KR20100067677A - 스핑고신-1-포스페이트 (ｓｐ1) 생물학적 활성을 갖는 아릴 또는 헤테로아릴 기를 함유하는 인돌 화합물 - Google Patents
스핑고신-1-포스페이트 (ｓｐ1) 생물학적 활성을 갖는 아릴 또는 헤테로아릴 기를 함유하는 인돌 화합물 Download PDFInfo
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- KR20100067677A KR20100067677A KR1020107008739A KR20107008739A KR20100067677A KR 20100067677 A KR20100067677 A KR 20100067677A KR 1020107008739 A KR1020107008739 A KR 1020107008739A KR 20107008739 A KR20107008739 A KR 20107008739A KR 20100067677 A KR20100067677 A KR 20100067677A
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- South Korea
- Prior art keywords
- heteroaryl
- compound
- pharmaceutically acceptable
- substituted
- disease
- Prior art date
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Classifications
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
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- C07—ORGANIC CHEMISTRY
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- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
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- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97451107P | 2007-09-24 | 2007-09-24 | |
| US60/974,511 | 2007-09-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20100067677A true KR20100067677A (ko) | 2010-06-21 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020107008739A Withdrawn KR20100067677A (ko) | 2007-09-24 | 2008-09-18 | 스핑고신-1-포스페이트 (ｓｐ1) 생물학적 활성을 갖는 아릴 또는 헤테로아릴 기를 함유하는 인돌 화합물 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US7888336B2 (https=) |
| EP (1) | EP2203424A1 (https=) |
| JP (1) | JP2010540543A (https=) |
| KR (1) | KR20100067677A (https=) |
| CN (1) | CN101918360A (https=) |
| AU (1) | AU2008304657B2 (https=) |
| BR (1) | BRPI0817397A2 (https=) |
| CA (1) | CA2700539A1 (https=) |
| RU (1) | RU2010112275A (https=) |
| WO (1) | WO2009042485A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006088246A1 (ja) * | 2005-02-18 | 2006-08-24 | Takeda Pharmaceutical Company Limited | Ｇｐｒ３４受容体機能調節剤 |
| US8524917B2 (en) * | 2007-01-11 | 2013-09-03 | Allergan, Inc. | 6-substituted indole-3-carboxylic acid amide compounds having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| JP2014518554A (ja) * | 2011-04-18 | 2014-07-31 | アラーガン インコーポレイテッド | スフィンゴシン−１リン酸受容体調節剤としての置換二環式メチルアミン誘導体 |
| GB201603745D0 (en) * | 2016-03-04 | 2016-04-20 | Galapagos Nv | Novel compounds and pharmaceutical compositions thereof for the treatment of fibrosis |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4363912A (en) * | 1980-12-15 | 1982-12-14 | Pfizer Inc. | Indole thromboxane synthetase inhibitors |
| EP0146810A3 (de) * | 1983-12-05 | 1987-05-13 | Solco Basel AG | Verfahren zur Herstellung von Sphingosinderivaten |
| US5110987A (en) * | 1988-06-17 | 1992-05-05 | Emory University | Method of preparing sphingosine derivatives |
| ZA902794B (en) * | 1989-04-18 | 1991-04-24 | Duphar Int Res | New 3-n substituted carbamoyl-indole derivatives |
| US5294722A (en) * | 1992-04-16 | 1994-03-15 | E. R. Squibb & Sons, Inc. | Process for the preparation of imidazoles useful in angiotensin II antagonism |
| US5403851A (en) * | 1994-04-05 | 1995-04-04 | Interneuron Pharmaceuticals, Inc. | Substituted tryptamines, phenalkylamines and related compounds |
| US5639780A (en) * | 1995-05-22 | 1997-06-17 | Merck Frosst Canada, Inc. | N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase inhibitors |
