229910019142 PO4 Inorganic materials 0.000 description 2
235000019483 Peanut oil Nutrition 0.000 description 2
239000004264 Petrolatum Substances 0.000 description 2
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
206010035226 Plasma cell myeloma Diseases 0.000 description 2
239000005062 Polybutadiene Substances 0.000 description 2
229920002367 Polyisobutene Polymers 0.000 description 2
229920002690 Polyoxyl 40 HydrogenatedCastorOil Polymers 0.000 description 2
229920001213 Polysorbate 20 Polymers 0.000 description 2
ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
ZTHYODDOHIVTJV-UHFFFAOYSA-N Propyl gallate Chemical compound CCCOC(=O)C1=CC(O)=C(O)C(O)=C1 ZTHYODDOHIVTJV-UHFFFAOYSA-N 0.000 description 2
241000589517 Pseudomonas aeruginosa Species 0.000 description 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 2
241000700159 Rattus Species 0.000 description 2
208000032430 Retinal dystrophy Diseases 0.000 description 2
206010038923 Retinopathy Diseases 0.000 description 2
206010070834 Sensitisation Diseases 0.000 description 2
235000021355 Stearic acid Nutrition 0.000 description 2
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 2
NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 2
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 description 2
210000000579 abdominal fat Anatomy 0.000 description 2
150000001241 acetals Chemical class 0.000 description 2
230000009471 action Effects 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
230000006978 adaptation Effects 0.000 description 2
239000008272 agar Substances 0.000 description 2
230000002776 aggregation Effects 0.000 description 2
238000004220 aggregation Methods 0.000 description 2
150000001298 alcohols Chemical class 0.000 description 2
229940072056 alginate Drugs 0.000 description 2
239000000783 alginic acid Substances 0.000 description 2
229960001126 alginic acid Drugs 0.000 description 2
150000004781 alginic acids Chemical class 0.000 description 2
125000003545 alkoxy group Chemical group 0.000 description 2
235000019194 all-trans-retinaldehyde Nutrition 0.000 description 2
239000011751 all-trans-retinaldehyde Substances 0.000 description 2
239000011717 all-trans-retinol Substances 0.000 description 2
229940100609 all-trans-retinol Drugs 0.000 description 2
235000019169 all-trans-retinol Nutrition 0.000 description 2
150000004347 all-trans-retinol derivatives Chemical class 0.000 description 2
BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 2
235000012211 aluminium silicate Nutrition 0.000 description 2
150000001412 amines Chemical class 0.000 description 2
229910021529 ammonia Inorganic materials 0.000 description 2
239000005557 antagonist Substances 0.000 description 2
ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 description 2
235000009697 arginine Nutrition 0.000 description 2
239000011668 ascorbic acid Substances 0.000 description 2
229960005070 ascorbic acid Drugs 0.000 description 2
238000010560 atom transfer radical polymerization reaction Methods 0.000 description 2
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
208000022362 bacterial infectious disease Diseases 0.000 description 2
230000003385 bacteriostatic effect Effects 0.000 description 2
230000004888 barrier function Effects 0.000 description 2
239000000440 bentonite Substances 0.000 description 2
229910000278 bentonite Inorganic materials 0.000 description 2
235000012216 bentonite Nutrition 0.000 description 2
SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 2
229960000686 benzalkonium chloride Drugs 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 2
WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 description 2
230000033228 biological regulation Effects 0.000 description 2
239000012472 biological sample Substances 0.000 description 2
230000036760 body temperature Effects 0.000 description 2
125000001246 bromo group Chemical group Br* 0.000 description 2
244000309464 bull Species 0.000 description 2
229920005549 butyl rubber Polymers 0.000 description 2
235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
229940095259 butylated hydroxytoluene Drugs 0.000 description 2
229960002681 calcium alginate Drugs 0.000 description 2
235000010410 calcium alginate Nutrition 0.000 description 2
239000000648 calcium alginate Substances 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
235000010216 calcium carbonate Nutrition 0.000 description 2
OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 description 2
125000002837 carbocyclic group Chemical group 0.000 description 2
239000001569 carbon dioxide Substances 0.000 description 2
229960004424 carbon dioxide Drugs 0.000 description 2
229910002092 carbon dioxide Inorganic materials 0.000 description 2
239000011203 carbon fibre reinforced carbon Substances 0.000 description 2
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
125000002843 carboxylic acid group Chemical group 0.000 description 2
239000008112 carboxymethyl-cellulose Substances 0.000 description 2
229940105329 carboxymethylcellulose Drugs 0.000 description 2
235000010418 carrageenan Nutrition 0.000 description 2
229920001525 carrageenan Polymers 0.000 description 2
239000000679 carrageenan Substances 0.000 description 2
229940113118 carrageenan Drugs 0.000 description 2
239000004359 castor oil Substances 0.000 description 2
235000019438 castor oil Nutrition 0.000 description 2
230000001413 cellular effect Effects 0.000 description 2
229920006217 cellulose acetate butyrate Polymers 0.000 description 2
229940081734 cellulose acetate phthalate Drugs 0.000 description 2
229920001727 cellulose butyrate Polymers 0.000 description 2
229920006218 cellulose propionate Polymers 0.000 description 2
229960000541 cetyl alcohol Drugs 0.000 description 2
230000008859 change Effects 0.000 description 2
239000002738 chelating agent Substances 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
239000003153 chemical reaction reagent Substances 0.000 description 2
239000007910 chewable tablet Substances 0.000 description 2
125000001309 chloro group Chemical group Cl* 0.000 description 2
OSASVXMJTNOKOY-UHFFFAOYSA-N chlorobutanol Chemical compound CC(C)(O)C(Cl)(Cl)Cl OSASVXMJTNOKOY-UHFFFAOYSA-N 0.000 description 2
210000000349 chromosome Anatomy 0.000 description 2
238000000576 coating method Methods 0.000 description 2
229940110456 cocoa butter Drugs 0.000 description 2
235000019868 cocoa butter Nutrition 0.000 description 2
229940125782 compound 2 Drugs 0.000 description 2
229940126214 compound 3 Drugs 0.000 description 2
238000007796 conventional method Methods 0.000 description 2
239000008120 corn starch Substances 0.000 description 2
229960000913 crospovidone Drugs 0.000 description 2
239000002577 cryoprotective agent Substances 0.000 description 2
125000004122 cyclic group Chemical group 0.000 description 2
229940097362 cyclodextrins Drugs 0.000 description 2
JBDSSBMEKXHSJF-UHFFFAOYSA-N cyclopentanecarboxylic acid Chemical compound OC(=O)C1CCCC1 JBDSSBMEKXHSJF-UHFFFAOYSA-N 0.000 description 2
210000000805 cytoplasm Anatomy 0.000 description 2
230000000254 damaging effect Effects 0.000 description 2
230000034994 death Effects 0.000 description 2
230000007812 deficiency Effects 0.000 description 2
230000002950 deficient Effects 0.000 description 2
230000006735 deficit Effects 0.000 description 2
230000003111 delayed effect Effects 0.000 description 2
OSVXSBDYLRYLIG-UHFFFAOYSA-N dioxidochlorine(.) Chemical compound O=Cl=O OSVXSBDYLRYLIG-UHFFFAOYSA-N 0.000 description 2
238000004090 dissolution Methods 0.000 description 2
231100000673 dose–response relationship Toxicity 0.000 description 2
230000002526 effect on cardiovascular system Effects 0.000 description 2
230000001804 emulsifying effect Effects 0.000 description 2
210000002472 endoplasmic reticulum Anatomy 0.000 description 2
239000007920 enema Substances 0.000 description 2
238000005516 engineering process Methods 0.000 description 2
239000003623 enhancer Substances 0.000 description 2
239000002662 enteric coated tablet Substances 0.000 description 2
239000002702 enteric coating Substances 0.000 description 2
238000009505 enteric coating Methods 0.000 description 2
229920005558 epichlorohydrin rubber Polymers 0.000 description 2
150000002148 esters Chemical class 0.000 description 2
BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 description 2
235000019326 ethyl hydroxyethyl cellulose Nutrition 0.000 description 2
MMXKVMNBHPAILY-UHFFFAOYSA-N ethyl laurate Chemical compound CCCCCCCCCCCC(=O)OCC MMXKVMNBHPAILY-UHFFFAOYSA-N 0.000 description 2
235000010944 ethyl methyl cellulose Nutrition 0.000 description 2
LVGKNOAMLMIIKO-QXMHVHEDSA-N ethyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC LVGKNOAMLMIIKO-QXMHVHEDSA-N 0.000 description 2
