KR20100059902A - 질병의 발달을 모니터링하고 치료의 효율을 평가하기 위한 새로운 바이오마커 - Google Patents
질병의 발달을 모니터링하고 치료의 효율을 평가하기 위한 새로운 바이오마커 Download PDFInfo
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- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
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- G01N2800/00—Detection or diagnosis of diseases
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- G01N2800/56—Staging of a disease; Further complications associated with the disease
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FI20070795A FI20070795A0 (fi) | 2007-10-24 | 2007-10-24 | Uusi biomarkkeri sairauksien kehittämisen tarkkailuun ja terapioiden tehon arviointiin |
| FI20070795 | 2007-10-24 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167005473A Division KR20160029869A (ko) | 2007-10-24 | 2008-10-15 | 질병의 발달을 모니터링하고 치료의 효율을 평가하기 위한 새로운 바이오마커 |
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| Publication Number | Publication Date |
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| KR20100059902A true KR20100059902A (ko) | 2010-06-04 |
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Family Applications (2)
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| KR1020107006430A Ceased KR20100059902A (ko) | 2007-10-24 | 2008-10-15 | 질병의 발달을 모니터링하고 치료의 효율을 평가하기 위한 새로운 바이오마커 |
| KR1020167005473A Ceased KR20160029869A (ko) | 2007-10-24 | 2008-10-15 | 질병의 발달을 모니터링하고 치료의 효율을 평가하기 위한 새로운 바이오마커 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020167005473A Ceased KR20160029869A (ko) | 2007-10-24 | 2008-10-15 | 질병의 발달을 모니터링하고 치료의 효율을 평가하기 위한 새로운 바이오마커 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US20100209942A1 (enExample) |
| EP (2) | EP2201376B1 (enExample) |
| JP (2) | JP4982610B2 (enExample) |
| KR (2) | KR20100059902A (enExample) |
| CA (1) | CA2702635A1 (enExample) |
| CY (2) | CY1113403T1 (enExample) |
| DK (2) | DK2201376T3 (enExample) |
| ES (2) | ES2389751T3 (enExample) |
| FI (1) | FI20070795A0 (enExample) |
| HR (2) | HRP20120743T1 (enExample) |
| PL (2) | PL2201376T3 (enExample) |
| PT (2) | PT2201376E (enExample) |
| SI (2) | SI2503338T1 (enExample) |
| WO (1) | WO2009053523A1 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150118107A (ko) * | 2013-02-14 | 2015-10-21 | 파론 파머수티컬스 오와이 | 급성 호흡 곤란 증후군 (ards) 관련 바이오마커를 결정하는 방법, 환자의 ards 의 발달을 모니터링하고 치료하는 방법 |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CA2712303C (en) | 2008-01-18 | 2015-03-31 | President And Fellows Of Harvard College | Methods of detecting signatures of disease or conditions in bodily fluids |
| BR112013001754A2 (pt) | 2010-07-23 | 2016-05-31 | Harvard College | método para detectar marcas de doença ou condições em fluídos corpóreos |
| EP2596134B1 (en) | 2010-07-23 | 2020-04-08 | President and Fellows of Harvard College | Methods of detecting diseases or conditions using phagocytic cells |
| WO2012012694A2 (en) | 2010-07-23 | 2012-01-26 | President And Fellows Of Harvard College | Methods of detecting autoimmune or immune-related diseases or conditions |
| US20130203624A1 (en) | 2010-07-23 | 2013-08-08 | President And Fellows Of Harvard College | Methods of Detecting Prenatal or Pregnancy-Related Diseases or Conditions |
| US20130210647A1 (en) | 2010-07-23 | 2013-08-15 | President And Fellows Of Harvard College | Methods of Detecting Cardiovascular Diseases or Conditions |
| BR112014031365A2 (pt) | 2012-06-15 | 2017-06-27 | Stylli Harry | métodos de detectar doenças ou condições |
| SG11201408383SA (en) | 2012-06-15 | 2015-01-29 | Harry Stylli | Methods of detecting diseases or conditions using circulating diseased cells |
| EP4513187A3 (en) | 2013-03-09 | 2025-05-21 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| WO2014164366A1 (en) | 2013-03-09 | 2014-10-09 | Harry Stylli | Methods of detecting cancer |
