CN101873852A - 治疗视黄醇相关性疾病的方法和化合物 - Google Patents

治疗视黄醇相关性疾病的方法和化合物 Download PDF

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Publication number
CN101873852A
CN101873852A CN200880107835A CN200880107835A CN101873852A CN 101873852 A CN101873852 A CN 101873852A CN 200880107835 A CN200880107835 A CN 200880107835A CN 200880107835 A CN200880107835 A CN 200880107835A CN 101873852 A CN101873852 A CN 101873852A
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China
Prior art keywords
alkyl
formula
compound
optionally substituted
butyl
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Pending
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CN200880107835A
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English (en)
Chinese (zh)
Inventor
内森·L·马塔
金·B·潘
塔姆·V·布伊
穆斯塔法·哈达赫
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Sirion Therapeutics Inc
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Sirion Therapeutics Inc
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Publication of CN101873852A publication Critical patent/CN101873852A/zh
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/167—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the nitrogen of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CN200880107835A 2007-09-27 2008-09-16 治疗视黄醇相关性疾病的方法和化合物 Pending CN101873852A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US97576507P 2007-09-27 2007-09-27
US60/975,765 2007-09-27
US98132207P 2007-10-19 2007-10-19
US60/981,322 2007-10-19
PCT/US2008/076499 WO2009042444A2 (en) 2007-09-27 2008-09-16 Methods and compounds for treating retinol-related diseases

Publications (1)

Publication Number Publication Date
CN101873852A true CN101873852A (zh) 2010-10-27

Family

ID=40512081

Family Applications (1)

Application Number Title Priority Date Filing Date
CN200880107835A Pending CN101873852A (zh) 2007-09-27 2008-09-16 治疗视黄醇相关性疾病的方法和化合物

Country Status (8)

Country Link
EP (1) EP2205234A4 (enExample)
JP (1) JP2010540541A (enExample)
KR (1) KR20100097098A (enExample)
CN (1) CN101873852A (enExample)
AU (1) AU2008305303A1 (enExample)
CA (1) CA2699773A1 (enExample)
IL (1) IL204728A0 (enExample)
WO (1) WO2009042444A2 (enExample)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009051244A1 (ja) * 2007-10-18 2009-04-23 Takeda Pharmaceutical Company Limited 複素環化合物
JP5706337B2 (ja) * 2009-04-16 2015-04-22 武田薬品工業株式会社 （とりわけ）糖尿病の予防または治療に有用なｎ−アシル−ｎ’−フェニルピペラジンの誘導体
US8980924B2 (en) 2010-11-24 2015-03-17 The Trustees Of Columbia University In The City Of New York Non-retinoid RBP4 antagonist for treatment of age-related macular degeneration and stargardt disease
TW201307376A (zh) * 2010-12-02 2013-02-16 Daiichi Sankyo Co Ltd 經修飾之單股多核苷酸
WO2013166037A1 (en) 2012-05-01 2013-11-07 The Trustees Of Columbia University In The City Of New York Non-retinoid antagonists for treatment of eye disorders
ES2700541T3 (es) 2013-03-14 2019-02-18 Univ Columbia Octahidrociclopentapirroles, su preparación y uso
US9938291B2 (en) 2013-03-14 2018-04-10 The Trustess Of Columbia University In The City Of New York N-alkyl-2-phenoxyethanamines, their preparation and use
EP2968304B1 (en) 2013-03-14 2018-10-10 The Trustees of Columbia University in the City of New York 4-phenylpiperidines, their preparation and use
WO2014151936A1 (en) 2013-03-14 2014-09-25 The Trustees Of Columbia University In The City Of New York Octahydropyrrolopyrroles, their preparation and use
WO2015168286A1 (en) 2014-04-30 2015-11-05 The Trustees Of Columbia University In The City Of New York Substituted 4-phenylpiperidines, their preparaiton and use
US9944596B2 (en) * 2014-10-24 2018-04-17 Takeda Pharmaceutical Company Limited Heterocyclic compound
HRP20210320T1 (hr) 2014-10-24 2021-04-30 Takeda Pharmaceutical Company Limited Spojevi heteroarila za liječenje oftalmičkih bolesti
CA3175197A1 (en) * 2020-04-29 2021-11-04 Joseph J. HIGGINS Compositions and methods for treatment of inherited macular degeneration

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2526534A (en) * 1948-07-03 1950-10-17 Dow Chemical Co Di-(aryloxy)-methanes
US4255152A (en) * 1978-09-05 1981-03-10 Ciba-Geigy Corporation Process for the dyeing of hydrophobic fibres
JPS577480A (en) * 1980-06-16 1982-01-14 Sankyo Co Ltd 4-alkoxy-6-phenoxymethyl-2-pyrone derivative
WO2005070126A2 (en) * 2004-01-08 2005-08-04 The Regents Of The University Of Colorado Methods and compositions for treating human diseases and wounds with ucp and fas inhibitors
WO2005092062A2 (en) * 2004-03-19 2005-10-06 Myriad Genetics, Inc. Compounds for neurodegenerative disorders
WO2005116010A1 (en) * 2004-05-26 2005-12-08 Merck Frosst Canada Ltd. Ep4 receptor agonist, compositions and methods thereof

Also Published As

Publication number Publication date
WO2009042444A3 (en) 2009-05-14
EP2205234A4 (en) 2010-12-22
IL204728A0 (en) 2010-11-30
KR20100097098A (ko) 2010-09-02
EP2205234A2 (en) 2010-07-14
AU2008305303A1 (en) 2009-04-02
CA2699773A1 (en) 2009-04-02
JP2010540541A (ja) 2010-12-24
WO2009042444A2 (en) 2009-04-02

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Application publication date: 20101027