229940093471 ethyl oleate Drugs 0.000 description 2
201000010934 exostosis Diseases 0.000 description 2
150000004665 fatty acids Chemical class 0.000 description 2
239000010685 fatty oil Substances 0.000 description 2
239000010408 film Substances 0.000 description 2
239000007941 film coated tablet Substances 0.000 description 2
238000009501 film coating Methods 0.000 description 2
239000007888 film coating Substances 0.000 description 2
125000001153 fluoro group Chemical group F* 0.000 description 2
235000013305 food Nutrition 0.000 description 2
201000006321 fundus dystrophy Diseases 0.000 description 2
239000003349 gelling agent Substances 0.000 description 2
230000002068 genetic effect Effects 0.000 description 2
ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
150000002334 glycols Chemical class 0.000 description 2
239000003979 granulating agent Substances 0.000 description 2
229940093915 gynecological organic acid Drugs 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
235000001050 hortel pimenta Nutrition 0.000 description 2
239000003906 humectant Substances 0.000 description 2
239000008172 hydrogenated vegetable oil Substances 0.000 description 2
125000004356 hydroxy functional group Chemical group O* 0.000 description 2
WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
229920003132 hydroxypropyl methylcellulose phthalate Polymers 0.000 description 2
201000010930 hyperostosis Diseases 0.000 description 2
230000001771 impaired effect Effects 0.000 description 2
238000002513 implantation Methods 0.000 description 2
230000001976 improved effect Effects 0.000 description 2
230000001939 inductive effect Effects 0.000 description 2
239000011261 inert gas Substances 0.000 description 2
238000001802 infusion Methods 0.000 description 2
208000017532 inherited retinal dystrophy Diseases 0.000 description 2
CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 description 2
229960000367 inositol Drugs 0.000 description 2
210000002660 insulin-secreting cell Anatomy 0.000 description 2
230000000968 intestinal effect Effects 0.000 description 2
210000000936 intestine Anatomy 0.000 description 2
230000003834 intracellular effect Effects 0.000 description 2
238000007918 intramuscular administration Methods 0.000 description 2
238000007912 intraperitoneal administration Methods 0.000 description 2
238000007914 intraventricular administration Methods 0.000 description 2
239000003456 ion exchange resin Substances 0.000 description 2
229920003303 ion-exchange polymer Polymers 0.000 description 2
229920000554 ionomer Polymers 0.000 description 2
125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 2
NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
210000003734 kidney Anatomy 0.000 description 2
238000002372 labelling Methods 0.000 description 2
235000010445 lecithin Nutrition 0.000 description 2
239000000787 lecithin Substances 0.000 description 2
229940067606 lecithin Drugs 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
210000005229 liver cell Anatomy 0.000 description 2
239000003589 local anesthetic agent Substances 0.000 description 2
229960005015 local anesthetics Drugs 0.000 description 2
208000018769 loss of vision Diseases 0.000 description 2
231100000864 loss of vision Toxicity 0.000 description 2
231100000053 low toxicity Toxicity 0.000 description 2
230000014759 maintenance of location Effects 0.000 description 2
239000001630 malic acid Substances 0.000 description 2
235000011090 malic acid Nutrition 0.000 description 2
239000002184 metal Substances 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
229910021645 metal ion Inorganic materials 0.000 description 2
239000004292 methyl p-hydroxybenzoate Substances 0.000 description 2
OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 2
229920003087 methylethyl cellulose Polymers 0.000 description 2
238000002156 mixing Methods 0.000 description 2
125000002950 monocyclic group Chemical group 0.000 description 2
239000002105 nanoparticle Substances 0.000 description 2
229920003052 natural elastomer Polymers 0.000 description 2
229920001194 natural rubber Polymers 0.000 description 2
125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 2
239000002736 nonionic surfactant Substances 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
102000039446 nucleic acids Human genes 0.000 description 2
108020004707 nucleic acids Proteins 0.000 description 2
150000007523 nucleic acids Chemical class 0.000 description 2
235000015097 nutrients Nutrition 0.000 description 2
229920001778 nylon Polymers 0.000 description 2
GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 2
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 2
239000006186 oral dosage form Substances 0.000 description 2
150000007524 organic acids Chemical class 0.000 description 2
235000005985 organic acids Nutrition 0.000 description 2
229920000620 organic polymer Polymers 0.000 description 2
201000002044 ossification of the posterior longitudinal ligament of spine Diseases 0.000 description 2
230000003647 oxidation Effects 0.000 description 2
238000007254 oxidation reaction Methods 0.000 description 2
239000001301 oxygen Substances 0.000 description 2
LXCFILQKKLGQFO-UHFFFAOYSA-N p-hydroxybenzoic acid methyl ester Natural products COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
239000003002 pH adjusting agent Substances 0.000 description 2
FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 2
230000008506 pathogenesis Effects 0.000 description 2
230000007170 pathology Effects 0.000 description 2
239000000312 peanut oil Substances 0.000 description 2
239000001814 pectin Substances 0.000 description 2
229920001277 pectin Polymers 0.000 description 2
235000010987 pectin Nutrition 0.000 description 2
230000035515 penetration Effects 0.000 description 2
229940066842 petrolatum Drugs 0.000 description 2
WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 2
235000021317 phosphate Nutrition 0.000 description 2
150000003013 phosphoric acid derivatives Chemical class 0.000 description 2
239000002504 physiological saline solution Substances 0.000 description 2
239000006187 pill Substances 0.000 description 2
239000004014 plasticizer Substances 0.000 description 2
229920001490 poly(butyl methacrylate) polymer Polymers 0.000 description 2
229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 2
229920003229 poly(methyl methacrylate) Polymers 0.000 description 2
239000004584 polyacrylic acid Substances 0.000 description 2
229920002857 polybutadiene Polymers 0.000 description 2
125000003367 polycyclic group Chemical group 0.000 description 2
229940068918 polyethylene glycol 400 Drugs 0.000 description 2
229920002338 polyhydroxyethylmethacrylate Polymers 0.000 description 2
229920001195 polyisoprene Polymers 0.000 description 2
239000004926 polymethyl methacrylate Substances 0.000 description 2
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
229920001184 polypeptide Polymers 0.000 description 2
229920001451 polypropylene glycol Polymers 0.000 description 2
229920001296 polysiloxane Polymers 0.000 description 2
229920000136 polysorbate Polymers 0.000 description 2
229940068968 polysorbate 80 Drugs 0.000 description 2
235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 2
229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 2
239000011591 potassium Substances 0.000 description 2
229910052700 potassium Inorganic materials 0.000 description 2
229920001592 potato starch Polymers 0.000 description 2
230000003389 potentiating effect Effects 0.000 description 2
208000022256 primary systemic amyloidosis Diseases 0.000 description 2
238000012545 processing Methods 0.000 description 2
230000000750 progressive effect Effects 0.000 description 2
239000003380 propellant Substances 0.000 description 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 2
239000004405 propyl p-hydroxybenzoate Substances 0.000 description 2
QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 description 2
125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 description 2
125000006239 protecting group Chemical group 0.000 description 2
238000011002 quantification Methods 0.000 description 2
150000004609 retinol derivatives Chemical class 0.000 description 2
229940081974 saccharin Drugs 0.000 description 2
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 2
235000019204 saccharin Nutrition 0.000 description 2
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 2
229960004889 salicylic acid Drugs 0.000 description 2
210000003296 saliva Anatomy 0.000 description 2
CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 description 2
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 2
230000008313 sensitization Effects 0.000 description 2