| EP4075139B1 (en) | 2014-09-11 | 2024-05-22 | Immunis.AI, Inc. | Methods of detecting prostate cancer |
| EP3789399A1 (en) | 2014-11-21 | 2021-03-10 | Bristol-Myers Squibb Company | Antibodies comprising modified heavy constant regions |
| LT3221363T (lt) | 2014-11-21 | 2020-08-10 | Bristol-Myers Squibb Company | Antikūnai prieš cd73 ir jų panaudojimas |
| GB201706747D0 (en) | 2017-04-27 | 2017-06-14 | Queen Mary | Method and apparatus for determining the efficacy of statins for treating inflammatory diseases in idividual patients |
Family Cites Families (12)
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| US5736343A (en) * | 1995-08-18 | 1998-04-07 | Landry; Donald | Detection of organic compounds through regulation of antibody-catalyzed reactions |
| EP0862652A1 (en) * | 1995-10-13 | 1998-09-09 | IMPERIAL COLLEGE OF SCIENCE, TECHNOLOGY & MEDICINE | Methods for predicting the outcome of persistent hbv infection and the outcome of cytokine therapy |
| HUP0002003A3 (en) * | 2000-05-24 | 2003-01-28 | Pronuk Biotechnologia Kft | Process and reagent-kit for determining of 5'-nucleotidase activity |
| WO2002077174A2 (en) * | 2001-03-27 | 2002-10-03 | Zymogenetics, Inc. | Human cytokine receptor |
| WO2004079013A1 (en) * | 2003-03-03 | 2004-09-16 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Ecto-5’-nucleotidase (cd73) used in the diagnosis and the treatment of pancreatic cancer |
| DE602004027797D1 (de) * | 2003-03-28 | 2010-08-05 | Faron Pharmaceuticals Oy | Erhöhung des adenosin-spiegels durch cytokin-induzierte expression von cd73 |
| FI20030467A0 (fi) * | 2003-03-28 | 2003-03-28 | Sirpa Jalkanen | Menetelmä tulehdustilojen hoitamiseen |
| WO2005000860A2 (en) * | 2003-06-03 | 2005-01-06 | The Regents Of The University Of California | Compositions and methods for treatment of disease with acetylated disaccharides |
| EP1917528B1 (en) * | 2005-08-24 | 2011-08-17 | Bristol-Myers Squibb Company | Biomarkers and methods for determining sensitivity to epidermal growth factor receptor modulators |
| FI20051003A0 (fi) | 2005-10-07 | 2005-10-07 | Faron Pharmaceuticals Oy | Menetelmä iskemiareperfuusiovaurion tai monielinhäiriön hoitamiseksi tai estämiseksi |
| EP2021350B1 (en) * | 2006-03-21 | 2016-12-21 | Rheinische Friedrich-Wilhelms-Universität Bonn | Phosphorylated a2a receptor agonists |
| AU2007273055B2 (en) * | 2006-07-14 | 2014-05-01 | The Regents Of The University Of California | Cancer biomarkers and methods of use thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20150118107A (ko) * | 2013-02-14 | 2015-10-21 | 파론 파머수티컬스 오와이 | 급성 호흡 곤란 증후군 (ards) 관련 바이오마커를 결정하는 방법, 환자의 ards 의 발달을 모니터링하고 치료하는 방법 |
Also Published As
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| DK2201376T3 (da) | 2012-10-15 |
| EP2201376B1 (en) | 2012-08-08 |
| PL2201376T3 (pl) | 2013-01-31 |
| EP2201376A4 (en) | 2011-03-23 |
| CY1113403T1 (el) | 2016-06-22 |
| FI20070795A0 (fi) | 2007-10-24 |
| EP2503338B1 (en) | 2014-12-24 |
| PT2503338E (pt) | 2015-03-05 |
| DK2503338T3 (en) | 2015-03-09 |
| HRP20120743T1 (hr) | 2012-10-31 |
| PL2503338T3 (pl) | 2015-06-30 |
| ES2532361T3 (es) | 2015-03-26 |
| EP2201376A1 (en) | 2010-06-30 |
| CY1116089T1 (el) | 2017-02-08 |
| CA2702635A1 (en) | 2009-04-30 |
| KR20160029869A (ko) | 2016-03-15 |
| ES2389751T3 (es) | 2012-10-31 |
| SI2201376T1 (sl) | 2012-09-28 |
| EP2503338A2 (en) | 2012-09-26 |
| PT2201376E (pt) | 2012-08-20 |
| JP2012159514A (ja) | 2012-08-23 |
| EP2503338A3 (en) | 2013-03-13 |
| JP2011501176A (ja) | 2011-01-06 |
| SI2503338T1 (sl) | 2015-06-30 |
| JP5619810B2 (ja) | 2014-11-05 |
| JP4982610B2 (ja) | 2012-07-25 |
| US20100209942A1 (en) | 2010-08-19 |
| HRP20150181T1 (hr) | 2015-06-19 |
| WO2009053523A1 (en) | 2009-04-30 |
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