| US5811425A (en) * | 1997-03-04 | 1998-09-22 | Abbott Laboratories | Heterocyclic compounds as COX-2 inhibitors |
| ATE314342T1 (de) * | 1997-03-12 | 2006-01-15 | Takara Bio Inc | Spingosinanaloga |
| ATE332888T1 (de) * | 1997-09-11 | 2006-08-15 | Takara Bio Inc | Sphingosinderivate und medizinische zubereitung |
| US6358992B1 (en) * | 1998-11-25 | 2002-03-19 | Cell Pathways, Inc. | Method of inhibiting neoplastic cells with indole derivatives |
| FR2814073B1 (fr) * | 2000-09-21 | 2005-06-24 | Yang Ji Chemical Company Ltd | Composition pharmaceutique antifongique et/ou antiparasitaire et nouveaux derives de l'indole a titre de principes actifs d'une telle composition |
| US7074817B2 (en) * | 2001-06-20 | 2006-07-11 | Wyeth | Substituted indole acid derivatives as inhibitors of plasminogen activator inhibitor-1 (PAI-1) |
| JP4430941B2 (ja) | 2002-01-18 | 2010-03-10 | メルク エンド カムパニー インコーポレーテッド | Ｅｄｇ受容体作動薬 |
| CA2473740A1 (en) | 2002-01-18 | 2003-07-31 | David Solow-Cordero | Methods of treating conditions associated with an edg receptor |
| US7323479B2 (en) | 2002-05-17 | 2008-01-29 | Celgene Corporation | Methods for treatment and management of brain cancer using 1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-methylisoindoline |
| PL378134A1 (pl) | 2003-02-11 | 2006-03-06 | Irm Llc | Nowe pochodne bicykliczne i kompozycje farmaceutyczne zawierające pochodne bicykliczne |
| CN1777575B (zh) | 2003-04-30 | 2010-05-12 | 诺瓦提斯公司 | 作为1-磷酸-鞘氨醇受体调节剂的氨基-丙醇衍生物 |
| MY150088A (en) | 2003-05-19 | 2013-11-29 | Irm Llc | Immunosuppressant compounds and compositions |
| US7582773B2 (en) * | 2003-09-25 | 2009-09-01 | Wyeth | Substituted phenyl indoles |
| AU2007214434B2 (en) * | 2006-02-15 | 2012-06-14 | Allergan, Inc. | Indole-3-carboxylic acid amide, ester, thioamide and thiol ester compounds bearing aryl or heteroaryl groups having sphingosine-1-phosphate (S1P) receptor antagonist biological activity |
| US8097644B2 (en) | 2006-03-28 | 2012-01-17 | Allergan, Inc. | Indole compounds having sphingosine-1-phosphate (S1P) receptor antagonist |
-
2008
- 2008-09-18 BR BRPI0817397 patent/BRPI0817397A2/pt not_active IP Right Cessation
- 2008-09-18 CN CN2008801163102A patent/CN101918360A/zh active Pending
- 2008-09-18 RU RU2010112275/04A patent/RU2010112275A/ru unknown
- 2008-09-18 AU AU2008304657A patent/AU2008304657B2/en not_active Ceased
- 2008-09-18 WO PCT/US2008/076792 patent/WO2009042485A1/en not_active Ceased
- 2008-09-18 EP EP08833361A patent/EP2203424A1/en not_active Withdrawn
- 2008-09-18 CA CA2700539A patent/CA2700539A1/en not_active Abandoned
- 2008-09-18 KR KR1020107008739A patent/KR20100067677A/ko not_active Withdrawn
- 2008-09-18 US US12/679,530 patent/US7888336B2/en not_active Expired - Fee Related
- 2008-09-18 JP JP2010527035A patent/JP2010540543A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| BRPI0817397A2 (pt) | 2015-04-07 |
| CA2700539A1 (en) | 2009-04-02 |
| RU2010112275A (ru) | 2011-11-10 |
| EP2203424A1 (en) | 2010-07-07 |
| US20100240614A1 (en) | 2010-09-23 |
| AU2008304657B2 (en) | 2013-09-05 |
| JP2010540543A (ja) | 2010-12-24 |
| AU2008304657A1 (en) | 2009-04-02 |
| WO2009042485A1 (en) | 2009-04-02 |
| US7888336B2 (en) | 2011-02-15 |
| CN101918360A (zh) | 2010-12-15 |
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Patent event date: 20100421 Patent event code: PA01051R01D Comment text: International Patent Application |
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