238000000926 separation method Methods 0.000 description 2
239000000741 silica gel Substances 0.000 description 2
229910002027 silica gel Inorganic materials 0.000 description 2
229940005550 sodium alginate Drugs 0.000 description 2
235000010413 sodium alginate Nutrition 0.000 description 2
239000000661 sodium alginate Substances 0.000 description 2
235000017557 sodium bicarbonate Nutrition 0.000 description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L sodium carbonate Substances [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
235000011121 sodium hydroxide Nutrition 0.000 description 2
229920003109 sodium starch glycolate Polymers 0.000 description 2
239000008109 sodium starch glycolate Substances 0.000 description 2
229940079832 sodium starch glycolate Drugs 0.000 description 2
239000007909 solid dosage form Substances 0.000 description 2
235000010199 sorbic acid Nutrition 0.000 description 2
239000004334 sorbic acid Substances 0.000 description 2
229940075582 sorbic acid Drugs 0.000 description 2
239000003549 soybean oil Substances 0.000 description 2
235000012424 soybean oil Nutrition 0.000 description 2
230000006641 stabilisation Effects 0.000 description 2
238000011105 stabilization Methods 0.000 description 2
229960004274 stearic acid Drugs 0.000 description 2
239000008117 stearic acid Substances 0.000 description 2
239000008223 sterile water Substances 0.000 description 2
210000002784 stomach Anatomy 0.000 description 2
238000009495 sugar coating Methods 0.000 description 2
239000011593 sulfur Substances 0.000 description 2
210000004243 sweat Anatomy 0.000 description 2
238000003786 synthesis reaction Methods 0.000 description 2
235000002906 tartaric acid Nutrition 0.000 description 2
239000011975 tartaric acid Substances 0.000 description 2
210000001138 tear Anatomy 0.000 description 2
229920001897 terpolymer Polymers 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
238000002560 therapeutic procedure Methods 0.000 description 2
229930003799 tocopherol Natural products 0.000 description 2
235000010384 tocopherol Nutrition 0.000 description 2
229960001295 tocopherol Drugs 0.000 description 2
239000011732 tocopherol Substances 0.000 description 2
JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 2
239000012049 topical pharmaceutical composition Substances 0.000 description 2
231100000419 toxicity Toxicity 0.000 description 2
230000001988 toxicity Effects 0.000 description 2
230000037317 transdermal delivery Effects 0.000 description 2
229940117013 triethanolamine oleate Drugs 0.000 description 2
LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 2
239000006217 urethral suppository Substances 0.000 description 2
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 2
150000003722 vitamin derivatives Chemical class 0.000 description 2
239000001993 wax Substances 0.000 description 2
238000001262 western blot Methods 0.000 description 2
238000009736 wetting Methods 0.000 description 2
UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 2
GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 1
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
GYYDPBCUIJTIBM-DYOGSRDZSA-N (2r,3s,4s,5r)-2-(hydroxymethyl)-6-[[(4r,5s)-4-hydroxy-3-methyl-2,6-dioxabicyclo[3.2.1]octan-8-yl]oxy]-4-methoxyoxane-3,5-diol Chemical compound O[C@@H]1[C@@H](OC)[C@@H](O)[C@@H](CO)OC1OC1[C@H]2OCC1OC(C)[C@H]2O GYYDPBCUIJTIBM-DYOGSRDZSA-N 0.000 description 1
XMQUEQJCYRFIQS-YFKPBYRVSA-N (2s)-2-amino-5-ethoxy-5-oxopentanoic acid Chemical compound CCOC(=O)CC[C@H](N)C(O)=O XMQUEQJCYRFIQS-YFKPBYRVSA-N 0.000 description 1
WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
229920002818 (Hydroxyethyl)methacrylate Polymers 0.000 description 1
YFMFNYKEUDLDTL-UHFFFAOYSA-N 1,1,1,2,3,3,3-heptafluoropropane Chemical compound FC(F)(F)C(F)C(F)(F)F YFMFNYKEUDLDTL-UHFFFAOYSA-N 0.000 description 1
LVGUZGTVOIAKKC-UHFFFAOYSA-N 1,1,1,2-tetrafluoroethane Chemical compound FCC(F)(F)F LVGUZGTVOIAKKC-UHFFFAOYSA-N 0.000 description 1
ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 1
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 description 1
NCYCYZXNIZJOKI-HPNHMNAASA-N 11Z-retinal Natural products CC(=C/C=O)C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C NCYCYZXNIZJOKI-HPNHMNAASA-N 0.000 description 1
WGIMXKDCVCTHGW-UHFFFAOYSA-N 2-(2-hydroxyethoxy)ethyl dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCCOCCO WGIMXKDCVCTHGW-UHFFFAOYSA-N 0.000 description 1
JKNCOURZONDCGV-UHFFFAOYSA-N 2-(dimethylamino)ethyl 2-methylprop-2-enoate Chemical compound CN(C)CCOC(=O)C(C)=C JKNCOURZONDCGV-UHFFFAOYSA-N 0.000 description 1
FKOKUHFZNIUSLW-UHFFFAOYSA-N 2-Hydroxypropyl stearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(C)O FKOKUHFZNIUSLW-UHFFFAOYSA-N 0.000 description 1
FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 description 1
CFWRDBDJAOHXSH-SECBINFHSA-N 2-azaniumylethyl [(2r)-2,3-diacetyloxypropyl] phosphate Chemical compound CC(=O)OC[C@@H](OC(C)=O)COP(O)(=O)OCCN CFWRDBDJAOHXSH-SECBINFHSA-N 0.000 description 1
QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
SSONCJTVDRSLNK-UHFFFAOYSA-N 2-methylprop-2-enoic acid;hydrochloride Chemical compound Cl.CC(=C)C(O)=O SSONCJTVDRSLNK-UHFFFAOYSA-N 0.000 description 1
PKRSYEPBQPFNRB-UHFFFAOYSA-N 2-phenoxybenzoic acid Chemical class OC(=O)C1=CC=CC=C1OC1=CC=CC=C1 PKRSYEPBQPFNRB-UHFFFAOYSA-N 0.000 description 1
LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
ODJQKYXPKWQWNK-UHFFFAOYSA-N 3,3'-Thiobispropanoic acid Chemical compound OC(=O)CCSCCC(O)=O ODJQKYXPKWQWNK-UHFFFAOYSA-N 0.000 description 1
UBLAMKHIFZBBSS-UHFFFAOYSA-N 3-Methylbutyl pentanoate Chemical compound CCCCC(=O)OCCC(C)C UBLAMKHIFZBBSS-UHFFFAOYSA-N 0.000 description 1
BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
CYDQOEWLBCCFJZ-UHFFFAOYSA-N 4-(4-fluorophenyl)oxane-4-carboxylic acid Chemical compound C=1C=C(F)C=CC=1C1(C(=O)O)CCOCC1 CYDQOEWLBCCFJZ-UHFFFAOYSA-N 0.000 description 1
NZAQRZWBQUIBSF-UHFFFAOYSA-N 4-(4-sulfobutoxy)butane-1-sulfonic acid Chemical compound OS(=O)(=O)CCCCOCCCCS(O)(=O)=O NZAQRZWBQUIBSF-UHFFFAOYSA-N 0.000 description 1
QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
229910002016 Aerosil® 200 Inorganic materials 0.000 description 1
229920000936 Agarose Polymers 0.000 description 1
102000009027 Albumins Human genes 0.000 description 1
108010088751 Albumins Proteins 0.000 description 1
229920001450 Alpha-Cyclodextrin Polymers 0.000 description 1
102000009091 Amyloidogenic Proteins Human genes 0.000 description 1
108010048112 Amyloidogenic Proteins Proteins 0.000 description 1
108010011485 Aspartame Proteins 0.000 description 1
208000023275 Autoimmune disease Diseases 0.000 description 1
239000005711 Benzoic acid Substances 0.000 description 1
208000037663 Best vitelliform macular dystrophy Diseases 0.000 description 1
BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
102000004506 Blood Proteins Human genes 0.000 description 1
108010017384 Blood Proteins Proteins 0.000 description 1
208000003174 Brain Neoplasms Diseases 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 1
241000282472 Canis lupus familiaris Species 0.000 description 1
241000283707 Capra Species 0.000 description 1
239000004215 Carbon black (E152) Substances 0.000 description 1
108010078791 Carrier Proteins Proteins 0.000 description 1
208000035484 Cellulite Diseases 0.000 description 1
LZZYPRNAOMGNLH-UHFFFAOYSA-M Cetrimonium bromide Chemical compound [Br-].CCCCCCCCCCCCCCCC[N+](C)(C)C LZZYPRNAOMGNLH-UHFFFAOYSA-M 0.000 description 1
241001227713 Chiron Species 0.000 description 1
229920002101 Chitin Polymers 0.000 description 1
239000004155 Chlorine dioxide Substances 0.000 description 1
241000206575 Chondrus crispus Species 0.000 description 1
241000207199 Citrus Species 0.000 description 1
235000008733 Citrus aurantifolia Nutrition 0.000 description 1
244000060011 Cocos nucifera Species 0.000 description 1
206010010356 Congenital anomaly Diseases 0.000 description 1
229920002785 Croscarmellose sodium Polymers 0.000 description 1
XUIIKFGFIJCVMT-GFCCVEGCSA-N D-thyroxine Chemical compound IC1=CC(C[C@@H](N)C(O)=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-GFCCVEGCSA-N 0.000 description 1
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 1
102100032260 DNA-directed RNA polymerase II subunit RPB4 Human genes 0.000 description 1
206010011878 Deafness Diseases 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
XBPCUCUWBYBCDP-UHFFFAOYSA-N Dicyclohexylamine Chemical compound C1CCCCC1NC1CCCCC1 XBPCUCUWBYBCDP-UHFFFAOYSA-N 0.000 description 1
102000016680 Dioxygenases Human genes 0.000 description 1
108010028143 Dioxygenases Proteins 0.000 description 1
241000283086 Equidae Species 0.000 description 1
JIGUQPWFLRLWPJ-UHFFFAOYSA-N Ethyl acrylate Chemical compound CCOC(=O)C=C JIGUQPWFLRLWPJ-UHFFFAOYSA-N 0.000 description 1
229920003134 Eudragit® polymer Polymers 0.000 description 1
102000018711 Facilitative Glucose Transport Proteins Human genes 0.000 description 1
108010027279 Facilitative Glucose Transport Proteins Proteins 0.000 description 1
208000034846 Familial Amyloid Neuropathies Diseases 0.000 description 1
101710163305 Fibril protein Proteins 0.000 description 1
206010017076 Fracture Diseases 0.000 description 1
229930091371 Fructose Natural products 0.000 description 1
239000005715 Fructose Substances 0.000 description 1
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
102400000321 Glucagon Human genes 0.000 description 1
108060003199 Glucagon Proteins 0.000 description 1
102000058061 Glucose Transporter Type 4 Human genes 0.000 description 1
206010018429 Glucose tolerance impaired Diseases 0.000 description 1
102000016354 Glucuronosyltransferase Human genes 0.000 description 1
108010092364 Glucuronosyltransferase Proteins 0.000 description 1
229920000569 Gum karaya Polymers 0.000 description 1
108010023302 HDL Cholesterol Proteins 0.000 description 1
239000012981 Hank's balanced salt solution Substances 0.000 description 1
206010019233 Headaches Diseases 0.000 description 1
HTTJABKRGRZYRN-UHFFFAOYSA-N Heparin Chemical compound OC1C(NC(=O)C)C(O)OC(COS(O)(=O)=O)C1OC1C(OS(O)(=O)=O)C(O)C(OC2C(C(OS(O)(=O)=O)C(OC3C(C(O)C(O)C(O3)C(O)=O)OS(O)(=O)=O)C(CO)O2)NS(O)(=O)=O)C(C(O)=O)O1 HTTJABKRGRZYRN-UHFFFAOYSA-N 0.000 description 1
229920001499 Heparinoid Polymers 0.000 description 1
208000003923 Hereditary Corneal Dystrophies Diseases 0.000 description 1
206010019889 Hereditary neuropathic amyloidosis Diseases 0.000 description 1
241000282412 Homo Species 0.000 description 1
101100161494 Homo sapiens ABCA4 gene Proteins 0.000 description 1
101001088177 Homo sapiens DNA-directed RNA polymerase II subunit RPB4 Proteins 0.000 description 1
101000831949 Homo sapiens Receptor for retinol uptake STRA6 Proteins 0.000 description 1
WOBHKFSMXKNTIM-UHFFFAOYSA-N Hydroxyethyl methacrylate Chemical compound CC(=C)C(=O)OCCO WOBHKFSMXKNTIM-UHFFFAOYSA-N 0.000 description 1
206010060378 Hyperinsulinaemia Diseases 0.000 description 1
206010020772 Hypertension Diseases 0.000 description 1
206010058359 Hypogonadism Diseases 0.000 description 1
238000012404 In vitro experiment Methods 0.000 description 1
208000026350 Inborn Genetic disease Diseases 0.000 description 1
108010001127 Insulin Receptor Proteins 0.000 description 1
102000003746 Insulin Receptor Human genes 0.000 description 1
208000007976 Ketosis Diseases 0.000 description 1
150000000994 L-ascorbates Chemical class 0.000 description 1
ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 1
FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 description 1
239000004166 Lanolin Substances 0.000 description 1
241000218652 Larix Species 0.000 description 1
235000005590 Larix decidua Nutrition 0.000 description 1
229920000161 Locust bean gum Polymers 0.000 description 1
208000032376 Lung infection Diseases 0.000 description 1
UPYKUZBSLRQECL-UKMVMLAPSA-N Lycopene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1C(=C)CCCC1(C)C)C=CC=C(/C)C=CC2C(=C)CCCC2(C)C UPYKUZBSLRQECL-UKMVMLAPSA-N 0.000 description 1
241000195947 Lycopodium Species 0.000 description 1
KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 description 1
239000004472 Lysine Substances 0.000 description 1
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
239000005913 Maltodextrin Substances 0.000 description 1
229920002774 Maltodextrin Polymers 0.000 description 1
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 description 1
240000003183 Manihot esculenta Species 0.000 description 1
235000016735 Manihot esculenta subsp esculenta Nutrition 0.000 description 1
208000001145 Metabolic Syndrome Diseases 0.000 description 1
CERQOIWHTDAKMF-UHFFFAOYSA-N Methacrylic acid Chemical compound CC(=C)C(O)=O CERQOIWHTDAKMF-UHFFFAOYSA-N 0.000 description 1
229920000715 Mucilage Polymers 0.000 description 1
208000023178 Musculoskeletal disease Diseases 0.000 description 1
FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 1
MBBZMMPHUWSWHV-BDVNFPICSA-N N-methylglucamine Chemical compound CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO MBBZMMPHUWSWHV-BDVNFPICSA-N 0.000 description 1
150000001204 N-oxides Chemical class 0.000 description 1
206010028748 Nasal obstruction Diseases 0.000 description 1
206010028980 Neoplasm Diseases 0.000 description 1
GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
208000022873 Ocular disease Diseases 0.000 description 1
239000005642 Oleic acid Substances 0.000 description 1
ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
241000283973 Oryctolagus cuniculus Species 0.000 description 1
208000009469 Ossification of Posterior Longitudinal Ligament Diseases 0.000 description 1
108090000854 Oxidoreductases Proteins 0.000 description 1
102000004316 Oxidoreductases Human genes 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
208000018737 Parkinson disease Diseases 0.000 description 1
206010049752 Peau d'orange Diseases 0.000 description 1
241001494479 Pecora Species 0.000 description 1
108010067902 Peptide Library Proteins 0.000 description 1
206010034972 Photosensitivity reaction Diseases 0.000 description 1
229920012485 Plasticized Polyvinyl chloride Polymers 0.000 description 1
229920002845 Poly(methacrylic acid) Polymers 0.000 description 1
229920000148 Polycarbophil calcium Polymers 0.000 description 1
239000004743 Polypropylene Substances 0.000 description 1
241000288906 Primates Species 0.000 description 1
HCBIBCJNVBAKAB-UHFFFAOYSA-N Procaine hydrochloride Chemical compound Cl.CCN(CC)CCOC(=O)C1=CC=C(N)C=C1 HCBIBCJNVBAKAB-UHFFFAOYSA-N 0.000 description 1
HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 description 1
239000004373 Pullulan Substances 0.000 description 1
229920001218 Pullulan Polymers 0.000 description 1
102100024235 Receptor for retinol uptake STRA6 Human genes 0.000 description 1
208000007014 Retinitis pigmentosa Diseases 0.000 description 1
102100022941 Retinol-binding protein 1 Human genes 0.000 description 1
108050008744 Retinol-binding protein 1 Proteins 0.000 description 1
108091006300 SLC2A4 Proteins 0.000 description 1
235000019485 Safflower oil Nutrition 0.000 description 1
ILRCGYURZSFMEG-RKQHYHRCSA-N Salidroside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OCCC1=CC=C(O)C=C1 ILRCGYURZSFMEG-RKQHYHRCSA-N 0.000 description 1
229920002305 Schizophyllan Polymers 0.000 description 1
208000032023 Signs and Symptoms Diseases 0.000 description 1
VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
239000004147 Sorbitan trioleate Substances 0.000 description 1
PRXRUNOAOLTIEF-ADSICKODSA-N Sorbitan trioleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC[C@@H](OC(=O)CCCCCCC\C=C/CCCCCCCC)[C@H]1OC[C@H](O)[C@H]1OC(=O)CCCCCCC\C=C/CCCCCCCC PRXRUNOAOLTIEF-ADSICKODSA-N 0.000 description 1
206010058660 Spinal ligament ossification Diseases 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
235000019486 Sunflower oil Nutrition 0.000 description 1
240000006474 Theobroma bicolor Species 0.000 description 1
239000003490 Thiodipropionic acid Substances 0.000 description 1
102000009488 Thyroxine-Binding Proteins Human genes 0.000 description 1
108010048889 Thyroxine-Binding Proteins Proteins 0.000 description 1
235000011941 Tilia x europaea Nutrition 0.000 description 1
208000009205 Tinnitus Diseases 0.000 description 1
108060008539 Transglutaminase Proteins 0.000 description 1
HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
XCCTYIAWTASOJW-XVFCMESISA-N Uridine-5'-Diphosphate Chemical compound O[C@@H]1[C@H](O)[C@@H](COP(O)(=O)OP(O)(O)=O)O[C@H]1N1C(=O)NC(=O)C=C1 XCCTYIAWTASOJW-XVFCMESISA-N 0.000 description 1
108010059993 Vancomycin Proteins 0.000 description 1
108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 description 1
206010047513 Vision blurred Diseases 0.000 description 1
208000010011 Vitamin A Deficiency Diseases 0.000 description 1
238000002441 X-ray diffraction Methods 0.000 description 1
TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 description 1
XJLXINKUBYWONI-DQQFMEOOSA-N [[(2r,3r,4r,5r)-5-(6-aminopurin-9-yl)-3-hydroxy-4-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2s,3r,4s,5s)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate Chemical compound NC(=O)C1=CC=C[N+]([C@@H]2[C@H]([C@@H](O)[C@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](OP(O)(O)=O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 XJLXINKUBYWONI-DQQFMEOOSA-N 0.000 description 1
210000001015 abdomen Anatomy 0.000 description 1
230000003187 abdominal effect Effects 0.000 description 1
201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 description 1
230000005856 abnormality Effects 0.000 description 1
238000002835 absorbance Methods 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
230000002745 absorbent Effects 0.000 description 1
239000003655 absorption accelerator Substances 0.000 description 1
238000000862 absorption spectrum Methods 0.000 description 1
SPEUIVXLLWOEMJ-UHFFFAOYSA-N acetaldehyde dimethyl acetal Natural products COC(C)OC SPEUIVXLLWOEMJ-UHFFFAOYSA-N 0.000 description 1
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 1
ZUAAPNNKRHMPKG-UHFFFAOYSA-N acetic acid;butanedioic acid;methanol;propane-1,2-diol Chemical compound OC.CC(O)=O.CC(O)CO.OC(=O)CCC(O)=O ZUAAPNNKRHMPKG-UHFFFAOYSA-N 0.000 description 1
230000002378 acidificating effect Effects 0.000 description 1
150000001252 acrylic acid derivatives Chemical class 0.000 description 1
230000004913 activation Effects 0.000 description 1
239000000853 adhesive Substances 0.000 description 1
150000001299 aldehydes Chemical class 0.000 description 1
IAJILQKETJEXLJ-QTBDOELSSA-N aldehydo-D-glucuronic acid Chemical class O=C[C@H](O)[C@@H](O)[C@H](O)[C@H](O)C(O)=O IAJILQKETJEXLJ-QTBDOELSSA-N 0.000 description 1
125000001931 aliphatic group Chemical group 0.000 description 1
229910052783 alkali metal Inorganic materials 0.000 description 1
229910052784 alkaline earth metal Inorganic materials 0.000 description 1
125000004414 alkyl thio group Chemical group 0.000 description 1
SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
HFHDHCJBZVLPGP-RWMJIURBSA-N alpha-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO HFHDHCJBZVLPGP-RWMJIURBSA-N 0.000 description 1
229940043377 alpha-cyclodextrin Drugs 0.000 description 1
VREFGVBLTWBCJP-UHFFFAOYSA-N alprazolam Chemical compound C12=CC(Cl)=CC=C2N2C(C)=NN=C2CN=C1C1=CC=CC=C1 VREFGVBLTWBCJP-UHFFFAOYSA-N 0.000 description 1
230000004075 alteration Effects 0.000 description 1
PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 1
235000019270 ammonium chloride Nutrition 0.000 description 1
150000003863 ammonium salts Chemical class 0.000 description 1
BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
229910052921 ammonium sulfate Inorganic materials 0.000 description 1
235000011130 ammonium sulphate Nutrition 0.000 description 1
239000002280 amphoteric surfactant Substances 0.000 description 1
230000003941 amyloidogenesis Effects 0.000 description 1
230000003942 amyloidogenic effect Effects 0.000 description 1
229940035674 anesthetics Drugs 0.000 description 1
230000002491 angiogenic effect Effects 0.000 description 1
229940031955 anhydrous lanolin Drugs 0.000 description 1
125000000129 anionic group Chemical group 0.000 description 1
239000003945 anionic surfactant Substances 0.000 description 1
239000000420 anogeissus latifolia wall. gum Substances 0.000 description 1
239000003242 anti bacterial agent Substances 0.000 description 1
230000000845 anti-microbial effect Effects 0.000 description 1
229940088710 antibiotic agent Drugs 0.000 description 1
229940027983 antiseptic and disinfectant quaternary ammonium compound Drugs 0.000 description 1
239000012062 aqueous buffer Substances 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000008122 artificial sweetener Substances 0.000 description 1
235000021311 artificial sweeteners Nutrition 0.000 description 1
125000005110 aryl thio group Chemical group 0.000 description 1
239000000605 aspartame Substances 0.000 description 1
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 1
235000010357 aspartame Nutrition 0.000 description 1
229960003438 aspartame Drugs 0.000 description 1
239000012911 assay medium Substances 0.000 description 1
239000000305 astragalus gummifer gum Substances 0.000 description 1
230000005784 autoimmunity Effects 0.000 description 1
210000003403 autonomic nervous system Anatomy 0.000 description 1
230000001580 bacterial effect Effects 0.000 description 1
230000009286 beneficial effect Effects 0.000 description 1
UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 1
229960001950 benzethonium chloride Drugs 0.000 description 1
235000010233 benzoic acid Nutrition 0.000 description 1
229960004365 benzoic acid Drugs 0.000 description 1
235000011175 beta-cyclodextrine Nutrition 0.000 description 1
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 description 1
229920000249 biocompatible polymer Polymers 0.000 description 1
229920002988 biodegradable polymer Polymers 0.000 description 1
239000004621 biodegradable polymer Substances 0.000 description 1
230000008033 biological extinction Effects 0.000 description 1
230000005540 biological transmission Effects 0.000 description 1
239000000090 biomarker Substances 0.000 description 1
230000000903 blocking effect Effects 0.000 description 1
230000036770 blood supply Effects 0.000 description 1
210000001124 body fluid Anatomy 0.000 description 1
239000010839 body fluid Substances 0.000 description 1
230000008468 bone growth Effects 0.000 description 1
229910021538 borax Inorganic materials 0.000 description 1
KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
239000004327 boric acid Substances 0.000 description 1
150000001642 boronic acid derivatives Chemical class 0.000 description 1
210000004556 brain Anatomy 0.000 description 1
239000006172 buffering agent Substances 0.000 description 1
KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
125000004369 butenyl group Chemical group C(=CCC)* 0.000 description 1
125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
235000019282 butylated hydroxyanisole Nutrition 0.000 description 1
239000011575 calcium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
229910001628 calcium chloride Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
201000011510 cancer Diseases 0.000 description 1
DKVNPHBNOWQYFE-UHFFFAOYSA-N carbamodithioic acid Chemical compound NC(S)=S DKVNPHBNOWQYFE-UHFFFAOYSA-N 0.000 description 1
229960001631 carbomer Drugs 0.000 description 1
150000001721 carbon Chemical group 0.000 description 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 description 1
150000001735 carboxylic acids Chemical class 0.000 description 1
229940084030 carboxymethylcellulose calcium Drugs 0.000 description 1
239000004203 carnauba wax Substances 0.000 description 1
235000013869 carnauba wax Nutrition 0.000 description 1
150000001746 carotenes Chemical class 0.000 description 1
235000005473 carotenes Nutrition 0.000 description 1
230000001925 catabolic effect Effects 0.000 description 1
238000006555 catalytic reaction Methods 0.000 description 1
239000003729 cation exchange resin Substances 0.000 description 1
229940023913 cation exchange resins Drugs 0.000 description 1
125000002091 cationic group Chemical group 0.000 description 1
239000003093 cationic surfactant Substances 0.000 description 1
150000001768 cations Chemical class 0.000 description 1
230000024245 cell differentiation Effects 0.000 description 1
210000000170 cell membrane Anatomy 0.000 description 1
239000013553 cell monolayer Substances 0.000 description 1
230000036232 cellulite Effects 0.000 description 1
WZNRVWBKYDHTKI-UHFFFAOYSA-N cellulose, acetate 1,2,4-benzenetricarboxylate Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(O)C(O)C1O.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.CC(=O)OCC1OC(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(COC(C)=O)O1.OC(=O)C1=CC(C(=O)O)=CC=C1C(=O)OCC1C(OC2C(C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(OC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)C(COC(=O)C=3C(=CC(=CC=3)C(O)=O)C(O)=O)O2)OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)C(OC(=O)C=2C(=CC(=CC=2)C(O)=O)C(O)=O)O1 WZNRVWBKYDHTKI-UHFFFAOYSA-N 0.000 description 1
229960001927 cetylpyridinium chloride Drugs 0.000 description 1
NFCRBQADEGXVDL-UHFFFAOYSA-M cetylpyridinium chloride monohydrate Chemical compound O.[Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 NFCRBQADEGXVDL-UHFFFAOYSA-M 0.000 description 1
150000005829 chemical entities Chemical class 0.000 description 1
239000003638 chemical reducing agent Substances 0.000 description 1
230000001055 chewing effect Effects 0.000 description 1
235000015218 chewing gum Nutrition 0.000 description 1
150000001805 chlorine compounds Chemical class 0.000 description 1
235000019398 chlorine dioxide Nutrition 0.000 description 1
229960004926 chlorobutanol Drugs 0.000 description 1
238000013375 chromatographic separation Methods 0.000 description 1
BWRHOYDPVJPXMF-UHFFFAOYSA-N cis-Caran Natural products C1C(C)CCC2C(C)(C)C12 BWRHOYDPVJPXMF-UHFFFAOYSA-N 0.000 description 1
150000001860 citric acid derivatives Chemical class 0.000 description 1
235000020971 citrus fruits Nutrition 0.000 description 1
239000004927 clay Substances 0.000 description 1
239000011248 coating agent Substances 0.000 description 1
239000003240 coconut oil Substances 0.000 description 1
235000019864 coconut oil Nutrition 0.000 description 1
229940075614 colloidal silicon dioxide Drugs 0.000 description 1
239000000084 colloidal system Substances 0.000 description 1
230000004456 color vision Effects 0.000 description 1
238000002648 combination therapy Methods 0.000 description 1
230000000295 complement effect Effects 0.000 description 1
238000010668 complexation reaction Methods 0.000 description 1
238000003271 compound fluorescence assay Methods 0.000 description 1
235000009508 confectionery Nutrition 0.000 description 1
239000003433 contraceptive agent Substances 0.000 description 1
229940124558 contraceptive agent Drugs 0.000 description 1
239000000599 controlled substance Substances 0.000 description 1
230000001276 controlling effect Effects 0.000 description 1
230000002596 correlated effect Effects 0.000 description 1
230000000875 corresponding effect Effects 0.000 description 1
229930003836 cresol Natural products 0.000 description 1
229940013361 cresol Drugs 0.000 description 1
229960005168 croscarmellose Drugs 0.000 description 1
229920006037 cross link polymer Polymers 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
239000001767 crosslinked sodium carboxy methyl cellulose Substances 0.000 description 1
239000013078 crystal Substances 0.000 description 1
125000004093 cyano group Chemical group *C#N 0.000 description 1
125000000392 cycloalkenyl group Chemical group 0.000 description 1
231100000895 deafness Toxicity 0.000 description 1
230000018044 dehydration Effects 0.000 description 1
238000006297 dehydration reaction Methods 0.000 description 1
239000003405 delayed action preparation Substances 0.000 description 1
238000012217 deletion Methods 0.000 description 1
230000037430 deletion Effects 0.000 description 1
238000000326 densiometry Methods 0.000 description 1
230000001419 dependent effect Effects 0.000 description 1
230000000368 destabilizing effect Effects 0.000 description 1
229960000633 dextran sulfate Drugs 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
239000008355 dextrose injection Substances 0.000 description 1
230000029087 digestion Effects 0.000 description 1
230000001079 digestive effect Effects 0.000 description 1
SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 1
239000004205 dimethyl polysiloxane Substances 0.000 description 1
238000007907 direct compression Methods 0.000 description 1
239000012990 dithiocarbamate Substances 0.000 description 1
229940000406 drug candidate Drugs 0.000 description 1
238000012377 drug delivery Methods 0.000 description 1
208000011325 dry age related macular degeneration Diseases 0.000 description 1
238000007908 dry granulation Methods 0.000 description 1
238000001035 drying Methods 0.000 description 1
230000009977 dual effect Effects 0.000 description 1
230000004064 dysfunction Effects 0.000 description 1
208000033530 early-onset macular degeneration Diseases 0.000 description 1
235000013399 edible fruits Nutrition 0.000 description 1
230000002500 effect on skin Effects 0.000 description 1
238000001962 electrophoresis Methods 0.000 description 1
238000004520 electroporation Methods 0.000 description 1
238000003821 enantio-separation Methods 0.000 description 1
230000002124 endocrine Effects 0.000 description 1
229940095399 enema Drugs 0.000 description 1
229940079360 enema for constipation Drugs 0.000 description 1
210000002919 epithelial cell Anatomy 0.000 description 1
CCIVGXIOQKPBKL-UHFFFAOYSA-M ethanesulfonate Chemical compound CCS([O-])(=O)=O CCIVGXIOQKPBKL-UHFFFAOYSA-M 0.000 description 1
HQQADJVZYDDRJT-UHFFFAOYSA-N ethene;prop-1-ene Chemical group C=C.CC=C HQQADJVZYDDRJT-UHFFFAOYSA-N 0.000 description 1
SUPCQIBBMFXVTL-UHFFFAOYSA-N ethyl 2-methylprop-2-enoate Chemical compound CCOC(=O)C(C)=C SUPCQIBBMFXVTL-UHFFFAOYSA-N 0.000 description 1
239000005038 ethylene vinyl acetate Substances 0.000 description 1
238000011156 evaluation Methods 0.000 description 1
230000007717 exclusion Effects 0.000 description 1
230000029142 excretion Effects 0.000 description 1
239000003777 experimental drug Substances 0.000 description 1
208000030533 eye disease Diseases 0.000 description 1
208000012955 familial cardiomyopathy Diseases 0.000 description 1
150000002191 fatty alcohols Chemical class 0.000 description 1
230000002349 favourable effect Effects 0.000 description 1
210000003608 fece Anatomy 0.000 description 1
230000001605 fetal effect Effects 0.000 description 1
238000001914 filtration Methods 0.000 description 1
238000005189 flocculation Methods 0.000 description 1
230000016615 flocculation Effects 0.000 description 1
238000000799 fluorescence microscopy Methods 0.000 description 1
238000002866 fluorescence resonance energy transfer Methods 0.000 description 1
238000002189 fluorescence spectrum Methods 0.000 description 1
229960002714 fluticasone Drugs 0.000 description 1
MGNNYOODZCAHBA-GQKYHHCASA-N fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 description 1
125000000524 functional group Chemical group 0.000 description 1
ZZUFCTLCJUWOSV-UHFFFAOYSA-N furosemide Chemical compound C1=C(Cl)C(S(=O)(=O)N)=CC(C(O)=O)=C1NCC1=CC=CO1 ZZUFCTLCJUWOSV-UHFFFAOYSA-N 0.000 description 1
230000014509 gene expression Effects 0.000 description 1
239000003193 general anesthetic agent Substances 0.000 description 1
208000016361 genetic disease Diseases 0.000 description 1
230000004034 genetic regulation Effects 0.000 description 1
MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 description 1
229960004666 glucagon Drugs 0.000 description 1
229960002989 glutamic acid Drugs 0.000 description 1
125000005456 glyceride group Chemical group 0.000 description 1
229940075507 glyceryl monostearate Drugs 0.000 description 1
210000002288 golgi apparatus Anatomy 0.000 description 1
238000000227 grinding Methods 0.000 description 1
239000007952 growth promoter Substances 0.000 description 1
235000019314 gum ghatti Nutrition 0.000 description 1
239000010440 gypsum Substances 0.000 description 1
229910052602 gypsum Inorganic materials 0.000 description 1
239000007902 hard capsule Substances 0.000 description 1
230000009931 harmful effect Effects 0.000 description 1
231100000869 headache Toxicity 0.000 description 1
208000016354 hearing loss disease Diseases 0.000 description 1
210000002216 heart Anatomy 0.000 description 1
208000019622 heart disease Diseases 0.000 description 1
210000005003 heart tissue Anatomy 0.000 description 1
229910001385 heavy metal Inorganic materials 0.000 description 1
229960002897 heparin Drugs 0.000 description 1
229920000669 heparin Polymers 0.000 description 1
239000002554 heparinoid Substances 0.000 description 1
229940025770 heparinoids Drugs 0.000 description 1
125000005842 heteroatom Chemical group 0.000 description 1
125000000623 heterocyclic group Chemical group 0.000 description 1
FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
239000010903 husk Substances 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
239000008173 hydrogenated soybean oil Substances 0.000 description 1
238000006460 hydrolysis reaction Methods 0.000 description 1
239000008311 hydrophilic ointment Substances 0.000 description 1
229920001600 hydrophobic polymer Polymers 0.000 description 1
229960004337 hydroquinone Drugs 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
229940031704 hydroxypropyl methylcellulose phthalate Drugs 0.000 description 1
208000013403 hyperactivity Diseases 0.000 description 1
230000003345 hyperglycaemic effect Effects 0.000 description 1
201000001421 hyperglycemia Diseases 0.000 description 1
230000003451 hyperinsulinaemic effect Effects 0.000 description 1
201000008980 hyperinsulinism Diseases 0.000 description 1
208000003532 hypothyroidism Diseases 0.000 description 1
239000012729 immediate-release (IR) formulation Substances 0.000 description 1
230000036039 immunity Effects 0.000 description 1
238000003018 immunoassay Methods 0.000 description 1
239000007943 implant Substances 0.000 description 1
238000000099 in vitro assay Methods 0.000 description 1
238000011534 incubation Methods 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
239000007972 injectable composition Substances 0.000 description 1
238000003780 insertion Methods 0.000 description 1
230000037431 insertion Effects 0.000 description 1
230000002452 interceptive effect Effects 0.000 description 1
210000001596 intra-abdominal fat Anatomy 0.000 description 1
238000001361 intraarterial administration Methods 0.000 description 1
230000006525 intracellular process Effects 0.000 description 1
238000007917 intracranial administration Methods 0.000 description 1
238000010255 intramuscular injection Methods 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
238000007913 intrathecal administration Methods 0.000 description 1
238000010253 intravenous injection Methods 0.000 description 1
125000002346 iodo group Chemical group I* 0.000 description 1
150000002500 ions Chemical class 0.000 description 1
230000007794 irritation Effects 0.000 description 1
238000006317 isomerization reaction Methods 0.000 description 1
QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
238000010902 jet-milling Methods 0.000 description 1
229960000829 kaolin Drugs 0.000 description 1
235000010494 karaya gum Nutrition 0.000 description 1
230000004140 ketosis Effects 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
239000004816 latex Substances 0.000 description 1
229920000126 latex Polymers 0.000 description 1
239000007942 layered tablet Substances 0.000 description 1
231100000518 lethal Toxicity 0.000 description 1
230000001665 lethal effect Effects 0.000 description 1
229960004873 levomenthol Drugs 0.000 description 1
210000003041 ligament Anatomy 0.000 description 1
239000004571 lime Substances 0.000 description 1
229940057995 liquid paraffin Drugs 0.000 description 1
235000010420 locust bean gum Nutrition 0.000 description 1
239000000711 locust bean gum Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000006210 lotion Substances 0.000 description 1
238000004020 luminiscence type Methods 0.000 description 1
231100000516 lung damage Toxicity 0.000 description 1
230000004199 lung function Effects 0.000 description 1
239000008176 lyophilized powder Substances 0.000 description 1
239000011777 magnesium Substances 0.000 description 1
229910052749 magnesium Inorganic materials 0.000 description 1
229910001629 magnesium chloride Inorganic materials 0.000 description 1
159000000003 magnesium salts Chemical class 0.000 description 1
229910052943 magnesium sulfate Inorganic materials 0.000 description 1
235000019341 magnesium sulphate Nutrition 0.000 description 1
238000012423 maintenance Methods 0.000 description 1
230000031852 maintenance of location in cell Effects 0.000 description 1
229940035034 maltodextrin Drugs 0.000 description 1
229960001855 mannitol Drugs 0.000 description 1
238000005259 measurement Methods 0.000 description 1
230000001404 mediated effect Effects 0.000 description 1
229940057917 medium chain triglycerides Drugs 0.000 description 1
201000001441 melanoma Diseases 0.000 description 1
238000007909 melt granulation Methods 0.000 description 1
238000002844 melting Methods 0.000 description 1
230000008018 melting Effects 0.000 description 1
239000001525 mentha piperita l. herb oil Substances 0.000 description 1
229940041616 menthol Drugs 0.000 description 1
HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 description 1
108020004999 messenger RNA Proteins 0.000 description 1
230000002503 metabolic effect Effects 0.000 description 1
230000037345 metabolism of vitamins Effects 0.000 description 1
125000005395 methacrylic acid group Chemical group 0.000 description 1
229940098779 methanesulfonic acid Drugs 0.000 description 1
229930182817 methionine Natural products 0.000 description 1
229960001047 methyl salicylate Drugs 0.000 description 1
229960002216 methylparaben Drugs 0.000 description 1
230000000813 microbial effect Effects 0.000 description 1
244000005700 microbiome Species 0.000 description 1
239000003094 microcapsule Substances 0.000 description 1
229940016286 microcrystalline cellulose Drugs 0.000 description 1
239000008108 microcrystalline cellulose Substances 0.000 description 1
239000004200 microcrystalline wax Substances 0.000 description 1
235000019808 microcrystalline wax Nutrition 0.000 description 1
235000013336 milk Nutrition 0.000 description 1
239000008267 milk Substances 0.000 description 1
210000004080 milk Anatomy 0.000 description 1
235000010755 mineral Nutrition 0.000 description 1
239000003607 modifier Substances 0.000 description 1
235000013379 molasses Nutrition 0.000 description 1
238000012544 monitoring process Methods 0.000 description 1
239000001788 mono and diglycerides of fatty acids Substances 0.000 description 1
150000004682 monohydrates Chemical group 0.000 description 1
239000000178 monomer Substances 0.000 description 1
PJUIMOJAAPLTRJ-UHFFFAOYSA-N monothioglycerol Chemical compound OCC(O)CS PJUIMOJAAPLTRJ-UHFFFAOYSA-N 0.000 description 1
238000000465 moulding Methods 0.000 description 1
210000004400 mucous membrane Anatomy 0.000 description 1
210000003205 muscle Anatomy 0.000 description 1
210000000663 muscle cell Anatomy 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
239000002077 nanosphere Substances 0.000 description 1
239000007923 nasal drop Substances 0.000 description 1
229940100662 nasal drops Drugs 0.000 description 1
239000006199 nebulizer Substances 0.000 description 1
208000015122 neurodegenerative disease Diseases 0.000 description 1
229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
229910017604 nitric acid Inorganic materials 0.000 description 1
QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
230000036963 noncompetitive effect Effects 0.000 description 1
239000000346 nonvolatile oil Substances 0.000 description 1
239000002773 nucleotide Substances 0.000 description 1
125000003729 nucleotide group Chemical group 0.000 description 1
235000016709 nutrition Nutrition 0.000 description 1
ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
150000007530 organic bases Chemical class 0.000 description 1
239000003960 organic solvent Substances 0.000 description 1
125000001181 organosilyl group Chemical group [SiH3]* 0.000 description 1
201000008482 osteoarthritis Diseases 0.000 description 1
239000003346 palm kernel oil Substances 0.000 description 1
235000019865 palm kernel oil Nutrition 0.000 description 1
125000000913 palmityl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
210000000496 pancreas Anatomy 0.000 description 1
206010033675 panniculitis Diseases 0.000 description 1
239000012188 paraffin wax Substances 0.000 description 1
239000006072 paste Substances 0.000 description 1
230000037361 pathway Effects 0.000 description 1
229960000292 pectin Drugs 0.000 description 1
229940043138 pentosan polysulfate Drugs 0.000 description 1
125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
PNJWIWWMYCMZRO-UHFFFAOYSA-N pent‐4‐en‐2‐one Natural products CC(=O)CC=C PNJWIWWMYCMZRO-UHFFFAOYSA-N 0.000 description 1
235000019477 peppermint oil Nutrition 0.000 description 1
125000005010 perfluoroalkyl group Chemical group 0.000 description 1
230000010412 perfusion Effects 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
210000001428 peripheral nervous system Anatomy 0.000 description 1
230000000144 pharmacologic effect Effects 0.000 description 1
229960003742 phenol Drugs 0.000 description 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
239000008363 phosphate buffer Substances 0.000 description 1
230000036211 photosensitivity Effects 0.000 description 1
230000035790 physiological processes and functions Effects 0.000 description 1
229920001308 poly(aminoacid) Polymers 0.000 description 1
229920001084 poly(chloroprene) Polymers 0.000 description 1
229920000747 poly(lactic acid) Polymers 0.000 description 1
229920002401 polyacrylamide Polymers 0.000 description 1
229920000058 polyacrylate Polymers 0.000 description 1
229920001281 polyalkylene Polymers 0.000 description 1
229950005134 polycarbophil Drugs 0.000 description 1
229940057838 polyethylene glycol 4000 Drugs 0.000 description 1
229920000151 polyglycol Polymers 0.000 description 1
239000010695 polyglycol Substances 0.000 description 1
229920005597 polymer membrane Polymers 0.000 description 1
229920005862 polyol Polymers 0.000 description 1
150000003077 polyols Chemical class 0.000 description 1
229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
229920002503 polyoxyethylene-polyoxypropylene Polymers 0.000 description 1
229920001155 polypropylene Polymers 0.000 description 1
229940068977 polysorbate 20 Drugs 0.000 description 1
229920002635 polyurethane Polymers 0.000 description 1
239000004814 polyurethane Substances 0.000 description 1
230000000291 postprandial effect Effects 0.000 description 1
239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
159000000001 potassium salts Chemical class 0.000 description 1
229920003124 powdered cellulose Polymers 0.000 description 1
235000019814 powdered cellulose Nutrition 0.000 description 1
201000009104 prediabetes syndrome Diseases 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
229960001309 procaine hydrochloride Drugs 0.000 description 1
230000001737 promoting effect Effects 0.000 description 1
235000010409 propane-1,2-diol alginate Nutrition 0.000 description 1
239000000770 propane-1,2-diol alginate Substances 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
238000011321 prophylaxis Methods 0.000 description 1
239000000473 propyl gallate Substances 0.000 description 1
235000010388 propyl gallate Nutrition 0.000 description 1
229940075579 propyl gallate Drugs 0.000 description 1
RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
229940093625 propylene glycol monostearate Drugs 0.000 description 1
229960003415 propylparaben Drugs 0.000 description 1
230000029983 protein stabilization Effects 0.000 description 1
239000003586 protic polar solvent Substances 0.000 description 1
235000019423 pullulan Nutrition 0.000 description 1
235000021251 pulses Nutrition 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
239000008175 ready-to-use sterile solution Substances 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
230000000306 recurrent effect Effects 0.000 description 1
230000033458 reproduction Effects 0.000 description 1
238000011160 research Methods 0.000 description 1
230000000241 respiratory effect Effects 0.000 description 1
210000003583 retinal pigment epithelium Anatomy 0.000 description 1
229930002330 retinoic acid Natural products 0.000 description 1
WWDMJSSVVPXVSV-YCNIQYBTSA-N retinyl ester Chemical compound CC1CCCC(C)(C)C1\C=C\C(\C)=C\C=C\C(\C)=C\C(O)=O WWDMJSSVVPXVSV-YCNIQYBTSA-N 0.000 description 1
206010039083 rhinitis Diseases 0.000 description 1
229940085605 saccharin sodium Drugs 0.000 description 1
235000005713 safflower oil Nutrition 0.000 description 1
239000003813 safflower oil Substances 0.000 description 1
231100000241 scar Toxicity 0.000 description 1
230000036573 scar formation Effects 0.000 description 1
HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
238000012216 screening Methods 0.000 description 1
230000003248 secreting effect Effects 0.000 description 1
235000019613 sensory perceptions of taste Nutrition 0.000 description 1
208000027653 severe early-childhood-onset retinal dystrophy Diseases 0.000 description 1
230000009528 severe injury Effects 0.000 description 1
239000004945 silicone rubber Substances 0.000 description 1
239000001632 sodium acetate Substances 0.000 description 1
235000017281 sodium acetate Nutrition 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
239000008354 sodium chloride injection Substances 0.000 description 1
239000001509 sodium citrate Substances 0.000 description 1
NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 1
235000011083 sodium citrates Nutrition 0.000 description 1
235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
229910001415 sodium ion Inorganic materials 0.000 description 1
239000001540 sodium lactate Substances 0.000 description 1
235000011088 sodium lactate Nutrition 0.000 description 1
229940005581 sodium lactate Drugs 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000001488 sodium phosphate Substances 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
235000011008 sodium phosphates Nutrition 0.000 description 1
235000010339 sodium tetraborate Nutrition 0.000 description 1
AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
235000019345 sodium thiosulphate Nutrition 0.000 description 1
229940035049 sorbitan monooleate Drugs 0.000 description 1
235000011069 sorbitan monooleate Nutrition 0.000 description 1
239000001593 sorbitan monooleate Substances 0.000 description 1
235000019337 sorbitan trioleate Nutrition 0.000 description 1
229960000391 sorbitan trioleate Drugs 0.000 description 1
241000894007 species Species 0.000 description 1
238000001694 spray drying Methods 0.000 description 1
210000004500 stellate cell Anatomy 0.000 description 1
150000003431 steroids Chemical class 0.000 description 1
230000000638 stimulation Effects 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
210000000352 storage cell Anatomy 0.000 description 1
210000004003 subcutaneous fat Anatomy 0.000 description 1
125000001424 substituent group Chemical group 0.000 description 1
239000000758 substrate Substances 0.000 description 1
229940097346 sulfobutylether-beta-cyclodextrin Drugs 0.000 description 1
229940124530 sulfonamide Drugs 0.000 description 1
150000003456 sulfonamides Chemical class 0.000 description 1
150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
239000002600 sunflower oil Substances 0.000 description 1
230000009469 supplementation Effects 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
230000001360 synchronised effect Effects 0.000 description 1
230000002195 synergetic effect Effects 0.000 description 1
229920001059 synthetic polymer Polymers 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
230000035488 systolic blood pressure Effects 0.000 description 1
230000035923 taste sensation Effects 0.000 description 1
230000002123 temporal effect Effects 0.000 description 1
KKEYFWRCBNTPAC-UHFFFAOYSA-L terephthalate(2-) Chemical compound [O-]C(=O)C1=CC=C(C([O-])=O)C=C1 KKEYFWRCBNTPAC-UHFFFAOYSA-L 0.000 description 1
ZUHZGEOKBKGPSW-UHFFFAOYSA-N tetraglyme Chemical compound COCCOCCOCCOCCOC ZUHZGEOKBKGPSW-UHFFFAOYSA-N 0.000 description 1
150000003536 tetrazoles Chemical class 0.000 description 1
RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
229940033663 thimerosal Drugs 0.000 description 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 description 1
235000019303 thiodipropionic acid Nutrition 0.000 description 1
125000003396 thiol group Chemical class [H]S* 0.000 description 1
150000003573 thiols Chemical class 0.000 description 1
150000004764 thiosulfuric acid derivatives Chemical class 0.000 description 1
230000009974 thixotropic effect Effects 0.000 description 1
210000000115 thoracic cavity Anatomy 0.000 description 1
229940034208 thyroxine Drugs 0.000 description 1
XUIIKFGFIJCVMT-UHFFFAOYSA-N thyroxine-binding globulin Natural products IC1=CC(CC([NH3+])C([O-])=O)=CC(I)=C1OC1=CC(I)=C(O)C(I)=C1 XUIIKFGFIJCVMT-UHFFFAOYSA-N 0.000 description 1
231100000886 tinnitus Toxicity 0.000 description 1
NLVFBUXFDBBNBW-PBSUHMDJSA-N tobramycin Chemical compound N[C@@H]1C[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N NLVFBUXFDBBNBW-PBSUHMDJSA-N 0.000 description 1
229960000707 tobramycin Drugs 0.000 description 1
239000003440 toxic substance Substances 0.000 description 1
238000012546 transfer Methods 0.000 description 1
102000003601 transglutaminase Human genes 0.000 description 1
230000007704 transition Effects 0.000 description 1
201000007905 transthyretin amyloidosis Diseases 0.000 description 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
229960001727 tretinoin Drugs 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
YFNKIDBQEZZDLK-UHFFFAOYSA-N triglyme Chemical compound COCCOCCOCCOC YFNKIDBQEZZDLK-UHFFFAOYSA-N 0.000 description 1
BSVBQGMMJUBVOD-UHFFFAOYSA-N trisodium borate Chemical compound [Na+].[Na+].[Na+].[O-]B([O-])[O-] BSVBQGMMJUBVOD-UHFFFAOYSA-N 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
238000002604 ultrasonography Methods 0.000 description 1
229920011532 unplasticized polyvinyl chloride Polymers 0.000 description 1
125000004417 unsaturated alkyl group Chemical group 0.000 description 1
MYPYJXKWCTUITO-LYRMYLQWSA-N vancomycin Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)NC)[C@H]1C[C@](C)(N)[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-N 0.000 description 1
229960003165 vancomycin Drugs 0.000 description 1
MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 description 1
230000002792 vascular Effects 0.000 description 1
230000006444 vascular growth Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
210000003462 vein Anatomy 0.000 description 1
229920002554 vinyl polymer Polymers 0.000 description 1
210000001835 viscera Anatomy 0.000 description 1
150000002266 vitamin A derivatives Chemical class 0.000 description 1
235000020797 vitamin A status Nutrition 0.000 description 1
201000007790 vitelliform macular dystrophy Diseases 0.000 description 1
208000020938 vitelliform macular dystrophy 2 Diseases 0.000 description 1
235000012431 wafers Nutrition 0.000 description 1
238000005406 washing Methods 0.000 description 1
235000019786 weight gain Nutrition 0.000 description 1
230000004584 weight gain Effects 0.000 description 1
238000005550 wet granulation Methods 0.000 description 1
239000003871 white petrolatum Substances 0.000 description 1
208000027121 wild type ATTR amyloidosis Diseases 0.000 description 1
239000002023 wood Substances 0.000 description 1
239000000811 xylitol Substances 0.000 description 1
HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
235000010447 xylitol Nutrition 0.000 description 1
229960002675 xylitol Drugs 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1